Click here to switch to the map view.

The map label for this gene is pgi [H]

Identifier: 82701603

GI number: 82701603

Start: 523946

End: 525586

Strand: Reverse

Name: pgi [H]

Synonym: Nmul_A0469

Alternate gene names: 82701603

Gene position: 525586-523946 (Counterclockwise)

Preceding gene: 82701604

Following gene: 82701602

Centisome position: 16.51

GC content: 54.72

Gene sequence:

>1641_bases
ATGACGAAACCCATGATCACGCCCCTGACGCAAAGGCCTGCCTGGAAGGCACTGGAAGCGCACTACCAGACGATCAAAGG
CATGCATTTGCGTCAGCTCTTCGCTGACGATCCGAAGCGGGGTGAGCGATTTACGGCCGAGGCCGTCGGCCTGTACCTGG
ATTATTCGAAAAATCGCATCACTGATGAAACGCTTCATCTACTGGTGCAGCTTGCCGAAGAATGCGGCCTGCGCGAGCGC
ATTGAAGCCATGTTCAGGGGTGACGCCATCAATGTGACAGAACAGCGTGCTGTACTCCACATCGCCTTGCGCGCGCCTCG
TAATGAAAAAATCCTCGTCGACGGAAATGACGTTGTGCCCGGGGTGCATGCCGTGCTCGACCGTATGGCGGATTTCTCCG
ACAAGATACGCAGCGGGGACTGGCAGGGGCATACTGGCAAGCGAATTCGCAATATCATCAATATCGGTATCGGCGGCTCC
GATCTGGGCCCGGTGATGGCGTATGAAGCGCTGCGCCACTACAGTCTGCACAATCTCAGCTTTCGTTTCATCTCCAATGT
TGATGGCACGGATTTCGTGGAGGCTACACGAGGTCTTGATCCCGAAGAAACCCTGTTCATTATCTGCTCCAAGACATTCA
CGACAACGGAAACGCTGGCCAATGCCCACACCGCCCGGCGGTGGATGCTGCGACAGATAAAGGACCTGGAGGGGGTGCGC
AAGCACTTCGTCGCTGTTTCCACCAATGCGGAGGAAGTAGCCAGATTCGGCATCGATACCGCCAACATGTTCGAATTCTG
GGACTGGGTAGGTGGACGCTATTCCATGGACTCCGCGATCGGACTCTCAACCATGATTGCCGTCGGCCCAGAGAATTTCC
GTGAGATGCTTGCCGGCTTCCATGCAATGGACCAGCACTTCTATTCCGCTCCGTTCGACAGGAATCTTCCTGTCCTGATG
GGATTGCTGTCGCTCTGGTATAACAATTTCTTTGGCGCGCAGACACTCGCCGTACTGCCCTACGAGCAATATTTGAAGCG
CTTTCCGGCTTACCTCCAGCAACTGACAATGGAGAGCAATGGAAAGCACATTACACTGAATGGCTCCCAGGTTGACTACC
AGACCTCACCTATCGTGTGGGGAGAACCCGGCACCAACGGACAACATTCGTTTTACCAGCTCATCCATCAGGGAACCCGA
TTGATTCCCTGTGATTTTATCGGCTTCTGCCAAACCCTGAACCCCTTGGGCGATCACCATGACCTCCTCATGGCGAATCT
GTTTGCCCAGACCGAGGCGCTTGCTTTCGGAAAAACGGAAGATGAAGTCAAAGCTGAAGGTGTCCCGGACTGGCTTTGCC
CGCATCGCAGTTTTGAGGGGAATCGCCCCACCAATACGATACTTGCCGAGCGCCTCACACCCCACACCCTCGGTGCCCTT
GTCGCTCTTTATGAGCAGAGTGTTTTTACACAGGGGACAATCTGGCAGATCGATTCGTTCGATCAATGGGGCGTCGAACT
CGGCAAAGTGCTGGCACACCGCATCGGGCAGGAACTGGAGGATGAAAACGGCAAGTCCCTGAAACATGATAGCTCCACCA
ACGCCCTGATACAGCGGTACAACAGGCTGAAACAAAAATAG

Upstream 100 bases:

>100_bases
TGTTCAGCCTGTTTTTTCTGTACGCCTTGTCGGGTTATGCCATGTGGACCTGGCGGCGGCTGGCCAAAAGAAAACGAAAG
ATGGTCGAGGGGCAACAAGC

Downstream 100 bases:

>100_bases
CTGTGAACATTGGCTCCTGTCAGGAGTCGAAAAGTATGGTTTTCTACAACTTCCCCTGGGCGCCGGCTCCGCTGCGACGG
GTGGGGAAATCCGTAATATT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTKPMITPLTQRPAWKALEAHYQTIKGMHLRQLFADDPKRGERFTAEAVGLYLDYSKNRITDETLHLLVQLAEECGLRER
IEAMFRGDAINVTEQRAVLHIALRAPRNEKILVDGNDVVPGVHAVLDRMADFSDKIRSGDWQGHTGKRIRNIINIGIGGS
DLGPVMAYEALRHYSLHNLSFRFISNVDGTDFVEATRGLDPEETLFIICSKTFTTTETLANAHTARRWMLRQIKDLEGVR
KHFVAVSTNAEEVARFGIDTANMFEFWDWVGGRYSMDSAIGLSTMIAVGPENFREMLAGFHAMDQHFYSAPFDRNLPVLM
GLLSLWYNNFFGAQTLAVLPYEQYLKRFPAYLQQLTMESNGKHITLNGSQVDYQTSPIVWGEPGTNGQHSFYQLIHQGTR
LIPCDFIGFCQTLNPLGDHHDLLMANLFAQTEALAFGKTEDEVKAEGVPDWLCPHRSFEGNRPTNTILAERLTPHTLGAL
VALYEQSVFTQGTIWQIDSFDQWGVELGKVLAHRIGQELEDENGKSLKHDSSTNALIQRYNRLKQK

Sequences:

>Translated_546_residues
MTKPMITPLTQRPAWKALEAHYQTIKGMHLRQLFADDPKRGERFTAEAVGLYLDYSKNRITDETLHLLVQLAEECGLRER
IEAMFRGDAINVTEQRAVLHIALRAPRNEKILVDGNDVVPGVHAVLDRMADFSDKIRSGDWQGHTGKRIRNIINIGIGGS
DLGPVMAYEALRHYSLHNLSFRFISNVDGTDFVEATRGLDPEETLFIICSKTFTTTETLANAHTARRWMLRQIKDLEGVR
KHFVAVSTNAEEVARFGIDTANMFEFWDWVGGRYSMDSAIGLSTMIAVGPENFREMLAGFHAMDQHFYSAPFDRNLPVLM
GLLSLWYNNFFGAQTLAVLPYEQYLKRFPAYLQQLTMESNGKHITLNGSQVDYQTSPIVWGEPGTNGQHSFYQLIHQGTR
LIPCDFIGFCQTLNPLGDHHDLLMANLFAQTEALAFGKTEDEVKAEGVPDWLCPHRSFEGNRPTNTILAERLTPHTLGAL
VALYEQSVFTQGTIWQIDSFDQWGVELGKVLAHRIGQELEDENGKSLKHDSSTNALIQRYNRLKQK
>Mature_545_residues
TKPMITPLTQRPAWKALEAHYQTIKGMHLRQLFADDPKRGERFTAEAVGLYLDYSKNRITDETLHLLVQLAEECGLRERI
EAMFRGDAINVTEQRAVLHIALRAPRNEKILVDGNDVVPGVHAVLDRMADFSDKIRSGDWQGHTGKRIRNIINIGIGGSD
LGPVMAYEALRHYSLHNLSFRFISNVDGTDFVEATRGLDPEETLFIICSKTFTTTETLANAHTARRWMLRQIKDLEGVRK
HFVAVSTNAEEVARFGIDTANMFEFWDWVGGRYSMDSAIGLSTMIAVGPENFREMLAGFHAMDQHFYSAPFDRNLPVLMG
LLSLWYNNFFGAQTLAVLPYEQYLKRFPAYLQQLTMESNGKHITLNGSQVDYQTSPIVWGEPGTNGQHSFYQLIHQGTRL
IPCDFIGFCQTLNPLGDHHDLLMANLFAQTEALAFGKTEDEVKAEGVPDWLCPHRSFEGNRPTNTILAERLTPHTLGALV
ALYEQSVFTQGTIWQIDSFDQWGVELGKVLAHRIGQELEDENGKSLKHDSSTNALIQRYNRLKQK

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=556, Percent_Identity=53.4172661870504, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI296080693, Length=558, Percent_Identity=49.8207885304659, Blast_Score=527, Evalue=1e-150,
Organism=Escherichia coli, GI1790457, Length=544, Percent_Identity=58.0882352941177, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=544, Percent_Identity=53.3088235294118, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71996703, Length=544, Percent_Identity=53.3088235294118, Blast_Score=571, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319673, Length=540, Percent_Identity=53.1481481481481, Blast_Score=586, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24651916, Length=554, Percent_Identity=53.2490974729242, Blast_Score=580, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24651914, Length=554, Percent_Identity=53.2490974729242, Blast_Score=580, Evalue=1e-166,
Organism=Drosophila melanogaster, GI17737445, Length=554, Percent_Identity=53.2490974729242, Blast_Score=580, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61830; Mature: 61699

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPMITPLTQRPAWKALEAHYQTIKGMHLRQLFADDPKRGERFTAEAVGLYLDYSKNRI
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHEEEEECCCCCC
TDETLHLLVQLAEECGLRERIEAMFRGDAINVTEQRAVLHIALRAPRNEKILVDGNDVVP
CHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEEEEEEEECCCCCEEEECCCCCCC
GVHAVLDRMADFSDKIRSGDWQGHTGKRIRNIINIGIGGSDLGPVMAYEALRHYSLHNLS
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCE
FRFISNVDGTDFVEATRGLDPEETLFIICSKTFTTTETLANAHTARRWMLRQIKDLEGVR
EEEECCCCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHFVAVSTNAEEVARFGIDTANMFEFWDWVGGRYSMDSAIGLSTMIAVGPENFREMLAGF
HHHEEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHEEECHHHHHHHHHHH
HAMDQHFYSAPFDRNLPVLMGLLSLWYNNFFGAQTLAVLPYEQYLKRFPAYLQQLTMESN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHEEECCHHHHHHHHHHHHHHHHHCCC
GKHITLNGSQVDYQTSPIVWGEPGTNGQHSFYQLIHQGTRLIPCDFIGFCQTLNPLGDHH
CCEEEECCCEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHH
DLLMANLFAQTEALAFGKTEDEVKAEGVPDWLCPHRSFEGNRPTNTILAERLTPHTLGAL
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHH
VALYEQSVFTQGTIWQIDSFDQWGVELGKVLAHRIGQELEDENGKSLKHDSSTNALIQRY
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
NRLKQK
HHHCCC
>Mature Secondary Structure 
TKPMITPLTQRPAWKALEAHYQTIKGMHLRQLFADDPKRGERFTAEAVGLYLDYSKNRI
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHEEEEECCCCCC
TDETLHLLVQLAEECGLRERIEAMFRGDAINVTEQRAVLHIALRAPRNEKILVDGNDVVP
CHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEEEEEEEECCCCCEEEECCCCCCC
GVHAVLDRMADFSDKIRSGDWQGHTGKRIRNIINIGIGGSDLGPVMAYEALRHYSLHNLS
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCE
FRFISNVDGTDFVEATRGLDPEETLFIICSKTFTTTETLANAHTARRWMLRQIKDLEGVR
EEEECCCCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHFVAVSTNAEEVARFGIDTANMFEFWDWVGGRYSMDSAIGLSTMIAVGPENFREMLAGF
HHHEEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHEEECHHHHHHHHHHH
HAMDQHFYSAPFDRNLPVLMGLLSLWYNNFFGAQTLAVLPYEQYLKRFPAYLQQLTMESN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHEEECCHHHHHHHHHHHHHHHHHCCC
GKHITLNGSQVDYQTSPIVWGEPGTNGQHSFYQLIHQGTRLIPCDFIGFCQTLNPLGDHH
CCEEEECCCEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHH
DLLMANLFAQTEALAFGKTEDEVKAEGVPDWLCPHRSFEGNRPTNTILAERLTPHTLGAL
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHH
VALYEQSVFTQGTIWQIDSFDQWGVELGKVLAHRIGQELEDENGKSLKHDSSTNALIQRY
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
NRLKQK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA