Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 82701602

GI number: 82701602

Start: 521612

End: 523735

Strand: Reverse

Name: tkt [H]

Synonym: Nmul_A0468

Alternate gene names: 82701602

Gene position: 523735-521612 (Counterclockwise)

Preceding gene: 82701603

Following gene: 82701601

Centisome position: 16.45

GC content: 58.57

Gene sequence:

>2124_bases
ATGAGCGAACAGACCGATCTGGACCAAACCTGTATCAACACGCTTCGCAGCCTCTCCATCGACCAGGTGGAAAAAGCCCA
CTCCGGTCACCCCGGTACCCCGATGGGTGCAGCTCCTACAGCCTTTTGTCTCTGGCAGCGCTTTCTGCGTTACGATCCGG
ATAATCCGGACTGGCCCAATCGCGACCGTTTCGTACTTTCTGCCGGTCACGCTTCAGCGCTGCTCTACAGTCTCCTCCAT
CTGACAGGAATAAAGGGAACCAGTCCCTCTTACGAGGGTGAAGACCGGTTGGCCGTAACGATGGAGGACCTCAAGACGTT
TCGCCAGGCAGGCAGCCGTTGCACCGGCCATCCGGAATATGGATGGACTTCGGGAGTGGAAACGACGACGGGACCGCTGG
GCCAGGGTGTGGGAGACAGCGTCGGCATGGCGATCGCCGGGCAATGGCTTGCGGCCACTTACAACCGGCCCGGTTTCGAA
TTGTTCAACCACAACGTTTATGCCTTGTGCAGTGACGGCGACATGATGGAAGGTGTCAGCAGCGAGGCGGCATCCCTGGC
CGGGCATCTCAAGCTTGGAAACCTGTGCTGGATATATGACGATAACCGCATCACAATCGAAGGATCGACCGATCTCACCT
TCACGGAAGATGTAGCCGCACGGTTTTCCGCATACGGGTGGAGTGTCGCCCACGTGGATGATGCAAACGGATTATCGCTC
CTGACGGAAGCTTACGAGACGTTCCTGCACACCGATAATCGTCCCACGCTGATTATCGTGCATAGCCATATCGGTTATGG
GGCGCCGCACAAGCATGACTCGCGGGAAGCGCACGGTGAACCGCTGGGCCCTGAAGAATCTCGCCTCGCCAAGGAATTCT
ACGGGTGCGACCCCGACAAGCAGTTTTATGTACCGGATGGAGTCCGGGAATACTTTCAGACAGGGTTCGGTGAGCGCGGC
AGAGCTGCACACGCAGGCTGGCGCGTACAGTATGATGCCTACCGGAAGCAATATCCGGACCTGGCGGAGCAGATCGACCG
CATGCAACAACGCGGCTTGCCGGCAGGCTGGGATAGCGAATTACCGATCTTCCCTGCGGATGAGAAGGGCATGGCCACCA
GGGAGTCATCCGGCAAGGTACTGAATGCCATTGCAGGGAAAATTGCCTGGTTGCTGGGCGGAGCCGCCGATCTCGCGCCT
TCCACAAAAACAGAACTGAAAGGGGATTTCTACGGACAGTTTCAGCCGCCTGACCAGTACGAAAACGCAAAGGGCAACTA
CCGCGGACGCAATTTTCACTTCGGCTTGCGTGAGCATGCCATGTGCGCCATTGCCAACGGAATGAGTCTATCGAAATTGC
GTCCCTATGCGGCAAGCTTCCTCGTATTCAGCGACTACGGGCGAGCCGCGCTCCGGCTGAGCGCAATGATGGAGATTCCC
ATCATCTACATCTGGACCCACGATTCCATCAGCCTGGGAGAGGACGGTCCCACGCATCAGCCCATAGCGCATCTGGCTTC
CCTGCGCGCCATCCCCGGTCTGATTGTTCTGCGGCCGGCGGATGCGAATGAAGTGGTGGAAGCATGGCGGCTCATCATGC
AACTCACTGACCGGCCCGTTTGCCTGATATTGACGCGGCAAGCAGTGCCGACTCTCGACCGGACCCGTTATGCGGCCGCG
AACGGCCTGGCGCGCGGCGCCTACGTATTGGCCGACGCCGAAGACGGGAGGCCGGCCGTGCTGCTGCTGGCGACTGGAAG
CGAGGTCGCGCTTTGTGTGGCTGCCCACGAACAGCTCAAGAAAGAAGGAATATCATCACGCGTGGTGAGCATGCCATCAT
GGGAAGTTTTCGAACATCAAGGCCAGGAATATCGGGACGAAATTTTGCCCCCGGGAATATTGGCGCGTGTGGCGGTCGAG
GAGGCATCGAGCTTCGGATGGGAGCGCTATACAGGTGCAGGCGGCTGCATCATTGCCATGCATTGCTTCGGTCTATCGGC
GCCGGCAAAAGTTGTTGCGCGACGCTTCGGATTCGAACCCGGACACATAGCCGCAGCCGCCAAGGAGCAGATTGCCCGGC
ACAATACGAAGAGTACGAAAAGCGAGAGCGAAAAAGCCCGCTGA

Upstream 100 bases:

>100_bases
ATATTGACGGAAGACGAAAAGCGCATTGCTCACAGCCCCATGGAATCCCATTAACGGGTTTCTGTAATTCGCGTAAGGTC
GCTTTTACGGGAGCACTCTC

Downstream 100 bases:

>100_bases
GCTTCGCATGCTCGCGCTCCCGCCGGAGCTCGCTGCCAGTGGCCAACTGGATGAGAAAAGTCTGCTGCTTAAAAAAACAA
CATGAAAATAAATCCTAACG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 707; Mature: 706

Protein sequence:

>707_residues
MSEQTDLDQTCINTLRSLSIDQVEKAHSGHPGTPMGAAPTAFCLWQRFLRYDPDNPDWPNRDRFVLSAGHASALLYSLLH
LTGIKGTSPSYEGEDRLAVTMEDLKTFRQAGSRCTGHPEYGWTSGVETTTGPLGQGVGDSVGMAIAGQWLAATYNRPGFE
LFNHNVYALCSDGDMMEGVSSEAASLAGHLKLGNLCWIYDDNRITIEGSTDLTFTEDVAARFSAYGWSVAHVDDANGLSL
LTEAYETFLHTDNRPTLIIVHSHIGYGAPHKHDSREAHGEPLGPEESRLAKEFYGCDPDKQFYVPDGVREYFQTGFGERG
RAAHAGWRVQYDAYRKQYPDLAEQIDRMQQRGLPAGWDSELPIFPADEKGMATRESSGKVLNAIAGKIAWLLGGAADLAP
STKTELKGDFYGQFQPPDQYENAKGNYRGRNFHFGLREHAMCAIANGMSLSKLRPYAASFLVFSDYGRAALRLSAMMEIP
IIYIWTHDSISLGEDGPTHQPIAHLASLRAIPGLIVLRPADANEVVEAWRLIMQLTDRPVCLILTRQAVPTLDRTRYAAA
NGLARGAYVLADAEDGRPAVLLLATGSEVALCVAAHEQLKKEGISSRVVSMPSWEVFEHQGQEYRDEILPPGILARVAVE
EASSFGWERYTGAGGCIIAMHCFGLSAPAKVVARRFGFEPGHIAAAAKEQIARHNTKSTKSESEKAR

Sequences:

>Translated_707_residues
MSEQTDLDQTCINTLRSLSIDQVEKAHSGHPGTPMGAAPTAFCLWQRFLRYDPDNPDWPNRDRFVLSAGHASALLYSLLH
LTGIKGTSPSYEGEDRLAVTMEDLKTFRQAGSRCTGHPEYGWTSGVETTTGPLGQGVGDSVGMAIAGQWLAATYNRPGFE
LFNHNVYALCSDGDMMEGVSSEAASLAGHLKLGNLCWIYDDNRITIEGSTDLTFTEDVAARFSAYGWSVAHVDDANGLSL
LTEAYETFLHTDNRPTLIIVHSHIGYGAPHKHDSREAHGEPLGPEESRLAKEFYGCDPDKQFYVPDGVREYFQTGFGERG
RAAHAGWRVQYDAYRKQYPDLAEQIDRMQQRGLPAGWDSELPIFPADEKGMATRESSGKVLNAIAGKIAWLLGGAADLAP
STKTELKGDFYGQFQPPDQYENAKGNYRGRNFHFGLREHAMCAIANGMSLSKLRPYAASFLVFSDYGRAALRLSAMMEIP
IIYIWTHDSISLGEDGPTHQPIAHLASLRAIPGLIVLRPADANEVVEAWRLIMQLTDRPVCLILTRQAVPTLDRTRYAAA
NGLARGAYVLADAEDGRPAVLLLATGSEVALCVAAHEQLKKEGISSRVVSMPSWEVFEHQGQEYRDEILPPGILARVAVE
EASSFGWERYTGAGGCIIAMHCFGLSAPAKVVARRFGFEPGHIAAAAKEQIARHNTKSTKSESEKAR
>Mature_706_residues
SEQTDLDQTCINTLRSLSIDQVEKAHSGHPGTPMGAAPTAFCLWQRFLRYDPDNPDWPNRDRFVLSAGHASALLYSLLHL
TGIKGTSPSYEGEDRLAVTMEDLKTFRQAGSRCTGHPEYGWTSGVETTTGPLGQGVGDSVGMAIAGQWLAATYNRPGFEL
FNHNVYALCSDGDMMEGVSSEAASLAGHLKLGNLCWIYDDNRITIEGSTDLTFTEDVAARFSAYGWSVAHVDDANGLSLL
TEAYETFLHTDNRPTLIIVHSHIGYGAPHKHDSREAHGEPLGPEESRLAKEFYGCDPDKQFYVPDGVREYFQTGFGERGR
AAHAGWRVQYDAYRKQYPDLAEQIDRMQQRGLPAGWDSELPIFPADEKGMATRESSGKVLNAIAGKIAWLLGGAADLAPS
TKTELKGDFYGQFQPPDQYENAKGNYRGRNFHFGLREHAMCAIANGMSLSKLRPYAASFLVFSDYGRAALRLSAMMEIPI
IYIWTHDSISLGEDGPTHQPIAHLASLRAIPGLIVLRPADANEVVEAWRLIMQLTDRPVCLILTRQAVPTLDRTRYAAAN
GLARGAYVLADAEDGRPAVLLLATGSEVALCVAAHEQLKKEGISSRVVSMPSWEVFEHQGQEYRDEILPPGILARVAVEE
ASSFGWERYTGAGGCIIAMHCFGLSAPAKVVARRFGFEPGHIAAAAKEQIARHNTKSTKSESEKAR

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=601, Percent_Identity=26.1231281198003, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4507521, Length=601, Percent_Identity=26.1231281198003, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI133778974, Length=276, Percent_Identity=28.9855072463768, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637461, Length=165, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI225637459, Length=165, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI225637463, Length=165, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI48994911, Length=682, Percent_Identity=44.1348973607038, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1788808, Length=683, Percent_Identity=43.9238653001464, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17539652, Length=615, Percent_Identity=26.5040650406504, Blast_Score=152, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=709, Percent_Identity=43.5825105782793, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319593, Length=701, Percent_Identity=40.0855920114123, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45551847, Length=288, Percent_Identity=31.5972222222222, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI45550715, Length=288, Percent_Identity=31.5972222222222, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24645119, Length=259, Percent_Identity=31.6602316602317, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666278, Length=270, Percent_Identity=30, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 77497; Mature: 77366

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQTDLDQTCINTLRSLSIDQVEKAHSGHPGTPMGAAPTAFCLWQRFLRYDPDNPDWPN
CCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSAGHASALLYSLLHLTGIKGTSPSYEGEDRLAVTMEDLKTFRQAGSRCTGHPEY
CCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCC
GWTSGVETTTGPLGQGVGDSVGMAIAGQWLAATYNRPGFELFNHNVYALCSDGDMMEGVS
CCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHCCCCCCEECCCCEEEEECCCCHHHCCH
SEAASLAGHLKLGNLCWIYDDNRITIEGSTDLTFTEDVAARFSAYGWSVAHVDDANGLSL
HHHHHHHHCEEECCEEEEEECCEEEEECCCCCEEHHHHHHHHHHCCCEEEEECCCCCHHH
LTEAYETFLHTDNRPTLIIVHSHIGYGAPHKHDSREAHGEPLGPEESRLAKEFYGCDPDK
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCC
QFYVPDGVREYFQTGFGERGRAAHAGWRVQYDAYRKQYPDLAEQIDRMQQRGLPAGWDSE
EEECCHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
LPIFPADEKGMATRESSGKVLNAIAGKIAWLLGGAADLAPSTKTELKGDFYGQFQPPDQY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHCCCCCCCCCCCCCHH
ENAKGNYRGRNFHFGLREHAMCAIANGMSLSKLRPYAASFLVFSDYGRAALRLSAMMEIP
CCCCCCCCCCCEECCHHHHHHHHHHCCCCHHHHCHHHHHEEEECCCCHHHHHHHHHEECC
IIYIWTHDSISLGEDGPTHQPIAHLASLRAIPGLIVLRPADANEVVEAWRLIMQLTDRPV
EEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCE
CLILTRQAVPTLDRTRYAAANGLARGAYVLADAEDGRPAVLLLATGSEVALCVAAHEQLK
EEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCEEEHHHHHHHHH
KEGISSRVVSMPSWEVFEHQGQEYRDEILPPGILARVAVEEASSFGWERYTGAGGCIIAM
HCCCHHHEECCCCHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCCCCCEEEEE
HCFGLSAPAKVVARRFGFEPGHIAAAAKEQIARHNTKSTKSESEKAR
EHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure 
SEQTDLDQTCINTLRSLSIDQVEKAHSGHPGTPMGAAPTAFCLWQRFLRYDPDNPDWPN
CCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSAGHASALLYSLLHLTGIKGTSPSYEGEDRLAVTMEDLKTFRQAGSRCTGHPEY
CCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCC
GWTSGVETTTGPLGQGVGDSVGMAIAGQWLAATYNRPGFELFNHNVYALCSDGDMMEGVS
CCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHCCCCCCEECCCCEEEEECCCCHHHCCH
SEAASLAGHLKLGNLCWIYDDNRITIEGSTDLTFTEDVAARFSAYGWSVAHVDDANGLSL
HHHHHHHHCEEECCEEEEEECCEEEEECCCCCEEHHHHHHHHHHCCCEEEEECCCCCHHH
LTEAYETFLHTDNRPTLIIVHSHIGYGAPHKHDSREAHGEPLGPEESRLAKEFYGCDPDK
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCC
QFYVPDGVREYFQTGFGERGRAAHAGWRVQYDAYRKQYPDLAEQIDRMQQRGLPAGWDSE
EEECCHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
LPIFPADEKGMATRESSGKVLNAIAGKIAWLLGGAADLAPSTKTELKGDFYGQFQPPDQY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHCCCCCCCCCCCCCHH
ENAKGNYRGRNFHFGLREHAMCAIANGMSLSKLRPYAASFLVFSDYGRAALRLSAMMEIP
CCCCCCCCCCCEECCHHHHHHHHHHCCCCHHHHCHHHHHEEEECCCCHHHHHHHHHEECC
IIYIWTHDSISLGEDGPTHQPIAHLASLRAIPGLIVLRPADANEVVEAWRLIMQLTDRPV
EEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCE
CLILTRQAVPTLDRTRYAAANGLARGAYVLADAEDGRPAVLLLATGSEVALCVAAHEQLK
EEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCEEEHHHHHHHHH
KEGISSRVVSMPSWEVFEHQGQEYRDEILPPGILARVAVEEASSFGWERYTGAGGCIIAM
HCCCHHHEECCCCHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCCCCCEEEEE
HCFGLSAPAKVVARRFGFEPGHIAAAAKEQIARHNTKSTKSESEKAR
EHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]