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The map label for this gene is ntpA [H]

Identifier: 82701737

GI number: 82701737

Start: 686195

End: 686668

Strand: Direct

Name: ntpA [H]

Synonym: Nmul_A0604

Alternate gene names: 82701737

Gene position: 686195-686668 (Clockwise)

Preceding gene: 82701736

Following gene: 82701738

Centisome position: 21.55

GC content: 55.91

Gene sequence:

>474_bases
GTGGTGAGAATCTACAAGATTCCGGTTTCCATTCTGGTAATTATCCATACGCCCGACATGCAGGTCCTGCTGCTTGAACG
GGCTGACCATCCCGGCTACTGGCAGTCTGTTACGGGCAGCCAGGACGAAGGCGAGACACTCGTGCAAACGGCGGTGCGGG
AAGTGGCGGAGGAGACCGGGCTGGATGCCCGCCGCTACGCATTGACCGACTGGAACATTGTGAACGAATATGAGATCTAT
GAGGAATGGCGCTGGCGTTACGCCCCCGAAGTAACCCATAACACCGAGCATGTCTTTGGCCTGCTTGTGCCGCACCCGGT
CCCGGTTTCCGTTGCGGCAAGAGAACATTTGCGTCATACCTGGCTCCCCTGGCAGGAGGCGGCGGAAAAAGTATTTTCCC
CAAGCAATGCCGAAGCGATCAGGAGATTGGCAACACTTGGCGGTAAAGGTAATAACGGTAATAAAGGGCAGTAA

Upstream 100 bases:

>100_bases
AAGCAAGGGCGCGGGGTGGAAGCGCAGAAGCGTGGAGATTGGGAAAATCGTTTTTCCGAAAGCGAAGATTTTCTGATTCC
GTTCCTACTCCTGGTGCACA

Downstream 100 bases:

>100_bases
AGAGCAGAAAAAGGCAGTAGGGGTAGGCAGTGGAAGCATTCCCGCGAAAATGAGGAACGGGGAAAGCCCGATCGAACCGA
TGGCGGGTATGCGGGTCCAA

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MVRIYKIPVSILVIIHTPDMQVLLLERADHPGYWQSVTGSQDEGETLVQTAVREVAEETGLDARRYALTDWNIVNEYEIY
EEWRWRYAPEVTHNTEHVFGLLVPHPVPVSVAAREHLRHTWLPWQEAAEKVFSPSNAEAIRRLATLGGKGNNGNKGQ

Sequences:

>Translated_157_residues
MVRIYKIPVSILVIIHTPDMQVLLLERADHPGYWQSVTGSQDEGETLVQTAVREVAEETGLDARRYALTDWNIVNEYEIY
EEWRWRYAPEVTHNTEHVFGLLVPHPVPVSVAAREHLRHTWLPWQEAAEKVFSPSNAEAIRRLATLGGKGNNGNKGQ
>Mature_157_residues
MVRIYKIPVSILVIIHTPDMQVLLLERADHPGYWQSVTGSQDEGETLVQTAVREVAEETGLDARRYALTDWNIVNEYEIY
EEWRWRYAPEVTHNTEHVFGLLVPHPVPVSVAAREHLRHTWLPWQEAAEKVFSPSNAEAIRRLATLGGKGNNGNKGQ

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=144, Percent_Identity=46.5277777777778, Blast_Score=111, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17935; Mature: 17935

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRIYKIPVSILVIIHTPDMQVLLLERADHPGYWQSVTGSQDEGETLVQTAVREVAEETG
CEEEEEECEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
LDARRYALTDWNIVNEYEIYEEWRWRYAPEVTHNTEHVFGLLVPHPVPVSVAAREHLRHT
CCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHC
WLPWQEAAEKVFSPSNAEAIRRLATLGGKGNNGNKGQ
CCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVRIYKIPVSILVIIHTPDMQVLLLERADHPGYWQSVTGSQDEGETLVQTAVREVAEETG
CEEEEEECEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
LDARRYALTDWNIVNEYEIYEEWRWRYAPEVTHNTEHVFGLLVPHPVPVSVAAREHLRHT
CCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHC
WLPWQEAAEKVFSPSNAEAIRRLATLGGKGNNGNKGQ
CCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]