Click here to switch to the map view.

The map label for this gene is pepA

Identifier: 82701879

GI number: 82701879

Start: 869107

End: 870663

Strand: Reverse

Name: pepA

Synonym: Nmul_A0746

Alternate gene names: 82701879

Gene position: 870663-869107 (Counterclockwise)

Preceding gene: 82701883

Following gene: 82701878

Centisome position: 27.34

GC content: 57.16

Gene sequence:

>1557_bases
GTGAAATTTAATATAAAGAACGGAACACCCGAAAAACAGCGTAGTGCCTGTGTGGTTGCAGGTATTTTCGAACAACAAAA
ATTGACCCCTGCTGCCGAAGCGCTGGACAAATCTGCAAACGGCTATATTACCGGCATCCTGAGCCGGGGGGATATGAAAG
GCAAAGCGGGCGCGACCCTGATGCTCCATAATGTGCCCAACAGCGCCTGCGAGCGCGTATTGCTGGTGGGGCTTGGCAAG
GAGCAGGAACTCGGCGACAAGGGATACCGCGATGCAGTACGCGCAGTGTTCAAGGCACTCTCTGACACTGGCGCTGCCGA
TGCCACTCTGTTTCTGCTGGAAGCGCCCGTAAAAAACCGCGATCTCTCCTGGAAAGTCCTGCAAATCGCGGTCGGCGGGC
TGGAGAGCATGTACCGCTTCGACCGGCTGAAAAGCAAGGTCGAGGAAGCCGAGCCGAAGCTGCAAAAAATTACCCTCGGT
ATTATCAAGTCACTCACCGAGGAGGAACAGACCGCCAGTGAGGAGGCTCTGCAACAAGGACTGGCTGTGGGCGATGGCAT
GAGTCTGGCCAAGGATCTGGGCAATCTTGCACCTAACATCTGCACTCCGACCTATCTTGCGGAGCAGGCCATGAATATGG
CCAAGACTTACAAGCTCAAAGTGACGGTGCTGGAGCAAAAGGATATGGAGGATCTGGGCATGGGCGCATTGCTGGCCGTG
GCGCGCGGAAGCCGCCAGCCTCCCAAGCTGATTGCCCTGGAATATTGGGGAGGGGCGAAGAAGGGAAAACCTGTTGTGCT
GGTAGGCAAGGGCGTCACCTTCGATACGGGCGGCATTTCCCTCAAGCCAGCCGGGGAAATGGATGAAATGAAGTACGACA
TGTGCGGGGCCGCCAGCGTACTGGGCACCGTTCACGCTGTTGCAAAAATGGGTCTTCCAATCAATGTGGTCGGCATTATT
CCAGCCACCGAAAACATGCCTGGCGGCAATGCCACCAAACCTGGCGACGTCGTCACGAGCATGTCGGGACAAACCATAGA
AATTCTCAATACGGATGCCGAAGGCAGGCTGATCCTGTGCGACGCGCTGGCCTACACCGAACGCTACGAACCGGAAGCAG
TAATCGATATTGCTACGCTCACCGGCGCCTGTGTCATAGCGCTCGGTCACGTTGCCTCGGGCCTGCTGAGCAATGACGAC
GAACTGGCCCGGGAACTGTTGGATGCTTCGGAGCGTGCAGTGGATCGCGCCTGGCGTCTGCCGCTGTTCGACGAATATCA
GGAGCAACTGAAAAGTAATTTCGCCGATGTGGCCAATATCGGAGGTCGCGCTGCGGGAACCATTACCGCCGCCTGCTTCC
TGGCGCGATTCACCAAAAAATATCGCTGGGCGCACCTCGACATAGCCGGGACGGCCTGGAAATCCGGCAAGGAAAAAGGC
GCGACCGGACGTCCGGTACCGCTGCTCACCCAGTTTTTGATCAGCCGGACTACCAGACAACCCGGTAGCACTGGCGAGAC
CGGCAGCCGCAAGAACCGGCGCAAATCGAAGGAATGA

Upstream 100 bases:

>100_bases
TCCCGTATCTGCTTTGACTTTATGCGAATAGTCCGGCGATAATCGAAGCATTATCCGGTTTGAACAATCGGCCCGCAAGC
CTTGAATCGAGGAGCAAGCT

Downstream 100 bases:

>100_bases
CGGAAATCGACTTCTACTCGGGCGGGGGAGACCGGCTCCATACCGCCTGTCGTCTGGTTGCAACAGCCGTGCGGAAAGGA
TTCAAGGTCATGATTTACGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MKFNIKNGTPEKQRSACVVAGIFEQQKLTPAAEALDKSANGYITGILSRGDMKGKAGATLMLHNVPNSACERVLLVGLGK
EQELGDKGYRDAVRAVFKALSDTGAADATLFLLEAPVKNRDLSWKVLQIAVGGLESMYRFDRLKSKVEEAEPKLQKITLG
IIKSLTEEEQTASEEALQQGLAVGDGMSLAKDLGNLAPNICTPTYLAEQAMNMAKTYKLKVTVLEQKDMEDLGMGALLAV
ARGSRQPPKLIALEYWGGAKKGKPVVLVGKGVTFDTGGISLKPAGEMDEMKYDMCGAASVLGTVHAVAKMGLPINVVGII
PATENMPGGNATKPGDVVTSMSGQTIEILNTDAEGRLILCDALAYTERYEPEAVIDIATLTGACVIALGHVASGLLSNDD
ELARELLDASERAVDRAWRLPLFDEYQEQLKSNFADVANIGGRAAGTITAACFLARFTKKYRWAHLDIAGTAWKSGKEKG
ATGRPVPLLTQFLISRTTRQPGSTGETGSRKNRRKSKE

Sequences:

>Translated_518_residues
MKFNIKNGTPEKQRSACVVAGIFEQQKLTPAAEALDKSANGYITGILSRGDMKGKAGATLMLHNVPNSACERVLLVGLGK
EQELGDKGYRDAVRAVFKALSDTGAADATLFLLEAPVKNRDLSWKVLQIAVGGLESMYRFDRLKSKVEEAEPKLQKITLG
IIKSLTEEEQTASEEALQQGLAVGDGMSLAKDLGNLAPNICTPTYLAEQAMNMAKTYKLKVTVLEQKDMEDLGMGALLAV
ARGSRQPPKLIALEYWGGAKKGKPVVLVGKGVTFDTGGISLKPAGEMDEMKYDMCGAASVLGTVHAVAKMGLPINVVGII
PATENMPGGNATKPGDVVTSMSGQTIEILNTDAEGRLILCDALAYTERYEPEAVIDIATLTGACVIALGHVASGLLSNDD
ELARELLDASERAVDRAWRLPLFDEYQEQLKSNFADVANIGGRAAGTITAACFLARFTKKYRWAHLDIAGTAWKSGKEKG
ATGRPVPLLTQFLISRTTRQPGSTGETGSRKNRRKSKE
>Mature_518_residues
MKFNIKNGTPEKQRSACVVAGIFEQQKLTPAAEALDKSANGYITGILSRGDMKGKAGATLMLHNVPNSACERVLLVGLGK
EQELGDKGYRDAVRAVFKALSDTGAADATLFLLEAPVKNRDLSWKVLQIAVGGLESMYRFDRLKSKVEEAEPKLQKITLG
IIKSLTEEEQTASEEALQQGLAVGDGMSLAKDLGNLAPNICTPTYLAEQAMNMAKTYKLKVTVLEQKDMEDLGMGALLAV
ARGSRQPPKLIALEYWGGAKKGKPVVLVGKGVTFDTGGISLKPAGEMDEMKYDMCGAASVLGTVHAVAKMGLPINVVGII
PATENMPGGNATKPGDVVTSMSGQTIEILNTDAEGRLILCDALAYTERYEPEAVIDIATLTGACVIALGHVASGLLSNDD
ELARELLDASERAVDRAWRLPLFDEYQEQLKSNFADVANIGGRAAGTITAACFLARFTKKYRWAHLDIAGTAWKSGKEKG
ATGRPVPLLTQFLISRTTRQPGSTGETGSRKNRRKSKE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=501, Percent_Identity=37.7245508982036, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI47155554, Length=363, Percent_Identity=32.2314049586777, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1790710, Length=499, Percent_Identity=56.9138276553106, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI87082123, Length=305, Percent_Identity=40, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=312, Percent_Identity=33.0128205128205, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=277, Percent_Identity=32.129963898917, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI20129969, Length=500, Percent_Identity=31.8, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24661038, Length=353, Percent_Identity=35.6940509915014, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21355725, Length=353, Percent_Identity=34.8441926345609, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI21355645, Length=500, Percent_Identity=29.8, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24662223, Length=500, Percent_Identity=29.8, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24662227, Length=505, Percent_Identity=29.9009900990099, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI161077148, Length=498, Percent_Identity=30.3212851405622, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20130057, Length=498, Percent_Identity=30.3212851405622, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129963, Length=501, Percent_Identity=28.9421157684631, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI19922386, Length=501, Percent_Identity=29.3413173652695, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21357381, Length=295, Percent_Identity=32.5423728813559, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379063, Length=295, Percent_Identity=32.5423728813559, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379062, Length=295, Percent_Identity=32.5423728813559, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646701, Length=323, Percent_Identity=28.4829721362229, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646703, Length=323, Percent_Identity=28.4829721362229, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21358201, Length=323, Percent_Identity=28.4829721362229, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_NITMU (Q2YB18)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411445.1
- HSSP:   P00727
- ProteinModelPortal:   Q2YB18
- SMR:   Q2YB18
- STRING:   Q2YB18
- MEROPS:   M17.003
- GeneID:   3786570
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0746
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   CINDARN
- PhylomeDB:   Q2YB18
- ProtClustDB:   PRK00913
- BioCyc:   NMUL323848:NMUL_A0746-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 55476; Mature: 55476

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 282-282 ACT_SITE 356-356

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFNIKNGTPEKQRSACVVAGIFEQQKLTPAAEALDKSANGYITGILSRGDMKGKAGATL
CEEECCCCCCHHHHCCEEEEEHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCEE
MLHNVPNSACERVLLVGLGKEQELGDKGYRDAVRAVFKALSDTGAADATLFLLEAPVKNR
EEECCCCHHHHHEEEEECCCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
DLSWKVLQIAVGGLESMYRFDRLKSKVEEAEPKLQKITLGIIKSLTEEEQTASEEALQQG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LAVGDGMSLAKDLGNLAPNICTPTYLAEQAMNMAKTYKLKVTVLEQKDMEDLGMGALLAV
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCHHHHCHHHHHHH
ARGSRQPPKLIALEYWGGAKKGKPVVLVGKGVTFDTGGISLKPAGEMDEMKYDMCGAASV
HCCCCCCCCEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHH
LGTVHAVAKMGLPINVVGIIPATENMPGGNATKPGDVVTSMSGQTIEILNTDAEGRLILC
HHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEE
DALAYTERYEPEAVIDIATLTGACVIALGHVASGLLSNDDELARELLDASERAVDRAWRL
EHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
PLFDEYQEQLKSNFADVANIGGRAAGTITAACFLARFTKKYRWAHLDIAGTAWKSGKEKG
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCC
ATGRPVPLLTQFLISRTTRQPGSTGETGSRKNRRKSKE
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MKFNIKNGTPEKQRSACVVAGIFEQQKLTPAAEALDKSANGYITGILSRGDMKGKAGATL
CEEECCCCCCHHHHCCEEEEEHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCEE
MLHNVPNSACERVLLVGLGKEQELGDKGYRDAVRAVFKALSDTGAADATLFLLEAPVKNR
EEECCCCHHHHHEEEEECCCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
DLSWKVLQIAVGGLESMYRFDRLKSKVEEAEPKLQKITLGIIKSLTEEEQTASEEALQQG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LAVGDGMSLAKDLGNLAPNICTPTYLAEQAMNMAKTYKLKVTVLEQKDMEDLGMGALLAV
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCHHHHCHHHHHHH
ARGSRQPPKLIALEYWGGAKKGKPVVLVGKGVTFDTGGISLKPAGEMDEMKYDMCGAASV
HCCCCCCCCEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHH
LGTVHAVAKMGLPINVVGIIPATENMPGGNATKPGDVVTSMSGQTIEILNTDAEGRLILC
HHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEE
DALAYTERYEPEAVIDIATLTGACVIALGHVASGLLSNDDELARELLDASERAVDRAWRL
EHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
PLFDEYQEQLKSNFADVANIGGRAAGTITAACFLARFTKKYRWAHLDIAGTAWKSGKEKG
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCC
ATGRPVPLLTQFLISRTTRQPGSTGETGSRKNRRKSKE
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA