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The map label for this gene is trxC [C]

Identifier: 82701188

GI number: 82701188

Start: 60014

End: 60454

Strand: Reverse

Name: trxC [C]

Synonym: Nmul_A0053

Alternate gene names: 82701188

Gene position: 60454-60014 (Counterclockwise)

Preceding gene: 82701191

Following gene: 82701187

Centisome position: 1.9

GC content: 57.37

Gene sequence:

>441_bases
ATGAGTGATTCCCTGCATCTCGTCTGCCCTCATTGTCACTCGATTAACCGTGTCCCCACTGCGCGCCTCGGCGAGCAGCC
CAACTGCGGACAATGCCATCAGCCGATATTCGCCGGCCAGCCATTGGAATTAACCGGTTCAACCTTCGCACGCTACATTA
ATAAAAACGATGTTCCAGTGCTGGTCGATTTCTGGGCACCGTGGTGCGGACCCTGCAAAATGATGGCGCCAGCCTTCAAA
GAAGCGGCGGCTCTGCTTGAGCCCCATGTTCGCCTCGCGAAGGTGAATACCGATGTGGAACAAACAGTCGGCGCGCAGTA
TCGCATTCGCAGTATTCCGACACTCATCCTGTTCAAGGACGGCCGGGAACTTGCGCGCCAGGCGGGCGCAATGACAACAC
AGGATATCGTGCGCTGGACGCGATCCCAGGCTTTGGGCTAG

Upstream 100 bases:

>100_bases
GTGACTCCCCGCCGCAAATAGTCATCGTCCTGGATTGAAAACGGAAGTACCCGGTTTACCGGCTATTATTGGAATTATTG
GATGATATGTGTAAATTCTT

Downstream 100 bases:

>100_bases
GCGAAGGGATAGAGGCGGGTAAAATCCTGAAACTCGTTGAGTTGTGGAAGCTGTTACACTCTGCTTTCGACCCTTGACCG
GGCGGAAGCCTTCGGAAAGA

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MSDSLHLVCPHCHSINRVPTARLGEQPNCGQCHQPIFAGQPLELTGSTFARYINKNDVPVLVDFWAPWCGPCKMMAPAFK
EAAALLEPHVRLAKVNTDVEQTVGAQYRIRSIPTLILFKDGRELARQAGAMTTQDIVRWTRSQALG

Sequences:

>Translated_146_residues
MSDSLHLVCPHCHSINRVPTARLGEQPNCGQCHQPIFAGQPLELTGSTFARYINKNDVPVLVDFWAPWCGPCKMMAPAFK
EAAALLEPHVRLAKVNTDVEQTVGAQYRIRSIPTLILFKDGRELARQAGAMTTQDIVRWTRSQALG
>Mature_145_residues
SDSLHLVCPHCHSINRVPTARLGEQPNCGQCHQPIFAGQPLELTGSTFARYINKNDVPVLVDFWAPWCGPCKMMAPAFKE
AAALLEPHVRLAKVNTDVEQTVGAQYRIRSIPTLILFKDGRELARQAGAMTTQDIVRWTRSQALG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI224493972, Length=118, Percent_Identity=30.5084745762712, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI42794771, Length=118, Percent_Identity=30.5084745762712, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI21361657, Length=105, Percent_Identity=38.0952380952381, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5803121, Length=97, Percent_Identity=36.0824742268041, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI5031973, Length=77, Percent_Identity=38.961038961039, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI4758304, Length=98, Percent_Identity=36.734693877551, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI20070125, Length=107, Percent_Identity=34.5794392523364, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788936, Length=135, Percent_Identity=40, Blast_Score=127, Evalue=3e-31,
Organism=Escherichia coli, GI87082331, Length=91, Percent_Identity=43.956043956044, Blast_Score=86, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17554386, Length=106, Percent_Identity=39.622641509434, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25144092, Length=100, Percent_Identity=38, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507915, Length=110, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17569137, Length=103, Percent_Identity=33.9805825242718, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=107, Percent_Identity=35.5140186915888, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=103, Percent_Identity=33.9805825242718, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=103, Percent_Identity=33.9805825242718, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=88, Percent_Identity=32.9545454545455, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=104, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=83, Percent_Identity=36.144578313253, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=38.3720930232558, Blast_Score=67, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=79, Percent_Identity=37.9746835443038, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=37.5, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319806, Length=106, Percent_Identity=33.9622641509434, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=34.0909090909091, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573567, Length=106, Percent_Identity=33.9622641509434, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19921434, Length=106, Percent_Identity=35.8490566037736, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647799, Length=98, Percent_Identity=39.7959183673469, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=38.3561643835616, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 16195; Mature: 16064

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSLHLVCPHCHSINRVPTARLGEQPNCGQCHQPIFAGQPLELTGSTFARYINKNDVPV
CCCCCEEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHCCCCCCE
LVDFWAPWCGPCKMMAPAFKEAAALLEPHVRLAKVNTDVEQTVGAQYRIRSIPTLILFKD
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCEEECCCCEEEEEEC
GRELARQAGAMTTQDIVRWTRSQALG
CHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDSLHLVCPHCHSINRVPTARLGEQPNCGQCHQPIFAGQPLELTGSTFARYINKNDVPV
CCCCEEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHCCCCCCE
LVDFWAPWCGPCKMMAPAFKEAAALLEPHVRLAKVNTDVEQTVGAQYRIRSIPTLILFKD
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCEEECCCCEEEEEEC
GRELARQAGAMTTQDIVRWTRSQALG
CHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]