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The map label for this gene is mucB [H]

Identifier: 82702871

GI number: 82702871

Start: 2000575

End: 2001561

Strand: Direct

Name: mucB [H]

Synonym: Nmul_A1748

Alternate gene names: 82702871

Gene position: 2000575-2001561 (Clockwise)

Preceding gene: 82702870

Following gene: 82702872

Centisome position: 62.83

GC content: 51.57

Gene sequence:

>987_bases
ATGACACAGGTTTCACTGTCTTCCCTGCTGCTGACAGTTATCGTTCAATCCGCATTTGCGCAGAATCCCTCCAGTTCATC
CCCCTCATCCCCCGAGGCGCTTAACTGGCTGCAAAAGATTGCCGCCGCCCCCCGCCATTACAACTATGTCGGGACATTCG
TCTATTCATCCGAGGGTCAGATAGAGACATCTCGCATCATCCATCTGGTGAATGAGGAAGGGGAGCAGGAAAAAAGCATG
GTGCTGGATGGTCCTCCCCGTGAGATTATCCGCAACAACGACGAAATGAGATGTTATCTTCCGGAAAACAAGACCGTGGT
GACGGAAAAACGATGGCTGCGAAAAGTTTTTCCCGCGCTGCTGCCTCAACCGCTGATCAATCTTGACCACAACTATGTCG
TCAAGAAAGGCAAGCAGGAGCGGGTCAGCGACTATGCCAGCCAGATCATCGAGTTGGAGCCCAGGGATGACAAGCGTTAT
GGTCAGAAATTATGGATGGATCCCAATACCGGCCTGTTGCTGAAAGCCGCCGTAATGGATAAAGGGCGGGTGGTGGAACA
ATTTGTATTCACCGACCTGAAAATTGGCGGTGAAATAGACAAAAGCCTGTTGAAATCCCAATATTCGGGCCAAGCTGCCG
AATGGCGCAAGACAAATCTTGTCTCCTCGACACAGGGAAGCGGAAAACTTGGCTGGCAAGTCAAAGATCCGCCTCCAGGA
TTCAAAAAGATTGTGGAAATGAAACGTAATCTCTCCGGCAAATCCCGTCCTGTTGCGCATATTGCTCTGTCGGATGGTCT
TGCTGCTGTCTCGGTATTTATCGAGCCCAGTTCGGGAGAGGCTTCCTCTCCTGTCGAGGGCCTCTATCACAGCCGCGGCG
CGATCAACATCTATACACGTACTCTCGGTGACAACAGGGTAACTGCCATAGGCGAAGTACCGCCGGCCACTGTAATGCAA
ATCGGTAATTCTGTTACCAGTCGCTAG

Upstream 100 bases:

>100_bases
CTATCTCCTGGCGCATCAGCAATTCTCGCCTAGCACCACCATGCACGGAGCAATCCCCTTCATGCGTACAGCTGCGGAAA
GCGCGCGATAACGTTCCCAG

Downstream 100 bases:

>100_bases
GTGGCCCTAAAGACCGTCGGGTCGGCTCGGATTGAATGCAGTCCTGGTACCAGGTACTACTATTCCCTTATTTTGGGCAG
ATGGATGAAGGATTCACCCG

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTQVSLSSLLLTVIVQSAFAQNPSSSSPSSPEALNWLQKIAAAPRHYNYVGTFVYSSEGQIETSRIIHLVNEEGEQEKSM
VLDGPPREIIRNNDEMRCYLPENKTVVTEKRWLRKVFPALLPQPLINLDHNYVVKKGKQERVSDYASQIIELEPRDDKRY
GQKLWMDPNTGLLLKAAVMDKGRVVEQFVFTDLKIGGEIDKSLLKSQYSGQAAEWRKTNLVSSTQGSGKLGWQVKDPPPG
FKKIVEMKRNLSGKSRPVAHIALSDGLAAVSVFIEPSSGEASSPVEGLYHSRGAINIYTRTLGDNRVTAIGEVPPATVMQ
IGNSVTSR

Sequences:

>Translated_328_residues
MTQVSLSSLLLTVIVQSAFAQNPSSSSPSSPEALNWLQKIAAAPRHYNYVGTFVYSSEGQIETSRIIHLVNEEGEQEKSM
VLDGPPREIIRNNDEMRCYLPENKTVVTEKRWLRKVFPALLPQPLINLDHNYVVKKGKQERVSDYASQIIELEPRDDKRY
GQKLWMDPNTGLLLKAAVMDKGRVVEQFVFTDLKIGGEIDKSLLKSQYSGQAAEWRKTNLVSSTQGSGKLGWQVKDPPPG
FKKIVEMKRNLSGKSRPVAHIALSDGLAAVSVFIEPSSGEASSPVEGLYHSRGAINIYTRTLGDNRVTAIGEVPPATVMQ
IGNSVTSR
>Mature_327_residues
TQVSLSSLLLTVIVQSAFAQNPSSSSPSSPEALNWLQKIAAAPRHYNYVGTFVYSSEGQIETSRIIHLVNEEGEQEKSMV
LDGPPREIIRNNDEMRCYLPENKTVVTEKRWLRKVFPALLPQPLINLDHNYVVKKGKQERVSDYASQIIELEPRDDKRYG
QKLWMDPNTGLLLKAAVMDKGRVVEQFVFTDLKIGGEIDKSLLKSQYSGQAAEWRKTNLVSSTQGSGKLGWQVKDPPPGF
KKIVEMKRNLSGKSRPVAHIALSDGLAAVSVFIEPSSGEASSPVEGLYHSRGAINIYTRTLGDNRVTAIGEVPPATVMQI
GNSVTSR

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=306, Percent_Identity=23.5294117647059, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 36322; Mature: 36191

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVSLSSLLLTVIVQSAFAQNPSSSSPSSPEALNWLQKIAAAPRHYNYVGTFVYSSEGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
IETSRIIHLVNEEGEQEKSMVLDGPPREIIRNNDEMRCYLPENKTVVTEKRWLRKVFPAL
EEHHHHHEECCCCCCCCCCEEECCCCHHHHCCCCCEEEECCCCCEEEHHHHHHHHHHHHH
LPQPLINLDHNYVVKKGKQERVSDYASQIIELEPRDDKRYGQKLWMDPNTGLLLKAAVMD
CCCHHHCCCCCCEECCCCHHHHHHHHHHHEECCCCCCHHHCCEEEECCCCCEEEEEEHHC
KGRVVEQFVFTDLKIGGEIDKSLLKSQYSGQAAEWRKTNLVSSTQGSGKLGWQVKDPPPG
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCH
FKKIVEMKRNLSGKSRPVAHIALSDGLAAVSVFIEPSSGEASSPVEGLYHSRGAINIYTR
HHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHCCCEEEEEEE
TLGDNRVTAIGEVPPATVMQIGNSVTSR
ECCCCCEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TQVSLSSLLLTVIVQSAFAQNPSSSSPSSPEALNWLQKIAAAPRHYNYVGTFVYSSEGQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
IETSRIIHLVNEEGEQEKSMVLDGPPREIIRNNDEMRCYLPENKTVVTEKRWLRKVFPAL
EEHHHHHEECCCCCCCCCCEEECCCCHHHHCCCCCEEEECCCCCEEEHHHHHHHHHHHHH
LPQPLINLDHNYVVKKGKQERVSDYASQIIELEPRDDKRYGQKLWMDPNTGLLLKAAVMD
CCCHHHCCCCCCEECCCCHHHHHHHHHHHEECCCCCCHHHCCEEEECCCCCEEEEEEHHC
KGRVVEQFVFTDLKIGGEIDKSLLKSQYSGQAAEWRKTNLVSSTQGSGKLGWQVKDPPPG
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCH
FKKIVEMKRNLSGKSRPVAHIALSDGLAAVSVFIEPSSGEASSPVEGLYHSRGAINIYTR
HHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHCCCEEEEEEE
TLGDNRVTAIGEVPPATVMQIGNSVTSR
ECCCCCEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]