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The map label for this gene is gcvPB

Identifier: 82701344

GI number: 82701344

Start: 222914

End: 224416

Strand: Reverse

Name: gcvPB

Synonym: Nmul_A0210

Alternate gene names: 82701344

Gene position: 224416-222914 (Counterclockwise)

Preceding gene: 82701345

Following gene: 82701343

Centisome position: 7.05

GC content: 57.42

Gene sequence:

>1503_bases
ATGCTGATATTTGAACATTCTCGCCCTGGCCGGCGCAATTATTCCCAATCTCCGAAAGCTGCGGAAGCAACGGATATTCC
GGAGAAGCTGTTGCGCAAGACCCTGCCGCTGCTGCCTGAAGTGTCGGAGATGGACGCAGTGCGCCACTACACCCGGCTGT
CGCAAAAGAATTTTTCGATAGACACGCATTTTTATCCGTTGGGTTCCTGCACGATGAAGTACAACCCAAGGGCGTGCAAC
TCCCTCGCGATGCTGCCCCAGTTTCTGGCGCGCCATCCCAGATCGCCGGAAAGCACCGGCCAGGGATTTCTTGCGTGCAT
GTACGAGCTGCAGGAAATTCTGAAAGATGTAACCGGTATGGCCGGGGTAAGCCTTACGCCCATGGCGGGAGCACAGGGCG
AGCTGATCGGCATCGCAATGATACGCGCCTATCACGAGTCGCGGGGGGACACGGCCCGAACCGAAATCATCGTTCCCGAT
GCGGCGCATGGCACCAACCCTGCTACAGCGGTCATGTGCGGCTACAAAGTCGTCGAGATCGCCACCGACAAGGAAGGTAA
TGTGGACATGGCTGCCCTGAAAGCCGCGGTCGGCCCGAAAACGGCTGGGCTGATGCTGACCAATCCTTCCACGCTCGGTG
TATTTGAAGAGAACGTCGCCGAGATGAGCAGGATTGTCCACCAGGCAGGCGGATTGCTCTATTACGATGGCGCAAACCTG
AACGCCATACTTGGTAAGGTCAAGCCAGGCGACATGGGCTTTGACGTCATTCACATCAATCTTCACAAGACGTTTTCCAC
TCCGCACGGCGGTGGAGGCCCGGGCTCGGCCCCGGTGGGCGTCGCACCGAGGCTGTTGCCGTTTATGCCTGTACCTATAG
TGGCATTTGAAAACGGAACCTATCGCTGGCAGACGGAGAAGGATATACCGCAATCGATCGGAAGGCTTTCGGCGCACATG
GGTAACGCAGGCGTTCTGTTGCGCGCCTATGTGTACGTGCGTCTGCTGGGGGCGGAAGGCATGCATCGAGTGGCCGAGTT
TGCGGCGCTTAACGCCAACTACCTGATGGCTGAACTGCGAAAGGCGGGTTTCGAGATCGCCTATCCCAACCGCAGGGCCA
GTCATGAATTTATCGTTACCCTGAAGGACCTGAAGGAAAAAACTGGCGTCACCGCGATGAATCTCGCCAAGCGTCTGCTG
GATAAGGGTTACCATGCTCCAACGACCTATTTTCCGCTCCTCGTGCCGGAATGCCTGCTGATTGAACCCGCTGAAACCGA
ATCAAAGGAGACGCTGGACGCCTTCGTAACAGCAATGAAGGAAATCCTGGAGGAAACCCGTACGCAGCCGGACCTGGTGA
AAAGCGCGCCTCATACCACGCCCGTCCGCCGGCTGGATGACGTAAAGGCCGCACGCGAGCTGGATCTGGCCTGGAAAGCA
CCCACGCGCAACATAACCAGGACTGAAACCCTCACCCCGATCCCAACCGTAAGCGTAGCTTAA

Upstream 100 bases:

>100_bases
ATACGCGCCCTCCTACTCGCGGCTCTGAGGCAGAGGAAGTCGGACTCCTGCCTGTCAATATCTTTCAACACATTCACTTA
GCAAACACCGGATTGAACCC

Downstream 100 bases:

>100_bases
CGATTCAGACTTTCCGGGCGCCTCCCATGCATACACTCATTTGCGGCTCCATCGCCTATGACACCATTATGGTTTTCGGC
GATCATTTCAGGAACCATAT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLIFEHSRPGRRNYSQSPKAAEATDIPEKLLRKTLPLLPEVSEMDAVRHYTRLSQKNFSIDTHFYPLGSCTMKYNPRACN
SLAMLPQFLARHPRSPESTGQGFLACMYELQEILKDVTGMAGVSLTPMAGAQGELIGIAMIRAYHESRGDTARTEIIVPD
AAHGTNPATAVMCGYKVVEIATDKEGNVDMAALKAAVGPKTAGLMLTNPSTLGVFEENVAEMSRIVHQAGGLLYYDGANL
NAILGKVKPGDMGFDVIHINLHKTFSTPHGGGGPGSAPVGVAPRLLPFMPVPIVAFENGTYRWQTEKDIPQSIGRLSAHM
GNAGVLLRAYVYVRLLGAEGMHRVAEFAALNANYLMAELRKAGFEIAYPNRRASHEFIVTLKDLKEKTGVTAMNLAKRLL
DKGYHAPTTYFPLLVPECLLIEPAETESKETLDAFVTAMKEILEETRTQPDLVKSAPHTTPVRRLDDVKAARELDLAWKA
PTRNITRTETLTPIPTVSVA

Sequences:

>Translated_500_residues
MLIFEHSRPGRRNYSQSPKAAEATDIPEKLLRKTLPLLPEVSEMDAVRHYTRLSQKNFSIDTHFYPLGSCTMKYNPRACN
SLAMLPQFLARHPRSPESTGQGFLACMYELQEILKDVTGMAGVSLTPMAGAQGELIGIAMIRAYHESRGDTARTEIIVPD
AAHGTNPATAVMCGYKVVEIATDKEGNVDMAALKAAVGPKTAGLMLTNPSTLGVFEENVAEMSRIVHQAGGLLYYDGANL
NAILGKVKPGDMGFDVIHINLHKTFSTPHGGGGPGSAPVGVAPRLLPFMPVPIVAFENGTYRWQTEKDIPQSIGRLSAHM
GNAGVLLRAYVYVRLLGAEGMHRVAEFAALNANYLMAELRKAGFEIAYPNRRASHEFIVTLKDLKEKTGVTAMNLAKRLL
DKGYHAPTTYFPLLVPECLLIEPAETESKETLDAFVTAMKEILEETRTQPDLVKSAPHTTPVRRLDDVKAARELDLAWKA
PTRNITRTETLTPIPTVSVA
>Mature_500_residues
MLIFEHSRPGRRNYSQSPKAAEATDIPEKLLRKTLPLLPEVSEMDAVRHYTRLSQKNFSIDTHFYPLGSCTMKYNPRACN
SLAMLPQFLARHPRSPESTGQGFLACMYELQEILKDVTGMAGVSLTPMAGAQGELIGIAMIRAYHESRGDTARTEIIVPD
AAHGTNPATAVMCGYKVVEIATDKEGNVDMAALKAAVGPKTAGLMLTNPSTLGVFEENVAEMSRIVHQAGGLLYYDGANL
NAILGKVKPGDMGFDVIHINLHKTFSTPHGGGGPGSAPVGVAPRLLPFMPVPIVAFENGTYRWQTEKDIPQSIGRLSAHM
GNAGVLLRAYVYVRLLGAEGMHRVAEFAALNANYLMAELRKAGFEIAYPNRRASHEFIVTLKDLKEKTGVTAMNLAKRLL
DKGYHAPTTYFPLLVPECLLIEPAETESKETLDAFVTAMKEILEETRTQPDLVKSAPHTTPVRRLDDVKAARELDLAWKA
PTRNITRTETLTPIPTVSVA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=459, Percent_Identity=39.4335511982571, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI1789269, Length=419, Percent_Identity=42.0047732696897, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17535605, Length=432, Percent_Identity=39.3518518518519, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI32564013, Length=389, Percent_Identity=39.0745501285347, Blast_Score=237, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6323843, Length=507, Percent_Identity=39.6449704142012, Blast_Score=302, Evalue=6e-83,
Organism=Drosophila melanogaster, GI24645648, Length=416, Percent_Identity=42.3076923076923, Blast_Score=281, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_NITMU (Q2YCK3)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_410910.1
- ProteinModelPortal:   Q2YCK3
- STRING:   Q2YCK3
- GeneID:   3784587
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0210
- eggNOG:   COG1003
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   NMUL323848:NMUL_A0210-MONOMER
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 54644; Mature: 54644

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIFEHSRPGRRNYSQSPKAAEATDIPEKLLRKTLPLLPEVSEMDAVRHYTRLSQKNFSI
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
DTHFYPLGSCTMKYNPRACNSLAMLPQFLARHPRSPESTGQGFLACMYELQEILKDVTGM
CEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AGVSLTPMAGAQGELIGIAMIRAYHESRGDTARTEIIVPDAAHGTNPATAVMCGYKVVEI
CCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHEEEECCEEEEE
ATDKEGNVDMAALKAAVGPKTAGLMLTNPSTLGVFEENVAEMSRIVHQAGGLLYYDGANL
ECCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCC
NAILGKVKPGDMGFDVIHINLHKTFSTPHGGGGPGSAPVGVAPRLLPFMPVPIVAFENGT
EEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCE
YRWQTEKDIPQSIGRLSAHMGNAGVLLRAYVYVRLLGAEGMHRVAEFAALNANYLMAELR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
KAGFEIAYPNRRASHEFIVTLKDLKEKTGVTAMNLAKRLLDKGYHAPTTYFPLLVPECLL
HCCCEEECCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCEE
IEPAETESKETLDAFVTAMKEILEETRTQPDLVKSAPHTTPVRRLDDVKAARELDLAWKA
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEECC
PTRNITRTETLTPIPTVSVA
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLIFEHSRPGRRNYSQSPKAAEATDIPEKLLRKTLPLLPEVSEMDAVRHYTRLSQKNFSI
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
DTHFYPLGSCTMKYNPRACNSLAMLPQFLARHPRSPESTGQGFLACMYELQEILKDVTGM
CEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AGVSLTPMAGAQGELIGIAMIRAYHESRGDTARTEIIVPDAAHGTNPATAVMCGYKVVEI
CCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHEEEECCEEEEE
ATDKEGNVDMAALKAAVGPKTAGLMLTNPSTLGVFEENVAEMSRIVHQAGGLLYYDGANL
ECCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCC
NAILGKVKPGDMGFDVIHINLHKTFSTPHGGGGPGSAPVGVAPRLLPFMPVPIVAFENGT
EEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCE
YRWQTEKDIPQSIGRLSAHMGNAGVLLRAYVYVRLLGAEGMHRVAEFAALNANYLMAELR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
KAGFEIAYPNRRASHEFIVTLKDLKEKTGVTAMNLAKRLLDKGYHAPTTYFPLLVPECLL
HCCCEEECCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCEE
IEPAETESKETLDAFVTAMKEILEETRTQPDLVKSAPHTTPVRRLDDVKAARELDLAWKA
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEECC
PTRNITRTETLTPIPTVSVA
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA