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The map label for this gene is luxQ [H]

Identifier: 82702620

GI number: 82702620

Start: 1703711

End: 1705801

Strand: Direct

Name: luxQ [H]

Synonym: Nmul_A1491

Alternate gene names: 82702620

Gene position: 1703711-1705801 (Clockwise)

Preceding gene: 82702615

Following gene: 82702621

Centisome position: 53.5

GC content: 52.61

Gene sequence:

>2091_bases
ATGGATAATAATGATGAAAGCCTGCCGCCCTCGGTTACCTTGCATACAAACGCCGTACTTCACGCCGGGCAACAGGTCGA
GCATGAGCTTCAGCGGGTCAAAAGGGCCCTTGAGGATAAAACGAAACAGCTTGATGAGTCACTATCTATCCTGCGAGCAA
CCATAGAATCCACTGCCGACGGAATACTGGTTACCGACGAGTATGGCCATATGCTTCGCTACAACGAACGATATCTGCAG
ATGTGGCAGATTAAGCTCCCCGATATCGTTGAATTGCATCAACATAGGCAATTGCAGAAACTTAGTTGCAAGTACTTGGC
GGACCCGAAGCAATATCTTGAGAGAATAGAGGAAATATATGATGCCTGGCCGCCCGAAACATACGACTTGCTGGAACTTA
CCGATGGCCGGATATTTGAACGGTATTCGAAGATTCAGTATGCAGAGGACCTGTGTGTAGGCCGCGTATGGAGCTTTAGA
GATATCACGGCCCGTAAACATGCCGAAGAGGCGCTGCAGGAAAGCACCGAGCGTCTCCACTTCATGGCTGAGGCCATGCC
GCAGAAAATATTCACTGCGCGCGCCGATGGGGCCGTGGATTATTTCAATCAGCAATGGAAAGATTACACCGGTCTTGCCC
GCGAGAAAATGCAGGGTTGGGAATGGATCAAGCTCATCCATCCTGACGACGCCCCGGAGTGCGTGCGGCGCTGGCAGCAC
TCGCTTAACACAGGGGAGCATCTGCAGATGGAGTGCCGTTTCCGCCAAGCGAACGGCACTTACCGCTGGCACCTGCTTCA
GGCACAGGCGCGGCGCGATACGAAAGGGTATATATCCATGTGGGTCGGTTCGAACACGGATATCGACACGCTAAAACGCG
CAGACGAAGAGAAAAAACAGCTCCTTGAGAATGAACGGATTGCGCGAAGCGAAGCCGAACGCGCGAACCGCATCAAGGAT
GATTTCCTGGCAACCCTATCCCATGAACTTAGAACACCGCTTAATGCCATCCTTGGATGGTCACAGCTCATCTTGCAGGG
GACAATGAAAAACGAAGACATTCAAAGGGGTCTGGAAACCATCGAGCGAAACGCCCGGGCACAGAATAAGCTTATCGAAG
ATCTTCTGGAAATGAGCAGCATCATTTCTAACAAAATCCGATTGGATATGCAGGAATGGGACCTTGGCGCAATAGCCGAG
GCAGCAGTCGAATCTGTTGCACCTGCAGCCGAGGCTAAAGGAATATGTATCCGAAGAACAATCGATGCCACTGCAGGACG
GGTTCTAGGGGATAACCATCGCCTTCAGCAGATAATATGGAACCTTCTTTCCAATGCCGTCAAGTTTACGCCTGACGGCG
GTACCGTAGAGGTAATCGTGGAACGCGCCGCATCGCAGCTTAGGGTCATCGTAAAAGATTCCGGGGTGGGTATCAAACCT
GAATTCCTGGCGTATGTTTTTGACCGCTTCCGGCAAGCCGACTCTTCCCTCACCCGGAATCATGGCGGCCTGGGCTTGGG
ACTTGCCATCGTGAAGCAGCTTGTGGGGCTGCATGGTGGAACGGTTTGCGCAGAGAGCAAGGGGGAAGGTCAGGGCGCCT
CATTTTGCGTTACCTTACCGCCTGCCCCGATCAAGGACGGCATGGACAGACAACTGCTGCCTGATGCCAAACCTTCCCAG
AAGGATGGCAATATCCTTCTCTCAGGGATGAGGATTCTCGTCATTGATGACGAACGGGACTCGCGTGAGCTCATCCATAA
AGTGCTCGCGCAGCACCGGGTTGAAGTCATTACCGCGGCAAACGCCATGGAAGGACTGTTGATACTGAAAAGCCAGATGC
CGGATGTAATGATCAGTGATATTGGCATGCCGGGAAAAGACGGCTACCAGTTTATTCGCGAAGTGAGAAGACTTCCTGCA
ATCCAGGGAGGAGAGATACCGGCAATCGCACTGAGCGCATTTGCGCATCCGGAAGACCGTACCTGCGCAATGATGGCGGG
TTACCAGATGCATCTCTCCAAACCCGTGGAATCAAAAGAACTGATCGCTTCCATCGGAAGCCTGATGGCGCGAGCAAAAA
CAGCGAGTTGA

Upstream 100 bases:

>100_bases
CTCTTGAACAGATCAGTTTACACGCATGCCTGCTGCCGGTGATTACCGCTTTAAGCCACCCTGGTTTGGACAAACTTCAT
AAAGGGGAATAAAACAGCAA

Downstream 100 bases:

>100_bases
CGCGGAAGGAACGTGACACTGGGTTAATACTCCGGCCAACTCCGATTGCATCGCACGATGGTCTCTATAATATTGCCACG
TTTACCCGCTTAACGTGGTA

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MDNNDESLPPSVTLHTNAVLHAGQQVEHELQRVKRALEDKTKQLDESLSILRATIESTADGILVTDEYGHMLRYNERYLQ
MWQIKLPDIVELHQHRQLQKLSCKYLADPKQYLERIEEIYDAWPPETYDLLELTDGRIFERYSKIQYAEDLCVGRVWSFR
DITARKHAEEALQESTERLHFMAEAMPQKIFTARADGAVDYFNQQWKDYTGLAREKMQGWEWIKLIHPDDAPECVRRWQH
SLNTGEHLQMECRFRQANGTYRWHLLQAQARRDTKGYISMWVGSNTDIDTLKRADEEKKQLLENERIARSEAERANRIKD
DFLATLSHELRTPLNAILGWSQLILQGTMKNEDIQRGLETIERNARAQNKLIEDLLEMSSIISNKIRLDMQEWDLGAIAE
AAVESVAPAAEAKGICIRRTIDATAGRVLGDNHRLQQIIWNLLSNAVKFTPDGGTVEVIVERAASQLRVIVKDSGVGIKP
EFLAYVFDRFRQADSSLTRNHGGLGLGLAIVKQLVGLHGGTVCAESKGEGQGASFCVTLPPAPIKDGMDRQLLPDAKPSQ
KDGNILLSGMRILVIDDERDSRELIHKVLAQHRVEVITAANAMEGLLILKSQMPDVMISDIGMPGKDGYQFIREVRRLPA
IQGGEIPAIALSAFAHPEDRTCAMMAGYQMHLSKPVESKELIASIGSLMARAKTAS

Sequences:

>Translated_696_residues
MDNNDESLPPSVTLHTNAVLHAGQQVEHELQRVKRALEDKTKQLDESLSILRATIESTADGILVTDEYGHMLRYNERYLQ
MWQIKLPDIVELHQHRQLQKLSCKYLADPKQYLERIEEIYDAWPPETYDLLELTDGRIFERYSKIQYAEDLCVGRVWSFR
DITARKHAEEALQESTERLHFMAEAMPQKIFTARADGAVDYFNQQWKDYTGLAREKMQGWEWIKLIHPDDAPECVRRWQH
SLNTGEHLQMECRFRQANGTYRWHLLQAQARRDTKGYISMWVGSNTDIDTLKRADEEKKQLLENERIARSEAERANRIKD
DFLATLSHELRTPLNAILGWSQLILQGTMKNEDIQRGLETIERNARAQNKLIEDLLEMSSIISNKIRLDMQEWDLGAIAE
AAVESVAPAAEAKGICIRRTIDATAGRVLGDNHRLQQIIWNLLSNAVKFTPDGGTVEVIVERAASQLRVIVKDSGVGIKP
EFLAYVFDRFRQADSSLTRNHGGLGLGLAIVKQLVGLHGGTVCAESKGEGQGASFCVTLPPAPIKDGMDRQLLPDAKPSQ
KDGNILLSGMRILVIDDERDSRELIHKVLAQHRVEVITAANAMEGLLILKSQMPDVMISDIGMPGKDGYQFIREVRRLPA
IQGGEIPAIALSAFAHPEDRTCAMMAGYQMHLSKPVESKELIASIGSLMARAKTAS
>Mature_696_residues
MDNNDESLPPSVTLHTNAVLHAGQQVEHELQRVKRALEDKTKQLDESLSILRATIESTADGILVTDEYGHMLRYNERYLQ
MWQIKLPDIVELHQHRQLQKLSCKYLADPKQYLERIEEIYDAWPPETYDLLELTDGRIFERYSKIQYAEDLCVGRVWSFR
DITARKHAEEALQESTERLHFMAEAMPQKIFTARADGAVDYFNQQWKDYTGLAREKMQGWEWIKLIHPDDAPECVRRWQH
SLNTGEHLQMECRFRQANGTYRWHLLQAQARRDTKGYISMWVGSNTDIDTLKRADEEKKQLLENERIARSEAERANRIKD
DFLATLSHELRTPLNAILGWSQLILQGTMKNEDIQRGLETIERNARAQNKLIEDLLEMSSIISNKIRLDMQEWDLGAIAE
AAVESVAPAAEAKGICIRRTIDATAGRVLGDNHRLQQIIWNLLSNAVKFTPDGGTVEVIVERAASQLRVIVKDSGVGIKP
EFLAYVFDRFRQADSSLTRNHGGLGLGLAIVKQLVGLHGGTVCAESKGEGQGASFCVTLPPAPIKDGMDRQLLPDAKPSQ
KDGNILLSGMRILVIDDERDSRELIHKVLAQHRVEVITAANAMEGLLILKSQMPDVMISDIGMPGKDGYQFIREVRRLPA
IQGGEIPAIALSAFAHPEDRTCAMMAGYQMHLSKPVESKELIASIGSLMARAKTAS

