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The map label for this gene is pdxA [H]

Identifier: 82701653

GI number: 82701653

Start: 589358

End: 590338

Strand: Reverse

Name: pdxA [H]

Synonym: Nmul_A0519

Alternate gene names: 82701653

Gene position: 590338-589358 (Counterclockwise)

Preceding gene: 82701654

Following gene: 82701652

Centisome position: 18.54

GC content: 58.82

Gene sequence:

>981_bases
TTGAATAATCCCAAGCTCGCGCTCACCGCAGGGGAACCCGCCGGCATCGGTCCCGACCTGTGCGTGCAGATCACGCAACT
CGGTTTGCCTTTCAAGCTCATTGTCATTGCCGATAGGGAATTGCTGCAGGAGCGCGCGCACTTGCTCCGGCTTCCCTTGA
CAATAACGGACTACTCCTCCCGCGCCGAACACAGGCCGGGCGAAGGGATTTTGCATGTGCTGCACATTCCTCTGGCCGAA
ACTGCCACTCCCGGTAAACCCGATGCCGCTAATGCGTCCTATGTGCTGAAGACGCTCGAGCGGGCTGTTGCTGGATGCGT
CAATGGCGAGTTTGATGCAATGGTAACGGCGCCGGTGCACAAAGGCGTCATCAATGACGCCGGCATTTCTTTTACTGGCC
ACACCGAATATCTCGCGCAACTGACAAACGGCCGCCCCGTCATGATGCTCGCCGGGGGCGGGATGCGGGTAGCACTCGCG
ACTACCCACCTCCCCCTGAAAGACGTCGCGAGTGCCATTACGAGCGATGCTTTGGAGCAGAAACTGCGCATCATCGAGCA
TGATCTGGTCACTCGCTGCGGTATTCCGAAGCCCCGCATTGCCGTTGCGGGCCTGAATCCTCATGCAGGGGAATCGGGTC
ATCTGGGCAGGGAAGAAATCGATATCATCATCCCTTCGCTCGACAAGCTGCGCGCCGGGGGGATGAGTCTGATCGGCCCC
CTGCCTGCCGATACACTTTTCAATCCATCGAAGCTGAAGGATTACGACTGCATATTCGCCATGTACCATGACCAGGGGCT
GCCGGTGCTCAAGCACGCGAGCTTTGGCACTGCCGTCAACGTCACTCTGGGATTGCCCATCATCCGTACCTCCGTGGATC
ATGGCACCGCGCTTGAATTGGCAGGAACAGGCAAAGCTGATCCGGGCAGCCTGGTGGCGGCAATCGAAATGGCGGCATCG
CTGGTTGCGCATCAGCGATAA

Upstream 100 bases:

>100_bases
CCAGGAATGGTTGCAGCGCCTGCGGGACCGGGCGTATGTCGAGTATCGGCTGGAAGAAGGCTAAGGGTCTGTTAACATTT
GTAAGAGACGGGGGCCGAAG

Downstream 100 bases:

>100_bases
CTCTCAACCCTGCATCCCGTTCACCTGAGCTTGTCAAAGGATGAACGAACCTGCAAACCCTCATAAACCATGCAGCACAC
CCCCCGCAGGCGTTTCGGCC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNNPKLALTAGEPAGIGPDLCVQITQLGLPFKLIVIADRELLQERAHLLRLPLTITDYSSRAEHRPGEGILHVLHIPLAE
TATPGKPDAANASYVLKTLERAVAGCVNGEFDAMVTAPVHKGVINDAGISFTGHTEYLAQLTNGRPVMMLAGGGMRVALA
TTHLPLKDVASAITSDALEQKLRIIEHDLVTRCGIPKPRIAVAGLNPHAGESGHLGREEIDIIIPSLDKLRAGGMSLIGP
LPADTLFNPSKLKDYDCIFAMYHDQGLPVLKHASFGTAVNVTLGLPIIRTSVDHGTALELAGTGKADPGSLVAAIEMAAS
LVAHQR

Sequences:

>Translated_326_residues
MNNPKLALTAGEPAGIGPDLCVQITQLGLPFKLIVIADRELLQERAHLLRLPLTITDYSSRAEHRPGEGILHVLHIPLAE
TATPGKPDAANASYVLKTLERAVAGCVNGEFDAMVTAPVHKGVINDAGISFTGHTEYLAQLTNGRPVMMLAGGGMRVALA
TTHLPLKDVASAITSDALEQKLRIIEHDLVTRCGIPKPRIAVAGLNPHAGESGHLGREEIDIIIPSLDKLRAGGMSLIGP
LPADTLFNPSKLKDYDCIFAMYHDQGLPVLKHASFGTAVNVTLGLPIIRTSVDHGTALELAGTGKADPGSLVAAIEMAAS
LVAHQR
>Mature_326_residues
MNNPKLALTAGEPAGIGPDLCVQITQLGLPFKLIVIADRELLQERAHLLRLPLTITDYSSRAEHRPGEGILHVLHIPLAE
TATPGKPDAANASYVLKTLERAVAGCVNGEFDAMVTAPVHKGVINDAGISFTGHTEYLAQLTNGRPVMMLAGGGMRVALA
TTHLPLKDVASAITSDALEQKLRIIEHDLVTRCGIPKPRIAVAGLNPHAGESGHLGREEIDIIIPSLDKLRAGGMSLIGP
LPADTLFNPSKLKDYDCIFAMYHDQGLPVLKHASFGTAVNVTLGLPIIRTSVDHGTALELAGTGKADPGSLVAAIEMAAS
LVAHQR

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=324, Percent_Identity=56.7901234567901, Blast_Score=357, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34412; Mature: 34412

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPKLALTAGEPAGIGPDLCVQITQLGLPFKLIVIADRELLQERAHLLRLPLTITDYSS
CCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEECCEEEECCCC
RAEHRPGEGILHVLHIPLAETATPGKPDAANASYVLKTLERAVAGCVNGEFDAMVTAPVH
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHH
KGVINDAGISFTGHTEYLAQLTNGRPVMMLAGGGMRVALATTHLPLKDVASAITSDALEQ
CCCCCCCCEEECCCHHHHHHHCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHH
KLRIIEHDLVTRCGIPKPRIAVAGLNPHAGESGHLGREEIDIIIPSLDKLRAGGMSLIGP
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCHHHHHCCCCEEECC
LPADTLFNPSKLKDYDCIFAMYHDQGLPVLKHASFGTAVNVTLGLPIIRTSVDHGTALEL
CCCCCCCCHHHCCCCEEEEEEEECCCCCEEEECCCCCEEEEEECCEEEEECCCCCCEEEE
AGTGKADPGSLVAAIEMAASLVAHQR
ECCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNPKLALTAGEPAGIGPDLCVQITQLGLPFKLIVIADRELLQERAHLLRLPLTITDYSS
CCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEECCEEEECCCC
RAEHRPGEGILHVLHIPLAETATPGKPDAANASYVLKTLERAVAGCVNGEFDAMVTAPVH
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHH
KGVINDAGISFTGHTEYLAQLTNGRPVMMLAGGGMRVALATTHLPLKDVASAITSDALEQ
CCCCCCCCEEECCCHHHHHHHCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHH
KLRIIEHDLVTRCGIPKPRIAVAGLNPHAGESGHLGREEIDIIIPSLDKLRAGGMSLIGP
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCHHHHHCCCCEEECC
LPADTLFNPSKLKDYDCIFAMYHDQGLPVLKHASFGTAVNVTLGLPIIRTSVDHGTALEL
CCCCCCCCHHHCCCCEEEEEEEECCCCCEEEECCCCCEEEEEECCEEEEECCCCCCEEEE
AGTGKADPGSLVAAIEMAASLVAHQR
ECCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]