Click here to switch to the map view.

The map label for this gene is gcvPA

Identifier: 82701346

GI number: 82701346

Start: 225133

End: 226491

Strand: Reverse

Name: gcvPA

Synonym: Nmul_A0212

Alternate gene names: 82701346

Gene position: 226491-225133 (Counterclockwise)

Preceding gene: 82701347

Following gene: 82701345

Centisome position: 7.11

GC content: 57.17

Gene sequence:

>1359_bases
ATGCCGTTCATTCCACATACTGAAGAAGATATACAAGCCATGCTCGCGAGCATTGGCGCAAACAGCATTGATGAGCTGTT
CGATGAAATTCCACCCGCGCTGAAGACCGGAAGCCTGAAGCGGGTGCCGCCCGGCTTGAGCGAAATGGAAATATCGCGTT
TGATGCTGGAGCGCGCCGAGCAGGATGGACGCTACCTGAATTTCATCGGTGCGGGTGCTTATGAGCACCATATTCCGGCG
GCTGTCTGGCAGATTGCCACGCGGGGGGAATTCTACTCCTCCTATACGCCTTATCAGGCGGAGGCCAGCCAGGGCACCCT
GCAATTGCTCTATGAGTACCAGACCATGATGGCGTCGCTGACGGGAATGGATGTTTCCAACGCCAGCATGTACGACGGTG
CCTCGGCCCTGGCGGAAGCCGCCCTGATGGCGGTGCGTTCGCATCGGACCTCGCGCCGGATTTTGATCCCGCAGACCGTG
CATCCCGTCTATCGCAGTGTGGTACGCGCCATTGTCAAAAACCAGGGAATTGAGGTGGTGGAGGTTCCCTACGACAAACT
TTCCGGGCAGACTTCGCTGGACGGGCTGAAAAACTTTGGCAGCGAAGAATTCGCAGCGCTCGTGATTCCCCAGCCGAACT
TTTTCGGCGTGCTTGAGGATGTCGATACGCTGACCGACTGGGCTCAGAGCAGAGATGCTTTTGCCATCGCCGTCGTGAAT
CCCATGGCACTGGCAATGCTGACTCCACCCGGCGAGTGGGGCGAGAAAGGGGCAGACATTGCCGTCGGTGAAGGGCAGCC
ATTGGGCATTCCCTTGTCCAGTGGAGGACCGTATTTCGGTTTTATGGCCTGCAAACAGCCCCTGGTGCGCCAGATGCCCG
GCCGCATTATCGGTCGCACGACGGATCAGGAAGGTAGCGATGGCTTCGTTCTTACGCTCCAGGCGCGGGAACAGCACATC
CGGCGATCCAAGGCCACCTCCAATATTTGTACCAATCAGGGACTCATGGTTACGGCCGCAACCATCTACCTGGCCTTGCT
GGGCCCGGAAGGCTTGCGCCGGACTGCTGCCCAGTCGCATGCAAATACGGCAGCATTACTGGAAAAACTGGAAAAGCTGA
AGGGCGTGAAAAGAGTATTCAGCGGGCCCGTGTTCCATGAAGCGGTTATCTCCCTGCCTCGTCCCTCTGCCAGTGTATTG
CAGGCACTCGAAGCCCGACGGATATTGGGTGGACTCAATCTCAAGGAGTACTATCCGGAACTTGGAGATGCCGTGCTGGT
GTGCGCAACCGAAACGAAAACGTCCGGGGACATGGAAAATTATGTCACGCAACTGGGCGAAGTCATCAGGAATTCATAG

Upstream 100 bases:

>100_bases
AGACCATTAATCAAATCACTTGAGGGAAATGGAACGGGGCCTTGCTCCCGCTGTCATTTCCCTGCCTTTTACGCCTCACC
GATGATTCACGGAACAAATC

Downstream 100 bases:

>100_bases
CACCGATATCGCATTGGACGTTTAGCAGCCATCCCACATCTTAAAGGAGAAACAGTATGGTTACCCTAGCCGGCAATCCC
ATCAAAGTTGAAGGCACCTT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPFIPHTEEDIQAMLASIGANSIDELFDEIPPALKTGSLKRVPPGLSEMEISRLMLERAEQDGRYLNFIGAGAYEHHIPA
AVWQIATRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASLTGMDVSNASMYDGASALAEAALMAVRSHRTSRRILIPQTV
HPVYRSVVRAIVKNQGIEVVEVPYDKLSGQTSLDGLKNFGSEEFAALVIPQPNFFGVLEDVDTLTDWAQSRDAFAIAVVN
PMALAMLTPPGEWGEKGADIAVGEGQPLGIPLSSGGPYFGFMACKQPLVRQMPGRIIGRTTDQEGSDGFVLTLQAREQHI
RRSKATSNICTNQGLMVTAATIYLALLGPEGLRRTAAQSHANTAALLEKLEKLKGVKRVFSGPVFHEAVISLPRPSASVL
QALEARRILGGLNLKEYYPELGDAVLVCATETKTSGDMENYVTQLGEVIRNS

Sequences:

>Translated_452_residues
MPFIPHTEEDIQAMLASIGANSIDELFDEIPPALKTGSLKRVPPGLSEMEISRLMLERAEQDGRYLNFIGAGAYEHHIPA
AVWQIATRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASLTGMDVSNASMYDGASALAEAALMAVRSHRTSRRILIPQTV
HPVYRSVVRAIVKNQGIEVVEVPYDKLSGQTSLDGLKNFGSEEFAALVIPQPNFFGVLEDVDTLTDWAQSRDAFAIAVVN
PMALAMLTPPGEWGEKGADIAVGEGQPLGIPLSSGGPYFGFMACKQPLVRQMPGRIIGRTTDQEGSDGFVLTLQAREQHI
RRSKATSNICTNQGLMVTAATIYLALLGPEGLRRTAAQSHANTAALLEKLEKLKGVKRVFSGPVFHEAVISLPRPSASVL
QALEARRILGGLNLKEYYPELGDAVLVCATETKTSGDMENYVTQLGEVIRNS
>Mature_451_residues
PFIPHTEEDIQAMLASIGANSIDELFDEIPPALKTGSLKRVPPGLSEMEISRLMLERAEQDGRYLNFIGAGAYEHHIPAA
VWQIATRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASLTGMDVSNASMYDGASALAEAALMAVRSHRTSRRILIPQTVH
PVYRSVVRAIVKNQGIEVVEVPYDKLSGQTSLDGLKNFGSEEFAALVIPQPNFFGVLEDVDTLTDWAQSRDAFAIAVVNP
MALAMLTPPGEWGEKGADIAVGEGQPLGIPLSSGGPYFGFMACKQPLVRQMPGRIIGRTTDQEGSDGFVLTLQAREQHIR
RSKATSNICTNQGLMVTAATIYLALLGPEGLRRTAAQSHANTAALLEKLEKLKGVKRVFSGPVFHEAVISLPRPSASVLQ
ALEARRILGGLNLKEYYPELGDAVLVCATETKTSGDMENYVTQLGEVIRNS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=367, Percent_Identity=34.3324250681199, Blast_Score=214, Evalue=2e-55,
Organism=Escherichia coli, GI1789269, Length=370, Percent_Identity=34.8648648648649, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17535605, Length=442, Percent_Identity=35.2941176470588, Blast_Score=203, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323843, Length=442, Percent_Identity=32.1266968325792, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24645648, Length=359, Percent_Identity=36.7688022284123, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_NITMU (Q2YCK1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_410912.1
- ProteinModelPortal:   Q2YCK1
- SMR:   Q2YCK1
- STRING:   Q2YCK1
- GeneID:   3784589
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0212
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   NMUL323848:NMUL_A0212-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49120; Mature: 48989

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFIPHTEEDIQAMLASIGANSIDELFDEIPPALKTGSLKRVPPGLSEMEISRLMLERAE
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QDGRYLNFIGAGAYEHHIPAAVWQIATRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASL
CCCCEEEEEECCCHHHHCHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TGMDVSNASMYDGASALAEAALMAVRSHRTSRRILIPQTVHPVYRSVVRAIVKNQGIEVV
HCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCEEE
EVPYDKLSGQTSLDGLKNFGSEEFAALVIPQPNFFGVLEDVDTLTDWAQSRDAFAIAVVN
ECCHHHCCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
PMALAMLTPPGEWGEKGADIAVGEGQPLGIPLSSGGPYFGFMACKQPLVRQMPGRIIGRT
CEEEEEECCCCCCCCCCCCEEECCCCCCEEEECCCCCEEHHHHHHHHHHHHCCCCEECCC
TDQEGSDGFVLTLQAREQHIRRSKATSNICTNQGLMVTAATIYLALLGPEGLRRTAAQSH
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
ANTAALLEKLEKLKGVKRVFSGPVFHEAVISLPRPSASVLQALEARRILGGLNLKEYYPE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHC
LGDAVLVCATETKTSGDMENYVTQLGEVIRNS
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFIPHTEEDIQAMLASIGANSIDELFDEIPPALKTGSLKRVPPGLSEMEISRLMLERAE
CCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QDGRYLNFIGAGAYEHHIPAAVWQIATRGEFYSSYTPYQAEASQGTLQLLYEYQTMMASL
CCCCEEEEEECCCHHHHCHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TGMDVSNASMYDGASALAEAALMAVRSHRTSRRILIPQTVHPVYRSVVRAIVKNQGIEVV
HCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCEEE
EVPYDKLSGQTSLDGLKNFGSEEFAALVIPQPNFFGVLEDVDTLTDWAQSRDAFAIAVVN
ECCHHHCCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
PMALAMLTPPGEWGEKGADIAVGEGQPLGIPLSSGGPYFGFMACKQPLVRQMPGRIIGRT
CEEEEEECCCCCCCCCCCCEEECCCCCCEEEECCCCCEEHHHHHHHHHHHHCCCCEECCC
TDQEGSDGFVLTLQAREQHIRRSKATSNICTNQGLMVTAATIYLALLGPEGLRRTAAQSH
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
ANTAALLEKLEKLKGVKRVFSGPVFHEAVISLPRPSASVLQALEARRILGGLNLKEYYPE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHC
LGDAVLVCATETKTSGDMENYVTQLGEVIRNS
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA