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The map label for this gene is frzE [H]

Identifier: 82701467

GI number: 82701467

Start: 361246

End: 363600

Strand: Direct

Name: frzE [H]

Synonym: Nmul_A0333

Alternate gene names: 82701467

Gene position: 361246-363600 (Clockwise)

Preceding gene: 82701466

Following gene: 82701468

Centisome position: 11.34

GC content: 52.91

Gene sequence:

>2355_bases
ATGCCTGACAAAAGGGATGTGCTTTTGGAAAGGCTCCTTGCAATGTTTCGCATCGAGGCAGAGGCCCACCTGAAGGATAT
ATCGTCGGGACTGCTCGCCCTGGAGGGAAAACCTGTAGATACCCCGGCGTTCGATATCATTGAGAACATGTTGCGGTGCG
CACACAGTCTCAAAGGCGCAGCACGAGCAGTCAATTTTGCCCAAGTCGAGGAGACCTGCCGTTCTCTGGAAAATGTATTC
TCCGCACTGAAAGATAAAAGCCTTGCTGTATCGTCATCGCTCATCGATCAGCTGCTTAAGGCGGTCGATGCCCTGGGGAC
ACTCGTTTCAGGAGAGGGCAGCATGGCTGAGCGGCAAAAGCTGTTGTCGGCTACAGTAACCCGACAGCTCAATGAAATGT
TGAAAAGTCCCACCAAAGAAGGACGTACGGGCTCCTCCTTATCGCAGGCCGCGTCCCCTTTATCTTTGCTTCCCCCTGAT
GAATCATCCGCAACCCGTGCCGATGTAGGGGCATATTTGCGAACCTCTATTCCGAGCCATGCATCTGCCACAATCAGAGT
GCCTACCGTAAAACTCGAAAAGGTTTTGCGTCAGGTTGAGGAATTTTTGCTGCCGTGCCTGACAGCGCGACAACGGGCCA
AGGAGCTAGGCGAAATCACTACGACACTTGCCGTATGGAAGAAACAGCGTCTGCAAATCCAGTCGGTGGTGCGCATTATT
GATCGCGAGATGACATCCAGCCTCAAGGATCGCTCCTTCCGGGAACAACACGGGCTTCCGAAGCTGCTCAAATACCTGGA
TGGGGAGCCGCTTCAAATGAAAGCGCTTGAGGAGCGGCTAGTGAGATTGCAGCGGACCATCGAGCAAGACCAACGCGTAC
TTGCCGGCATGACCGATTGCCTGATTCAGGATGTCAAAGAAATGCAATTACTGCCTTTCTCGACACTGTTGGATATTCTG
CCCCGATTCTCCCGCGAGCTGGCCCGCGAACAGGGCAAGAGCCTGGAGCTGGTGGTGAGTGGCGGCGAGGTGGAAATTGA
TCGGCATATTTTGGAAGAGATGAAAGATCCTCTGATCCATCTGGTGCGTAATTGCATCGACCACGGTATTGAGCAGCCCG
CCGCACGGTTGGCTAAAGGTAAGCCTTCGTCGGGAAGAATCACCTTCGCATGCTCGCAGAGCGATAGCGGCAAGGCTGAG
ATACGTGTAGCCGATGATGGGGGTGGAATCAATGTCGGTAAATTGAAAGCTGCGGCCCACAAGCTTGGCGTAATGTCCGA
GGAAGAGATGGAGCGACTGGGTGAGTCGGAATTGCTTGCGCTTATTTTTAGATCTGGCGTGACCACCAGCCCCCTCATTA
CCGATATCTCCGGACGCGGGCTGGGACTCGCGATTGTACGTGAAAAGGTTGAAGCTTTAGGCGGCAGCATCAAGGTCAAA
TCAAGTACTGATACTGGAACTGCTTTCCATATCTTACTGCCGTTAACGCTAACAAATACCCGGGGAGTTCTGGTTCATGC
CGCAGGACAGCTTTTTGTTATTCCTTCAAGCAGCGTTGAGCGCGTAGTCCGAATCGCCAAAAACGAAATTGAGACAGTGA
AAAATCGAGAAACCATTCTGGTAGATGAACAACCTGTTTCTCTGGTGAAGTTGGGCGATATACTGGAACTGGCTGGCAAT
TCGGCAGAAATGGAACCCGCGCACTATTTGCGAGGGATCGTTCTCAGTTCAGGTCTTGGTCGTGTTGCATTTCTCGTGGA
AGAGGTTCTCGGGGAGCAAGAGGTTGTGATAAAAGCACTCCTCCCGCCATTGAAGCGAGTAAGAAACGTCGCAGGTGTAT
GCATGCTGGGGACCGGGCGAGTGGTCCCGGTGCTTAACGTACCTGATCTTTTGAAATCCGCTGTGAAAGCATCCTCGGCT
CCATGCATCCCTACCCAGGACTCATCGGCTGAGAAGCAGGGAACATCAAGCAAGCACTCTATTTTAGTAGTGGACGATTC
CATTACTGCGCGGACACTGCTCAAACATATCCTGGAATCGGCAGGGTATCGTGTGACTACAGCTGTGGATGGAGTGGAGG
GCTATACCGCCCTTAAAACAGGCACCCACAGCCTGGTAGTCTCTGATGTCGAAATGCCGCGAATGGACGGCTTTGCCCTG
ACAGCCAAGATACGCGCTGACAAGCAGTTGGCGACGCTGCCGGTGGTATTGGTAACGGCATTGGATTCACGTGATCACCG
GGAGCGAGGCATCGATGTGGGAGCGAATGCATATATCGTGAAGAGTCGCTTTGACCAAGGCAACCTGCTGGAAGCGATCC
GACGCCTGATCAGCATCAGCAGCATTAATCCGTGA

Upstream 100 bases:

>100_bases
GCAGAATCAGCGGCACAAGGCTTGTATGAGATGGGGAATAAATTGAGTGTCCTCGTAGGCAGCAAGAAAGACCGTTTCGT
AGAGGAAGCGGGAAAAGTCC

Downstream 100 bases:

>100_bases
GTTTCCTCCCATGATAAACGTCCTGGTAGTGGAAGATTCACCGGTAGTGCGAGAGTTTCTTATTTACATACTCAATTCCG
ATCCTGATATCACTGTTATT

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MPDKRDVLLERLLAMFRIEAEAHLKDISSGLLALEGKPVDTPAFDIIENMLRCAHSLKGAARAVNFAQVEETCRSLENVF
SALKDKSLAVSSSLIDQLLKAVDALGTLVSGEGSMAERQKLLSATVTRQLNEMLKSPTKEGRTGSSLSQAASPLSLLPPD
ESSATRADVGAYLRTSIPSHASATIRVPTVKLEKVLRQVEEFLLPCLTARQRAKELGEITTTLAVWKKQRLQIQSVVRII
DREMTSSLKDRSFREQHGLPKLLKYLDGEPLQMKALEERLVRLQRTIEQDQRVLAGMTDCLIQDVKEMQLLPFSTLLDIL
PRFSRELAREQGKSLELVVSGGEVEIDRHILEEMKDPLIHLVRNCIDHGIEQPAARLAKGKPSSGRITFACSQSDSGKAE
IRVADDGGGINVGKLKAAAHKLGVMSEEEMERLGESELLALIFRSGVTTSPLITDISGRGLGLAIVREKVEALGGSIKVK
SSTDTGTAFHILLPLTLTNTRGVLVHAAGQLFVIPSSSVERVVRIAKNEIETVKNRETILVDEQPVSLVKLGDILELAGN
SAEMEPAHYLRGIVLSSGLGRVAFLVEEVLGEQEVVIKALLPPLKRVRNVAGVCMLGTGRVVPVLNVPDLLKSAVKASSA
PCIPTQDSSAEKQGTSSKHSILVVDDSITARTLLKHILESAGYRVTTAVDGVEGYTALKTGTHSLVVSDVEMPRMDGFAL
TAKIRADKQLATLPVVLVTALDSRDHRERGIDVGANAYIVKSRFDQGNLLEAIRRLISISSINP

Sequences:

>Translated_784_residues
MPDKRDVLLERLLAMFRIEAEAHLKDISSGLLALEGKPVDTPAFDIIENMLRCAHSLKGAARAVNFAQVEETCRSLENVF
SALKDKSLAVSSSLIDQLLKAVDALGTLVSGEGSMAERQKLLSATVTRQLNEMLKSPTKEGRTGSSLSQAASPLSLLPPD
ESSATRADVGAYLRTSIPSHASATIRVPTVKLEKVLRQVEEFLLPCLTARQRAKELGEITTTLAVWKKQRLQIQSVVRII
DREMTSSLKDRSFREQHGLPKLLKYLDGEPLQMKALEERLVRLQRTIEQDQRVLAGMTDCLIQDVKEMQLLPFSTLLDIL
PRFSRELAREQGKSLELVVSGGEVEIDRHILEEMKDPLIHLVRNCIDHGIEQPAARLAKGKPSSGRITFACSQSDSGKAE
IRVADDGGGINVGKLKAAAHKLGVMSEEEMERLGESELLALIFRSGVTTSPLITDISGRGLGLAIVREKVEALGGSIKVK
SSTDTGTAFHILLPLTLTNTRGVLVHAAGQLFVIPSSSVERVVRIAKNEIETVKNRETILVDEQPVSLVKLGDILELAGN
SAEMEPAHYLRGIVLSSGLGRVAFLVEEVLGEQEVVIKALLPPLKRVRNVAGVCMLGTGRVVPVLNVPDLLKSAVKASSA
PCIPTQDSSAEKQGTSSKHSILVVDDSITARTLLKHILESAGYRVTTAVDGVEGYTALKTGTHSLVVSDVEMPRMDGFAL
TAKIRADKQLATLPVVLVTALDSRDHRERGIDVGANAYIVKSRFDQGNLLEAIRRLISISSINP
>Mature_783_residues
PDKRDVLLERLLAMFRIEAEAHLKDISSGLLALEGKPVDTPAFDIIENMLRCAHSLKGAARAVNFAQVEETCRSLENVFS
ALKDKSLAVSSSLIDQLLKAVDALGTLVSGEGSMAERQKLLSATVTRQLNEMLKSPTKEGRTGSSLSQAASPLSLLPPDE
SSATRADVGAYLRTSIPSHASATIRVPTVKLEKVLRQVEEFLLPCLTARQRAKELGEITTTLAVWKKQRLQIQSVVRIID
REMTSSLKDRSFREQHGLPKLLKYLDGEPLQMKALEERLVRLQRTIEQDQRVLAGMTDCLIQDVKEMQLLPFSTLLDILP
RFSRELAREQGKSLELVVSGGEVEIDRHILEEMKDPLIHLVRNCIDHGIEQPAARLAKGKPSSGRITFACSQSDSGKAEI
RVADDGGGINVGKLKAAAHKLGVMSEEEMERLGESELLALIFRSGVTTSPLITDISGRGLGLAIVREKVEALGGSIKVKS
STDTGTAFHILLPLTLTNTRGVLVHAAGQLFVIPSSSVERVVRIAKNEIETVKNRETILVDEQPVSLVKLGDILELAGNS
AEMEPAHYLRGIVLSSGLGRVAFLVEEVLGEQEVVIKALLPPLKRVRNVAGVCMLGTGRVVPVLNVPDLLKSAVKASSAP
CIPTQDSSAEKQGTSSKHSILVVDDSITARTLLKHILESAGYRVTTAVDGVEGYTALKTGTHSLVVSDVEMPRMDGFALT
AKIRADKQLATLPVVLVTALDSRDHRERGIDVGANAYIVKSRFDQGNLLEAIRRLISISSINP

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=333, Percent_Identity=33.9339339339339, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1788191, Length=116, Percent_Identity=37.0689655172414, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788713, Length=120, Percent_Identity=39.1666666666667, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=38.2608695652174, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=43.1372549019608, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=31.6239316239316, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 85133; Mature: 85002

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDKRDVLLERLLAMFRIEAEAHLKDISSGLLALEGKPVDTPAFDIIENMLRCAHSLKGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
ARAVNFAQVEETCRSLENVFSALKDKSLAVSSSLIDQLLKAVDALGTLVSGEGSMAERQK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLSATVTRQLNEMLKSPTKEGRTGSSLSQAASPLSLLPPDESSATRADVGAYLRTSIPSH
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
ASATIRVPTVKLEKVLRQVEEFLLPCLTARQRAKELGEITTTLAVWKKQRLQIQSVVRII
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DREMTSSLKDRSFREQHGLPKLLKYLDGEPLQMKALEERLVRLQRTIEQDQRVLAGMTDC
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIQDVKEMQLLPFSTLLDILPRFSRELAREQGKSLELVVSGGEVEIDRHILEEMKDPLIH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHHHHHHHHH
LVRNCIDHGIEQPAARLAKGKPSSGRITFACSQSDSGKAEIRVADDGGGINVGKLKAAAH
HHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHH
KLGVMSEEEMERLGESELLALIFRSGVTTSPLITDISGRGLGLAIVREKVEALGGSIKVK
HHCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEE
SSTDTGTAFHILLPLTLTNTRGVLVHAAGQLFVIPSSSVERVVRIAKNEIETVKNRETIL
CCCCCCCEEEEEEEEEECCCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEE
VDEQPVSLVKLGDILELAGNSAEMEPAHYLRGIVLSSGLGRVAFLVEEVLGEQEVVIKAL
ECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHH
LPPLKRVRNVAGVCMLGTGRVVPVLNVPDLLKSAVKASSAPCIPTQDSSAEKQGTSSKHS
HHHHHHHHHHCCEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCE
ILVVDDSITARTLLKHILESAGYRVTTAVDGVEGYTALKTGTHSLVVSDVEMPRMDGFAL
EEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCEEEEECCCCCCCCCEEE
TAKIRADKQLATLPVVLVTALDSRDHRERGIDVGANAYIVKSRFDQGNLLEAIRRLISIS
EEEECCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHC
SINP
CCCC
>Mature Secondary Structure 
PDKRDVLLERLLAMFRIEAEAHLKDISSGLLALEGKPVDTPAFDIIENMLRCAHSLKGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
ARAVNFAQVEETCRSLENVFSALKDKSLAVSSSLIDQLLKAVDALGTLVSGEGSMAERQK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLSATVTRQLNEMLKSPTKEGRTGSSLSQAASPLSLLPPDESSATRADVGAYLRTSIPSH
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
ASATIRVPTVKLEKVLRQVEEFLLPCLTARQRAKELGEITTTLAVWKKQRLQIQSVVRII
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DREMTSSLKDRSFREQHGLPKLLKYLDGEPLQMKALEERLVRLQRTIEQDQRVLAGMTDC
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIQDVKEMQLLPFSTLLDILPRFSRELAREQGKSLELVVSGGEVEIDRHILEEMKDPLIH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHHHHHHHHH
LVRNCIDHGIEQPAARLAKGKPSSGRITFACSQSDSGKAEIRVADDGGGINVGKLKAAAH
HHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHH
KLGVMSEEEMERLGESELLALIFRSGVTTSPLITDISGRGLGLAIVREKVEALGGSIKVK
HHCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEE
SSTDTGTAFHILLPLTLTNTRGVLVHAAGQLFVIPSSSVERVVRIAKNEIETVKNRETIL
CCCCCCCEEEEEEEEEECCCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEE
VDEQPVSLVKLGDILELAGNSAEMEPAHYLRGIVLSSGLGRVAFLVEEVLGEQEVVIKAL
ECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHH
LPPLKRVRNVAGVCMLGTGRVVPVLNVPDLLKSAVKASSAPCIPTQDSSAEKQGTSSKHS
HHHHHHHHHHCCEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCE
ILVVDDSITARTLLKHILESAGYRVTTAVDGVEGYTALKTGTHSLVVSDVEMPRMDGFAL
EEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCEEEEECCCCCCCCCEEE
TAKIRADKQLATLPVVLVTALDSRDHRERGIDVGANAYIVKSRFDQGNLLEAIRRLISIS
EEEECCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHC
SINP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]