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The map label for this gene is yciK [H]

Identifier: 82703459

GI number: 82703459

Start: 2669290

End: 2670036

Strand: Reverse

Name: yciK [H]

Synonym: Nmul_A2342

Alternate gene names: 82703459

Gene position: 2670036-2669290 (Counterclockwise)

Preceding gene: 82703460

Following gene: 82703458

Centisome position: 83.85

GC content: 56.09

Gene sequence:

>747_bases
ATGAACGATTTGAAAAACTACATTGCACCGAACGACCTGCTCAAGGATCGTGTGATCCTGGTTACCGGCGCGGGTCAGGG
TATCGGTCGAACGGCCGCGTTGACATATGCTGCCCATGGCGCCACGGTTATCTTGCACGGTCGGAACGTGAAGAAACTGG
AAAGCGTCTATGACGAAATCGAGGCAGGAGGCGGGGCTCAGCCGTCAATTTTTCCGCTGGATCTGGAAAAAGCGGGGGAC
AAGGATTTTGCCGCTATTGCCCATGCCATTAAATTGCAGTTAGGCAGGCTGGATGGCATTCTGCATAATGCGGCGTTATT
ATTCAACCTGACACCGCTGGAGACGCAGACGCTGGAAGAATGGCTCGCCTTGCTGCGCGTCAACCTCATTGCGCCGTTTG
CCTTGACCCGCGCCTGCCTTCCGCTGCTGAAAGCTTCCCCCGATGCAAGCGTCATTATGACATCCGATGCGCACGGACAT
GTTCCCGCCGCCTACTGGGGTGGTTTCGCGGTAGCCAAGGCAGGAGTGGAGGCGCTGGTCAAGATCCAGGCGCAGGAGTG
GGAAATCCTTCCCACTCTGCGTATCAATACCTTGATTCCAGGGCCTGTGCATACGCCCCAGCGAACCAGAACGCACCCGG
GTGAAGTCAAGCAGAGTTTGAGCCAGCCGCAGGAGCTGATGTCCTGCTATTTGTATCTCATGGGTCCTGACAGCAAAGCG
GTCAGTGGCCAAACGATATTCTGCTAG

Upstream 100 bases:

>100_bases
CCAAAGGCACTTTCCATGGAGCCTTCATCGCTGTAAACCGGGAGCAACCTCTTAACGGAATTTGTTTCCAGCCGTAAGTA
TCTAGCCGTAAGTATCTTCT

Downstream 100 bases:

>100_bases
GGTGTTACTGCCCGTCGCGACGCTGTCCTCCATGCCGCCAAACTTGCCCGAGGCGCATGGCTGCTGTCGGAGGGAGAAAC
GGGTATAATTGTGTCCAGTT

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNDLKNYIAPNDLLKDRVILVTGAGQGIGRTAALTYAAHGATVILHGRNVKKLESVYDEIEAGGGAQPSIFPLDLEKAGD
KDFAAIAHAIKLQLGRLDGILHNAALLFNLTPLETQTLEEWLALLRVNLIAPFALTRACLPLLKASPDASVIMTSDAHGH
VPAAYWGGFAVAKAGVEALVKIQAQEWEILPTLRINTLIPGPVHTPQRTRTHPGEVKQSLSQPQELMSCYLYLMGPDSKA
VSGQTIFC

Sequences:

>Translated_248_residues
MNDLKNYIAPNDLLKDRVILVTGAGQGIGRTAALTYAAHGATVILHGRNVKKLESVYDEIEAGGGAQPSIFPLDLEKAGD
KDFAAIAHAIKLQLGRLDGILHNAALLFNLTPLETQTLEEWLALLRVNLIAPFALTRACLPLLKASPDASVIMTSDAHGH
VPAAYWGGFAVAKAGVEALVKIQAQEWEILPTLRINTLIPGPVHTPQRTRTHPGEVKQSLSQPQELMSCYLYLMGPDSKA
VSGQTIFC
>Mature_248_residues
MNDLKNYIAPNDLLKDRVILVTGAGQGIGRTAALTYAAHGATVILHGRNVKKLESVYDEIEAGGGAQPSIFPLDLEKAGD
KDFAAIAHAIKLQLGRLDGILHNAALLFNLTPLETQTLEEWLALLRVNLIAPFALTRACLPLLKASPDASVIMTSDAHGH
VPAAYWGGFAVAKAGVEALVKIQAQEWEILPTLRINTLIPGPVHTPQRTRTHPGEVKQSLSQPQELMSCYLYLMGPDSKA
VSGQTIFC

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=24.8062015503876, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI20149619, Length=200, Percent_Identity=26, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706318, Length=214, Percent_Identity=23.8317757009346, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4504505, Length=193, Percent_Identity=30.0518134715026, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=26.4227642276423, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=24.2914979757085, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1787526, Length=241, Percent_Identity=42.3236514522822, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789378, Length=263, Percent_Identity=28.5171102661597, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082100, Length=197, Percent_Identity=31.4720812182741, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=24.3801652892562, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=24.4979919678715, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=199, Percent_Identity=28.643216080402, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=193, Percent_Identity=27.4611398963731, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=185, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=26.8, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=201, Percent_Identity=29.8507462686567, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=220, Percent_Identity=31.3636363636364, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=194, Percent_Identity=27.319587628866, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=243, Percent_Identity=27.5720164609054, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=199, Percent_Identity=29.6482412060301, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=208, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=196, Percent_Identity=25.5102040816327, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=192, Percent_Identity=26.5625, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=245, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322227, Length=194, Percent_Identity=27.8350515463918, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=35.7142857142857, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571526, Length=198, Percent_Identity=30.8080808080808, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24644339, Length=194, Percent_Identity=29.3814432989691, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21357041, Length=227, Percent_Identity=28.1938325991189, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI18859837, Length=179, Percent_Identity=30.1675977653631, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26686; Mature: 26686

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLKNYIAPNDLLKDRVILVTGAGQGIGRTAALTYAAHGATVILHGRNVKKLESVYDEI
CCCHHHHCCCCHHHCCCEEEEEECCCCCCCHHHEEEECCCCEEEEECCCHHHHHHHHHHH
EAGGGAQPSIFPLDLEKAGDKDFAAIAHAIKLQLGRLDGILHNAALLFNLTPLETQTLEE
HCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHH
WLALLRVNLIAPFALTRACLPLLKASPDASVIMTSDAHGHVPAAYWGGFAVAKAGVEALV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KIQAQEWEILPTLRINTLIPGPVHTPQRTRTHPGEVKQSLSQPQELMSCYLYLMGPDSKA
EEECCCEEEECEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHEEEEEECCCCCC
VSGQTIFC
CCCCEECC
>Mature Secondary Structure
MNDLKNYIAPNDLLKDRVILVTGAGQGIGRTAALTYAAHGATVILHGRNVKKLESVYDEI
CCCHHHHCCCCHHHCCCEEEEEECCCCCCCHHHEEEECCCCEEEEECCCHHHHHHHHHHH
EAGGGAQPSIFPLDLEKAGDKDFAAIAHAIKLQLGRLDGILHNAALLFNLTPLETQTLEE
HCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHH
WLALLRVNLIAPFALTRACLPLLKASPDASVIMTSDAHGHVPAAYWGGFAVAKAGVEALV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KIQAQEWEILPTLRINTLIPGPVHTPQRTRTHPGEVKQSLSQPQELMSCYLYLMGPDSKA
EEECCCEEEECEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHEEEEEECCCCCC
VSGQTIFC
CCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]