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The map label for this gene is tmk

Identifier: 82702516

GI number: 82702516

Start: 1579338

End: 1579955

Strand: Reverse

Name: tmk

Synonym: Nmul_A1387

Alternate gene names: 82702516

Gene position: 1579955-1579338 (Counterclockwise)

Preceding gene: 82702518

Following gene: 82702515

Centisome position: 49.62

GC content: 53.24

Gene sequence:

>618_bases
ATGAGGGGCAAATTCATCACTCTGGAAGGCATTGACGGTGCGGGTAAGACGACGCATCTCCGGTGGCTGGAGTATTTCCT
GAAGGAAAGAGGAAAAAATGTGATGGTCACGCGGGAACCCGGCGGCACTCCCTTGGGGGAAGCATTGCGCGACATCCTGC
TGGACAGCCGGCAAACAATGCATGCGGAAACCGAGGCGCTGCTGATGTTCGCAGCACGGCGCGAACATCTGGACAAGGTC
ATCCTGCCTGCCTTGAGCCGTGGCGAGTGGGTAATATCGGACCGTTTCACCGATGCCAGCTTTGCCTATCAGGGTGGCGG
AAGGGGATTATCCCTGCAGAAATTGAATGAACTCGAATGCTGGGTGCAGGGAGAGTTTCAGCCGGATGTTACCCTTTATC
TCGATGTGTCTATCGCATCGGGAAGGCAGCGAACCAGCAACATCAGGCAGGCAGACCGGTTTGAAAAAGAACAGGATGAA
TTTTTCCGGAGAGTACGAGAAGCGTATCTGGAGCGGGCAAAAGAATTCCCTGAAAGAATACGGGTGATAGATGCCAACCA
GTCCCTGGAAGATGTCAGGCGGTCAGTTGAAAAAAGTATTGCAACGATTTACGCATGA

Upstream 100 bases:

>100_bases
GTTAAACTCGCCTTGACGCAGACTCTGTCCGGTATGCTTCTTTCCGGCTTACGAGCCAATGGCATTGCCAATATGGTAAT
TTTCAGGAACGACATCAAAT

Downstream 100 bases:

>100_bases
GTAATATTTATGGATGGCAGGAAGAAGTCTGGCGGAAACTTACGGGCGCGTTGGGGCACGCCCTGCTGTTACGAGGCAGA
AAGGGACTGGGCAAGCTTGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRGKFITLEGIDGAGKTTHLRWLEYFLKERGKNVMVTREPGGTPLGEALRDILLDSRQTMHAETEALLMFAARREHLDKV
ILPALSRGEWVISDRFTDASFAYQGGGRGLSLQKLNELECWVQGEFQPDVTLYLDVSIASGRQRTSNIRQADRFEKEQDE
FFRRVREAYLERAKEFPERIRVIDANQSLEDVRRSVEKSIATIYA

Sequences:

>Translated_205_residues
MRGKFITLEGIDGAGKTTHLRWLEYFLKERGKNVMVTREPGGTPLGEALRDILLDSRQTMHAETEALLMFAARREHLDKV
ILPALSRGEWVISDRFTDASFAYQGGGRGLSLQKLNELECWVQGEFQPDVTLYLDVSIASGRQRTSNIRQADRFEKEQDE
FFRRVREAYLERAKEFPERIRVIDANQSLEDVRRSVEKSIATIYA
>Mature_205_residues
MRGKFITLEGIDGAGKTTHLRWLEYFLKERGKNVMVTREPGGTPLGEALRDILLDSRQTMHAETEALLMFAARREHLDKV
ILPALSRGEWVISDRFTDASFAYQGGGRGLSLQKLNELECWVQGEFQPDVTLYLDVSIASGRQRTSNIRQADRFEKEQDE
FFRRVREAYLERAKEFPERIRVIDANQSLEDVRRSVEKSIATIYA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=41.9512195121951, Blast_Score=150, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_NITMU (Q2Y981)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412082.1
- HSSP:   P65248
- ProteinModelPortal:   Q2Y981
- SMR:   Q2Y981
- STRING:   Q2Y981
- GeneID:   3784482
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1387
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q2Y981
- ProtClustDB:   PRK00698
- BioCyc:   NMUL323848:NMUL_A1387-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23612; Mature: 23612

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKFITLEGIDGAGKTTHLRWLEYFLKERGKNVMVTREPGGTPLGEALRDILLDSRQTM
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCHHHH
HAETEALLMFAARREHLDKVILPALSRGEWVISDRFTDASFAYQGGGRGLSLQKLNELEC
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCCCCHHHHHHHHE
WVQGEFQPDVTLYLDVSIASGRQRTSNIRQADRFEKEQDEFFRRVREAYLERAKEFPERI
EEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
RVIDANQSLEDVRRSVEKSIATIYA
EEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGKFITLEGIDGAGKTTHLRWLEYFLKERGKNVMVTREPGGTPLGEALRDILLDSRQTM
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCHHHH
HAETEALLMFAARREHLDKVILPALSRGEWVISDRFTDASFAYQGGGRGLSLQKLNELEC
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCCCCHHHHHHHHE
WVQGEFQPDVTLYLDVSIASGRQRTSNIRQADRFEKEQDEFFRRVREAYLERAKEFPERI
EEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
RVIDANQSLEDVRRSVEKSIATIYA
EEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA