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The map label for this gene is guaA

Identifier: 82702328

GI number: 82702328

Start: 1385210

End: 1386778

Strand: Reverse

Name: guaA

Synonym: Nmul_A1199

Alternate gene names: 82702328

Gene position: 1386778-1385210 (Counterclockwise)

Preceding gene: 82702329

Following gene: 82702320

Centisome position: 43.55

GC content: 54.3

Gene sequence:

>1569_bases
TTGGTCATGCATCAAAAAATACTCATCCTTGACTTTGGTTCCCAATATACGCAGTTGATTGCCCGCCGCGTGCGGGAAAG
CAATGCCTACTGTGAAATTCATCCTTTTGACATAAGCTCGCAATTCATCGGGAATTTCGCTCCGGCAGGCATTATCCTTT
CCGGGGGGCCAGCCTCTGTGGCCGAGAATGAAACGCCCCGCGCTCCCCAGATCGTCTTTGAGCTGGGAGTGCCGGTAATG
GGCATCTGCTATGGCATGCAAACCATGGCGGCCCAGTTGGGTGGTTCAGTTGAAAACTCGAAGGTGCGGGAATTCGGTTA
CGCCGAATTGCAGGTAAAAAACCTTGCCGGCCTGCTTCAGGATATCCATGATCGTACTGATGCATCGCGCCAAAAGCTTC
TGGATGTGTGGATGAGCCACGGCGACAGCGTAAACACTCTTCCTCCCGGTTTCCAGGTCATGGCAAGCAATCCTGCCACC
CCCTTGGCTGCCATAGCGGATGGAGCGCGCAGGTTCTACGGAATGCAATTCCATCCGGAGGTCACTCATACCCCGCAAGG
CAAAGCCATTATAGACAGGTTTGTCCATGAAATTTGCGGACTCGCTTATGACTGGAACATGCCCGACTATCTGGAGGAAA
TGGTTGGCAGAATCCGTTCCGAAGTGGGACCGGACGAGGTTATTCTAGGGCTGTCCGGAGGTGTGGATTCCTCGGTTGCA
GCGGCACTCATTCATCGTGCTATTGGCAAGCAGCTTACCTGTGTTTTCGTGGACAACGGCCTGCTGCGCCTGAATGAGGC
CGAACAGGTAATGGACACCTTCAGCCGGAATCTCGGCGTAAAAGTCATTCATGTCGATGCCAGCGAAGAATTCTTAGGAC
ATTTGCAAGGCATTACGGATCCGGAAGCGAAGCGCCGCATTATCGGACGCGAATTCGTCGAGGTATTCCAGCGGGAAGCA
GCAAAAATCGCTAATGCGCGCTGGCTTGCGCAGGGCACGATTTATCCGGACGTCATCGAATCCGCCGGCGCCAAAACAAA
AAAGGCAAACACGATCAAATCCCACCACAATGTCGGCGGCCTGCCGGAAACATTGCATCTGAAGCTTCTGGAGCCATTGC
GGGAATTGTTCAAGGATGAAGTACGCGAGCTTGGACTGACCCTGGGGCTGCCGCACGATATGGTCTTTCGTCACCCTTTT
CCCGGACCGGGGCTTGGAGTGCGTATTCTCGGTGAAGTCAAGCGCGAGTATGCCGAGTTATTGCGGCGTGCCGATGCAAT
CTTCATCGAGGAATTACGCAATGCGGGCTGGTATGAAAAAACGTCTCAGGCATTCGCGGTCTTTCTACCGGTGAAATCGG
TGGGGGTGATGGGCGACGGCCGCACTTATGATTTTGTCGTAGCCCTGCGCGCCGTTCAGACAGAGGACTTCATGACGGCA
CGCTGGGCGGAACTGCCTTACGCCCTGCTCGCGAGAATATCCAGCCGCATCGTGAACGAAGTACGTGGAATAAATCGCGT
GGTCTATGATATCTCCGGCAAGCCGCCAGCCACTATAGAGTGGGAATGA

Upstream 100 bases:

>100_bases
TTCGGTTGCCCTGCTGCTTTCCTCCCCTCTTCACTGACAGCAATACATTTTAGGACGAATTCCCGCTCTCTGAATGCTCC
TATGATCGGGTCCGAGAGCT

Downstream 100 bases:

>100_bases
AAGCATCCGGAGGAAGCCCGAATGCTTTCCTGAATAAACTCACGACGGATTGGAAATTTCGGTAAGCGCATCCGCAACCG
GGCCGATATCGGAAGCATCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MVMHQKILILDFGSQYTQLIARRVRESNAYCEIHPFDISSQFIGNFAPAGIILSGGPASVAENETPRAPQIVFELGVPVM
GICYGMQTMAAQLGGSVENSKVREFGYAELQVKNLAGLLQDIHDRTDASRQKLLDVWMSHGDSVNTLPPGFQVMASNPAT
PLAAIADGARRFYGMQFHPEVTHTPQGKAIIDRFVHEICGLAYDWNMPDYLEEMVGRIRSEVGPDEVILGLSGGVDSSVA
AALIHRAIGKQLTCVFVDNGLLRLNEAEQVMDTFSRNLGVKVIHVDASEEFLGHLQGITDPEAKRRIIGREFVEVFQREA
AKIANARWLAQGTIYPDVIESAGAKTKKANTIKSHHNVGGLPETLHLKLLEPLRELFKDEVRELGLTLGLPHDMVFRHPF
PGPGLGVRILGEVKREYAELLRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVMGDGRTYDFVVALRAVQTEDFMTA
RWAELPYALLARISSRIVNEVRGINRVVYDISGKPPATIEWE

Sequences:

>Translated_522_residues
MVMHQKILILDFGSQYTQLIARRVRESNAYCEIHPFDISSQFIGNFAPAGIILSGGPASVAENETPRAPQIVFELGVPVM
GICYGMQTMAAQLGGSVENSKVREFGYAELQVKNLAGLLQDIHDRTDASRQKLLDVWMSHGDSVNTLPPGFQVMASNPAT
PLAAIADGARRFYGMQFHPEVTHTPQGKAIIDRFVHEICGLAYDWNMPDYLEEMVGRIRSEVGPDEVILGLSGGVDSSVA
AALIHRAIGKQLTCVFVDNGLLRLNEAEQVMDTFSRNLGVKVIHVDASEEFLGHLQGITDPEAKRRIIGREFVEVFQREA
AKIANARWLAQGTIYPDVIESAGAKTKKANTIKSHHNVGGLPETLHLKLLEPLRELFKDEVRELGLTLGLPHDMVFRHPF
PGPGLGVRILGEVKREYAELLRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVMGDGRTYDFVVALRAVQTEDFMTA
RWAELPYALLARISSRIVNEVRGINRVVYDISGKPPATIEWE
>Mature_522_residues
MVMHQKILILDFGSQYTQLIARRVRESNAYCEIHPFDISSQFIGNFAPAGIILSGGPASVAENETPRAPQIVFELGVPVM
GICYGMQTMAAQLGGSVENSKVREFGYAELQVKNLAGLLQDIHDRTDASRQKLLDVWMSHGDSVNTLPPGFQVMASNPAT
PLAAIADGARRFYGMQFHPEVTHTPQGKAIIDRFVHEICGLAYDWNMPDYLEEMVGRIRSEVGPDEVILGLSGGVDSSVA
AALIHRAIGKQLTCVFVDNGLLRLNEAEQVMDTFSRNLGVKVIHVDASEEFLGHLQGITDPEAKRRIIGREFVEVFQREA
AKIANARWLAQGTIYPDVIESAGAKTKKANTIKSHHNVGGLPETLHLKLLEPLRELFKDEVRELGLTLGLPHDMVFRHPF
PGPGLGVRILGEVKREYAELLRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVMGDGRTYDFVVALRAVQTEDFMTA
RWAELPYALLARISSRIVNEVRGINRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=562, Percent_Identity=35.5871886120996, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=65.0671785028791, Blast_Score=712, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=35.6896551724138, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=35.6896551724138, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=35.6896551724138, Blast_Score=300, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=527, Percent_Identity=51.6129032258064, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=36.8794326241135, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_NITMU (Q2Y9R9)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411894.1
- ProteinModelPortal:   Q2Y9R9
- SMR:   Q2Y9R9
- STRING:   Q2Y9R9
- GeneID:   3784310
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1199
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q2Y9R9
- ProtClustDB:   PRK00074
- BioCyc:   NMUL323848:NMUL_A1199-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57824; Mature: 57824

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 83-83 ACT_SITE 178-178 ACT_SITE 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMHQKILILDFGSQYTQLIARRVRESNAYCEIHPFDISSQFIGNFAPAGIILSGGPASV
CCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCEEEECCCCCC
AENETPRAPQIVFELGVPVMGICYGMQTMAAQLGGSVENSKVREFGYAELQVKNLAGLLQ
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHH
DIHDRTDASRQKLLDVWMSHGDSVNTLPPGFQVMASNPATPLAAIADGARRFYGMQFHPE
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEECCC
VTHTPQGKAIIDRFVHEICGLAYDWNMPDYLEEMVGRIRSEVGPDEVILGLSGGVDSSVA
CCCCCCCHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
AALIHRAIGKQLTCVFVDNGLLRLNEAEQVMDTFSRNLGVKVIHVDASEEFLGHLQGITD
HHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCC
PEAKRRIIGREFVEVFQREAAKIANARWLAQGTIYPDVIESAGAKTKKANTIKSHHNVGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCHHHHHHHHCCCCCC
LPETLHLKLLEPLRELFKDEVRELGLTLGLPHDMVFRHPFPGPGLGVRILGEVKREYAEL
CCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
LRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVMGDGRTYDFVVALRAVQTEDFMTA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RWAELPYALLARISSRIVNEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVMHQKILILDFGSQYTQLIARRVRESNAYCEIHPFDISSQFIGNFAPAGIILSGGPASV
CCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCEEEECCCCCC
AENETPRAPQIVFELGVPVMGICYGMQTMAAQLGGSVENSKVREFGYAELQVKNLAGLLQ
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHH
DIHDRTDASRQKLLDVWMSHGDSVNTLPPGFQVMASNPATPLAAIADGARRFYGMQFHPE
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEECCC
VTHTPQGKAIIDRFVHEICGLAYDWNMPDYLEEMVGRIRSEVGPDEVILGLSGGVDSSVA
CCCCCCCHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
AALIHRAIGKQLTCVFVDNGLLRLNEAEQVMDTFSRNLGVKVIHVDASEEFLGHLQGITD
HHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCC
PEAKRRIIGREFVEVFQREAAKIANARWLAQGTIYPDVIESAGAKTKKANTIKSHHNVGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCHHHHHHHHCCCCCC
LPETLHLKLLEPLRELFKDEVRELGLTLGLPHDMVFRHPFPGPGLGVRILGEVKREYAEL
CCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
LRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVMGDGRTYDFVVALRAVQTEDFMTA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RWAELPYALLARISSRIVNEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA