Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 82701794

GI number: 82701794

Start: 756202

End: 756999

Strand: Direct

Name: uppS [H]

Synonym: Nmul_A0661

Alternate gene names: 82701794

Gene position: 756202-756999 (Clockwise)

Preceding gene: 82701793

Following gene: 82701795

Centisome position: 23.75

GC content: 53.88

Gene sequence:

>798_bases
ATGCCAACCATCGTCAGTTCGACCCGGGAAATACCTGAAACTGGAGAAATTCCCCAGCACGTCGCCATTATCATGGACGG
CAATGGACGCTGGGCAAAAAACCGGTTCATGCCGCGCATGGCAGGCCACAAGCGTGGAGTGGAGACAGTACGTTCCGCAA
TCCGGGCCTGCATGGAGCGAGGTGTCAAATATCTGACGTTATTTGCCTTCAGCAGCGAAAACTGGCGCAGGCCACCTGAA
GAAGTCGCATTCCTGATGCAGTTGTTCATAAGCGTGCTGGAGCAGGAGGTATCCAAGCTGCATGAGAACGGTATCCGCTT
CAAGGTAATCGGAGATCTATCGAAATTCGAACCGAAGATAGTCGAGTTCATACGCAACGGCGAAGCGCTCACGGCCGCCA
ATGAACGGTTTACGCTTACTATCGCGGCCAATTACGGCGGACGGTGGGATATCATGCAAGCTGTTCGAAAAATGCTTGCC
GAATGCCCCCACCTGGCGACGACTTTCGATGAAAAAGACCTGATGCAGTATTTTGCCCTCAACCATGCACCGGAACCCGA
TCTATTCATTCGTACGGGAGGCGAGAAGCGCATCAGCAATTTCCTTCTCTGGCAACTGGCATACACCGAACTCTATTTTA
CCGACACGTTATGGCCGGATTTTGATGCGCGCGCTCTGGATCTCGCTATCCAGTCCTATCAGCAACGCGAACGCCGATTT
GGACGAACCAGCGAGCAGCTTCAGGCAGCGTCATCCTTGCGTGGGGGCAGAGAAGTCGCCGTGAAAGCGACGGCATAG

Upstream 100 bases:

>100_bases
CGGGAAGTGACAGTACATGTCTCCGCTTGGCTGTTCTGGAAAGCCGGACCTGAAATAAAAATACCCTTGATTTCAATTTT
GAATCTCAACCGTATTCTCC

Downstream 100 bases:

>100_bases
CTTCAACCCGTTCCGATCCGTGCTTTTTACTGATCGTCTCAACTATGCTCCGGGCACGGATTCTTACCGCCGTCATTATG
CTATCCGTCTTTCTGGCGGC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPTIVSSTREIPETGEIPQHVAIIMDGNGRWAKNRFMPRMAGHKRGVETVRSAIRACMERGVKYLTLFAFSSENWRRPPE
EVAFLMQLFISVLEQEVSKLHENGIRFKVIGDLSKFEPKIVEFIRNGEALTAANERFTLTIAANYGGRWDIMQAVRKMLA
ECPHLATTFDEKDLMQYFALNHAPEPDLFIRTGGEKRISNFLLWQLAYTELYFTDTLWPDFDARALDLAIQSYQQRERRF
GRTSEQLQAASSLRGGREVAVKATA

Sequences:

>Translated_265_residues
MPTIVSSTREIPETGEIPQHVAIIMDGNGRWAKNRFMPRMAGHKRGVETVRSAIRACMERGVKYLTLFAFSSENWRRPPE
EVAFLMQLFISVLEQEVSKLHENGIRFKVIGDLSKFEPKIVEFIRNGEALTAANERFTLTIAANYGGRWDIMQAVRKMLA
ECPHLATTFDEKDLMQYFALNHAPEPDLFIRTGGEKRISNFLLWQLAYTELYFTDTLWPDFDARALDLAIQSYQQRERRF
GRTSEQLQAASSLRGGREVAVKATA
>Mature_264_residues
PTIVSSTREIPETGEIPQHVAIIMDGNGRWAKNRFMPRMAGHKRGVETVRSAIRACMERGVKYLTLFAFSSENWRRPPEE
VAFLMQLFISVLEQEVSKLHENGIRFKVIGDLSKFEPKIVEFIRNGEALTAANERFTLTIAANYGGRWDIMQAVRKMLAE
CPHLATTFDEKDLMQYFALNHAPEPDLFIRTGGEKRISNFLLWQLAYTELYFTDTLWPDFDARALDLAIQSYQQRERRFG
RTSEQLQAASSLRGGREVAVKATA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=230, Percent_Identity=34.7826086956522, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI45580742, Length=230, Percent_Identity=34.7826086956522, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=51.0460251046025, Blast_Score=249, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=234, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=231, Percent_Identity=34.1991341991342, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=219, Percent_Identity=34.703196347032, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18857969, Length=252, Percent_Identity=34.5238095238095, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30352; Mature: 30221

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIVSSTREIPETGEIPQHVAIIMDGNGRWAKNRFMPRMAGHKRGVETVRSAIRACMER
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHC
GVKYLTLFAFSSENWRRPPEEVAFLMQLFISVLEQEVSKLHENGIRFKVIGDLSKFEPKI
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCHHH
VEFIRNGEALTAANERFTLTIAANYGGRWDIMQAVRKMLAECPHLATTFDEKDLMQYFAL
HHHHHCCCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHH
NHAPEPDLFIRTGGEKRISNFLLWQLAYTELYFTDTLWPDFDARALDLAIQSYQQRERRF
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHC
GRTSEQLQAASSLRGGREVAVKATA
CCCHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
PTIVSSTREIPETGEIPQHVAIIMDGNGRWAKNRFMPRMAGHKRGVETVRSAIRACMER
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHC
GVKYLTLFAFSSENWRRPPEEVAFLMQLFISVLEQEVSKLHENGIRFKVIGDLSKFEPKI
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCHHH
VEFIRNGEALTAANERFTLTIAANYGGRWDIMQAVRKMLAECPHLATTFDEKDLMQYFAL
HHHHHCCCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHH
NHAPEPDLFIRTGGEKRISNFLLWQLAYTELYFTDTLWPDFDARALDLAIQSYQQRERRF
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHC
GRTSEQLQAASSLRGGREVAVKATA
CCCHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]