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The map label for this gene is bioC [H]

Identifier: 82702261

GI number: 82702261

Start: 1301490

End: 1302413

Strand: Direct

Name: bioC [H]

Synonym: Nmul_A1132

Alternate gene names: 82702261

Gene position: 1301490-1302413 (Clockwise)

Preceding gene: 82702260

Following gene: 82702262

Centisome position: 40.87

GC content: 53.68

Gene sequence:

>924_bases
ATGAGTGGAAATGAGTCTGTAGTGAATTACGATCACTTCATCGATAAGCGCCGGGTGCGAAAGGCGTTTGAACGGGCTGC
GCCTTTATATGATCAGGCTGCGGTCCTTCAGCGTGAAGTATGCGACCGGATGCTGTCCCGCCTTGAATACATCAAATATA
TGCCCGATGTTGTTCTCGATGCCGGAAGCGGCACCGGCTATGGCACGTGCAAGCTGCTTGAACGCTACCCCGACGCCTCC
ATGCTCGCCATCGATATTGCGACCGGCATGCATCACCAAGCCCGGCAGCGGATGAATTCCATGATTCCGCGCTGGCGACA
GTTGTTCGGGGTGGGCCGCAATCAGCGTACAAGCCGGGTCCGTTATGTTGCAGGGGATATTGAGCAATTACCGTTGGAAG
ATTCCTGTGCCGGCCTTGTCTGGTCCAATCTGGCGCTGCAATGGTGTAATGATCTCAAAAAAACCTTTGATGAGATGCGG
CGTATCCTGAAAAATGGTGGTTTGTTCATGTTCAGCACTTTCGGGCCGGATACTCTGAAAGAATTGCGCCAGGCTTTTCG
CCATGCGGATGATTACAGTCATGTCAATCGCTTTGCGGACATGCACGACATAGGCGACATGCTGGTGCATAGCGGCTTTG
CCACCCCGGTCATGGATATGGAATATATTACCCTGACTTATGACGAAGTTATCAGCGTCATGCGCGATCTCAAAGCCATC
GGCGCCCATAATGCCACCGGGGCGCGGCATCGCGGGTTGACGGGAAAAAATGCGTGGCAAAAAGCTATCGGCCATTACGA
GACGCTGCGTACAGGGGGAAAATTGCCAGCGACTTTTGAAGTGGTGTATGGCCATGCCTGGAAACCGGCGCCCCGAACAT
CCATTCTTACACCGGAAACACGCCGCCACATCGGCCTGGAATAA

Upstream 100 bases:

>100_bases
TGTCGAGCTGGCCATGCTACCGAATTGCAGTCATGTGCCTTTCTTGTCCTATCCTGATAAATTCATTGCGAATATCGTTC
GCTTCGCCAGATGAGTTCAA

Downstream 100 bases:

>100_bases
GGATATGGGAATGGGAAAGGGGTATTTCGTCACCGGGACAGATACCGGCGTGGGTAAAACGCGCGTGACCTGCGCCCTGC
TGCATGCCTTTGCTGCCACC

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSGNESVVNYDHFIDKRRVRKAFERAAPLYDQAAVLQREVCDRMLSRLEYIKYMPDVVLDAGSGTGYGTCKLLERYPDAS
MLAIDIATGMHHQARQRMNSMIPRWRQLFGVGRNQRTSRVRYVAGDIEQLPLEDSCAGLVWSNLALQWCNDLKKTFDEMR
RILKNGGLFMFSTFGPDTLKELRQAFRHADDYSHVNRFADMHDIGDMLVHSGFATPVMDMEYITLTYDEVISVMRDLKAI
GAHNATGARHRGLTGKNAWQKAIGHYETLRTGGKLPATFEVVYGHAWKPAPRTSILTPETRRHIGLE

Sequences:

>Translated_307_residues
MSGNESVVNYDHFIDKRRVRKAFERAAPLYDQAAVLQREVCDRMLSRLEYIKYMPDVVLDAGSGTGYGTCKLLERYPDAS
MLAIDIATGMHHQARQRMNSMIPRWRQLFGVGRNQRTSRVRYVAGDIEQLPLEDSCAGLVWSNLALQWCNDLKKTFDEMR
RILKNGGLFMFSTFGPDTLKELRQAFRHADDYSHVNRFADMHDIGDMLVHSGFATPVMDMEYITLTYDEVISVMRDLKAI
GAHNATGARHRGLTGKNAWQKAIGHYETLRTGGKLPATFEVVYGHAWKPAPRTSILTPETRRHIGLE
>Mature_306_residues
SGNESVVNYDHFIDKRRVRKAFERAAPLYDQAAVLQREVCDRMLSRLEYIKYMPDVVLDAGSGTGYGTCKLLERYPDASM
LAIDIATGMHHQARQRMNSMIPRWRQLFGVGRNQRTSRVRYVAGDIEQLPLEDSCAGLVWSNLALQWCNDLKKTFDEMRR
ILKNGGLFMFSTFGPDTLKELRQAFRHADDYSHVNRFADMHDIGDMLVHSGFATPVMDMEYITLTYDEVISVMRDLKAIG
AHNATGARHRGLTGKNAWQKAIGHYETLRTGGKLPATFEVVYGHAWKPAPRTSILTPETRRHIGLE

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=281, Percent_Identity=27.7580071174377, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI86792933, Length=152, Percent_Identity=31.5789473684211, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786994, Length=264, Percent_Identity=34.0909090909091, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17535003, Length=283, Percent_Identity=24.0282685512367, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922210, Length=296, Percent_Identity=30.0675675675676, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 34986; Mature: 34854

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNESVVNYDHFIDKRRVRKAFERAAPLYDQAAVLQREVCDRMLSRLEYIKYMPDVVLD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEE
AGSGTGYGTCKLLERYPDASMLAIDIATGMHHQARQRMNSMIPRWRQLFGVGRNQRTSRV
CCCCCCCHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RYVAGDIEQLPLEDSCAGLVWSNLALQWCNDLKKTFDEMRRILKNGGLFMFSTFGPDTLK
HHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
ELRQAFRHADDYSHVNRFADMHDIGDMLVHSGFATPVMDMEYITLTYDEVISVMRDLKAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEECHHHHHHHHHHHHHH
GAHNATGARHRGLTGKNAWQKAIGHYETLRTGGKLPATFEVVYGHAWKPAPRTSILTPET
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCHH
RRHIGLE
HHCCCCC
>Mature Secondary Structure 
SGNESVVNYDHFIDKRRVRKAFERAAPLYDQAAVLQREVCDRMLSRLEYIKYMPDVVLD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEE
AGSGTGYGTCKLLERYPDASMLAIDIATGMHHQARQRMNSMIPRWRQLFGVGRNQRTSRV
CCCCCCCHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RYVAGDIEQLPLEDSCAGLVWSNLALQWCNDLKKTFDEMRRILKNGGLFMFSTFGPDTLK
HHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHH
ELRQAFRHADDYSHVNRFADMHDIGDMLVHSGFATPVMDMEYITLTYDEVISVMRDLKAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEECHHHHHHHHHHHHHH
GAHNATGARHRGLTGKNAWQKAIGHYETLRTGGKLPATFEVVYGHAWKPAPRTSILTPET
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCHH
RRHIGLE
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]