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The map label for this gene is malY [H]

Identifier: 82545116

GI number: 82545116

Start: 2706588

End: 2707796

Strand: Reverse

Name: malY [H]

Synonym: SBO_2704

Alternate gene names: 82545116

Gene position: 2707796-2706588 (Counterclockwise)

Preceding gene: 82545117

Following gene: 82545115

Centisome position: 59.91

GC content: 37.14

Gene sequence:

>1209_bases
ATGGATATTTTTAATACCTCAATTTCTCGTAAAGGAACATATTGCACACAATGGGACTTTTGTGAAGACAGATTTGGTGT
AAAAGATGTATTACCATTCTCTATTTCAGATATGGATCTTCCGATACCGGAAGCTATCATCAGAACATTAAAAAAACGTC
TGGAACACCCGATTTTAGGGTACAGTCGTTGGCAGCATGATGACTATCTGAATTCGATAGTCAATTGGTATCATCAACAA
TATAAAACAGAGATTCAACCAGAATGGATCACCTATAGCCCAAGCGTGATGTATTCAATATCTAAGGCAATAGAAATATT
GACATTGAATGGAGATAATATTCTCATTTTCACGCCTGTTTATAACGCATTTTTTGATGTGATTAAGCATAATGGTCGAA
ACATGCTAACAACCTCTTTGATGAAAGAAAATGGGAGAGGCTACGTTATCAACTGGCAAGACTTTGAGCTTAAAATTAAA
AGCGCGAAGATGGTGTTATTATGTAATCCTCATAACCCGACAGGAACGGTCTGGTCGGAAGACGATCTTCACAGAATCGC
AGCATGCTGTGCAAGGCATAATATTTGGTTATGTTCAGATGAAATACATAGTGATTTTGTTTTTAATCATAGTTTCACGT
CAGCGCTAACAATAAAAGATGACAAAGTGGTGGTGTTTAATTCGATTTCGAAAACATTTAATGTTCCTGCGCTAACCGGA
TCATATATGATTTCAACTGACGATAATTTTAATCATAAGTTCAGAACGATATCGAGGTATCGCGATTTCGTAAACTCCCC
ATCAGTACTGAATGTAATTGCGACCATTGTTGCCTATAATGAATGTGAAGAATGGTTAAAGTCATTAAAGGTACATATTG
CCTCTAACATTCAATTTACCTTGCAGTATTTAAATGAAAATATTCCGGAATTGATCGTATGGCCAGCTGAGGGCTGCTAT
TTTTCGTGGGTTGATTGCTCGGCCCTTGGTTATCCCTTTGATAAATTTTACCGTCGATTAATTAACGAAGGGAGAGTAGG
TATTATGGCGGGGCATGTTTATGGTACTGAAGGAGAGGGCTATCTGCGTCTTAATCTGGCCTGCAGTCGAGAAAAATTAT
ATATGGGGCTTGCGCGCCTTGCGAGTGTAATTAAAAATATTAATCAGGAAAAAGAAAATGAACAATACGGATCTTATCCA
TCTTATTAA

Upstream 100 bases:

>100_bases
TTGCGGTTGTGAAACTTGATCAAAATACCTTACAAGTCATTATCGGTACAAAAGTCATCGCCCTACGTCGGGATATGGAT
AATTACATGGGGATATGTTG

Downstream 100 bases:

>100_bases
ACGTTTTATGCGTAACGAACATAAAGCAGTAGAAGAGGTTATTGATTCCCCCCTTTCGGAAGTCGCGAATTTAATTAAAA
TATTACAATCTTGCCAGGGA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Cystathionine beta-lyase MalY; CBL; Beta-cystathionase; Cysteine lyase; Maltose regulon modulator [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDIFNTSISRKGTYCTQWDFCEDRFGVKDVLPFSISDMDLPIPEAIIRTLKKRLEHPILGYSRWQHDDYLNSIVNWYHQQ
YKTEIQPEWITYSPSVMYSISKAIEILTLNGDNILIFTPVYNAFFDVIKHNGRNMLTTSLMKENGRGYVINWQDFELKIK
SAKMVLLCNPHNPTGTVWSEDDLHRIAACCARHNIWLCSDEIHSDFVFNHSFTSALTIKDDKVVVFNSISKTFNVPALTG
SYMISTDDNFNHKFRTISRYRDFVNSPSVLNVIATIVAYNECEEWLKSLKVHIASNIQFTLQYLNENIPELIVWPAEGCY
FSWVDCSALGYPFDKFYRRLINEGRVGIMAGHVYGTEGEGYLRLNLACSREKLYMGLARLASVIKNINQEKENEQYGSYP
SY

Sequences:

>Translated_402_residues
MDIFNTSISRKGTYCTQWDFCEDRFGVKDVLPFSISDMDLPIPEAIIRTLKKRLEHPILGYSRWQHDDYLNSIVNWYHQQ
YKTEIQPEWITYSPSVMYSISKAIEILTLNGDNILIFTPVYNAFFDVIKHNGRNMLTTSLMKENGRGYVINWQDFELKIK
SAKMVLLCNPHNPTGTVWSEDDLHRIAACCARHNIWLCSDEIHSDFVFNHSFTSALTIKDDKVVVFNSISKTFNVPALTG
SYMISTDDNFNHKFRTISRYRDFVNSPSVLNVIATIVAYNECEEWLKSLKVHIASNIQFTLQYLNENIPELIVWPAEGCY
FSWVDCSALGYPFDKFYRRLINEGRVGIMAGHVYGTEGEGYLRLNLACSREKLYMGLARLASVIKNINQEKENEQYGSYP
SY
>Mature_402_residues
MDIFNTSISRKGTYCTQWDFCEDRFGVKDVLPFSISDMDLPIPEAIIRTLKKRLEHPILGYSRWQHDDYLNSIVNWYHQQ
YKTEIQPEWITYSPSVMYSISKAIEILTLNGDNILIFTPVYNAFFDVIKHNGRNMLTTSLMKENGRGYVINWQDFELKIK
SAKMVLLCNPHNPTGTVWSEDDLHRIAACCARHNIWLCSDEIHSDFVFNHSFTSALTIKDDKVVVFNSISKTFNVPALTG
SYMISTDDNFNHKFRTISRYRDFVNSPSVLNVIATIVAYNECEEWLKSLKVHIASNIQFTLQYLNENIPELIVWPAEGCY
FSWVDCSALGYPFDKFYRRLINEGRVGIMAGHVYGTEGEGYLRLNLACSREKLYMGLARLASVIKNINQEKENEQYGSYP
SY

Specific function: Acts as a beta-cystathionase and as a repressor of the maltose regulon [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=387, Percent_Identity=36.9509043927649, Blast_Score=290, Evalue=8e-80,
Organism=Escherichia coli, GI1786816, Length=299, Percent_Identity=26.7558528428094, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994472, Length=211, Percent_Identity=24.1706161137441, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=211, Percent_Identity=24.1706161137441, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=327, Percent_Identity=25.0764525993884, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 46557; Mature: 46557

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIFNTSISRKGTYCTQWDFCEDRFGVKDVLPFSISDMDLPIPEAIIRTLKKRLEHPILG
CCCCCCCCCCCCCEEECCCCHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
YSRWQHDDYLNSIVNWYHQQYKTEIQPEWITYSPSVMYSISKAIEILTLNGDNILIFTPV
CHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCEEEEEEECCCCEEEECCH
YNAFFDVIKHNGRNMLTTSLMKENGRGYVINWQDFELKIKSAKMVLLCNPHNPTGTVWSE
HHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCEEEEEECCEEEEEECCCCCCCCCCCC
DDLHRIAACCARHNIWLCSDEIHSDFVFNHSFTSALTIKDDKVVVFNSISKTFNVPALTG
HHHHHHHHHHHHCCEEEECCHHCCCEEEECCCCEEEEECCCCEEEEECCCHHCCCCEECC
SYMISTDDNFNHKFRTISRYRDFVNSPSVLNVIATIVAYNECEEWLKSLKVHIASNIQFT
CEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LQYLNENIPELIVWPAEGCYFSWVDCSALGYPFDKFYRRLINEGRVGIMAGHVYGTEGEG
HHHHHCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCC
YLRLNLACSREKLYMGLARLASVIKNINQEKENEQYGSYPSY
EEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDIFNTSISRKGTYCTQWDFCEDRFGVKDVLPFSISDMDLPIPEAIIRTLKKRLEHPILG
CCCCCCCCCCCCCEEECCCCHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
YSRWQHDDYLNSIVNWYHQQYKTEIQPEWITYSPSVMYSISKAIEILTLNGDNILIFTPV
CHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCEEEEEEECCCCEEEECCH
YNAFFDVIKHNGRNMLTTSLMKENGRGYVINWQDFELKIKSAKMVLLCNPHNPTGTVWSE
HHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCEEEEEECCEEEEEECCCCCCCCCCCC
DDLHRIAACCARHNIWLCSDEIHSDFVFNHSFTSALTIKDDKVVVFNSISKTFNVPALTG
HHHHHHHHHHHHCCEEEECCHHCCCEEEECCCCEEEEECCCCEEEEECCCHHCCCCEECC
SYMISTDDNFNHKFRTISRYRDFVNSPSVLNVIATIVAYNECEEWLKSLKVHIASNIQFT
CEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LQYLNENIPELIVWPAEGCYFSWVDCSALGYPFDKFYRRLINEGRVGIMAGHVYGTEGEG
HHHHHCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCC
YLRLNLACSREKLYMGLARLASVIKNINQEKENEQYGSYPSY
EEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 7665481; 10698925 [H]