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The map label for this gene is serA [H]

Identifier: 82701562

GI number: 82701562

Start: 474984

End: 475931

Strand: Reverse

Name: serA [H]

Synonym: Nmul_A0428

Alternate gene names: 82701562

Gene position: 475931-474984 (Counterclockwise)

Preceding gene: 82701563

Following gene: 82701561

Centisome position: 14.95

GC content: 56.22

Gene sequence:

>948_bases
ATGAACAAACTTGCGATTTCCACCTCGTCATTCGATGTCAGCCATAATAGTGCTCTCCGGCCTTTACAGGAGAGGGGCAT
ACCCATTGCCGAAAACAGTCATAAGAGGAAACTTACCGAGGATGAGGTTATCGCCCTGCTGGGCGAAGATACGGTGGGAA
TGATCGCAGGCGTGGAGCCTCTCACAGAGCGGGTTTTCTCCTGCGCGAGGAGCCTGAAAGTCGTATCGCGCTGCGGCAGC
GGCCTCGACAGCGTCGATCTTGGCGCAGCGAAACGGCATGGAATCAAGGTGTTGAACACGCCGGAAGCTCCCGCACAGGC
GGTTGCCGAGCTCTCGCTGGCCCTTATAATGGCAGCATTGAGGAAGATATGCCAGACAGATAAACAGGTTCGCGCGGGGC
AGTGGCCCCGGGCCCAGGGAGGTCTGCTGGCTGCCCAAAAGGTGGGAATTGTGGGGCTTGGACGGGTAGGATCACGTGTA
GCCCGATTGTGTCGTGCGTTCGAAGCGCAGGTGGTGGCGCACGATACTTATGTAAAGGAGATGCCTCCGGGAATGGAAGG
CGTGAAACTGGTACCCTTCGAAACCTTGATAGCCGAAGCGGATATCATCAGCCTGCACCTGACCTACGACGCGGACACTC
ACCATCTGTTGAATGAAAAAACGTTTGCACGGATGAAGCCTGGCGCGATCGTCATCAATACCGCCCGGGGTGGGCTGATA
GATGAAGCAGCGCTGGCCGATGCCCTGAACAGCGGGCAGCTTGGAGGAGCGGCAATGGACGTTTTCGAGCAGGAACCTTA
CCATGGCCCGTTACTGCAATGCGATAACGCAATACTGACCTCCCATATCGGCTCTCTTGCAAAGGAATCGCGTCAGCGTA
TGGAACTGGAAGCCGCGGAAAATCTGGTGCGCGGATTGATCGAAGCCGGTGTAATGGAAAAAGGTTAA

Upstream 100 bases:

>100_bases
GCAATATCGAGGCGGGCTTCAGTTTTCTTGGCTATGGCCTGGATATCCGCATTCTCGATACCGTCTGCCGCAGTCATCTG
CAAAACATCAGGGAAGCTCT

Downstream 100 bases:

>100_bases
AACAGCAGATGTCCAGCGAGATTGCCATTGTCTATGGCGCCAGCGGTTTTCTGGGCAGTCACGTTGCCGACGCGCTCTCC
GACTCGGGCTATCGGGTGCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MNKLAISTSSFDVSHNSALRPLQERGIPIAENSHKRKLTEDEVIALLGEDTVGMIAGVEPLTERVFSCARSLKVVSRCGS
GLDSVDLGAAKRHGIKVLNTPEAPAQAVAELSLALIMAALRKICQTDKQVRAGQWPRAQGGLLAAQKVGIVGLGRVGSRV
ARLCRAFEAQVVAHDTYVKEMPPGMEGVKLVPFETLIAEADIISLHLTYDADTHHLLNEKTFARMKPGAIVINTARGGLI
DEAALADALNSGQLGGAAMDVFEQEPYHGPLLQCDNAILTSHIGSLAKESRQRMELEAAENLVRGLIEAGVMEKG

Sequences:

>Translated_315_residues
MNKLAISTSSFDVSHNSALRPLQERGIPIAENSHKRKLTEDEVIALLGEDTVGMIAGVEPLTERVFSCARSLKVVSRCGS
GLDSVDLGAAKRHGIKVLNTPEAPAQAVAELSLALIMAALRKICQTDKQVRAGQWPRAQGGLLAAQKVGIVGLGRVGSRV
ARLCRAFEAQVVAHDTYVKEMPPGMEGVKLVPFETLIAEADIISLHLTYDADTHHLLNEKTFARMKPGAIVINTARGGLI
DEAALADALNSGQLGGAAMDVFEQEPYHGPLLQCDNAILTSHIGSLAKESRQRMELEAAENLVRGLIEAGVMEKG
>Mature_315_residues
MNKLAISTSSFDVSHNSALRPLQERGIPIAENSHKRKLTEDEVIALLGEDTVGMIAGVEPLTERVFSCARSLKVVSRCGS
GLDSVDLGAAKRHGIKVLNTPEAPAQAVAELSLALIMAALRKICQTDKQVRAGQWPRAQGGLLAAQKVGIVGLGRVGSRV
ARLCRAFEAQVVAHDTYVKEMPPGMEGVKLVPFETLIAEADIISLHLTYDADTHHLLNEKTFARMKPGAIVINTARGGLI
DEAALADALNSGQLGGAAMDVFEQEPYHGPLLQCDNAILTSHIGSLAKESRQRMELEAAENLVRGLIEAGVMEKG

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=286, Percent_Identity=38.1118881118881, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=33.7164750957854, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=33.7164750957854, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI145580578, Length=279, Percent_Identity=32.9749103942652, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4557499, Length=279, Percent_Identity=32.9749103942652, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI145580575, Length=279, Percent_Identity=32.9749103942652, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=32.7935222672065, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1789279, Length=252, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=31.3653136531365, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1787645, Length=243, Percent_Identity=31.2757201646091, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081824, Length=282, Percent_Identity=24.113475177305, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788660, Length=105, Percent_Identity=38.0952380952381, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=287, Percent_Identity=34.4947735191638, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=32.6771653543307, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=308, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=310, Percent_Identity=28.0645161290323, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=28.0632411067194, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=267, Percent_Identity=23.5955056179775, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=170, Percent_Identity=27.6470588235294, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=178, Percent_Identity=28.6516853932584, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646446, Length=263, Percent_Identity=34.6007604562738, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646448, Length=263, Percent_Identity=34.6007604562738, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646452, Length=263, Percent_Identity=34.6007604562738, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646450, Length=263, Percent_Identity=34.6007604562738, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI62472511, Length=263, Percent_Identity=34.6007604562738, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI19921140, Length=299, Percent_Identity=29.7658862876254, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585514, Length=264, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28574282, Length=264, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45552429, Length=264, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI28571528, Length=243, Percent_Identity=32.5102880658436, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574286, Length=244, Percent_Identity=29.9180327868852, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585516, Length=277, Percent_Identity=28.158844765343, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33650; Mature: 33650

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLAISTSSFDVSHNSALRPLQERGIPIAENSHKRKLTEDEVIALLGEDTVGMIAGVEP
CCCEEEECCCCCCCCCHHHCHHHHCCCCCCCCCCCCCCCHHHHHEEECCCCHHHHHCCHH
LTERVFSCARSLKVVSRCGSGLDSVDLGAAKRHGIKVLNTPEAPAQAVAELSLALIMAAL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHH
RKICQTDKQVRAGQWPRAQGGLLAAQKVGIVGLGRVGSRVARLCRAFEAQVVAHDTYVKE
HHHHHCHHHHHCCCCCCCCCCEEEHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
MPPGMEGVKLVPFETLIAEADIISLHLTYDADTHHLLNEKTFARMKPGAIVINTARGGLI
CCCCCCCEEECCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCH
DEAALADALNSGQLGGAAMDVFEQEPYHGPLLQCDNAILTSHIGSLAKESRQRMELEAAE
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
NLVRGLIEAGVMEKG
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MNKLAISTSSFDVSHNSALRPLQERGIPIAENSHKRKLTEDEVIALLGEDTVGMIAGVEP
CCCEEEECCCCCCCCCHHHCHHHHCCCCCCCCCCCCCCCHHHHHEEECCCCHHHHHCCHH
LTERVFSCARSLKVVSRCGSGLDSVDLGAAKRHGIKVLNTPEAPAQAVAELSLALIMAAL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHH
RKICQTDKQVRAGQWPRAQGGLLAAQKVGIVGLGRVGSRVARLCRAFEAQVVAHDTYVKE
HHHHHCHHHHHCCCCCCCCCCEEEHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
MPPGMEGVKLVPFETLIAEADIISLHLTYDADTHHLLNEKTFARMKPGAIVINTARGGLI
CCCCCCCEEECCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCH
DEAALADALNSGQLGGAAMDVFEQEPYHGPLLQCDNAILTSHIGSLAKESRQRMELEAAE
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
NLVRGLIEAGVMEKG
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]