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=258, Percent_Identity=37.2093023255814, Blast_Score=151, Evalue=2e-37,
Organism=Escherichia coli, GI48994928, Length=530, Percent_Identity=26.0377358490566, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788713, Length=590, Percent_Identity=24.9152542372881, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI87081816, Length=409, Percent_Identity=29.5843520782396, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=34.4827586206897, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786783, Length=249, Percent_Identity=30.9236947791165, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=28.7272727272727, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=30.7359307359307, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=29.3877551020408, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=28.110599078341, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1788549, Length=376, Percent_Identity=24.2021276595745, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=230, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=242, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789403, Length=231, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1786599, Length=121, Percent_Identity=33.0578512396694, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786911, Length=124, Percent_Identity=33.8709677419355, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=25.2066115702479, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78695; Mature: 78695

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNNDESLPPSVTLHTNAVLHAGQQVEHELQRVKRALEDKTKQLDESLSILRATIESTAD
CCCCCCCCCCCEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GILVTDEYGHMLRYNERYLQMWQIKLPDIVELHQHRQLQKLSCKYLADPKQYLERIEEIY
CEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DAWPPETYDLLELTDGRIFERYSKIQYAEDLCVGRVWSFRDITARKHAEEALQESTERLH
HCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
FMAEAMPQKIFTARADGAVDYFNQQWKDYTGLAREKMQGWEWIKLIHPDDAPECVRRWQH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
SLNTGEHLQMECRFRQANGTYRWHLLQAQARRDTKGYISMWVGSNTDIDTLKRADEEKKQ
HCCCCCEEEEEEEEEECCCEEEEEEEEHHHCCCCCCEEEEEECCCCCHHHHHHCCHHHHH
LLENERIARSEAERANRIKDDFLATLSHELRTPLNAILGWSQLILQGTMKNEDIQRGLET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IERNARAQNKLIEDLLEMSSIISNKIRLDMQEWDLGAIAEAAVESVAPAAEAKGICIRRT
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHCCHHHHHHHHHHHHCCHHHHCCEEEEEE
IDATAGRVLGDNHRLQQIIWNLLSNAVKFTPDGGTVEVIVERAASQLRVIVKDSGVGIKP
HHHHCCCCCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHEEEEEECCCCCCCH
EFLAYVFDRFRQADSSLTRNHGGLGLGLAIVKQLVGLHGGTVCAESKGEGQGASFCVTLP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEECC
PAPIKDGMDRQLLPDAKPSQKDGNILLSGMRILVIDDERDSRELIHKVLAQHRVEVITAA
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
NAMEGLLILKSQMPDVMISDIGMPGKDGYQFIREVRRLPAIQGGEIPAIALSAFAHPEDR
HHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
TCAMMAGYQMHLSKPVESKELIASIGSLMARAKTAS
CCHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNNDESLPPSVTLHTNAVLHAGQQVEHELQRVKRALEDKTKQLDESLSILRATIESTAD
CCCCCCCCCCCEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GILVTDEYGHMLRYNERYLQMWQIKLPDIVELHQHRQLQKLSCKYLADPKQYLERIEEIY
CEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DAWPPETYDLLELTDGRIFERYSKIQYAEDLCVGRVWSFRDITARKHAEEALQESTERLH
HCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
FMAEAMPQKIFTARADGAVDYFNQQWKDYTGLAREKMQGWEWIKLIHPDDAPECVRRWQH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
SLNTGEHLQMECRFRQANGTYRWHLLQAQARRDTKGYISMWVGSNTDIDTLKRADEEKKQ
HCCCCCEEEEEEEEEECCCEEEEEEEEHHHCCCCCCEEEEEECCCCCHHHHHHCCHHHHH
LLENERIARSEAERANRIKDDFLATLSHELRTPLNAILGWSQLILQGTMKNEDIQRGLET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IERNARAQNKLIEDLLEMSSIISNKIRLDMQEWDLGAIAEAAVESVAPAAEAKGICIRRT
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHCCHHHHHHHHHHHHCCHHHHCCEEEEEE
IDATAGRVLGDNHRLQQIIWNLLSNAVKFTPDGGTVEVIVERAASQLRVIVKDSGVGIKP
HHHHCCCCCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHEEEEEECCCCCCCH
EFLAYVFDRFRQADSSLTRNHGGLGLGLAIVKQLVGLHGGTVCAESKGEGQGASFCVTLP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEECC
PAPIKDGMDRQLLPDAKPSQKDGNILLSGMRILVIDDERDSRELIHKVLAQHRVEVITAA
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
NAMEGLLILKSQMPDVMISDIGMPGKDGYQFIREVRRLPAIQGGEIPAIALSAFAHPEDR
HHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
TCAMMAGYQMHLSKPVESKELIASIGSLMARAKTAS
CCHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]