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The map label for this gene is gcvT [H]

Identifier: 82701348

GI number: 82701348

Start: 227013

End: 228095

Strand: Reverse

Name: gcvT [H]

Synonym: Nmul_A0214

Alternate gene names: 82701348

Gene position: 228095-227013 (Counterclockwise)

Preceding gene: 82701357

Following gene: 82701347

Centisome position: 7.16

GC content: 56.6

Gene sequence:

>1083_bases
GTGAAAACAACTCCTCTAAATCAAACCCACCGCGATATGAACGCCAAGATGGTGGATTTTGGCGGCTGGGACATGCCCCT
GCATTACGGTTCGCAGCTTGATGAGCACCACAAGGTGCGCAGCGATGCGGGCATGTTCGATGTGTCCCATATGCTCGCCG
TCGACATCGAGGGAGAGAGCGCGCGCGCGTTCCTGCGGCAACTGGTTGCCAACAATATAGACAAACTGACGCAGCTAGGC
AAGGCGCTTTACTCCTGCATGCTCAACCCCGACGGCGGAGTAATAGATGATCTTATCATCTATTTTCTGACGGAATCGCA
TTTCCGGATGGTGGTCAATGCAGGGACCGCCGATAAGGATATGGCATGGATGCTTTCGCAACGCGACCGTATTGCCCCCG
GTCTTGAAATCACGCCCCGCAGGGATCTAGCGATGATCGCAGTGCAAGGCCCCAACGCCCGCGCCAAGGTGTGGCAGGTA
CTTCCGGGCTCTCAGACGGACACGGAGAATCTGAAGCTGTTCCAGGCAGCCTTTTTTGACAAGTACTTTATCGCCCGCAC
AGGTTACACCGGAGAAGACGGTTTCGAGATTACGCTTCCCGCAGCCGATGCCACGAATTTCTGGAATAAACTTCACGCCG
CGGGAGTGGCCCCCGCCGGCTTGGGGGCAAGAGATACGCTCCGGCTCGAAGCGGGCATGAACCTTTACGGGCAGGATATG
GATGAAACCATCAACCCCCTGGAAGCGGGGCTGGGCTGGACGGTGGATTTGAAGAGCGATCGCGACTTCATCGGGAAGCA
GGCGCTTCTGGACAGGCCCGTCACCCAGCAACTGACTGGGCTGGTGTTGTTGGATCGCGGAGTATTGCGCAGCCATCAGA
AGGTGGTTACACAAAACGACGGGGGCGAGGGTGAAATTACCAGCGGAGGCTTCTCGCCCACACTCAATCAGTCTATTGCT
CTGGCGCGCCTGCCTCTGGACGTCTCTCCCGGAGACGAAGTTCAGGTCGTTGTTCGGGATAAACGGCTGAAAGCGAAGGT
CGTGAAATATCCTTTCGTCCGCAATGGCAAGATTCTCGTTTGA

Upstream 100 bases:

>100_bases
GACGGAGCAGGGAAAATCCTGCCCGTAATCTCTCAGGTAAAAAGGACAGAGGGGTGAGGTCATCAGGCATGACCTCACCT
TTTTTTTGGGATATCGATCT

Downstream 100 bases:

>100_bases
TGAAACGGCAAAGCACTATCATTTAATTCTGGAGCAAAGACATGAGTATTCCGAATGATCTGAAATACACGAAATCCCAT
GAATGGGTGCGTCTCGAAGA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKTTPLNQTHRDMNAKMVDFGGWDMPLHYGSQLDEHHKVRSDAGMFDVSHMLAVDIEGESARAFLRQLVANNIDKLTQLG
KALYSCMLNPDGGVIDDLIIYFLTESHFRMVVNAGTADKDMAWMLSQRDRIAPGLEITPRRDLAMIAVQGPNARAKVWQV
LPGSQTDTENLKLFQAAFFDKYFIARTGYTGEDGFEITLPAADATNFWNKLHAAGVAPAGLGARDTLRLEAGMNLYGQDM
DETINPLEAGLGWTVDLKSDRDFIGKQALLDRPVTQQLTGLVLLDRGVLRSHQKVVTQNDGGEGEITSGGFSPTLNQSIA
LARLPLDVSPGDEVQVVVRDKRLKAKVVKYPFVRNGKILV

Sequences:

>Translated_360_residues
MKTTPLNQTHRDMNAKMVDFGGWDMPLHYGSQLDEHHKVRSDAGMFDVSHMLAVDIEGESARAFLRQLVANNIDKLTQLG
KALYSCMLNPDGGVIDDLIIYFLTESHFRMVVNAGTADKDMAWMLSQRDRIAPGLEITPRRDLAMIAVQGPNARAKVWQV
LPGSQTDTENLKLFQAAFFDKYFIARTGYTGEDGFEITLPAADATNFWNKLHAAGVAPAGLGARDTLRLEAGMNLYGQDM
DETINPLEAGLGWTVDLKSDRDFIGKQALLDRPVTQQLTGLVLLDRGVLRSHQKVVTQNDGGEGEITSGGFSPTLNQSIA
LARLPLDVSPGDEVQVVVRDKRLKAKVVKYPFVRNGKILV
>Mature_360_residues
MKTTPLNQTHRDMNAKMVDFGGWDMPLHYGSQLDEHHKVRSDAGMFDVSHMLAVDIEGESARAFLRQLVANNIDKLTQLG
KALYSCMLNPDGGVIDDLIIYFLTESHFRMVVNAGTADKDMAWMLSQRDRIAPGLEITPRRDLAMIAVQGPNARAKVWQV
LPGSQTDTENLKLFQAAFFDKYFIARTGYTGEDGFEITLPAADATNFWNKLHAAGVAPAGLGARDTLRLEAGMNLYGQDM
DETINPLEAGLGWTVDLKSDRDFIGKQALLDRPVTQQLTGLVLLDRGVLRSHQKVVTQNDGGEGEITSGGFSPTLNQSIA
LARLPLDVSPGDEVQVVVRDKRLKAKVVKYPFVRNGKILV

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=372, Percent_Identity=36.2903225806452, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI257796258, Length=350, Percent_Identity=35.7142857142857, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI257796254, Length=366, Percent_Identity=32.7868852459016, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=35.4430379746835, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24797151, Length=333, Percent_Identity=29.1291291291291, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI197927446, Length=289, Percent_Identity=26.9896193771626, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI21361378, Length=289, Percent_Identity=26.9896193771626, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194306651, Length=343, Percent_Identity=23.9067055393586, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789272, Length=363, Percent_Identity=55.3719008264463, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17560118, Length=378, Percent_Identity=34.1269841269841, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994052, Length=347, Percent_Identity=23.9193083573487, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=347, Percent_Identity=23.9193083573487, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=33.6814621409922, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20129441, Length=376, Percent_Identity=33.5106382978723, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28571104, Length=255, Percent_Identity=25.8823529411765, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20130091, Length=394, Percent_Identity=25.1269035532995, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39710; Mature: 39710

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTPLNQTHRDMNAKMVDFGGWDMPLHYGSQLDEHHKVRSDAGMFDVSHMLAVDIEGES
CCCCCCCHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCH
ARAFLRQLVANNIDKLTQLGKALYSCMLNPDGGVIDDLIIYFLTESHFRMVVNAGTADKD
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHH
MAWMLSQRDRIAPGLEITPRRDLAMIAVQGPNARAKVWQVLPGSQTDTENLKLFQAAFFD
HHHHHHCCCCCCCCCEECCCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
KYFIARTGYTGEDGFEITLPAADATNFWNKLHAAGVAPAGLGARDTLRLEAGMNLYGQDM
HEHEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCH
DETINPLEAGLGWTVDLKSDRDFIGKQALLDRPVTQQLTGLVLLDRGVLRSHQKVVTQND
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCHHHHHHCEEEECCHHHHHHHHHEECCC
GGEGEITSGGFSPTLNQSIALARLPLDVSPGDEVQVVVRDKRLKAKVVKYPFVRNGKILV
CCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHEECCEECCCEEEC
>Mature Secondary Structure
MKTTPLNQTHRDMNAKMVDFGGWDMPLHYGSQLDEHHKVRSDAGMFDVSHMLAVDIEGES
CCCCCCCHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCH
ARAFLRQLVANNIDKLTQLGKALYSCMLNPDGGVIDDLIIYFLTESHFRMVVNAGTADKD
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHH
MAWMLSQRDRIAPGLEITPRRDLAMIAVQGPNARAKVWQVLPGSQTDTENLKLFQAAFFD
HHHHHHCCCCCCCCCEECCCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
KYFIARTGYTGEDGFEITLPAADATNFWNKLHAAGVAPAGLGARDTLRLEAGMNLYGQDM
HEHEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCH
DETINPLEAGLGWTVDLKSDRDFIGKQALLDRPVTQQLTGLVLLDRGVLRSHQKVVTQND
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCHHHHHHCEEEECCHHHHHHHHHEECCC
GGEGEITSGGFSPTLNQSIALARLPLDVSPGDEVQVVVRDKRLKAKVVKYPFVRNGKILV
CCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHEECCEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA