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The map label for this gene is degS [H]

Identifier: 82702365

GI number: 82702365

Start: 1420012

End: 1422090

Strand: Reverse

Name: degS [H]

Synonym: Nmul_A1236

Alternate gene names: 82702365

Gene position: 1422090-1420012 (Counterclockwise)

Preceding gene: 82702375

Following gene: 82702364

Centisome position: 44.66

GC content: 50.75

Gene sequence:

>2079_bases
ATGAGAATCGGTTTTTTCACGAATTTCTCTCTCGCCTCCATCCTATTCGTGCTCACCGTGCTCATATTTCTTTCTTCTCG
GGCGTTAAACACGCTCGATGAGGTTACCGAGGCTGAACGTCAGAAGCACCGATCGCTACAACTGGCAAATGAGCTGTTTC
GCAGTTCCGAGGATTTGACCAGGATGGCTCGCACCTATGCAGTAACAGGTGATCCTGCCTATGAGCATAGCTTTTTTGAA
ATACTCGATATCCGGAATGGCATAAGGCCGCGGCCTCAGGATTATCCGATTGCCTATGCTCATCTGGAAAATACCCACCC
CCCCGGTGCAAGGGAAAATACGATTTCTCTCATGGAATTGATGCGCCGCGAAGGTTTCAGTGAAGGGGAACTGGATCTGC
TGCGGCAGTCGCAGGAAAATTCGGACAACCTCGTCAGGCTGGAAAAGCAGGCATTCGCCGCCGTAAAAGGACTATGTGAA
GATCAACAGGGGAATTTCAATGTGCCTTGCCCCTCCCGGCGCAATTTTGCGATCGATCTTTTGTTTGGCAAGCGTTATGA
GACTGAGAAAATCAGAATCATGGCACCCATCAACCAGTTCATGCTCGAACTCGACACACGCACCCGGAATAAACTCAGTA
ATCTGCAGCTCAAGTTCGAGCAACAAATCCTGCTGATACTGGTTGTACTATGCTTTGCGCTGTTCTTTGCGACTCTTGCC
ACTTTTTATACACGCCGCAACATTCTGCTTCCCCTCGATTACCTCAGACGCCAGGTAAGCGGTATTGCACAAGGCAATTA
TTCGACTCGTTGTGCTATTTCCACCCGCAATGAAATCGCCGAGCTGGGAGCAGGTTTCAATTCCATGGCAGAAGCCATTG
AACATGAAATTATCAAACTTAGACAAGTCGAAGAATCGCTGCGCGAACGGCTGAAGGAAATTAACTGCTTTTATTCGATC
CGGCGAGGCATGGAGTCCTCATCGCTGGAAGAAGTATGCGACACAATCGCGACCGAACTCATCGCAGCAATGCAGTTTCC
ACATCTCGCCGGTGTCAAAATCGAAATGGATGGCAAGGAACTTGTATCCGATCCATACCACGGAAATCATGTACATGAAT
TGCAAAAACAGATCACCGTTCACGGTGAGATACGTGGCTGGATAAAACTGTTTTATCGCGGGGACCGGTTCTTTCTGCTG
CCAGAGGAGCAGAATCTGATCGATGTAATCGGAGACGACCTGGGACGATGGCTGGAACACCAGCAGACCGAGGCACGGGT
TCTGGTGGAGCAGGAACTCCGGGTGCGTGACGCAGCGATACGGGAATTTGCCGCCCACCTCGAGCGAATGCGGGAAGAAG
ATCGCAAATATATTGCACGGGAGATCCATGATGAGCTCGGCCAGCTTCTGGCGGCGCTGCACCTGGAAATCTCGTTGCTA
AGAAGCGCGAAAGATCATGGCAGCGAACGGCTTGAAACCATCAGACACAACATGGCCGAACTCGTCGAGAAAGCGGGCCA
GAGCGTGCACAATGTGGCGGAACATTTACGTCCTGCTTCACTGGGACTGGGAATCGAATCGGCCCTTACAAAACTGACCA
GCGAGTTCAAAAAACATACCGGCATCTATTGTGACCTGCGACTACCCGAGGAACCGGTGAACCTGGACGAAGACCAGACT
GTTGCAATATTCCGTATCGTCCAGGAGTCACTGACAAACGTGACGCGGCACTCAGGGGCGAACCGTGTGGAAATCCGGTT
ATTCCGGGAAAAGGACGAAGTCATTGTCGAAATTTGCGACAATGGCAGAGGATTCGATCCCGAGAGTGCGAAAAAAGGAA
AGTCATTTGGATTGGTTGGAATGCGAGAACGGGCCGCAGCACTCCGGGGTTATATCGCTATCACAAGTGGGCCAGGTCAA
GGTGCGTTGGTTCGTGTATCAATTCCGCTGAGGCGAAACGAGCATTTTGATTGCACTGCCTCTGGCATTACAAATAGCCC
ATCCCTCCTTCATTCCATTGTTGCGGAGTACCGCGCGCTGCCCGTATCTTCACAAAATAATGGAATATCCGTTTCATGA

Upstream 100 bases:

>100_bases
AAAAACCCACCGCGGGTTCCTGATTATCGTGAATTTGTTCACGCTGATTTTCTGCAAAAAAAGCCCTGCTTGATGGCTAT
AGGGATATATATATAAAAAT

Downstream 100 bases:

>100_bases
GCATCGCTGAGTACCCGTTTTCAGGAGAGCGTGCTTGATCATCAAGACCTTTCTGGCTGACGATCATCGGCTTTTTCGTG
ATGGTTTGCGACGCATTCTT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 692

Protein sequence:

>692_residues
MRIGFFTNFSLASILFVLTVLIFLSSRALNTLDEVTEAERQKHRSLQLANELFRSSEDLTRMARTYAVTGDPAYEHSFFE
ILDIRNGIRPRPQDYPIAYAHLENTHPPGARENTISLMELMRREGFSEGELDLLRQSQENSDNLVRLEKQAFAAVKGLCE
DQQGNFNVPCPSRRNFAIDLLFGKRYETEKIRIMAPINQFMLELDTRTRNKLSNLQLKFEQQILLILVVLCFALFFATLA
TFYTRRNILLPLDYLRRQVSGIAQGNYSTRCAISTRNEIAELGAGFNSMAEAIEHEIIKLRQVEESLRERLKEINCFYSI
RRGMESSSLEEVCDTIATELIAAMQFPHLAGVKIEMDGKELVSDPYHGNHVHELQKQITVHGEIRGWIKLFYRGDRFFLL
PEEQNLIDVIGDDLGRWLEHQQTEARVLVEQELRVRDAAIREFAAHLERMREEDRKYIAREIHDELGQLLAALHLEISLL
RSAKDHGSERLETIRHNMAELVEKAGQSVHNVAEHLRPASLGLGIESALTKLTSEFKKHTGIYCDLRLPEEPVNLDEDQT
VAIFRIVQESLTNVTRHSGANRVEIRLFREKDEVIVEICDNGRGFDPESAKKGKSFGLVGMRERAAALRGYIAITSGPGQ
GALVRVSIPLRRNEHFDCTASGITNSPSLLHSIVAEYRALPVSSQNNGISVS

Sequences:

>Translated_692_residues
MRIGFFTNFSLASILFVLTVLIFLSSRALNTLDEVTEAERQKHRSLQLANELFRSSEDLTRMARTYAVTGDPAYEHSFFE
ILDIRNGIRPRPQDYPIAYAHLENTHPPGARENTISLMELMRREGFSEGELDLLRQSQENSDNLVRLEKQAFAAVKGLCE
DQQGNFNVPCPSRRNFAIDLLFGKRYETEKIRIMAPINQFMLELDTRTRNKLSNLQLKFEQQILLILVVLCFALFFATLA
TFYTRRNILLPLDYLRRQVSGIAQGNYSTRCAISTRNEIAELGAGFNSMAEAIEHEIIKLRQVEESLRERLKEINCFYSI
RRGMESSSLEEVCDTIATELIAAMQFPHLAGVKIEMDGKELVSDPYHGNHVHELQKQITVHGEIRGWIKLFYRGDRFFLL
PEEQNLIDVIGDDLGRWLEHQQTEARVLVEQELRVRDAAIREFAAHLERMREEDRKYIAREIHDELGQLLAALHLEISLL
RSAKDHGSERLETIRHNMAELVEKAGQSVHNVAEHLRPASLGLGIESALTKLTSEFKKHTGIYCDLRLPEEPVNLDEDQT
VAIFRIVQESLTNVTRHSGANRVEIRLFREKDEVIVEICDNGRGFDPESAKKGKSFGLVGMRERAAALRGYIAITSGPGQ
GALVRVSIPLRRNEHFDCTASGITNSPSLLHSIVAEYRALPVSSQNNGISVS
>Mature_692_residues
MRIGFFTNFSLASILFVLTVLIFLSSRALNTLDEVTEAERQKHRSLQLANELFRSSEDLTRMARTYAVTGDPAYEHSFFE
ILDIRNGIRPRPQDYPIAYAHLENTHPPGARENTISLMELMRREGFSEGELDLLRQSQENSDNLVRLEKQAFAAVKGLCE
DQQGNFNVPCPSRRNFAIDLLFGKRYETEKIRIMAPINQFMLELDTRTRNKLSNLQLKFEQQILLILVVLCFALFFATLA
TFYTRRNILLPLDYLRRQVSGIAQGNYSTRCAISTRNEIAELGAGFNSMAEAIEHEIIKLRQVEESLRERLKEINCFYSI
RRGMESSSLEEVCDTIATELIAAMQFPHLAGVKIEMDGKELVSDPYHGNHVHELQKQITVHGEIRGWIKLFYRGDRFFLL
PEEQNLIDVIGDDLGRWLEHQQTEARVLVEQELRVRDAAIREFAAHLERMREEDRKYIAREIHDELGQLLAALHLEISLL
RSAKDHGSERLETIRHNMAELVEKAGQSVHNVAEHLRPASLGLGIESALTKLTSEFKKHTGIYCDLRLPEEPVNLDEDQT
VAIFRIVQESLTNVTRHSGANRVEIRLFREKDEVIVEICDNGRGFDPESAKKGKSFGLVGMRERAAALRGYIAITSGPGQ
GALVRVSIPLRRNEHFDCTASGITNSPSLLHSIVAEYRALPVSSQNNGISVS

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=460, Percent_Identity=24.5652173913043, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI87082311, Length=230, Percent_Identity=30, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788812, Length=456, Percent_Identity=23.6842105263158, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78737; Mature: 78737

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGFFTNFSLASILFVLTVLIFLSSRALNTLDEVTEAERQKHRSLQLANELFRSSEDLT
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
RMARTYAVTGDPAYEHSFFEILDIRNGIRPRPQDYPIAYAHLENTHPPGARENTISLMEL
HHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
MRREGFSEGELDLLRQSQENSDNLVRLEKQAFAAVKGLCEDQQGNFNVPCPSRRNFAIDL
HHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
LFGKRYETEKIRIMAPINQFMLELDTRTRNKLSNLQLKFEQQILLILVVLCFALFFATLA
EECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFYTRRNILLPLDYLRRQVSGIAQGNYSTRCAISTRNEIAELGAGFNSMAEAIEHEIIKL
HHHHHCCCEECHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHHH
RQVEESLRERLKEINCFYSIRRGMESSSLEEVCDTIATELIAAMQFPHLAGVKIEMDGKE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHH
LVSDPYHGNHVHELQKQITVHGEIRGWIKLFYRGDRFFLLPEEQNLIDVIGDDLGRWLEH
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCCCCCHHHHHHHHHHHHHHH
QQTEARVLVEQELRVRDAAIREFAAHLERMREEDRKYIAREIHDELGQLLAALHLEISLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSAKDHGSERLETIRHNMAELVEKAGQSVHNVAEHLRPASLGLGIESALTKLTSEFKKHT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHC
GIYCDLRLPEEPVNLDEDQTVAIFRIVQESLTNVTRHSGANRVEIRLFREKDEVIVEICD
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHC
NGRGFDPESAKKGKSFGLVGMRERAAALRGYIAITSGPGQGALVRVSIPLRRNEHFDCTA
CCCCCCCCHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCEEEEEEECCCCCCCCCEEC
SGITNSPSLLHSIVAEYRALPVSSQNNGISVS
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIGFFTNFSLASILFVLTVLIFLSSRALNTLDEVTEAERQKHRSLQLANELFRSSEDLT
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
RMARTYAVTGDPAYEHSFFEILDIRNGIRPRPQDYPIAYAHLENTHPPGARENTISLMEL
HHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
MRREGFSEGELDLLRQSQENSDNLVRLEKQAFAAVKGLCEDQQGNFNVPCPSRRNFAIDL
HHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
LFGKRYETEKIRIMAPINQFMLELDTRTRNKLSNLQLKFEQQILLILVVLCFALFFATLA
EECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFYTRRNILLPLDYLRRQVSGIAQGNYSTRCAISTRNEIAELGAGFNSMAEAIEHEIIKL
HHHHHCCCEECHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHHH
RQVEESLRERLKEINCFYSIRRGMESSSLEEVCDTIATELIAAMQFPHLAGVKIEMDGKE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHH
LVSDPYHGNHVHELQKQITVHGEIRGWIKLFYRGDRFFLLPEEQNLIDVIGDDLGRWLEH
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCCCCCHHHHHHHHHHHHHHH
QQTEARVLVEQELRVRDAAIREFAAHLERMREEDRKYIAREIHDELGQLLAALHLEISLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSAKDHGSERLETIRHNMAELVEKAGQSVHNVAEHLRPASLGLGIESALTKLTSEFKKHT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHC
GIYCDLRLPEEPVNLDEDQTVAIFRIVQESLTNVTRHSGANRVEIRLFREKDEVIVEICD
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHC
NGRGFDPESAKKGKSFGLVGMRERAAALRGYIAITSGPGQGALVRVSIPLRRNEHFDCTA
CCCCCCCCHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCEEEEEEECCCCCCCCCEEC
SGITNSPSLLHSIVAEYRALPVSSQNNGISVS
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]