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The map label for this gene is panC

Identifier: 82702007

GI number: 82702007

Start: 999255

End: 1000094

Strand: Reverse

Name: panC

Synonym: Nmul_A0878

Alternate gene names: 82702007

Gene position: 1000094-999255 (Counterclockwise)

Preceding gene: 82702008

Following gene: 82702005

Centisome position: 31.41

GC content: 56.9

Gene sequence:

>840_bases
TTGGACGTCATCACGGATATCTCACCGCTGCGAACCCGCCTCGTGGGCGAATCCTCCATCGCCTTCGTGCCGACGATGGG
CGGATTGCACGAGGGACACTTGTCCCTGATTCGGGCCGCCCGGCAACATCGGGAATGCGTAATCGCAAGTATTTTTGTAA
ATCGCCTGCAGTTTGCCCCCACCGAGGATTTTGACCGCTATCCCCGCACGCTGGAGCAGGACTGCGCGCTTCTCGAAGAG
CAGGGCGTTCACATCGTGTTCGCGCCGGAAGAAAAAACCCTTTATCCCGTGCCGCAAGAATTCATGGTGGAACCCTCCCC
CATCGCAAACATGCTGGAAGGGAAGTACCGGCCCGGCTTTTTTCGGGGCGTGGCAACTGTCGTGCTAAAGCTCTTCAATA
TCGTGCAGCCGCAGACCGCGGTATTCGGAAAAAAGGATTATCAGCAATTGCATATTGTACGCGAACTGGCGCGGCAGTTT
AATTTACCCATAGAGATCGTTGCCGGGGAAACAGTTCGCGCCTCGGACAACCTGGCATTGAGCTCGCGTAACCGCTACCT
TCGTGAGGAGGAGCGCGCCGAGGCAATCCGGCTGTATCAGGTGCTGTCGCAAGTCAAGCGGGAGATAGAAGGCGGCAATC
GCAATTTTGCCGGACTAGAGGAAAACGCGATGAAAATTCTTGCCACCCACGGCTGGAACACCGACTACGTCTCGATACGC
GAGAGAGATACCCTGGCGCCAGCCCAGCCCAGGGATGGGAATATGGTGGTGCTGGGAGCAGCCCGCCTGGGTGAAACCCG
GCTCATCGATAACCTCGAAATCACCCCGAAAAAGGAATAG

Upstream 100 bases:

>100_bases
GGCGCGGGCAGCATCGAGGAGGCTGTGCAAAACTATACCAGGGCGGTCAAAACCGGGGAATTTCCTGGGCCCGAGCATAC
ATTCTGACTACCGATCCAAG

Downstream 100 bases:

>100_bases
AGGGGATGAAAGCCGGGTCAGCGGTTGGGCTGCAGTCTCAAACTCTTCCCGCTGTACCCCTGCCGGTGAAGGCTCTGCCC
CTCCCGAGGCAGTTTTTCAC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MDVITDISPLRTRLVGESSIAFVPTMGGLHEGHLSLIRAARQHRECVIASIFVNRLQFAPTEDFDRYPRTLEQDCALLEE
QGVHIVFAPEEKTLYPVPQEFMVEPSPIANMLEGKYRPGFFRGVATVVLKLFNIVQPQTAVFGKKDYQQLHIVRELARQF
NLPIEIVAGETVRASDNLALSSRNRYLREEERAEAIRLYQVLSQVKREIEGGNRNFAGLEENAMKILATHGWNTDYVSIR
ERDTLAPAQPRDGNMVVLGAARLGETRLIDNLEITPKKE

Sequences:

>Translated_279_residues
MDVITDISPLRTRLVGESSIAFVPTMGGLHEGHLSLIRAARQHRECVIASIFVNRLQFAPTEDFDRYPRTLEQDCALLEE
QGVHIVFAPEEKTLYPVPQEFMVEPSPIANMLEGKYRPGFFRGVATVVLKLFNIVQPQTAVFGKKDYQQLHIVRELARQF
NLPIEIVAGETVRASDNLALSSRNRYLREEERAEAIRLYQVLSQVKREIEGGNRNFAGLEENAMKILATHGWNTDYVSIR
ERDTLAPAQPRDGNMVVLGAARLGETRLIDNLEITPKKE
>Mature_279_residues
MDVITDISPLRTRLVGESSIAFVPTMGGLHEGHLSLIRAARQHRECVIASIFVNRLQFAPTEDFDRYPRTLEQDCALLEE
QGVHIVFAPEEKTLYPVPQEFMVEPSPIANMLEGKYRPGFFRGVATVVLKLFNIVQPQTAVFGKKDYQQLHIVRELARQF
NLPIEIVAGETVRASDNLALSSRNRYLREEERAEAIRLYQVLSQVKREIEGGNRNFAGLEENAMKILATHGWNTDYVSIR
ERDTLAPAQPRDGNMVVLGAARLGETRLIDNLEITPKKE

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=263, Percent_Identity=45.2471482889734, Blast_Score=222, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322046, Length=243, Percent_Identity=40.7407407407407, Blast_Score=168, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_NITMU (Q2YAP0)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411573.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q2YAP0
- SMR:   Q2YAP0
- STRING:   Q2YAP0
- GeneID:   3785920
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0878
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q2YAP0
- ProtClustDB:   PRK00380
- BioCyc:   NMUL323848:NMUL_A0878-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31596; Mature: 31596

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 149-149 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVITDISPLRTRLVGESSIAFVPTMGGLHEGHLSLIRAARQHRECVIASIFVNRLQFAP
CCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TEDFDRYPRTLEQDCALLEEQGVHIVFAPEEKTLYPVPQEFMVEPSPIANMLEGKYRPGF
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHCCCCCHHHHHHCCCCCCHH
FRGVATVVLKLFNIVQPQTAVFGKKDYQQLHIVRELARQFNLPIEIVAGETVRASDNLAL
HHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCEEE
SSRNRYLREEERAEAIRLYQVLSQVKREIEGGNRNFAGLEENAMKILATHGWNTDYVSIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCEEEEEECCCCCCEEEEE
ERDTLAPAQPRDGNMVVLGAARLGETRLIDNLEITPKKE
CCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MDVITDISPLRTRLVGESSIAFVPTMGGLHEGHLSLIRAARQHRECVIASIFVNRLQFAP
CCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TEDFDRYPRTLEQDCALLEEQGVHIVFAPEEKTLYPVPQEFMVEPSPIANMLEGKYRPGF
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHCCCCCHHHHHHCCCCCCHH
FRGVATVVLKLFNIVQPQTAVFGKKDYQQLHIVRELARQFNLPIEIVAGETVRASDNLAL
HHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCEEE
SSRNRYLREEERAEAIRLYQVLSQVKREIEGGNRNFAGLEENAMKILATHGWNTDYVSIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCEEEEEECCCCCCEEEEE
ERDTLAPAQPRDGNMVVLGAARLGETRLIDNLEITPKKE
CCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA