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The map label for this gene is nuoL [H]

Identifier: 82702231

GI number: 82702231

Start: 1267776

End: 1269728

Strand: Direct

Name: nuoL [H]

Synonym: Nmul_A1102

Alternate gene names: 82702231

Gene position: 1267776-1269728 (Clockwise)

Preceding gene: 82702230

Following gene: 82702232

Centisome position: 39.81

GC content: 55.04

Gene sequence:

>1953_bases
ATGACTGAGATGCAAAATCTATACCTGTTGGTGCCTCTGGCGCCGCTGGCGGGGGCGCTCATAGCCGGCCTGCTTGGACG
TGTGATTGGTCCTGCCGCAAGCCATCGCGTCACCATTGCCCTTATGTTCGTTTGCCTGGCAGCGTCCATTGCCGTGTTCC
TCGATGTGCTGAAAGGAAACGTGTACAACGGCACGGTTTATACCTGGCTGACATCGGGCGGTGTGCGTTTCGAAGTAGGG
TTTCTGATCGATCAGCTTTCCGCGACCATGATGATTGTGGTGAGTTTCGTATCGCTGATGGTGCATATCTATACCATCGG
TTATATGCATGACGACCCAGGCTATCAGCGCTTTTTCAGCTATATCTCGCTTTTTACCTTCTCCATGCTGATGCTGGTGA
TGTCCAACAATTTCCTCCAGCTGTTCTTCGGATGGGAAGCGGTAGGGCTGGTCTCATATCTCCTGATCGGCTTCTGGTAT
ACGCGCCCGACGGCCATTTACGCGAATCTGAAGGCGTTCCTGGTCAATCGTGTCGGGGACTTCGGTTTTCTCCTCGGCAT
CGGTCTAGTACTGGTGTATTTCGGCACGCTGGATTATGCTGCCGTGTTTGCCCAGGCGCCCAACGTCGCGGCTGAGACGA
TCGAAATCACTTCCGGTTCGCCTTGGGCAATACTGACCGTCATCTGTATCCTGCTTTTCGTCGGCGCCATGGGTAAATCG
GCTCAGTTCCCGCTCCATGTATGGCTGCCGGATTCGATGGAAGGTCCCACGCCCATTTCGGCGCTGATTCATGCTGCAAC
CATGGTTACCGCCGGTATTTTCATGGTGGCGCGCATGTCACCCCTGTTCGAACTGACCGAGACCGCACTCTCCGTAGTGC
TGGTGATAGGCGGCATCACGACCTTGTTCATGGCGCTGGTGGCGATCGTCCAGTATGACATCAAGCGCGTCGTGGCATAC
TCGACCCTGTCGCAACTCGGCTACATGACGGTGGCGCTCGGGGCGTCCGCTTATCCGGCCGCGATTTTTCACCTCATGAC
GCATGCCTTTTTCAAGGCGGTGCTGTTCCTGGGCGCAGGTTCCGTGATTATTGCGATGCATCATGAACAGGATATGCGCA
AGATGGGCGGGCTCAAGAAATACATGCCCATTACTTACTGGACAATGTTTGTTGCCGCACTCGCCAGTGCCGGTGTCCCG
GGCCTCTCGGGCTTCTTCTCGAAGGAGTCGATCATAGAAGCGGTGCACCTTGCCGATATCCCCGGGGCTGGCTTTGCCTA
TTTCTGTGCCGTGGCTACTGTCTTCGTAACCGCATTTTATACCTTTCGCCTGCTGTTCATGACGTTCCACGGTCAGCCGC
GCATGGACCATCACACTGAAGAGCACTTGCATGAATCTCCCTGGGTAGTGACCCTGCCTCTCGTTGCTCTCGCCATACCG
ACCGTCGGCGCAGGCTGGCTGATAGGCCCGATGCTGTTTGGCGATTACTTTGCCAATACGATACAGATCGCGCCTCAACA
CGAAGCAATGGCGAAATTGGCAGCGGAGTTTCACGGCATACCGGAAATGATGAGGCATGCGCTTTCCACCATCCCCTTCT
GGTTATCCGTTGCTGGTATCTTTGCCGCCTGGTATCTCTATATTGCAAAACCCGATCTGCCCGGGAAAATCAAGTGGGCG
GCGGGACCGTTTGCAACGCTGCTTGAGCGCAAATACTTCATAGACGAACTCTATTCCTGGCTGTTTGCAGGCGGTGCGCG
CCTGCTTGGCCGGGGATTGTGGAAGTTCGGGGATGTCAAGGTAATTGACGGGTTCTTTGTGAATGGCACGGCGGGGTTAG
TAGCCGGAGCCTCCACATTGATGCGCCGCTTCCAGACCGGCTACATCTATCACTACGCGTTTACCATGATCGTTGGCGTG
TTTATACTGATGAGTTTGTGGTTGTTCTGGTAA

Upstream 100 bases:

>100_bases
CGATGTCGATGACCTGGATAGCCTTAAAGGCTGACGGGCTAATCCAGGGTCAATAGTTCGGAGTCGGTATCGCTGGTTCA
AAAACAAAAACCTGAATTTC

Downstream 100 bases:

>100_bases
TGGGACAACGAAAAATACAATAAAAATGTTAGTTGTGGGACCCTCCCGCATCCGCTGCACGCTAATGAAAAAAATGGAAT
AGACATGTTGTTTGGTTTCC

Product: proton-translocating NADH-quinone oxidoreductase, chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MTEMQNLYLLVPLAPLAGALIAGLLGRVIGPAASHRVTIALMFVCLAASIAVFLDVLKGNVYNGTVYTWLTSGGVRFEVG
FLIDQLSATMMIVVSFVSLMVHIYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWY
TRPTAIYANLKAFLVNRVGDFGFLLGIGLVLVYFGTLDYAAVFAQAPNVAAETIEITSGSPWAILTVICILLFVGAMGKS
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELTETALSVVLVIGGITTLFMALVAIVQYDIKRVVAY
STLSQLGYMTVALGASAYPAAIFHLMTHAFFKAVLFLGAGSVIIAMHHEQDMRKMGGLKKYMPITYWTMFVAALASAGVP
GLSGFFSKESIIEAVHLADIPGAGFAYFCAVATVFVTAFYTFRLLFMTFHGQPRMDHHTEEHLHESPWVVTLPLVALAIP
TVGAGWLIGPMLFGDYFANTIQIAPQHEAMAKLAAEFHGIPEMMRHALSTIPFWLSVAGIFAAWYLYIAKPDLPGKIKWA
AGPFATLLERKYFIDELYSWLFAGGARLLGRGLWKFGDVKVIDGFFVNGTAGLVAGASTLMRRFQTGYIYHYAFTMIVGV
FILMSLWLFW

Sequences:

>Translated_650_residues
MTEMQNLYLLVPLAPLAGALIAGLLGRVIGPAASHRVTIALMFVCLAASIAVFLDVLKGNVYNGTVYTWLTSGGVRFEVG
FLIDQLSATMMIVVSFVSLMVHIYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWY
TRPTAIYANLKAFLVNRVGDFGFLLGIGLVLVYFGTLDYAAVFAQAPNVAAETIEITSGSPWAILTVICILLFVGAMGKS
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELTETALSVVLVIGGITTLFMALVAIVQYDIKRVVAY
STLSQLGYMTVALGASAYPAAIFHLMTHAFFKAVLFLGAGSVIIAMHHEQDMRKMGGLKKYMPITYWTMFVAALASAGVP
GLSGFFSKESIIEAVHLADIPGAGFAYFCAVATVFVTAFYTFRLLFMTFHGQPRMDHHTEEHLHESPWVVTLPLVALAIP
TVGAGWLIGPMLFGDYFANTIQIAPQHEAMAKLAAEFHGIPEMMRHALSTIPFWLSVAGIFAAWYLYIAKPDLPGKIKWA
AGPFATLLERKYFIDELYSWLFAGGARLLGRGLWKFGDVKVIDGFFVNGTAGLVAGASTLMRRFQTGYIYHYAFTMIVGV
FILMSLWLFW
>Mature_649_residues
TEMQNLYLLVPLAPLAGALIAGLLGRVIGPAASHRVTIALMFVCLAASIAVFLDVLKGNVYNGTVYTWLTSGGVRFEVGF
LIDQLSATMMIVVSFVSLMVHIYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYT
RPTAIYANLKAFLVNRVGDFGFLLGIGLVLVYFGTLDYAAVFAQAPNVAAETIEITSGSPWAILTVICILLFVGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELTETALSVVLVIGGITTLFMALVAIVQYDIKRVVAYS
TLSQLGYMTVALGASAYPAAIFHLMTHAFFKAVLFLGAGSVIIAMHHEQDMRKMGGLKKYMPITYWTMFVAALASAGVPG
LSGFFSKESIIEAVHLADIPGAGFAYFCAVATVFVTAFYTFRLLFMTFHGQPRMDHHTEEHLHESPWVVTLPLVALAIPT
VGAGWLIGPMLFGDYFANTIQIAPQHEAMAKLAAEFHGIPEMMRHALSTIPFWLSVAGIFAAWYLYIAKPDLPGKIKWAA
GPFATLLERKYFIDELYSWLFAGGARLLGRGLWKFGDVKVIDGFFVNGTAGLVAGASTLMRRFQTGYIYHYAFTMIVGVF
ILMSLWLFW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=480, Percent_Identity=37.5, Blast_Score=296, Evalue=5e-80,
Organism=Escherichia coli, GI1788614, Length=523, Percent_Identity=41.3001912045889, Blast_Score=343, Evalue=3e-95,
Organism=Escherichia coli, GI1788829, Length=429, Percent_Identity=32.1678321678322, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI1788827, Length=457, Percent_Identity=28.0087527352298, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788831, Length=350, Percent_Identity=29.4285714285714, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI2367154, Length=230, Percent_Identity=33.9130434782609, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788613, Length=360, Percent_Identity=24.4444444444444, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI145693160, Length=307, Percent_Identity=24.4299674267101, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71433; Mature: 71301

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMQNLYLLVPLAPLAGALIAGLLGRVIGPAASHRVTIALMFVCLAASIAVFLDVLKGN
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VYNGTVYTWLTSGGVRFEVGFLIDQLSATMMIVVSFVSLMVHIYTIGYMHDDPGYQRFFS
CCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHH
YISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIYANLKAFLVNRVGD
HHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
FGFLLGIGLVLVYFGTLDYAAVFAQAPNVAAETIEITSGSPWAILTVICILLFVGAMGKS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCC
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELTETALSVVLVIGGIT
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFMALVAIVQYDIKRVVAYSTLSQLGYMTVALGASAYPAAIFHLMTHAFFKAVLFLGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SVIIAMHHEQDMRKMGGLKKYMPITYWTMFVAALASAGVPGLSGFFSKESIIEAVHLADI
CEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCC
PGAGFAYFCAVATVFVTAFYTFRLLFMTFHGQPRMDHHTEEHLHESPWVVTLPLVALAIP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEHHHHHHHHHC
TVGAGWLIGPMLFGDYFANTIQIAPQHEAMAKLAAEFHGIPEMMRHALSTIPFWLSVAGI
CCCCHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FAAWYLYIAKPDLPGKIKWAAGPFATLLERKYFIDELYSWLFAGGARLLGRGLWKFGDVK
HHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEE
VIDGFFVNGTAGLVAGASTLMRRFQTGYIYHYAFTMIVGVFILMSLWLFW
EECCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TEMQNLYLLVPLAPLAGALIAGLLGRVIGPAASHRVTIALMFVCLAASIAVFLDVLKGN
CCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VYNGTVYTWLTSGGVRFEVGFLIDQLSATMMIVVSFVSLMVHIYTIGYMHDDPGYQRFFS
CCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHH
YISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIYANLKAFLVNRVGD
HHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
FGFLLGIGLVLVYFGTLDYAAVFAQAPNVAAETIEITSGSPWAILTVICILLFVGAMGKS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCC
AQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELTETALSVVLVIGGIT
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFMALVAIVQYDIKRVVAYSTLSQLGYMTVALGASAYPAAIFHLMTHAFFKAVLFLGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SVIIAMHHEQDMRKMGGLKKYMPITYWTMFVAALASAGVPGLSGFFSKESIIEAVHLADI
CEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCC
PGAGFAYFCAVATVFVTAFYTFRLLFMTFHGQPRMDHHTEEHLHESPWVVTLPLVALAIP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEHHHHHHHHHC
TVGAGWLIGPMLFGDYFANTIQIAPQHEAMAKLAAEFHGIPEMMRHALSTIPFWLSVAGI
CCCCHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FAAWYLYIAKPDLPGKIKWAAGPFATLLERKYFIDELYSWLFAGGARLLGRGLWKFGDVK
HHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEE
VIDGFFVNGTAGLVAGASTLMRRFQTGYIYHYAFTMIVGVFILMSLWLFW
EECCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]