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The map label for this gene is hycC [H]

Identifier: 82545202

GI number: 82545202

Start: 2802800

End: 2804236

Strand: Direct

Name: hycC [H]

Synonym: SBO_2795

Alternate gene names: 82545202

Gene position: 2802800-2804236 (Clockwise)

Preceding gene: 82545195

Following gene: 82545203

Centisome position: 62.01

GC content: 57.13

Gene sequence:

>1437_bases
ATGACTATTTGGGAAATAAGCGAGAAAGCCGATTACATCGCACAGCGGCATCGTCGCCTACAGGACCAGTGGCACATCTA
CTGCAATTCGCTGGTTCAGGGGATCACGTTATCGAAAGCGCGCCTGCATCACGCCATGAGCTGCGCGCCGGACAAAGAAC
TCTGTTTCGTCCTTTTTGAACATTTTCGTATTTACGTCACCCTGGCGGATGGCTTTAACAGCCACACCATCGAGTATTAC
GTCGAAACAAAAGAGGGCAAACTGTGGTTTGCGCTGGGGCGTCTTGGCACTCTGCTGCTGGCGATTGCTTGCTGGCTGCT
GTGGCAGCGTTATGGCACGCTGGATCTGCGCCTGCTGGATATGCGTATGCAACAGCTGCCGCTCGGTTCCGATATCTGGC
TGCTCGGTGTGATTGGCTTTGGCCTGCTCGCCGGGATTATTCCGCTGCACGGCTGGGTGCCGCAGGCACATGCTAACGCC
TCTGCGCCAGCTGCCGCGTTGTTTTCTACGGTAGTCATGAAAATTGGCCTGCTGGGCATTTTAACCCTGTCACTGCTGGG
CGGTAATGCACCGCTGTGGTGGGGGATCGTGCTGCTGGTGCTCGGCATGATCACCGCGTTTGTCGGTGGTCTGTATGCGC
TGATGGAGCACAACATCCAGCGCCTGCTGGCTTACCACACCCTGGAAAATATCGGCATTATCCTGCTGGGGCTGGGCGCT
GGCGTAACGGGTATCGCGCTCGAACAACCGGCGCTGATTGCTCTTGGCCTGGTCGGTGGTCTGTACCATCTGCTTAACCA
TAGCCTGTTCAAAAGCGTACTGTTCCTCGGGGCGGGGAGCGTCTGGTTCCGTACCGGTCATCGCGATATCGAAAAACTCG
GTGGTATTGGCAAGAAAATGCCGGTTATCTCCATCGCCATGTTAGTCGGGTTGATGGCAATGGCTGCGCTGCCGCCGCTG
AACGGGTTTGCCGGGGAATGGGTTATCTATCAATCCTTTTTCAAACTGAGCAATAGTGGCGCGTTTGTTGCCCGTCTGCT
GGGGCCGCTGCTCGCTGTGGGTCTGGCAATTACCGGTGCGCTGGCGGTGATGTGTATGGCGAAAGTCTATGGCGTCACGT
TCCTCGGCGCGCCGCGTACCAAAGAAGCCGAAAACGCCACCTGTGCGCCGCTCCTGATGAGCGTAAGCGTAGTGGCACTG
GCGATTTGCTGCGTAATTGGCGGTGTTGCTGCGCCGTGGCTGCTGCCGATGCTCTCTGCTGCCGTACCTCTGCCTCTGGA
GCCTGCTAACACCACCGTTTCTCAACCAATGATCACATTGCTGCTGATTGCCTGCCCGCTGCTGCCATTCATCATTATGG
CGATTTGCAAAGGCGACCGCCTGCCGTCACGTTCCCGCGGTGCGGCCTGGGTGTGCGGCTACGACCATGAAAAATAA

Upstream 100 bases:

>100_bases
AATTCATCTTTAGCTTAAAAATCGTTTTAATAACAATAAATTAAAAATTGGCACAGAAAATGCTTAAAGCTGGCATCTCT
GTTAAACGGGTAACCTGACA

Downstream 100 bases:

>100_bases
ATGGTGATTACCGCTCACGGTTTTGCCATGCCGGTTAAACAGGCGTTTGCGCCAGTGCTGAAACTGCGCAAATGGCTGAA
TCCGGTGTCGCTGGTGCCGG

Product: membrane-spanning protein of hydrogenase 3

Products: NA

Alternate protein names: FHL subunit 3; Hydrogenase-3 component C [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFEHFRIYVTLADGFNSHTIEYY
VETKEGKLWFALGRLGTLLLAIACWLLWQRYGTLDLRLLDMRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANA
SAPAAALFSTVVMKIGLLGILTLSLLGGNAPLWWGIVLLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGA
GVTGIALEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIAMLVGLMAMAALPPL
NGFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVAL
AICCVIGGVAAPWLLPMLSAAVPLPLEPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEK

Sequences:

>Translated_478_residues
MTIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFEHFRIYVTLADGFNSHTIEYY
VETKEGKLWFALGRLGTLLLAIACWLLWQRYGTLDLRLLDMRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANA
SAPAAALFSTVVMKIGLLGILTLSLLGGNAPLWWGIVLLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGA
GVTGIALEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIAMLVGLMAMAALPPL
NGFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVAL
AICCVIGGVAAPWLLPMLSAAVPLPLEPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEK
>Mature_477_residues
TIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFEHFRIYVTLADGFNSHTIEYYV
ETKEGKLWFALGRLGTLLLAIACWLLWQRYGTLDLRLLDMRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANAS
APAAALFSTVVMKIGLLGILTLSLLGGNAPLWWGIVLLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGAG
VTGIALEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIAMLVGLMAMAALPPLN
GFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALA
ICCVIGGVAAPWLLPMLSAAVPLPLEPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEK

Specific function: Hydrogen metabolism; FHL pathway. [C]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=239, Percent_Identity=26.3598326359833, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI2367154, Length=467, Percent_Identity=86.7237687366167, Blast_Score=731, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=447, Percent_Identity=41.3870246085011, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI1789080, Length=87, Percent_Identity=97.7011494252874, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1788831, Length=197, Percent_Identity=36.0406091370558, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788829, Length=191, Percent_Identity=28.2722513089005, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788614, Length=251, Percent_Identity=29.0836653386454, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788613, Length=193, Percent_Identity=27.979274611399, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: NA

Molecular weight: Translated: 51665; Mature: 51533

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFE
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HFRIYVTLADGFNSHTIEYYVETKEGKLWFALGRLGTLLLAIACWLLWQRYGTLDLRLLD
HHEEEEEEECCCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
MRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LTLSLLGGNAPLWWGIVLLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GVTGIALEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKM
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCHHHHHHCCCCCCC
PVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSA
HHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPLPLEPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
TIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFE
CEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HFRIYVTLADGFNSHTIEYYVETKEGKLWFALGRLGTLLLAIACWLLWQRYGTLDLRLLD
HHEEEEEEECCCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
MRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LTLSLLGGNAPLWWGIVLLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GVTGIALEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKM
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCHHHHHHCCCCCCC
PVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSA
HHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPLPLEPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2187144; 9278503 [H]