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The map label for this gene is yhdG [H]

Identifier: 82702381

GI number: 82702381

Start: 1439163

End: 1440608

Strand: Reverse

Name: yhdG [H]

Synonym: Nmul_A1252

Alternate gene names: 82702381

Gene position: 1440608-1439163 (Counterclockwise)

Preceding gene: 82702382

Following gene: 82702380

Centisome position: 45.24

GC content: 56.64

Gene sequence:

>1446_bases
GTGCTGTTTGAGCGCGTCAAACCTGTGGATCAAATTCTGGAGTCGGCTGAAACCCGAGGGCTCAAACGACAGCTTGGCGC
ATTTGATCTGACCATGCTGGGAATTGGCGCCGTCATCGGCACCGGCATCTTTGTATTGACTTCGGTTGCCGCGGACAAGG
CAGGTCCGGGCATGATGTTTTCCTTCCTCATAGCCGGGTTTGTCTGCGCGCTCGCCGCCCTTGTCTATTCTGAAATTGCC
GCGATCGTACCGGTGGCAGGATCGGCCTACACCTACTCTTATGCGGTGTTCGGTGAACTCGCCGCATGGATGGTCGGCTG
GGCGCTGATTCTGGAGTATGCGATCGCCGCAGCAGCGGTAGCCGTTGGCTGGTCCGGTTATATCAATGGCTTCCTGAACG
AAATAGGCTACGGGCTGCCGGTTGCCCTGACGGCAGGACCGGCGGACACGATTGCCGGGGCGGACGGGACCCCATCGGCA
GGAGGATTCAACCTGCTGGCATTTCTGGTGTCGTTGTTCGTCACCGTGCTGCTGGTCATGGGCACGACAAAAAGCGCGAG
GTTTACGGCAGTTCTGGTTGTCATAAAAATTATCGCGCTTACTGCATTTATCATTCTTGCCTTGCCGGCGGTAAATTCCG
TAAATTTCCAACCCATGCTGCCCAACGGATGGGGCACACCGCTTTCAGGAGTGGGAATCCTGGGTGCCGCTGCCTCCATC
TTCTTTGCCTATGTCGGATTCGATGCTGTTTCCACCGCAGCCGAAGAAACGAGCAACCCAAACCGTAATGTGCCGATAGG
ATTGATAGCTTCATTGACGATTTGCACTCTCATTTATCTCGTCGTCGCCTACGCCGCAGTCGGAGCAGTGGGAGCGCAGC
CGGGAGGTGATTTGTCCCTCTCCAAAGAACCGCTGGCATTTGTGCTGCGCGAGGTCGGTTACCCGACCATAGGCAACTGG
GTGGCTTCGGCGGCAATTGTCGCACTGCCCTCCGTCGTGCTCATGATGCTCTATGGACAGACCCGCGTCCTCTTCACCAT
GTCTCATGATGGATTGATGCCCAGTATTTTTTCTCATGTACACAAACGCTTTCACACTCCCCATATTGTCACCCTGGTCA
CGGGAACGGCCGTCGCGCTGTTCGCTGCCATGTTTCCGGTAGGCATGCTGGCTGATATTTCCAATTCCGGGACGCTCTTC
GCTTTCTTCATGGTCGCTCTCGGCGTGATGGTCCTGCGGCGCCGTGCGCCCGATCTCCATCGGCCTTTCAAGACCCCTAT
GCTGTGGATGGTCGGCCCCCTGGCAATGGGGGGCTGCGGTCTGCTGTTCGTCAGCCTGGGGTGGGAAACAATCAGGCTAT
TCCTTGCTTGGGCAGGTACCGGCCTGATTATCTATTTCGCATATGCCCGCAAGCACAGCCATCTTGGAAAACAACAGGCA
AACTAG

Upstream 100 bases:

>100_bases
TGCTGGTTTAAAATAACGATCTTGCCCGCAACCGCCGAGCTTGAGCGAAACCGGTTAAAATCCAACTGAAATCCTTTGCA
TTTATTACTGGAGAGACATT

Downstream 100 bases:

>100_bases
TGCTTTCAGATTAAAATGACCGACATGTTTTCCCAATCCCGGTACCATGATTTTGGGTCCACCCGCCCATTCCATGAGTC
GCACTGCCCCTGACAATTCG

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MLFERVKPVDQILESAETRGLKRQLGAFDLTMLGIGAVIGTGIFVLTSVAADKAGPGMMFSFLIAGFVCALAALVYSEIA
AIVPVAGSAYTYSYAVFGELAAWMVGWALILEYAIAAAAVAVGWSGYINGFLNEIGYGLPVALTAGPADTIAGADGTPSA
GGFNLLAFLVSLFVTVLLVMGTTKSARFTAVLVVIKIIALTAFIILALPAVNSVNFQPMLPNGWGTPLSGVGILGAAASI
FFAYVGFDAVSTAAEETSNPNRNVPIGLIASLTICTLIYLVVAYAAVGAVGAQPGGDLSLSKEPLAFVLREVGYPTIGNW
VASAAIVALPSVVLMMLYGQTRVLFTMSHDGLMPSIFSHVHKRFHTPHIVTLVTGTAVALFAAMFPVGMLADISNSGTLF
AFFMVALGVMVLRRRAPDLHRPFKTPMLWMVGPLAMGGCGLLFVSLGWETIRLFLAWAGTGLIIYFAYARKHSHLGKQQA
N

Sequences:

>Translated_481_residues
MLFERVKPVDQILESAETRGLKRQLGAFDLTMLGIGAVIGTGIFVLTSVAADKAGPGMMFSFLIAGFVCALAALVYSEIA
AIVPVAGSAYTYSYAVFGELAAWMVGWALILEYAIAAAAVAVGWSGYINGFLNEIGYGLPVALTAGPADTIAGADGTPSA
GGFNLLAFLVSLFVTVLLVMGTTKSARFTAVLVVIKIIALTAFIILALPAVNSVNFQPMLPNGWGTPLSGVGILGAAASI
FFAYVGFDAVSTAAEETSNPNRNVPIGLIASLTICTLIYLVVAYAAVGAVGAQPGGDLSLSKEPLAFVLREVGYPTIGNW
VASAAIVALPSVVLMMLYGQTRVLFTMSHDGLMPSIFSHVHKRFHTPHIVTLVTGTAVALFAAMFPVGMLADISNSGTLF
AFFMVALGVMVLRRRAPDLHRPFKTPMLWMVGPLAMGGCGLLFVSLGWETIRLFLAWAGTGLIIYFAYARKHSHLGKQQA
N
>Mature_481_residues
MLFERVKPVDQILESAETRGLKRQLGAFDLTMLGIGAVIGTGIFVLTSVAADKAGPGMMFSFLIAGFVCALAALVYSEIA
AIVPVAGSAYTYSYAVFGELAAWMVGWALILEYAIAAAAVAVGWSGYINGFLNEIGYGLPVALTAGPADTIAGADGTPSA
GGFNLLAFLVSLFVTVLLVMGTTKSARFTAVLVVIKIIALTAFIILALPAVNSVNFQPMLPNGWGTPLSGVGILGAAASI
FFAYVGFDAVSTAAEETSNPNRNVPIGLIASLTICTLIYLVVAYAAVGAVGAQPGGDLSLSKEPLAFVLREVGYPTIGNW
VASAAIVALPSVVLMMLYGQTRVLFTMSHDGLMPSIFSHVHKRFHTPHIVTLVTGTAVALFAAMFPVGMLADISNSGTLF
AFFMVALGVMVLRRRAPDLHRPFKTPMLWMVGPLAMGGCGLLFVSLGWETIRLFLAWAGTGLIIYFAYARKHSHLGKQQA
N

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI114326544, Length=433, Percent_Identity=35.1039260969977, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI114326550, Length=433, Percent_Identity=35.1039260969977, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI4507047, Length=440, Percent_Identity=34.0909090909091, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI258614005, Length=428, Percent_Identity=32.7102803738318, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI258614003, Length=428, Percent_Identity=32.7102803738318, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI258645169, Length=428, Percent_Identity=33.1775700934579, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI181337167, Length=423, Percent_Identity=32.1513002364066, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI110347453, Length=417, Percent_Identity=34.5323741007194, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI115648063, Length=441, Percent_Identity=25.3968253968254, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI115648022, Length=441, Percent_Identity=25.3968253968254, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33286428, Length=419, Percent_Identity=24.582338902148, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI7657683, Length=378, Percent_Identity=26.7195767195767, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI186910308, Length=477, Percent_Identity=24.5283018867925, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI186910306, Length=477, Percent_Identity=24.5283018867925, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI186910304, Length=477, Percent_Identity=24.5283018867925, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI187423910, Length=491, Percent_Identity=22.4032586558045, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI7657591, Length=491, Percent_Identity=22.4032586558045, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI71979932, Length=214, Percent_Identity=28.9719626168224, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI9790235, Length=334, Percent_Identity=24.5508982035928, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786302, Length=409, Percent_Identity=24.4498777506112, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=24.8837209302326, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082250, Length=472, Percent_Identity=23.9406779661017, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788480, Length=366, Percent_Identity=24.0437158469945, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081869, Length=476, Percent_Identity=22.4789915966387, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081708, Length=494, Percent_Identity=24.6963562753036, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790653, Length=471, Percent_Identity=23.3545647558386, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081915, Length=368, Percent_Identity=23.0978260869565, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786602, Length=430, Percent_Identity=24.1860465116279, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=425, Percent_Identity=33.1764705882353, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17531343, Length=412, Percent_Identity=31.0679611650485, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17533459, Length=424, Percent_Identity=31.3679245283019, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17540018, Length=430, Percent_Identity=24.4186046511628, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32566699, Length=428, Percent_Identity=25.4672897196262, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537453, Length=318, Percent_Identity=24.8427672955975, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221512776, Length=430, Percent_Identity=32.7906976744186, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24666159, Length=430, Percent_Identity=32.7906976744186, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24668806, Length=426, Percent_Identity=32.1596244131455, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI21356285, Length=426, Percent_Identity=32.1596244131455, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24668802, Length=426, Percent_Identity=32.1596244131455, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24667468, Length=415, Percent_Identity=32.0481927710843, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281366235, Length=429, Percent_Identity=32.4009324009324, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI116007820, Length=429, Percent_Identity=32.4009324009324, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI116007818, Length=420, Percent_Identity=32.3809523809524, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI85725152, Length=420, Percent_Identity=32.3809523809524, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI161077963, Length=428, Percent_Identity=30.1401869158879, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21357367, Length=447, Percent_Identity=23.7136465324385, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550968, Length=448, Percent_Identity=23.4375, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921172, Length=448, Percent_Identity=23.4375, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641995, Length=423, Percent_Identity=25.0591016548463, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641993, Length=423, Percent_Identity=25.0591016548463, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50514; Mature: 50514

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00079 MULTICOPPER_OXIDASE1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFERVKPVDQILESAETRGLKRQLGAFDLTMLGIGAVIGTGIFVLTSVAADKAGPGMMF
CCCHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SFLIAGFVCALAALVYSEIAAIVPVAGSAYTYSYAVFGELAAWMVGWALILEYAIAAAAV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGWSGYINGFLNEIGYGLPVALTAGPADTIAGADGTPSAGGFNLLAFLVSLFVTVLLVM
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GTTKSARFTAVLVVIKIIALTAFIILALPAVNSVNFQPMLPNGWGTPLSGVGILGAAASI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
FFAYVGFDAVSTAAEETSNPNRNVPIGLIASLTICTLIYLVVAYAAVGAVGAQPGGDLSL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SKEPLAFVLREVGYPTIGNWVASAAIVALPSVVLMMLYGQTRVLFTMSHDGLMPSIFSHV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
HKRFHTPHIVTLVTGTAVALFAAMFPVGMLADISNSGTLFAFFMVALGVMVLRRRAPDLH
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
RPFKTPMLWMVGPLAMGGCGLLFVSLGWETIRLFLAWAGTGLIIYFAYARKHSHLGKQQA
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
N
C
>Mature Secondary Structure
MLFERVKPVDQILESAETRGLKRQLGAFDLTMLGIGAVIGTGIFVLTSVAADKAGPGMMF
CCCHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SFLIAGFVCALAALVYSEIAAIVPVAGSAYTYSYAVFGELAAWMVGWALILEYAIAAAAV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGWSGYINGFLNEIGYGLPVALTAGPADTIAGADGTPSAGGFNLLAFLVSLFVTVLLVM
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GTTKSARFTAVLVVIKIIALTAFIILALPAVNSVNFQPMLPNGWGTPLSGVGILGAAASI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
FFAYVGFDAVSTAAEETSNPNRNVPIGLIASLTICTLIYLVVAYAAVGAVGAQPGGDLSL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SKEPLAFVLREVGYPTIGNWVASAAIVALPSVVLMMLYGQTRVLFTMSHDGLMPSIFSHV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
HKRFHTPHIVTLVTGTAVALFAAMFPVGMLADISNSGTLFAFFMVALGVMVLRRRAPDLH
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
RPFKTPMLWMVGPLAMGGCGLLFVSLGWETIRLFLAWAGTGLIIYFAYARKHSHLGKQQA
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]