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The map label for this gene is sdhA [H]

Identifier: 82701990

GI number: 82701990

Start: 979758

End: 981521

Strand: Reverse

Name: sdhA [H]

Synonym: Nmul_A0861

Alternate gene names: 82701990

Gene position: 981521-979758 (Counterclockwise)

Preceding gene: 82701991

Following gene: 82701989

Centisome position: 30.82

GC content: 57.94

Gene sequence:

>1764_bases
GTGACAGTAGCACGGCGAAAATTCGATGCGGTCATCGTTGGCGCAGGCGGCGGCGGAATGCGCGCAGCGCTGCAATTGTC
GGAAGCGGGCCTCAAGGTGGCCGTACTGTCCAAGGTTTTCCCCACCCGCTCCCATACGGTTGCCGCCCAAGGCGGCATCG
CCGCGGCGCTCGGAAACGTCACCGAAGACAACTGGCACTGGCACATGTACGACACGGTAAAAGGTTCCGATTATCTCGGC
GACCAGGACGCGATCGAATTCATGTGCCGCCAGGCAAGCGAAGTGGTATATGAGCTCGAACATTACGGCATGCCTTTCGA
CCGGCTGGAAAACGGAAAGATTTACCAGCGCCCTTTCGGGGGGCAATCGCAGAATTTCGGGGGCGCACAGGCAACGCGTT
CATGCGCCGTTGCTGACCGCACTGGCCATGCCATGCTGCACACGCTTTATCAGCGCAATGTGCGGGCAAATACCCAGTTT
TTTGTCGAATGGATGGGGCTCGATCTCATTCGTGACGAGCATGGTGATGTGTTAGGCGTCTCAGCGCTCGACATCGAAAC
CGGCGAAGTCATGATCCTGCAGGCAAGAGCGACACTGTTTGCAACCGGCGGGGGAGCACGGATATTCAGTGCCAGCACCA
ATGCTTTCATCAACACGGGCGACGGTCTGGCGATGGCGGCGCGCGCGGGGGTGCCATTACAGGACATGGAATTCTGGCAG
TTTCACCCGACGGGAGTATATGGTGTAGGAATCCTTATCAGCGAGGCGGTGCGTGGGGAAGGCGGTTACCTGCTCAATAA
GGACGGCGAGCGTTTCATGGAGCGCTATGCGCCGCATGCGAAAGACCTTGCCAGCCGCGATGTCGTCTCGCGCGCGATGA
CGACGGAAATCAAGGAAGGGCGCGGATGCGGCAGGGACGCTGATCATCTGCTGCTAAAGCTGGATCATCTGGGAGGGAAC
GTTATCAAGGCGCGGCTGCCTGGCATACGTGAAATTGCCATAAAGTTTGCTCACGCAGACCCGGTCCAGGAGCCCATTCC
GGTAGTCCCCACCGCGCATTACATGATGGGAGGAATTCCGACGAATTTTCATGGTCAGGTAGTAGCGCCCTACAAAACGG
GCCCCGAGGAAGTGGTGCAGGGATTCTATGCCGTGGGTGAATGCGCGTGCGTATCCGTGCATGGCGCCAATCGGCTGGGA
ACCAATTCGCTGCTCGATATACTGGTATTCGGTCGCGCTGCGGGCAACCAGATCATCGAAGACTTGAAAAGGAATACCCA
TCATAAACATTTACCCGGAGACGCGGCAGACAAGGCGCTCGCCCGACTGGCGCGGCTGGATTCCCGGAAGGACGGCGAGA
ACGTGGCGCAGGTAGGGGATATGCTGCGCAAGACCATGCAGGCGCATTGCGGCGTATTCCGTTTTGCAGATTTGCTCAAG
CAAGGGGTCGATAAAATCTCGGAAGTGGCGGAGCGCGTCAAAAATACCGAGATCAGGGATAAAAGCCGGGTGTTCAATAC
TGCGCGGGTAGAAGCGCTGGAACTCGATAATCTGGTGGAAGTCGCCCTGGCGACGATGGTTTCGGCCCAAGCCCGCAAGG
AAAGCCGGGGGGCCCATGCGCGGGATGACTTTCCCCATCGTGATGACGACAAGTGGCTCAAACACACATTGTATTTCAGC
GAAGACCGGCGACTCGATTACAAGCCGGTACGGCTGAAGCCCTTGACGGTCGAATCCTTTCCACCGAAGGCACGAACTTA
TTAG

Upstream 100 bases:

>100_bases
CCTGCTGGTATCCGCCTCATTCTGGAAATACTGGTCATACTGTCACTGCTGTCTTATGCCATCTGGTCTGTGGAAATTCT
CTGGATAGGTGAAGGATAGC

Downstream 100 bases:

>100_bases
AAACACGAACCTGCTGGAAACACATATTGCTTAGGGCCAAACCGGAATGAAATCATGAAATTCTCGATCTACCGCTTCGA
TCCGGACAAGGACGAAAAGC

Product: succinate dehydrogenase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MTVARRKFDAVIVGAGGGGMRAALQLSEAGLKVAVLSKVFPTRSHTVAAQGGIAAALGNVTEDNWHWHMYDTVKGSDYLG
DQDAIEFMCRQASEVVYELEHYGMPFDRLENGKIYQRPFGGQSQNFGGAQATRSCAVADRTGHAMLHTLYQRNVRANTQF
FVEWMGLDLIRDEHGDVLGVSALDIETGEVMILQARATLFATGGGARIFSASTNAFINTGDGLAMAARAGVPLQDMEFWQ
FHPTGVYGVGILISEAVRGEGGYLLNKDGERFMERYAPHAKDLASRDVVSRAMTTEIKEGRGCGRDADHLLLKLDHLGGN
VIKARLPGIREIAIKFAHADPVQEPIPVVPTAHYMMGGIPTNFHGQVVAPYKTGPEEVVQGFYAVGECACVSVHGANRLG
TNSLLDILVFGRAAGNQIIEDLKRNTHHKHLPGDAADKALARLARLDSRKDGENVAQVGDMLRKTMQAHCGVFRFADLLK
QGVDKISEVAERVKNTEIRDKSRVFNTARVEALELDNLVEVALATMVSAQARKESRGAHARDDFPHRDDDKWLKHTLYFS
EDRRLDYKPVRLKPLTVESFPPKARTY

Sequences:

>Translated_587_residues
MTVARRKFDAVIVGAGGGGMRAALQLSEAGLKVAVLSKVFPTRSHTVAAQGGIAAALGNVTEDNWHWHMYDTVKGSDYLG
DQDAIEFMCRQASEVVYELEHYGMPFDRLENGKIYQRPFGGQSQNFGGAQATRSCAVADRTGHAMLHTLYQRNVRANTQF
FVEWMGLDLIRDEHGDVLGVSALDIETGEVMILQARATLFATGGGARIFSASTNAFINTGDGLAMAARAGVPLQDMEFWQ
FHPTGVYGVGILISEAVRGEGGYLLNKDGERFMERYAPHAKDLASRDVVSRAMTTEIKEGRGCGRDADHLLLKLDHLGGN
VIKARLPGIREIAIKFAHADPVQEPIPVVPTAHYMMGGIPTNFHGQVVAPYKTGPEEVVQGFYAVGECACVSVHGANRLG
TNSLLDILVFGRAAGNQIIEDLKRNTHHKHLPGDAADKALARLARLDSRKDGENVAQVGDMLRKTMQAHCGVFRFADLLK
QGVDKISEVAERVKNTEIRDKSRVFNTARVEALELDNLVEVALATMVSAQARKESRGAHARDDFPHRDDDKWLKHTLYFS
EDRRLDYKPVRLKPLTVESFPPKARTY
>Mature_586_residues
TVARRKFDAVIVGAGGGGMRAALQLSEAGLKVAVLSKVFPTRSHTVAAQGGIAAALGNVTEDNWHWHMYDTVKGSDYLGD
QDAIEFMCRQASEVVYELEHYGMPFDRLENGKIYQRPFGGQSQNFGGAQATRSCAVADRTGHAMLHTLYQRNVRANTQFF
VEWMGLDLIRDEHGDVLGVSALDIETGEVMILQARATLFATGGGARIFSASTNAFINTGDGLAMAARAGVPLQDMEFWQF
HPTGVYGVGILISEAVRGEGGYLLNKDGERFMERYAPHAKDLASRDVVSRAMTTEIKEGRGCGRDADHLLLKLDHLGGNV
IKARLPGIREIAIKFAHADPVQEPIPVVPTAHYMMGGIPTNFHGQVVAPYKTGPEEVVQGFYAVGECACVSVHGANRLGT
NSLLDILVFGRAAGNQIIEDLKRNTHHKHLPGDAADKALARLARLDSRKDGENVAQVGDMLRKTMQAHCGVFRFADLLKQ
GVDKISEVAERVKNTEIRDKSRVFNTARVEALELDNLVEVALATMVSAQARKESRGAHARDDFPHRDDDKWLKHTLYFSE
DRRLDYKPVRLKPLTVESFPPKARTY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=52.4701873935264, Blast_Score=594, Evalue=1e-170,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=58.843537414966, Blast_Score=684, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=576, Percent_Identity=40.625, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788928, Length=557, Percent_Identity=32.8545780969479, Blast_Score=236, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17550100, Length=587, Percent_Identity=52.2998296422487, Blast_Score=603, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17505833, Length=588, Percent_Identity=52.3809523809524, Blast_Score=597, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=53.728813559322, Blast_Score=622, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=54.4067796610169, Blast_Score=614, Evalue=1e-176,
Organism=Drosophila melanogaster, GI17137288, Length=609, Percent_Identity=52.7093596059113, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24655642, Length=609, Percent_Identity=52.7093596059113, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24655647, Length=609, Percent_Identity=52.7093596059113, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24663005, Length=607, Percent_Identity=47.7759472817133, Blast_Score=547, Evalue=1e-156,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64505; Mature: 64374

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVARRKFDAVIVGAGGGGMRAALQLSEAGLKVAVLSKVFPTRSHTVAAQGGIAAALGNV
CCCCCEECCEEEEECCCCCCHHHEEHHHCCCEEEEHHHHCCCCCCEEEECCCHHHHHCCC
TEDNWHWHMYDTVKGSDYLGDQDAIEFMCRQASEVVYELEHYGMPFDRLENGKIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCC
GQSQNFGGAQATRSCAVADRTGHAMLHTLYQRNVRANTQFFVEWMGLDLIRDEHGDVLGV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHEEHHHHHHHHEECCCCCEEEE
SALDIETGEVMILQARATLFATGGGARIFSASTNAFINTGDGLAMAARAGVPLQDMEFWQ
EEEEECCCCEEEEEEEEEEEECCCCCEEEECCCCCEEECCCCCEEHHHCCCCCCCCCCEE
FHPTGVYGVGILISEAVRGEGGYLLNKDGERFMERYAPHAKDLASRDVVSRAMTTEIKEG
ECCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGCGRDADHLLLKLDHLGGNVIKARLPGIREIAIKFAHADPVQEPIPVVPTAHYMMGGIP
CCCCCCHHHEEEEEECCCCCEEEECCCCHHHHHEEHHCCCCCCCCCCCCCCHHHHHCCCC
TNFHGQVVAPYKTGPEEVVQGFYAVGECACVSVHGANRLGTNSLLDILVFGRAAGNQIIE
CCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHH
DLKRNTHHKHLPGDAADKALARLARLDSRKDGENVAQVGDMLRKTMQAHCGVFRFADLLK
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QGVDKISEVAERVKNTEIRDKSRVFNTARVEALELDNLVEVALATMVSAQARKESRGAHA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RDDFPHRDDDKWLKHTLYFSEDRRLDYKPVRLKPLTVESFPPKARTY
CCCCCCCCCHHHHHHHEEECCCCCCCCCCEEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TVARRKFDAVIVGAGGGGMRAALQLSEAGLKVAVLSKVFPTRSHTVAAQGGIAAALGNV
CCCCEECCEEEEECCCCCCHHHEEHHHCCCEEEEHHHHCCCCCCEEEECCCHHHHHCCC
TEDNWHWHMYDTVKGSDYLGDQDAIEFMCRQASEVVYELEHYGMPFDRLENGKIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCC
GQSQNFGGAQATRSCAVADRTGHAMLHTLYQRNVRANTQFFVEWMGLDLIRDEHGDVLGV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHEEHHHHHHHHEECCCCCEEEE
SALDIETGEVMILQARATLFATGGGARIFSASTNAFINTGDGLAMAARAGVPLQDMEFWQ
EEEEECCCCEEEEEEEEEEEECCCCCEEEECCCCCEEECCCCCEEHHHCCCCCCCCCCEE
FHPTGVYGVGILISEAVRGEGGYLLNKDGERFMERYAPHAKDLASRDVVSRAMTTEIKEG
ECCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGCGRDADHLLLKLDHLGGNVIKARLPGIREIAIKFAHADPVQEPIPVVPTAHYMMGGIP
CCCCCCHHHEEEEEECCCCCEEEECCCCHHHHHEEHHCCCCCCCCCCCCCCHHHHHCCCC
TNFHGQVVAPYKTGPEEVVQGFYAVGECACVSVHGANRLGTNSLLDILVFGRAAGNQIIE
CCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHH
DLKRNTHHKHLPGDAADKALARLARLDSRKDGENVAQVGDMLRKTMQAHCGVFRFADLLK
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QGVDKISEVAERVKNTEIRDKSRVFNTARVEALELDNLVEVALATMVSAQARKESRGAHA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RDDFPHRDDDKWLKHTLYFSEDRRLDYKPVRLKPLTVESFPPKARTY
CCCCCCCCCHHHHHHHEEECCCCCCCCCCEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]