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The map label for this gene is guaB [H]

Identifier: 82702329

GI number: 82702329

Start: 1386932

End: 1388392

Strand: Reverse

Name: guaB [H]

Synonym: Nmul_A1200

Alternate gene names: 82702329

Gene position: 1388392-1386932 (Counterclockwise)

Preceding gene: 82702330

Following gene: 82702328

Centisome position: 43.6

GC content: 56.4

Gene sequence:

>1461_bases
ATGCGACTGGTTGAGAAAGCTTTAACCTTTGACGATGTCCTGCTGCTTCCCGCCCACTCCGTTGTTTTACCGCGCAATGT
CAATCTGACAACGCGACTCACGCGCGAGATCTCCCTCAATATTCCTCTTGTATCAGCCGCCATGGATACCGTTACCGAGT
CGCGGCTCGCAATCGCACTCGCCCAGGAAGGGGGAATCGGCATCATACACAAGAATATGCCGGCGGAATCCCAGGCTGCC
CAGGTCTCCAATGTCAAGCGCTTCGAAAGCGGCGTGGTAAAAGATCCCATTACCATTCCGCCTGACATGACGGTGCGGGA
AGTGCTCAACCTGATCCACAAATTCAGGATTTCAGGCTTACCCGTGGTGGAAGGTTCGAAAGTGGTGGGGATTGTGACAA
ACCGCGATCTTCGCTTCGAAACCAACCTGGATCAGCCGATCCGGAATATCATGACCTTGAAGGAGCGGCTGGTCACGGTG
AACGAAGGCGCCAGTCGTGAAGAAGCAATGGCCCTGCTGCACAAATACCGGCTGGAGCGTGTGCTCGTCGTGAATAACGA
CTTCGAGTTGCGCGGACTGATCACCGTGAAAGATATCATCAAGACATCCGAACACCCAAACGCCTGCAAGGACGAACAAG
GCCGGCTGCGTGTTGGCGCTGCGATAGGGGTTGGCGAAGGCAGTGAAGAGCGCGCGGAGGCGCTGGTCGATGCAGGTGTG
GACGTGATTGTCGTGGATACCGCACATGGACACTCACAGGGTGTGCTTGAACGGGTACGGTGGGTAAAGAAACGGTTCCC
TAAAATCCAGGTCATCGGCGGCAATGTAGGTACTGCCGCCGCTGCCAGGGCTTTGGTGGATCATGGCGCCGACGCGGTAA
AGGTAGGAATCGGTCCCGGTTCGATATGCACCACCCGCATTGTGGCGGGAGTGGGAATACCTCAGATTACGGCCATCAAA
AACGTTTCTGCAGAACTGGCAGGCAGCGGCGTGCCGCTGATCTCCGACGGCGGCATCCGCTATTCGGGGGACATTGCAAA
GGCACTGGCCGCCGGGGCGAGTTCAATCATGCTCGGGGGCTTGTTCGCAGGCACGGAAGAATCACCAGGAGAAATAGAAC
TGTTCCAGGGGCGCTCATACAAGACCTATCGTGGAATGGGTTCACTTTCGGCAATGCAGCAGGGTTCGAGCGACCGCTAT
TTCCAGCAGGCCGAGCAGGACTCCAGGAAGCTCGTGCCGGAAGGCGTGGAAGGCAGGGTTCCTTTCAAGGGAAGCGTCAT
CGCGGTCATCCATCAGTTGATTGGCGGCGTACGCTCGGGCATGGGCTATCTGGGCTGCGAAACAATCGATGACATGCACG
CCAAGGCAGAGTTTATCGAGATTACTGCCGCAGGCATTCGTGAATCCCACGTCCACAACGTACAGATTACCAAAGAGGCC
CCGAACTATCATATCGATTAG

Upstream 100 bases:

>100_bases
ATAGGAAAGCTTCGATCGTTCCTGCGCTTCGTCTTCGTTCGGGATGATTCCCCATAGCATCCATGTTCGCTATAATGCCG
CTTTGTGAAGGATCACTATC

Downstream 100 bases:

>100_bases
GCGGAAATGACGGTGCATGGCAATAACATATGTCTCAGCCTAACTGTTGCACCTTCGGTTGCCCTGCTGCTTTCCTCCCC
TCTTCACTGACAGCAATACA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLVEKALTFDDVLLLPAHSVVLPRNVNLTTRLTREISLNIPLVSAAMDTVTESRLAIALAQEGGIGIIHKNMPAESQAA
QVSNVKRFESGVVKDPITIPPDMTVREVLNLIHKFRISGLPVVEGSKVVGIVTNRDLRFETNLDQPIRNIMTLKERLVTV
NEGASREEAMALLHKYRLERVLVVNNDFELRGLITVKDIIKTSEHPNACKDEQGRLRVGAAIGVGEGSEERAEALVDAGV
DVIVVDTAHGHSQGVLERVRWVKKRFPKIQVIGGNVGTAAAARALVDHGADAVKVGIGPGSICTTRIVAGVGIPQITAIK
NVSAELAGSGVPLISDGGIRYSGDIAKALAAGASSIMLGGLFAGTEESPGEIELFQGRSYKTYRGMGSLSAMQQGSSDRY
FQQAEQDSRKLVPEGVEGRVPFKGSVIAVIHQLIGGVRSGMGYLGCETIDDMHAKAEFIEITAAGIRESHVHNVQITKEA
PNYHID

Sequences:

>Translated_486_residues
MRLVEKALTFDDVLLLPAHSVVLPRNVNLTTRLTREISLNIPLVSAAMDTVTESRLAIALAQEGGIGIIHKNMPAESQAA
QVSNVKRFESGVVKDPITIPPDMTVREVLNLIHKFRISGLPVVEGSKVVGIVTNRDLRFETNLDQPIRNIMTLKERLVTV
NEGASREEAMALLHKYRLERVLVVNNDFELRGLITVKDIIKTSEHPNACKDEQGRLRVGAAIGVGEGSEERAEALVDAGV
DVIVVDTAHGHSQGVLERVRWVKKRFPKIQVIGGNVGTAAAARALVDHGADAVKVGIGPGSICTTRIVAGVGIPQITAIK
NVSAELAGSGVPLISDGGIRYSGDIAKALAAGASSIMLGGLFAGTEESPGEIELFQGRSYKTYRGMGSLSAMQQGSSDRY
FQQAEQDSRKLVPEGVEGRVPFKGSVIAVIHQLIGGVRSGMGYLGCETIDDMHAKAEFIEITAAGIRESHVHNVQITKEA
PNYHID
>Mature_486_residues
MRLVEKALTFDDVLLLPAHSVVLPRNVNLTTRLTREISLNIPLVSAAMDTVTESRLAIALAQEGGIGIIHKNMPAESQAA
QVSNVKRFESGVVKDPITIPPDMTVREVLNLIHKFRISGLPVVEGSKVVGIVTNRDLRFETNLDQPIRNIMTLKERLVTV
NEGASREEAMALLHKYRLERVLVVNNDFELRGLITVKDIIKTSEHPNACKDEQGRLRVGAAIGVGEGSEERAEALVDAGV
DVIVVDTAHGHSQGVLERVRWVKKRFPKIQVIGGNVGTAAAARALVDHGADAVKVGIGPGSICTTRIVAGVGIPQITAIK
NVSAELAGSGVPLISDGGIRYSGDIAKALAAGASSIMLGGLFAGTEESPGEIELFQGRSYKTYRGMGSLSAMQQGSSDRY
FQQAEQDSRKLVPEGVEGRVPFKGSVIAVIHQLIGGVRSGMGYLGCETIDDMHAKAEFIEITAAGIRESHVHNVQITKEA
PNYHID

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=40.5405405405405, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI217035146, Length=450, Percent_Identity=42.6666666666667, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI34328928, Length=450, Percent_Identity=42.6666666666667, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI34328930, Length=450, Percent_Identity=42.6666666666667, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI156616279, Length=450, Percent_Identity=42.6666666666667, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=42.6008968609865, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI217035148, Length=450, Percent_Identity=42, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI217035150, Length=450, Percent_Identity=39.7777777777778, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=38.8663967611336, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=38.8663967611336, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=38.8663967611336, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=38.8663967611336, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=35.4961832061069, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=62.7572016460905, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1786293, Length=245, Percent_Identity=34.2857142857143, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=39.2033542976939, Blast_Score=304, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=39.9049881235154, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17560440, Length=222, Percent_Identity=38.2882882882883, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.6694214876033, Blast_Score=330, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.5491803278689, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.2561983471074, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.4615384615385, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=40.1408450704225, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24641071, Length=486, Percent_Identity=40.7407407407407, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24641073, Length=486, Percent_Identity=40.7407407407407, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=41.2162162162162, Blast_Score=298, Evalue=4e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52137; Mature: 52137

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVEKALTFDDVLLLPAHSVVLPRNVNLTTRLTREISLNIPLVSAAMDTVTESRLAIAL
CCHHHHHCCCCCEEEECCCCEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCEEEEE
AQEGGIGIIHKNMPAESQAAQVSNVKRFESGVVKDPITIPPDMTVREVLNLIHKFRISGL
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVVEGSKVVGIVTNRDLRFETNLDQPIRNIMTLKERLVTVNEGASREEAMALLHKYRLER
CEECCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCE
VLVVNNDFELRGLITVKDIIKTSEHPNACKDEQGRLRVGAAIGVGEGSEERAEALVDAGV
EEEECCCEEEEEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSQGVLERVRWVKKRFPKIQVIGGNVGTAAAARALVDHGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGIPQITAIKNVSAELAGSGVPLISDGGIRYSGDIAKALAAGASSIMLGG
CHHHHHHHHCCCCCCCHHHHCCCHHHCCCCCCEEECCCEEECCHHHHHHHCCCHHHEEEE
LFAGTEESPGEIELFQGRSYKTYRGMGSLSAMQQGSSDRYFQQAEQDSRKLVPEGVEGRV
EEECCCCCCCCEEEEECCCCCHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
PFKGSVIAVIHQLIGGVRSGMGYLGCETIDDMHAKAEFIEITAAGIRESHVHNVQITKEA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCEEEEEEECC
PNYHID
CCCCCC
>Mature Secondary Structure
MRLVEKALTFDDVLLLPAHSVVLPRNVNLTTRLTREISLNIPLVSAAMDTVTESRLAIAL
CCHHHHHCCCCCEEEECCCCEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCEEEEE
AQEGGIGIIHKNMPAESQAAQVSNVKRFESGVVKDPITIPPDMTVREVLNLIHKFRISGL
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVVEGSKVVGIVTNRDLRFETNLDQPIRNIMTLKERLVTVNEGASREEAMALLHKYRLER
CEECCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCE
VLVVNNDFELRGLITVKDIIKTSEHPNACKDEQGRLRVGAAIGVGEGSEERAEALVDAGV
EEEECCCEEEEEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSQGVLERVRWVKKRFPKIQVIGGNVGTAAAARALVDHGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGIPQITAIKNVSAELAGSGVPLISDGGIRYSGDIAKALAAGASSIMLGG
CHHHHHHHHCCCCCCCHHHHCCCHHHCCCCCCEEECCCEEECCHHHHHHHCCCHHHEEEE
LFAGTEESPGEIELFQGRSYKTYRGMGSLSAMQQGSSDRYFQQAEQDSRKLVPEGVEGRV
EEECCCCCCCCEEEEECCCCCHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
PFKGSVIAVIHQLIGGVRSGMGYLGCETIDDMHAKAEFIEITAAGIRESHVHNVQITKEA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCEEEEEEECC
PNYHID
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA