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The map label for this gene is ppiD [H]

Identifier: 82703453

GI number: 82703453

Start: 2660638

End: 2662518

Strand: Reverse

Name: ppiD [H]

Synonym: Nmul_A2336

Alternate gene names: 82703453

Gene position: 2662518-2660638 (Counterclockwise)

Preceding gene: 82703454

Following gene: 82703451

Centisome position: 83.62

GC content: 54.17

Gene sequence:

>1881_bases
ATGTTTGATTTCGTCAACAAGAAAAGACGCATCGTTCAGATCATCCTGGGACTTGCCACGTTACCGTTCGTTTTCTGGGG
TGTGGAATCCTATCGCAATGCGGATGCAGGTGACCATGTTGCGCTTGCCGCAGGAGAAAAAATTTCCCGCCAGGAATTTG
AGCAGGCGCTGCGCAACCAGCAGGAGAATATGCGCGCCACCCTGGGAGAGAATTTCAGCCCGGCGCTGCTGGAAAAGCCC
GAAGTGAGAGCGGCCATCCTGGAAGGACTGATCCAGCAGCGCTTGCTGCGGCAGGAGGCATCTCGCGTTGGACTAGGGGT
AGCCGACGCCCAGCTGATCGAGATGATCCAGAACATCGATTTATTTCAGGAAGACGGAAATTTTTCGAAGCAGCGCTATG
AAGAATGGCTGCGGAACCAGGGAATGAACGCGCGTGCTTTTGAAGCACGCCTGCGTCAGGATTTAATGCGACAGCAACTG
GTTGATCCTTTCTCCAAAAATGCGTTTATTTCCCATTCAGTGGCGGAAAGAATCCTGCGCCTGGGTGACGAAAAGCGTGA
AGTGAGGGTTGTTCAAATCCAACCGGAGCAGTTTCTGGCGAATGTCAAACCGGGTAATGACGCCATCAGAGCCTACTATG
AGGCGCATAAGGCTGAATTCCAGGTGCCGGAGCAGGCGCGGGTCGAGTATGTAGTGTTATCGATGGATGCGCTGGCCGAG
AAGGCGCAGGTAACTGCGGATGAAGCGCTGGCCTATTACGAGGAGCACAAGCACGAATTCGGACAACCCGAAGAACGCCG
CGCGAGTCATATCCTCATAAGCGCCCCTGCCTCCGCTTCCGATCGCGCGACAGCGCGCGCCAAAGCTGAGGAACTGCTGG
CCGAAGTCAGAAAATCCCCGCAGCGTTTTACGGAATTGGCGAAACAGCATTCCCAGGATCCGGGCTCGGCGCCGACCGGG
GGAGATCTCGGTTTCTTCGCGCGCAACATGATGACGAAGTCATTTGAAGACGCGGTTTTCCGGATGAAGCCGGGTGAAAT
CAGCGATATCGTGGAGACTGAGCATGGATTTCATATCATCCTGCTCGCGGAGGCAAGAGGCGGAAAGCAGGCGAGTCTCG
AGGAAGTGAAGAAGCAGGTTGAACAGGAAGTCAGGAAACAGAAAGCTGCAAAGACGTTTGGTGAAATGGCGGACAGCTTC
AGTAACATGGTGTATGAGCAGAGCGATAGCCTGAAACCGGTCGCGGAAAGTCTTGGCTTGACCATACAGGAGAGCGGCTG
GATTCGGATGAACTCGGATGAGCCACCTTATCTCAACAATGCACGGTTGCTTCAGGCAATATTTTCGGAAGACGCGATCA
AGGATAAACGCAACACGGAGGCGATCGAAGTTTCTTCCAACACGCTTGTTTCGGCCAGAGTGGTGGACTACAAACCGGCC
GCTACTCCTTCTGTGGATGAATTGAGGGATAAAATCGCGGCGTTGGTCGCCCGGGAGGAGGCTTCCAGAGCGGCGATAAA
TGAAGGGAAGGAGCAGCTTGCGCAACTGCAGCAGGGAAAGACTGCCCCAATCAAATGGACTCCCGGCCAGCAGGTTTCCA
GAAGGGAGCGCCAGGGTTTTGACAATGAGACGGTGCAGGCGATTTTCAGGGCTGAAACAAATCATCTCCCGGCCTATTCA
GGCCTGCCGAATGCCCAAGGTGGTTTTACCCTGATTCGCGTTGACCGGGTCATCGAGTCACGGCCGCCCAGCGCAGAGGA
GCGAAAAACTTTTGCAGGTCAACTGAGCCAGTTGTTCGCCCAGGAAGAGTTTTCATCCTATCTGGATGGAATCAAGAAAA
GGTATGATGTATCGGTCAGGAGTGAAAGCCTCGAGAAATAG

Upstream 100 bases:

>100_bases
CACGCCGGGGGTCGCGGGTTCGAGTCCCGTCCACTCCGCCATATCTGTTTCCATCAGGGCGAACGCGAGTTCGCCTTTTT
TATTCGTTTTCCGTCATTCC

Downstream 100 bases:

>100_bases
GCATGCTCCGGGATTAGAGGGTATCGAAGGCAATCGTGTTGAATCCGGCATCGACATGGGTAATTTCGCCTGTTATGCCG
CTTGCCAGATCACTGCATAG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MFDFVNKKRRIVQIILGLATLPFVFWGVESYRNADAGDHVALAAGEKISRQEFEQALRNQQENMRATLGENFSPALLEKP
EVRAAILEGLIQQRLLRQEASRVGLGVADAQLIEMIQNIDLFQEDGNFSKQRYEEWLRNQGMNARAFEARLRQDLMRQQL
VDPFSKNAFISHSVAERILRLGDEKREVRVVQIQPEQFLANVKPGNDAIRAYYEAHKAEFQVPEQARVEYVVLSMDALAE
KAQVTADEALAYYEEHKHEFGQPEERRASHILISAPASASDRATARAKAEELLAEVRKSPQRFTELAKQHSQDPGSAPTG
GDLGFFARNMMTKSFEDAVFRMKPGEISDIVETEHGFHIILLAEARGGKQASLEEVKKQVEQEVRKQKAAKTFGEMADSF
SNMVYEQSDSLKPVAESLGLTIQESGWIRMNSDEPPYLNNARLLQAIFSEDAIKDKRNTEAIEVSSNTLVSARVVDYKPA
ATPSVDELRDKIAALVAREEASRAAINEGKEQLAQLQQGKTAPIKWTPGQQVSRRERQGFDNETVQAIFRAETNHLPAYS
GLPNAQGGFTLIRVDRVIESRPPSAEERKTFAGQLSQLFAQEEFSSYLDGIKKRYDVSVRSESLEK

Sequences:

>Translated_626_residues
MFDFVNKKRRIVQIILGLATLPFVFWGVESYRNADAGDHVALAAGEKISRQEFEQALRNQQENMRATLGENFSPALLEKP
EVRAAILEGLIQQRLLRQEASRVGLGVADAQLIEMIQNIDLFQEDGNFSKQRYEEWLRNQGMNARAFEARLRQDLMRQQL
VDPFSKNAFISHSVAERILRLGDEKREVRVVQIQPEQFLANVKPGNDAIRAYYEAHKAEFQVPEQARVEYVVLSMDALAE
KAQVTADEALAYYEEHKHEFGQPEERRASHILISAPASASDRATARAKAEELLAEVRKSPQRFTELAKQHSQDPGSAPTG
GDLGFFARNMMTKSFEDAVFRMKPGEISDIVETEHGFHIILLAEARGGKQASLEEVKKQVEQEVRKQKAAKTFGEMADSF
SNMVYEQSDSLKPVAESLGLTIQESGWIRMNSDEPPYLNNARLLQAIFSEDAIKDKRNTEAIEVSSNTLVSARVVDYKPA
ATPSVDELRDKIAALVAREEASRAAINEGKEQLAQLQQGKTAPIKWTPGQQVSRRERQGFDNETVQAIFRAETNHLPAYS
GLPNAQGGFTLIRVDRVIESRPPSAEERKTFAGQLSQLFAQEEFSSYLDGIKKRYDVSVRSESLEK
>Mature_626_residues
MFDFVNKKRRIVQIILGLATLPFVFWGVESYRNADAGDHVALAAGEKISRQEFEQALRNQQENMRATLGENFSPALLEKP
EVRAAILEGLIQQRLLRQEASRVGLGVADAQLIEMIQNIDLFQEDGNFSKQRYEEWLRNQGMNARAFEARLRQDLMRQQL
VDPFSKNAFISHSVAERILRLGDEKREVRVVQIQPEQFLANVKPGNDAIRAYYEAHKAEFQVPEQARVEYVVLSMDALAE
KAQVTADEALAYYEEHKHEFGQPEERRASHILISAPASASDRATARAKAEELLAEVRKSPQRFTELAKQHSQDPGSAPTG
GDLGFFARNMMTKSFEDAVFRMKPGEISDIVETEHGFHIILLAEARGGKQASLEEVKKQVEQEVRKQKAAKTFGEMADSF
SNMVYEQSDSLKPVAESLGLTIQESGWIRMNSDEPPYLNNARLLQAIFSEDAIKDKRNTEAIEVSSNTLVSARVVDYKPA
ATPSVDELRDKIAALVAREEASRAAINEGKEQLAQLQQGKTAPIKWTPGQQVSRRERQGFDNETVQAIFRAETNHLPAYS
GLPNAQGGFTLIRVDRVIESRPPSAEERKTFAGQLSQLFAQEEFSSYLDGIKKRYDVSVRSESLEK

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=115, Percent_Identity=38.2608695652174, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786645, Length=631, Percent_Identity=25.8320126782884, Blast_Score=202, Evalue=7e-53,
Organism=Escherichia coli, GI1786238, Length=102, Percent_Identity=37.2549019607843, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322478, Length=118, Percent_Identity=39.8305084745763, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 70485; Mature: 70485

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDFVNKKRRIVQIILGLATLPFVFWGVESYRNADAGDHVALAAGEKISRQEFEQALRNQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHH
QENMRATLGENFSPALLEKPEVRAAILEGLIQQRLLRQEASRVGLGVADAQLIEMIQNID
HHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCH
LFQEDGNFSKQRYEEWLRNQGMNARAFEARLRQDLMRQQLVDPFSKNAFISHSVAERILR
HHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHH
LGDEKREVRVVQIQPEQFLANVKPGNDAIRAYYEAHKAEFQVPEQARVEYVVLSMDALAE
CCCCCCCEEEEEECHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEHHHHHH
KAQVTADEALAYYEEHKHEFGQPEERRASHILISAPASASDRATARAKAEELLAEVRKSP
HHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCH
QRFTELAKQHSQDPGSAPTGGDLGFFARNMMTKSFEDAVFRMKPGEISDIVETEHGFHII
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEE
LLAEARGGKQASLEEVKKQVEQEVRKQKAAKTFGEMADSFSNMVYEQSDSLKPVAESLGL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
TIQESGWIRMNSDEPPYLNNARLLQAIFSEDAIKDKRNTEAIEVSSNTLVSARVVDYKPA
EEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCC
ATPSVDELRDKIAALVAREEASRAAINEGKEQLAQLQQGKTAPIKWTPGQQVSRRERQGF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHCCC
DNETVQAIFRAETNHLPAYSGLPNAQGGFTLIRVDRVIESRPPSAEERKTFAGQLSQLFA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHH
QEEFSSYLDGIKKRYDVSVRSESLEK
HHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure
MFDFVNKKRRIVQIILGLATLPFVFWGVESYRNADAGDHVALAAGEKISRQEFEQALRNQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHH
QENMRATLGENFSPALLEKPEVRAAILEGLIQQRLLRQEASRVGLGVADAQLIEMIQNID
HHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCH
LFQEDGNFSKQRYEEWLRNQGMNARAFEARLRQDLMRQQLVDPFSKNAFISHSVAERILR
HHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHH
LGDEKREVRVVQIQPEQFLANVKPGNDAIRAYYEAHKAEFQVPEQARVEYVVLSMDALAE
CCCCCCCEEEEEECHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEHHHHHH
KAQVTADEALAYYEEHKHEFGQPEERRASHILISAPASASDRATARAKAEELLAEVRKSP
HHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCH
QRFTELAKQHSQDPGSAPTGGDLGFFARNMMTKSFEDAVFRMKPGEISDIVETEHGFHII
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEE
LLAEARGGKQASLEEVKKQVEQEVRKQKAAKTFGEMADSFSNMVYEQSDSLKPVAESLGL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
TIQESGWIRMNSDEPPYLNNARLLQAIFSEDAIKDKRNTEAIEVSSNTLVSARVVDYKPA
EEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCC
ATPSVDELRDKIAALVAREEASRAAINEGKEQLAQLQQGKTAPIKWTPGQQVSRRERQGF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHCCC
DNETVQAIFRAETNHLPAYSGLPNAQGGFTLIRVDRVIESRPPSAEERKTFAGQLSQLFA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHH
QEEFSSYLDGIKKRYDVSVRSESLEK
HHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]