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The map label for this gene is yeiG [H]

Identifier: 82703391

GI number: 82703391

Start: 2584476

End: 2585345

Strand: Direct

Name: yeiG [H]

Synonym: Nmul_A2273

Alternate gene names: 82703391

Gene position: 2584476-2585345 (Clockwise)

Preceding gene: 82703390

Following gene: 82703392

Centisome position: 81.16

GC content: 53.33

Gene sequence:

>870_bases
ATGAATCAGAATCCAGAGGAGTTGCAATTTCTCTCATCGCATCGTTCGTTCGACGGATGGCAAAAACGCTACAGACACTT
TTCGCCATCGCTGAACTGCGAAATGAATTTTTCCATCTATCTTCCACCGGCGACAGACCAGGGCGAAAAGGTGCCCGCTG
TCTACTGGCTGTCCGGCTTGACCTGCACGGACGAGAACTTCACGATTAAGGCCGGGGCGCAGCGAGGGGCGGCAGAATAT
GGCATCGCGCTGATCATGCCAGATACCAGTCCGCGGGGAGAAAAAGTGGCGCGAGCAATCGATCATGCCTACGACTTGGG
CCTGGGCGCGGGTTTCTACGTGAATGCCACGCAGGAGCCATGGAGCCGGCATTACCGGATGTATGACTATATCGTCGATG
AGTTGCCGGCCCTGATGGAGAAACACTTTCCACTCGATGACCGGCGATCGATCAGCGGTCATTCGATGGGGGGGCATGGC
GCTTTGATGATCGCCTTGCGCAATCCGCAGCGCTATCGGTCAGTATCCGCCTTTTCACCTATTGTGAATCCCACCACCAG
TCCGTGGGGCATAAAGGCTTTCAGTCACTATCTGGGAGATGACGTCAAGAACTGGTGGAACTATGACGCCTCTTTGCTTA
TAGAATCTGCACGTCCACGGGAGTATCTCCCCATGCTGATCGACCAGGGGTCTGCTGATGAGTTTCTGGCCGAGCAACTG
AAAATCGAACGCTTTATCGCAGCATGTAATACAGCGAATTACCCTGTGCAAATCAACATGCGCGAAGGCTACGATCATAG
CTATTTCTTTATCAGCACGTTTATCGGAGAGCACTTGCGTTTTCACGCACGCGCCCTCAAGAATCCTTGA

Upstream 100 bases:

>100_bases
AAGGCATTCGACCTCATGCATGAGGGCAAGTCCATCCGAACGGTGATACATTTCGACAAATGATCTGTACGGTTTCCGTT
AACCGCAAAGGTTTGTATCC

Downstream 100 bases:

>100_bases
ATAGATTTCCTGAACCTGTAAACGGAATATTCCCGTCCCCATCCCCTACGATAAGGGTGCGACAATTTGCCACATTCCCA
GAGGGGTGAAAATCCATTAT

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNQNPEELQFLSSHRSFDGWQKRYRHFSPSLNCEMNFSIYLPPATDQGEKVPAVYWLSGLTCTDENFTIKAGAQRGAAEY
GIALIMPDTSPRGEKVARAIDHAYDLGLGAGFYVNATQEPWSRHYRMYDYIVDELPALMEKHFPLDDRRSISGHSMGGHG
ALMIALRNPQRYRSVSAFSPIVNPTTSPWGIKAFSHYLGDDVKNWWNYDASLLIESARPREYLPMLIDQGSADEFLAEQL
KIERFIAACNTANYPVQINMREGYDHSYFFISTFIGEHLRFHARALKNP

Sequences:

>Translated_289_residues
MNQNPEELQFLSSHRSFDGWQKRYRHFSPSLNCEMNFSIYLPPATDQGEKVPAVYWLSGLTCTDENFTIKAGAQRGAAEY
GIALIMPDTSPRGEKVARAIDHAYDLGLGAGFYVNATQEPWSRHYRMYDYIVDELPALMEKHFPLDDRRSISGHSMGGHG
ALMIALRNPQRYRSVSAFSPIVNPTTSPWGIKAFSHYLGDDVKNWWNYDASLLIESARPREYLPMLIDQGSADEFLAEQL
KIERFIAACNTANYPVQINMREGYDHSYFFISTFIGEHLRFHARALKNP
>Mature_289_residues
MNQNPEELQFLSSHRSFDGWQKRYRHFSPSLNCEMNFSIYLPPATDQGEKVPAVYWLSGLTCTDENFTIKAGAQRGAAEY
GIALIMPDTSPRGEKVARAIDHAYDLGLGAGFYVNATQEPWSRHYRMYDYIVDELPALMEKHFPLDDRRSISGHSMGGHG
ALMIALRNPQRYRSVSAFSPIVNPTTSPWGIKAFSHYLGDDVKNWWNYDASLLIESARPREYLPMLIDQGSADEFLAEQL
KIERFIAACNTANYPVQINMREGYDHSYFFISTFIGEHLRFHARALKNP

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=53.7366548042705, Blast_Score=314, Evalue=7e-86,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=58.7813620071685, Blast_Score=341, Evalue=3e-95,
Organism=Escherichia coli, GI1786551, Length=280, Percent_Identity=53.9285714285714, Blast_Score=315, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=47.8723404255319, Blast_Score=249, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6322393, Length=281, Percent_Identity=46.6192170818505, Blast_Score=238, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24648347, Length=284, Percent_Identity=49.6478873239437, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=49.6478873239437, Blast_Score=282, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 33015; Mature: 33015

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNPEELQFLSSHRSFDGWQKRYRHFSPSLNCEMNFSIYLPPATDQGEKVPAVYWLSGL
CCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCE
TCTDENFTIKAGAQRGAAEYGIALIMPDTSPRGEKVARAIDHAYDLGLGAGFYVNATQEP
EECCCCEEEECCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCH
WSRHYRMYDYIVDELPALMEKHFPLDDRRSISGHSMGGHGALMIALRNPQRYRSVSAFSP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCC
IVNPTTSPWGIKAFSHYLGDDVKNWWNYDASLLIESARPREYLPMLIDQGSADEFLAEQL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCHHHHHHHHH
KIERFIAACNTANYPVQINMREGYDHSYFFISTFIGEHLRFHARALKNP
HHHHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQNPEELQFLSSHRSFDGWQKRYRHFSPSLNCEMNFSIYLPPATDQGEKVPAVYWLSGL
CCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCE
TCTDENFTIKAGAQRGAAEYGIALIMPDTSPRGEKVARAIDHAYDLGLGAGFYVNATQEP
EECCCCEEEECCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCH
WSRHYRMYDYIVDELPALMEKHFPLDDRRSISGHSMGGHGALMIALRNPQRYRSVSAFSP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCC
IVNPTTSPWGIKAFSHYLGDDVKNWWNYDASLLIESARPREYLPMLIDQGSADEFLAEQL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCHHHHHHHHH
KIERFIAACNTANYPVQINMREGYDHSYFFISTFIGEHLRFHARALKNP
HHHHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA