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The map label for this gene is arpR [H]

Identifier: 82701826

GI number: 82701826

Start: 800237

End: 800860

Strand: Direct

Name: arpR [H]

Synonym: Nmul_A0693

Alternate gene names: 82701826

Gene position: 800237-800860 (Clockwise)

Preceding gene: 82701820

Following gene: 82701827

Centisome position: 25.13

GC content: 51.92

Gene sequence:

>624_bases
ATGGCCCGAAAAACCAAGGAAAACGCGGAATTGACACGGCAGCGCATTGTAGATGCGGCGCGCCAGGTTTTTCTGGAGCG
AGGCGTGGCCCGCAGCACCATGGAGCATATCGCGCGCGAGGCCGGCGTTACAAGAGGAGCGATTTACTGGCATTTCAACA
ATAAAATCGAGTTGATTCAGGCAATGCGGGAGCAGGTATTCCTGCCTCTCATCGATCGCATGGACGATACTTTGCTGGTT
GAAGGCGTGGACGATCCTCTCGCCTGCATCGAAAATTTCCTGTGCGGCACGATCCAGGTTCTGATGGATAGTAAGGAGAC
CCGCCAGACATACGAAATCATGATGATCAAGTGCGAATACGTGGATGAGTTCGCTATGGTCTTGCAGCAGATTTTATTCA
ATTGTGCCCATATTTCCGAGAAGCTGAAGCTGGTTTACGAACGCGCCAGGATGCAGCAATTACTGCATTCATCCCATGAC
CTCGTGCAACTGGCCATTGATACCCATCTGTTCTTTATCGGGTTGCTGCACATGTGGGTGAAGGATACGGAGGGAAATCA
GTTCCGGCACCAGGCAATTGAACTGGTAGAGGCGCATATGAGACTGCGCCGCATTTCCCTCTGA

Upstream 100 bases:

>100_bases
GTCATTCATGCTCCGTGCAGCTAAATTTGGAACTTGCATACATACGTGTATGTATGTAAATTATAAACCAACCTTCACAG
ATGTAAAGAGCGATTCGTAC

Downstream 100 bases:

>100_bases
GCGACTGTTCGCTATCCCTGAATCGGTTGGACTGAAGTCGTCTCGGTAGGTCCGATACGATACGAGGAGAACTCATGGCG
GAATTCCGCTCCTGCCATTC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MARKTKENAELTRQRIVDAARQVFLERGVARSTMEHIAREAGVTRGAIYWHFNNKIELIQAMREQVFLPLIDRMDDTLLV
EGVDDPLACIENFLCGTIQVLMDSKETRQTYEIMMIKCEYVDEFAMVLQQILFNCAHISEKLKLVYERARMQQLLHSSHD
LVQLAIDTHLFFIGLLHMWVKDTEGNQFRHQAIELVEAHMRLRRISL

Sequences:

>Translated_207_residues
MARKTKENAELTRQRIVDAARQVFLERGVARSTMEHIAREAGVTRGAIYWHFNNKIELIQAMREQVFLPLIDRMDDTLLV
EGVDDPLACIENFLCGTIQVLMDSKETRQTYEIMMIKCEYVDEFAMVLQQILFNCAHISEKLKLVYERARMQQLLHSSHD
LVQLAIDTHLFFIGLLHMWVKDTEGNQFRHQAIELVEAHMRLRRISL
>Mature_206_residues
ARKTKENAELTRQRIVDAARQVFLERGVARSTMEHIAREAGVTRGAIYWHFNNKIELIQAMREQVFLPLIDRMDDTLLVE
GVDDPLACIENFLCGTIQVLMDSKETRQTYEIMMIKCEYVDEFAMVLQQILFNCAHISEKLKLVYERARMQQLLHSSHDL
VQLAIDTHLFFIGLLHMWVKDTEGNQFRHQAIELVEAHMRLRRISL

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=196, Percent_Identity=29.5918367346939, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789664, Length=206, Percent_Identity=29.6116504854369, Blast_Score=84, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24258; Mature: 24127

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKENAELTRQRIVDAARQVFLERGVARSTMEHIAREAGVTRGAIYWHFNNKIELIQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMREQVFLPLIDRMDDTLLVEGVDDPLACIENFLCGTIQVLMDSKETRQTYEIMMIKCEY
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VDEFAMVLQQILFNCAHISEKLKLVYERARMQQLLHSSHDLVQLAIDTHLFFIGLLHMWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KDTEGNQFRHQAIELVEAHMRLRRISL
HCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARKTKENAELTRQRIVDAARQVFLERGVARSTMEHIAREAGVTRGAIYWHFNNKIELIQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMREQVFLPLIDRMDDTLLVEGVDDPLACIENFLCGTIQVLMDSKETRQTYEIMMIKCEY
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VDEFAMVLQQILFNCAHISEKLKLVYERARMQQLLHSSHDLVQLAIDTHLFFIGLLHMWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KDTEGNQFRHQAIELVEAHMRLRRISL
HCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]