Click here to switch to the map view.

The map label for this gene is trpF

Identifier: 82703034

GI number: 82703034

Start: 2203454

End: 2204080

Strand: Reverse

Name: trpF

Synonym: Nmul_A1913

Alternate gene names: 82703034

Gene position: 2204080-2203454 (Counterclockwise)

Preceding gene: 82703035

Following gene: 82703033

Centisome position: 69.22

GC content: 55.82

Gene sequence:

>627_bases
ATGTCGATTCGAGTAAAAGTTTGCGGTATAACCCGAGTGGAAGATGCGCTTGCGGCAGTGCATCTCGGAGCGAATGCCGT
GGGCTTTGTCTTCTGGGAGCAGAGCGCGCGCTATATTTCACCGGCTGAAGCGCGCGGAATCGTGTCCACGCTGCCGCCAT
TCGTTACTTCAGTGGGTGTCTATGTCGACCCTGAGGCGGGGTGGGTAGACGAAAGCATTTCGGTTGCCGGCCTGAACCTG
TTGCAATTTCACGGTAGCGAAAGCCCCGAGTTCTGCCAGCAATTTTCGCTTCCCTATATAAAGGCGGTAAGAGTCAGGCC
GGGGCTGGATTTGCTACAATACGCATCCCTTTATACGGGAGCCACCGGTTTGCTGCTGGATACGTATGTGGAAGGGGAAC
CGGGGGGAACCGGAGAGGCGTTTGACTGGAACCTGATTCCGCGCAATTTGCCGCTGCCGCTGATTCTTTCGGGGGGACTA
CACGCAGGCAACGTTACGAGCGCAATCCAGCAGGCCCATCCTTGGGCGGTGGATGTGTCCAGTGGCGTGGAAGCCGCGAA
GGGCATTAAAGATTCGGGGAAAATTGCAGCATTCATGCGAGGAGTTGGAATCAGTGAAAGTCTATGA

Upstream 100 bases:

>100_bases
CCGCAATAGTGCCGGGCACAAACAGGCCGGCTATCCTCACATCATGGGCGACAAGTGGCGGAAACCCAGTTGCGGGCGCA
ACACCGGAAGTCAGGGATAT

Downstream 100 bases:

>100_bases
TCTTCCGGACAGTCATGGGCACTTTGGTCCGTATGGCGGCATCTTTGTCGCTGAAACGCTGATCTCGGCACTGGAGGATT
TACGCATACAGTACGAGCGC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSIRVKVCGITRVEDALAAVHLGANAVGFVFWEQSARYISPAEARGIVSTLPPFVTSVGVYVDPEAGWVDESISVAGLNL
LQFHGSESPEFCQQFSLPYIKAVRVRPGLDLLQYASLYTGATGLLLDTYVEGEPGGTGEAFDWNLIPRNLPLPLILSGGL
HAGNVTSAIQQAHPWAVDVSSGVEAAKGIKDSGKIAAFMRGVGISESL

Sequences:

>Translated_208_residues
MSIRVKVCGITRVEDALAAVHLGANAVGFVFWEQSARYISPAEARGIVSTLPPFVTSVGVYVDPEAGWVDESISVAGLNL
LQFHGSESPEFCQQFSLPYIKAVRVRPGLDLLQYASLYTGATGLLLDTYVEGEPGGTGEAFDWNLIPRNLPLPLILSGGL
HAGNVTSAIQQAHPWAVDVSSGVEAAKGIKDSGKIAAFMRGVGISESL
>Mature_207_residues
SIRVKVCGITRVEDALAAVHLGANAVGFVFWEQSARYISPAEARGIVSTLPPFVTSVGVYVDPEAGWVDESISVAGLNLL
QFHGSESPEFCQQFSLPYIKAVRVRPGLDLLQYASLYTGATGLLLDTYVEGEPGGTGEAFDWNLIPRNLPLPLILSGGLH
AGNVTSAIQQAHPWAVDVSSGVEAAKGIKDSGKIAAFMRGVGISESL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=201, Percent_Identity=30.3482587064677, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320210, Length=212, Percent_Identity=33.4905660377358, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_NITMU (Q2Y7R3)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412600.1
- ProteinModelPortal:   Q2Y7R3
- SMR:   Q2Y7R3
- STRING:   Q2Y7R3
- GeneID:   3784151
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1913
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q2Y7R3
- ProtClustDB:   PRK01222
- BioCyc:   NMUL323848:NMUL_A1913-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 21998; Mature: 21867

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRVKVCGITRVEDALAAVHLGANAVGFVFWEQSARYISPAEARGIVSTLPPFVTSVGV
CEEEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHCCHHHHHCCE
YVDPEAGWVDESISVAGLNLLQFHGSESPEFCQQFSLPYIKAVRVRPGLDLLQYASLYTG
EECCCCCCCCCCCHHCCEEEEEECCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCC
ATGLLLDTYVEGEPGGTGEAFDWNLIPRNLPLPLILSGGLHAGNVTSAIQQAHPWAVDVS
CCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEECC
SGVEAAKGIKDSGKIAAFMRGVGISESL
CCHHHHHCCCCCCCEEEHHHCCCCCCCC
>Mature Secondary Structure 
SIRVKVCGITRVEDALAAVHLGANAVGFVFWEQSARYISPAEARGIVSTLPPFVTSVGV
EEEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHCCHHHHHCCE
YVDPEAGWVDESISVAGLNLLQFHGSESPEFCQQFSLPYIKAVRVRPGLDLLQYASLYTG
EECCCCCCCCCCCHHCCEEEEEECCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCC
ATGLLLDTYVEGEPGGTGEAFDWNLIPRNLPLPLILSGGLHAGNVTSAIQQAHPWAVDVS
CCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEECC
SGVEAAKGIKDSGKIAAFMRGVGISESL
CCHHHHHCCCCCCCEEEHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA