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The map label for this gene is frmA [H]

Identifier: 82703390

GI number: 82703390

Start: 2583314

End: 2584438

Strand: Direct

Name: frmA [H]

Synonym: Nmul_A2272

Alternate gene names: 82703390

Gene position: 2583314-2584438 (Clockwise)

Preceding gene: 82703383

Following gene: 82703391

Centisome position: 81.13

GC content: 56.53

Gene sequence:

>1125_bases
ATGGATACGATAAAAACCCGCGCGGCAGTAGCTTGGGGACCAGGCCAGCCTTTGAAGATCGAGGAAGTGGACTTGATGCC
GCCAAGGAAAGGTGAGGTGCTGGTGCGCATAGTCGCCACGGGAGTCTGTCATACAGACGCATATACTTTGTCCGGAAAAG
ACCCCGAAGGCAAATTTCCAGCTATTCTGGGGCATGAAGGCGGCGGCATCGTCGAGGCGGTCGGCGACGGGGTAACCAGC
GTGGCGGTAGGCGATCATGTCATCCCGTTGTATACCCCCGAATGCCGCGAGTGCAAGTTCTGCAGATCGGGGAAAACCAA
CCTGTGCCAGGCGATAAGGACAACCCAGGGACAGGGGCTGATGCCGGACGGCACTACCCGTTTTTCGAAGGATGGAAAAC
CCATTTATCATTACATGGGCACCTCGACTTTTTCCGAATATACGGTAATCCCTGAGATTGCATTGGCCAGGATCAGCAAG
GAAGCGCCGCTGGAAAAGGTCTGCCTGCTCGGCTGCGGCGTTACCACCGGCTTGGGCGCGGTGACCCATACTGCAAAGGT
AAAGGCAGGCGATACGGTAGCGGTATTCGGGCTGGGCGGCATAGGCCTTGCCGTGATAATCGGGGCCGTGATGGCCAAAG
CTGGACGCATCATCGCTATCGACATCAATCCGGACAAATTTGAAATTGCGCGCCAACTGGGCGCTACCGACGTGGTGAAT
CCCCAAGATCACGACAAGCCGATCCAGGAGGTGATCATCGGGATGACCGGGGGAGGCGTGGATTTTTCCTTCGAATGCAT
CGGCAACGTAAAGGTCATGCGATCGGCCCTGGAATGCTGTCATAAGGGTTGGGGGGAGTCGGTGATTATCGGCGTTGCCG
GGGCGGGAGAAGAAATCTGCACGCGCCCCTTTCAGCTCGTTACCGGCCGCGTCTGGCGCGGCTCCGCTTTTGGGGGAGTG
AAGGGCCGCAGCGAACTGCCCGGCTATGTACAGCGCTATCTTGATGGAGAATTCGAACTGGATACCTTCATTACCCACAC
GATGGGATTGGAGGATATCAATAAGGCATTCGACCTCATGCATGAGGGCAAGTCCATCCGAACGGTGATACATTTCGACA
AATGA

Upstream 100 bases:

>100_bases
ATACCGATTATTCATACCTCGTTTTCGTACCTCATTTGTAAGTCGCCCGCTTCCTCCTGCATACTAGCGAGATCATGCAA
AAATAAGGAGCATGCGTTAC

Downstream 100 bases:

>100_bases
TCTGTACGGTTTCCGTTAACCGCAAAGGTTTGTATCCATGAATCAGAATCCAGAGGAGTTGCAATTTCTCTCATCGCATC
GTTCGTTCGACGGATGGCAA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MDTIKTRAAVAWGPGQPLKIEEVDLMPPRKGEVLVRIVATGVCHTDAYTLSGKDPEGKFPAILGHEGGGIVEAVGDGVTS
VAVGDHVIPLYTPECRECKFCRSGKTNLCQAIRTTQGQGLMPDGTTRFSKDGKPIYHYMGTSTFSEYTVIPEIALARISK
EAPLEKVCLLGCGVTTGLGAVTHTAKVKAGDTVAVFGLGGIGLAVIIGAVMAKAGRIIAIDINPDKFEIARQLGATDVVN
PQDHDKPIQEVIIGMTGGGVDFSFECIGNVKVMRSALECCHKGWGESVIIGVAGAGEEICTRPFQLVTGRVWRGSAFGGV
KGRSELPGYVQRYLDGEFELDTFITHTMGLEDINKAFDLMHEGKSIRTVIHFDK

Sequences:

>Translated_374_residues
MDTIKTRAAVAWGPGQPLKIEEVDLMPPRKGEVLVRIVATGVCHTDAYTLSGKDPEGKFPAILGHEGGGIVEAVGDGVTS
VAVGDHVIPLYTPECRECKFCRSGKTNLCQAIRTTQGQGLMPDGTTRFSKDGKPIYHYMGTSTFSEYTVIPEIALARISK
EAPLEKVCLLGCGVTTGLGAVTHTAKVKAGDTVAVFGLGGIGLAVIIGAVMAKAGRIIAIDINPDKFEIARQLGATDVVN
PQDHDKPIQEVIIGMTGGGVDFSFECIGNVKVMRSALECCHKGWGESVIIGVAGAGEEICTRPFQLVTGRVWRGSAFGGV
KGRSELPGYVQRYLDGEFELDTFITHTMGLEDINKAFDLMHEGKSIRTVIHFDK
>Mature_374_residues
MDTIKTRAAVAWGPGQPLKIEEVDLMPPRKGEVLVRIVATGVCHTDAYTLSGKDPEGKFPAILGHEGGGIVEAVGDGVTS
VAVGDHVIPLYTPECRECKFCRSGKTNLCQAIRTTQGQGLMPDGTTRFSKDGKPIYHYMGTSTFSEYTVIPEIALARISK
EAPLEKVCLLGCGVTTGLGAVTHTAKVKAGDTVAVFGLGGIGLAVIIGAVMAKAGRIIAIDINPDKFEIARQLGATDVVN
PQDHDKPIQEVIIGMTGGGVDFSFECIGNVKVMRSALECCHKGWGESVIIGVAGAGEEICTRPFQLVTGRVWRGSAFGGV
KGRSELPGYVQRYLDGEFELDTFITHTMGLEDINKAFDLMHEGKSIRTVIHFDK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=64.4986449864499, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=50.9485094850949, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=51.4745308310992, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=50.1355013550135, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=50.1355013550135, Blast_Score=387, Evalue=1e-108,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=49.7297297297297, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=49.7297297297297, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=48.2384823848238, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=48.4848484848485, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI156627571, Length=373, Percent_Identity=24.6648793565684, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=69.6476964769648, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI87082125, Length=381, Percent_Identity=26.7716535433071, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790045, Length=369, Percent_Identity=26.2872628726287, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=25.3521126760563, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788073, Length=363, Percent_Identity=24.7933884297521, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786825, Length=247, Percent_Identity=27.5303643724696, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87081918, Length=229, Percent_Identity=29.6943231441048, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788407, Length=228, Percent_Identity=26.7543859649123, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=251, Percent_Identity=27.4900398406374, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI226510992, Length=353, Percent_Identity=22.3796033994334, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=56.5333333333333, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=56.2334217506631, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=56.268221574344, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562584, Length=363, Percent_Identity=28.099173553719, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=377, Percent_Identity=28.1167108753316, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=374, Percent_Identity=23.5294117647059, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=364, Percent_Identity=26.0989010989011, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=271, Percent_Identity=25.4612546125461, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=59.4666666666667, Blast_Score=458, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6323099, Length=390, Percent_Identity=28.2051282051282, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=378, Percent_Identity=28.3068783068783, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=376, Percent_Identity=27.1276595744681, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=372, Percent_Identity=25.8064516129032, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=372, Percent_Identity=25.5376344086022, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=282, Percent_Identity=25.886524822695, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=61.9946091644205, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17137530, Length=364, Percent_Identity=24.7252747252747, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39891; Mature: 39891

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIKTRAAVAWGPGQPLKIEEVDLMPPRKGEVLVRIVATGVCHTDAYTLSGKDPEGKFP
CCCCCCCEEEEECCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCC
AILGHEGGGIVEAVGDGVTSVAVGDHVIPLYTPECRECKFCRSGKTNLCQAIRTTQGQGL
EEEECCCCCEEEECCCCCEEEEECCEEEEECCCCHHCCHHHHCCCHHHHHHHHHCCCCCC
MPDGTTRFSKDGKPIYHYMGTSTFSEYTVIPEIALARISKEAPLEKVCLLGCGVTTGLGA
CCCCCCCCCCCCCEEEEECCCCCCCCEEEHHHHHHHHHCCCCCHHHHHHHHCCHHHCCCH
VTHTAKVKAGDTVAVFGLGGIGLAVIIGAVMAKAGRIIAIDINPDKFEIARQLGATDVVN
HEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCC
PQDHDKPIQEVIIGMTGGGVDFSFECIGNVKVMRSALECCHKGWGESVIIGVAGAGEEIC
CCCCCCHHHHHEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
TRPFQLVTGRVWRGSAFGGVKGRSELPGYVQRYLDGEFELDTFITHTMGLEDINKAFDLM
CCCHHHHHCCEECCCCCCCCCCCCCCHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHH
HEGKSIRTVIHFDK
HCCCCEEEEEEECC
>Mature Secondary Structure
MDTIKTRAAVAWGPGQPLKIEEVDLMPPRKGEVLVRIVATGVCHTDAYTLSGKDPEGKFP
CCCCCCCEEEEECCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCC
AILGHEGGGIVEAVGDGVTSVAVGDHVIPLYTPECRECKFCRSGKTNLCQAIRTTQGQGL
EEEECCCCCEEEECCCCCEEEEECCEEEEECCCCHHCCHHHHCCCHHHHHHHHHCCCCCC
MPDGTTRFSKDGKPIYHYMGTSTFSEYTVIPEIALARISKEAPLEKVCLLGCGVTTGLGA
CCCCCCCCCCCCCEEEEECCCCCCCCEEEHHHHHHHHHCCCCCHHHHHHHHCCHHHCCCH
VTHTAKVKAGDTVAVFGLGGIGLAVIIGAVMAKAGRIIAIDINPDKFEIARQLGATDVVN
HEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCC
PQDHDKPIQEVIIGMTGGGVDFSFECIGNVKVMRSALECCHKGWGESVIIGVAGAGEEIC
CCCCCCHHHHHEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
TRPFQLVTGRVWRGSAFGGVKGRSELPGYVQRYLDGEFELDTFITHTMGLEDINKAFDLM
CCCHHHHHCCEECCCCCCCCCCCCCCHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHH
HEGKSIRTVIHFDK
HCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]