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The map label for this gene is tpm

Identifier: 82703377

GI number: 82703377

Start: 2569977

End: 2570639

Strand: Direct

Name: tpm

Synonym: Nmul_A2259

Alternate gene names: 82703377

Gene position: 2569977-2570639 (Clockwise)

Preceding gene: 82703370

Following gene: 82703378

Centisome position: 80.71

GC content: 53.24

Gene sequence:

>663_bases
ATGAAGAAAGAGTACTGGCTGGAACGCTGGAGACAGGAAGAAATCGGTTTTCACCAGCGCGAGATCAATCCATATTTAAG
CCGATATTGGCCGGAATTACAGGTTGCGCCCGGGAAACGGGTATTCGTTCCCCTCTGCGGTAAAAGCCGTGACATGATAT
GGCTTCGCGAGCAGAACCTTTCTGTACTGGGGGTGGAATTAAGTCCTCTGGCAGTAGAGGCGTTCTTCAAGGAAAACGGC
TATTCCCCCCGCCACATCATCGGCGAGAAATTCGATCAGTGGGATGCTGACGGCATCCATCTTCTGTGCGGAGATTTTTT
CGACCTGAAAAAAGACCATCTGGCGCAGGTGGACGCAGTGTACGACCGCGCCTCCCTCGTCGCCTTGCCCCCGGAAACCC
GCCATGCATACACGGACCACTTGCTGTGCATTTTGCCGCCTGCAATCCGGATACTGCTCATTACTTTCGATTATCCCCAA
GCTGAAATGTCCGGTCCGCCTTTTGCGGTTTCCACAGCCGAGGTAGAGGCACTTTACGGAAAGCGCACGGATATTCGTCT
GCTCGCAAAATTCGACGTGCTGACGGAGAATCCGCGCTTTCAACAACGAGGCATAAGCCGGCTTCAGGAAAGCATCTTCC
TTCTCATGACACGGACGGCATAA

Upstream 100 bases:

>100_bases
TTTTATATCGGCGAATCATTGTCAGCCTAATCTTTTACCAGCTCAAGTGAATGGCGACAGGATAAATTTATCTTAAATAA
TGCTGGGAGAACACAGGAAA

Downstream 100 bases:

>100_bases
CACTTAAAGGAATCCCCCGGCACCTTGCCCCATCGTGAGAGAGATTCAAAGGCGCCTGTCTATTAATAACGTGGTGTTTT
TAATCCAGATTAAACTATGC

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKKEYWLERWRQEEIGFHQREINPYLSRYWPELQVAPGKRVFVPLCGKSRDMIWLREQNLSVLGVELSPLAVEAFFKENG
YSPRHIIGEKFDQWDADGIHLLCGDFFDLKKDHLAQVDAVYDRASLVALPPETRHAYTDHLLCILPPAIRILLITFDYPQ
AEMSGPPFAVSTAEVEALYGKRTDIRLLAKFDVLTENPRFQQRGISRLQESIFLLMTRTA

Sequences:

>Translated_220_residues
MKKEYWLERWRQEEIGFHQREINPYLSRYWPELQVAPGKRVFVPLCGKSRDMIWLREQNLSVLGVELSPLAVEAFFKENG
YSPRHIIGEKFDQWDADGIHLLCGDFFDLKKDHLAQVDAVYDRASLVALPPETRHAYTDHLLCILPPAIRILLITFDYPQ
AEMSGPPFAVSTAEVEALYGKRTDIRLLAKFDVLTENPRFQQRGISRLQESIFLLMTRTA
>Mature_220_residues
MKKEYWLERWRQEEIGFHQREINPYLSRYWPELQVAPGKRVFVPLCGKSRDMIWLREQNLSVLGVELSPLAVEAFFKENG
YSPRHIIGEKFDQWDADGIHLLCGDFFDLKKDHLAQVDAVYDRASLVALPPETRHAYTDHLLCILPPAIRILLITFDYPQ
AEMSGPPFAVSTAEVEALYGKRTDIRLLAKFDVLTENPRFQQRGISRLQESIFLLMTRTA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=221, Percent_Identity=34.841628959276, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_NITMU (Q2Y6S0)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412943.1
- ProteinModelPortal:   Q2Y6S0
- SMR:   Q2Y6S0
- STRING:   Q2Y6S0
- GeneID:   3785036
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2259
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   NMUL323848:NMUL_A2259-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 25564; Mature: 25564

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEYWLERWRQEEIGFHQREINPYLSRYWPELQVAPGKRVFVPLCGKSRDMIWLREQNL
CCCHHHHHHHHHHHCCCHHHHCCHHHHHHCCCEEECCCCEEEEEECCCCCCEEEEEECCC
SVLGVELSPLAVEAFFKENGYSPRHIIGEKFDQWDADGIHLLCGDFFDLKKDHLAQVDAV
EEEEEEECHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEECCHHHCCHHHHHHHHHH
YDRASLVALPPETRHAYTDHLLCILPPAIRILLITFDYPQAEMSGPPFAVSTAEVEALYG
HCCCEEEEECCCCCHHHHHCEEEEECCCCEEEEEEECCCHHHCCCCCEEEEHHHHHHHHC
KRTDIRLLAKFDVLTENPRFQQRGISRLQESIFLLMTRTA
CCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MKKEYWLERWRQEEIGFHQREINPYLSRYWPELQVAPGKRVFVPLCGKSRDMIWLREQNL
CCCHHHHHHHHHHHCCCHHHHCCHHHHHHCCCEEECCCCEEEEEECCCCCCEEEEEECCC
SVLGVELSPLAVEAFFKENGYSPRHIIGEKFDQWDADGIHLLCGDFFDLKKDHLAQVDAV
EEEEEEECHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEECCHHHCCHHHHHHHHHH
YDRASLVALPPETRHAYTDHLLCILPPAIRILLITFDYPQAEMSGPPFAVSTAEVEALYG
HCCCEEEEECCCCCHHHHHCEEEEECCCCEEEEEEECCCHHHCCCCCEEEEHHHHHHHHC
KRTDIRLLAKFDVLTENPRFQQRGISRLQESIFLLMTRTA
CCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA