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The map label for this gene is clpP4

Identifier: 78780133

GI number: 78780133

Start: 1638876

End: 1639535

Strand: Direct

Name: clpP4

Synonym: PMT9312_1748

Alternate gene names: 78780133

Gene position: 1638876-1639535 (Clockwise)

Preceding gene: 78780132

Following gene: 78780134

Centisome position: 95.89

GC content: 35.0

Gene sequence:

>660_bases
GTGGAAAACTATTTTGTGAACTCAGAAAAAAAACATTTAATCCAAAGCTCAATAAGTTCTTACGAAAGTATTCATAAAAC
TATTGGAGCGGTGCCTACTGTTATAGAACAATCTGGTAGAGGAGAAAGAGCTTTTGATATTTATTCACGACTATTGAGGG
AGAGAATAATTTTTTTAGGTAGTGGAATTAACGATCAAGTATCAGACTCTCTTGTTGCACAATTATTATTTCTTGAAGCT
GAAGATCCCGAAAAAGACATACAAATATATATCAATTCTCCTGGAGGCTCAGTAACTGCAGGAATGGCCATATACGATAC
TATGCAACAAATATCCCCAGATGTAGTGACAATATGTTTTGGAGTAGCTGCAAGTATGGGAGCATTTCTACTTTCTGGAG
GTGCAAAGGGGAAAAGATTGGCTTTACCTAATTCTAGGATCATGATTCATCAGCCTCTTGGAGGTGCACAAGGTCAAGCA
GTAGAGATTGAAATACAAGCAAAAGAAATACTTTTTCTTAAGAAAACATTAAATTCGCTCTTAGCAGAACATACCGGTCA
ACCTTTGGAAAAAATTAATGAAGATACAGAAAGAGATTACTTTTTATCTCCTTCAGAAGCAGTCGAATATGGATTAATTG
ATAAAGTTATCAAAAAGTGA

Upstream 100 bases:

>100_bases
CAAAAACAACAAAAGCCACAAAAACTCAAAATAAAAAAGAAAAAAAATAATTTATGAAATTTCCTACTAATTAAACAAAA
ACCCCTTAAATTATCTATAA

Downstream 100 bases:

>100_bases
CAAGGGATACTGATTTTTTAAGAATATGATGACGAATCGATATTTATAAGCAATCCTAGTGAATAGGGAATATTTAACAC
CTTTCACATTAAAACTTATA

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 4

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MENYFVNSEKKHLIQSSISSYESIHKTIGAVPTVIEQSGRGERAFDIYSRLLRERIIFLGSGINDQVSDSLVAQLLFLEA
EDPEKDIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQA
VEIEIQAKEILFLKKTLNSLLAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK

Sequences:

>Translated_219_residues
MENYFVNSEKKHLIQSSISSYESIHKTIGAVPTVIEQSGRGERAFDIYSRLLRERIIFLGSGINDQVSDSLVAQLLFLEA
EDPEKDIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQA
VEIEIQAKEILFLKKTLNSLLAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK
>Mature_219_residues
MENYFVNSEKKHLIQSSISSYESIHKTIGAVPTVIEQSGRGERAFDIYSRLLRERIIFLGSGINDQVSDSLVAQLLFLEA
EDPEKDIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQA
VEIEIQAKEILFLKKTLNSLLAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=219, Percent_Identity=51.5981735159817, Blast_Score=230, Evalue=7e-61,
Organism=Escherichia coli, GI1786641, Length=187, Percent_Identity=68.9839572192513, Blast_Score=276, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17538017, Length=194, Percent_Identity=52.5773195876289, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=53.8860103626943, Blast_Score=224, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP4_PROM9 (Q317Y6)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_398245.1
- ProteinModelPortal:   Q317Y6
- SMR:   Q317Y6
- STRING:   Q317Y6
- MEROPS:   S14.001
- GeneID:   3766574
- eggNOG:   COG0740
- OMA:   TGQPFER
- ProtClustDB:   CLSK922244
- BioCyc:   PMAR74546:PMT9312_1748-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 24033; Mature: 24033

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 125-125 ACT_SITE 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENYFVNSEKKHLIQSSISSYESIHKTIGAVPTVIEQSGRGERAFDIYSRLLRERIIFLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
SGINDQVSDSLVAQLLFLEAEDPEKDIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICF
CCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHH
GVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTLNSL
HHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHH
LAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK
HHHHCCCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENYFVNSEKKHLIQSSISSYESIHKTIGAVPTVIEQSGRGERAFDIYSRLLRERIIFLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
SGINDQVSDSLVAQLLFLEAEDPEKDIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICF
CCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHH
GVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTLNSL
HHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHH
LAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK
HHHHCCCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA