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The map label for this gene is msrA [H]

Identifier: 82703567

GI number: 82703567

Start: 2803016

End: 2803492

Strand: Reverse

Name: msrA [H]

Synonym: Nmul_A2452

Alternate gene names: 82703567

Gene position: 2803492-2803016 (Counterclockwise)

Preceding gene: 82703568

Following gene: 82703563

Centisome position: 88.04

GC content: 54.72

Gene sequence:

>477_bases
ATGACAGAAAAAGCGATTTTTGGAGCAGGCTGCTTTTGGGGCGTGGAGGCCGCTTTTCGTGCTGTCAAAGGCGTAAAGGA
GGTTACCAGCGGCTACTCCGGCGGCCATATGAAAAATCCTTCCTATCGCGACGTATGCACTGATAAAACCGGCCACGCCG
AGGTAGTGCAGGTGGAATACGATCCGTCGCAGGTCAGCTATGATGAGTTGCTCGACGTCTTCTGGAACTGCCATAATCCC
ACTACGCTCAACCGGCAGGGACCGGACGTGGGTAAACAGTACCGCTCTGCCATATTCTTTTACACCCCTGAACAGGAGAG
TGCGGCGCGCGCGTCGAAGGAAAAACTGGAGCAAAGCGGCCGCTGGCGCGCCCCGGTCGTGACTGAAATTACACCCGCCT
CAGATTTTTATCCTGCTGAGGAATATCATCAGCGCTACCTCGAAAAGCGCGGTATCTCCGGACACTGCCATATGTAA

Upstream 100 bases:

>100_bases
CCGATTGATTTGCGCGGGGGAAACCCCATTTAACCGATTAAGTGATTGACCGGTGTAGTCAGTCCGTCGAACCGGGTTTA
TATAACGTAGAGGCACAGCA

Downstream 100 bases:

>100_bases
GCGCTGACTAGCCATCAGAAAGCCTCTGCCGGCTTTGCCAAGGCGCAAATTCTAGTCCTCAGGCCGTCGAAGGGGAAAGC
GGCATTCAGGCGAGGCTTCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MTEKAIFGAGCFWGVEAAFRAVKGVKEVTSGYSGGHMKNPSYRDVCTDKTGHAEVVQVEYDPSQVSYDELLDVFWNCHNP
TTLNRQGPDVGKQYRSAIFFYTPEQESAARASKEKLEQSGRWRAPVVTEITPASDFYPAEEYHQRYLEKRGISGHCHM

Sequences:

>Translated_158_residues
MTEKAIFGAGCFWGVEAAFRAVKGVKEVTSGYSGGHMKNPSYRDVCTDKTGHAEVVQVEYDPSQVSYDELLDVFWNCHNP
TTLNRQGPDVGKQYRSAIFFYTPEQESAARASKEKLEQSGRWRAPVVTEITPASDFYPAEEYHQRYLEKRGISGHCHM
>Mature_157_residues
TEKAIFGAGCFWGVEAAFRAVKGVKEVTSGYSGGHMKNPSYRDVCTDKTGHAEVVQVEYDPSQVSYDELLDVFWNCHNPT
TLNRQGPDVGKQYRSAIFFYTPEQESAARASKEKLEQSGRWRAPVVTEITPASDFYPAEEYHQRYLEKRGISGHCHM

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=47.7987421383648, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=47.7987421383648, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=47.787610619469, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=51.9736842105263, Blast_Score=155, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=36.1111111111111, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=151, Percent_Identity=39.0728476821192, Blast_Score=107, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=44.4444444444444, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=43.0555555555556, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=43.1654676258993, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 17848; Mature: 17717

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKAIFGAGCFWGVEAAFRAVKGVKEVTSGYSGGHMKNPSYRDVCTDKTGHAEVVQVEY
CCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEE
DPSQVSYDELLDVFWNCHNPTTLNRQGPDVGKQYRSAIFFYTPEQESAARASKEKLEQSG
CCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCC
RWRAPVVTEITPASDFYPAEEYHQRYLEKRGISGHCHM
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TEKAIFGAGCFWGVEAAFRAVKGVKEVTSGYSGGHMKNPSYRDVCTDKTGHAEVVQVEY
CCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEE
DPSQVSYDELLDVFWNCHNPTTLNRQGPDVGKQYRSAIFFYTPEQESAARASKEKLEQSG
CCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCC
RWRAPVVTEITPASDFYPAEEYHQRYLEKRGISGHCHM
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA