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The map label for this gene is ndk

Identifier: 82703495

GI number: 82703495

Start: 2707572

End: 2707997

Strand: Reverse

Name: ndk

Synonym: Nmul_A2380

Alternate gene names: 82703495

Gene position: 2707997-2707572 (Counterclockwise)

Preceding gene: 82703496

Following gene: 82703494

Centisome position: 85.04

GC content: 50.23

Gene sequence:

>426_bases
ATGGCTGTCGAACGAACCCTGTCTATCATCAAGCCGGATGCAGTGGCAAAAAATATAATAGGAGAAATTTACTCCCGCTT
TGAACGGAACGGACTGAAAATAGTCGCATCACGGATGGTGCGTCTATCCCAGGCTGATGCTGAGGGTTTTTATGCAGTCC
ACCGGGAACGGCCGTTCTTCAATGATCTGGTGAAATTCATGATTTCCGGTCCCGTCATGGTACAGGTACTGGAAGGTGAG
GATGCCATCAGAAAAAACCGGGATCTGATGGGGGCGACCGATCCGAGGAAGGCCGAAAAGGGGACGATTCGGGCAGATTT
TGCCGAGAGTATCGATGCAAACGCTGTGCATGGCTCGGATGCACCTGAAACAGCGGCGGTTGAGATCGCCTATTTTTTTC
CGGAACTCAACATTTATACGCGATAA

Upstream 100 bases:

>100_bases
GAGCGCGTCCTCCACCGCCAGCATATCGGTCCAATTTAGGGACTTTAAAGCTGGTTCTTGTTAGAATAATAAAGATTTAC
ATAATTACTTGGAGTATTTG

Downstream 100 bases:

>100_bases
GGGGGATCACGGCTCAGGTATGAGCATCAATCTTCTGGATTTTGATGCGAAAGGGCTTACCGGTTTCTGTGCGGAAATCG
GTGAGAAGCCGTTCCGCGCC

Product: nucleoside-diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAVERTLSIIKPDAVAKNIIGEIYSRFERNGLKIVASRMVRLSQADAEGFYAVHRERPFFNDLVKFMISGPVMVQVLEGE
DAIRKNRDLMGATDPRKAEKGTIRADFAESIDANAVHGSDAPETAAVEIAYFFPELNIYTR

Sequences:

>Translated_141_residues
MAVERTLSIIKPDAVAKNIIGEIYSRFERNGLKIVASRMVRLSQADAEGFYAVHRERPFFNDLVKFMISGPVMVQVLEGE
DAIRKNRDLMGATDPRKAEKGTIRADFAESIDANAVHGSDAPETAAVEIAYFFPELNIYTR
>Mature_140_residues
AVERTLSIIKPDAVAKNIIGEIYSRFERNGLKIVASRMVRLSQADAEGFYAVHRERPFFNDLVKFMISGPVMVQVLEGED
AIRKNRDLMGATDPRKAEKGTIRADFAESIDANAVHGSDAPETAAVEIAYFFPELNIYTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=48.4848484848485, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392227, Length=134, Percent_Identity=41.7910447761194, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392205, Length=134, Percent_Identity=41.7910447761194, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4505409, Length=134, Percent_Identity=41.7910447761194, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392192, Length=134, Percent_Identity=41.7910447761194, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392203, Length=134, Percent_Identity=41.7910447761194, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI38045913, Length=134, Percent_Identity=41.044776119403, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=41.044776119403, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=39.2307692307692, Blast_Score=109, Evalue=9e-25,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=38.1294964028777, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=38.1294964028777, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=38.5714285714286, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=35.9712230215827, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=35.036496350365, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI148839372, Length=141, Percent_Identity=29.7872340425532, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=57.4468085106383, Blast_Score=175, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=41.726618705036, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=131, Percent_Identity=41.9847328244275, Blast_Score=120, Evalue=8e-29,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=43.0656934306569, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24645457, Length=136, Percent_Identity=33.0882352941176, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=32.6086956521739, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_NITMU (Q2Y6F2)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_413061.1
- ProteinModelPortal:   Q2Y6F2
- SMR:   Q2Y6F2
- STRING:   Q2Y6F2
- GeneID:   3784971
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2380
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- PhylomeDB:   Q2Y6F2
- BioCyc:   NMUL323848:NMUL_A2380-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15750; Mature: 15619

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVERTLSIIKPDAVAKNIIGEIYSRFERNGLKIVASRMVRLSQADAEGFYAVHRERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCH
NDLVKFMISGPVMVQVLEGEDAIRKNRDLMGATDPRKAEKGTIRADFAESIDANAVHGSD
HHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCCCCC
APETAAVEIAYFFPELNIYTR
CCCHHEEEEEEECCCCEEECC
>Mature Secondary Structure 
AVERTLSIIKPDAVAKNIIGEIYSRFERNGLKIVASRMVRLSQADAEGFYAVHRERPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCH
NDLVKFMISGPVMVQVLEGEDAIRKNRDLMGATDPRKAEKGTIRADFAESIDANAVHGSD
HHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCCCCC
APETAAVEIAYFFPELNIYTR
CCCHHEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA