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The map label for this gene is uvrB [H]

Identifier: 78780126

GI number: 78780126

Start: 1629325

End: 1631364

Strand: Reverse

Name: uvrB [H]

Synonym: PMT9312_1741

Alternate gene names: 78780126

Gene position: 1631364-1629325 (Counterclockwise)

Preceding gene: 78780127

Following gene: 78780123

Centisome position: 95.45

GC content: 33.82

Gene sequence:

>2040_bases
ATGAAAAACTATAAGCTTCAAGCTCCTTACGAACCAAATGGAGATCAACCTGAAGCTATAAAAAAATTAGTTAGAGGGGT
TAATAGTGGGAAAGAGTTTCAGACCCTTTTAGGAGCTACTGGGACTGGTAAAACATTTACTATTGCGAATGTAATTCAAC
AAACAGGAAGGCCAGCTCTTGTATTAGCTCATAACAAAACGTTAGCTGCACAACTATGTAATGAATTAAGGGAGTTCTTT
CCAAAAAATGCTGTTGAGTACTTTATTTCTTACTACGATTATTATCAACCTGAAGCTTACGTCCCTGTAAGTGATACATA
CATAGCGAAAACCGCTTCAATTAATGAAGAAATAGATATGCTTAGGCATTCTGCAACACGCTCATTATTTGAGAGAAAAG
ATGTGATTGTCGTAGCATCCATAAGTTGTATTTATGGTCTTGGTATACCAAGTGAATATTTAAAAGCTGCAGTTAAATTT
GAAGTTGGAAAATCTATAAATCTACGTTCTTCTTTAAGGTCGCTCGTTGAAAATCAATATACTAGAAATGATATTGAAAT
TACTAGAGGTAGATTCAGAATTAAAGGTGATGTTTTAGAAATTGGTCCTGCTTATGAAGATAGATTGATAAGAATTGAAT
TATTTGGTGATGAAGTCGAGGCTATTAGATATGTTGACCCTACTACTGGAGAGATCCTTGAAAGTTTAGAACAAATAAGC
GTTTACCCAGCGAAGCATTTTGTTACTCCAAAAGAAAGACTTGAGAGTGCAATAAGTGCAATTAAAAGTGAATTAAAAAC
TCAACTCGACAAATTTACATACGAAGGAAAATTATTAGAGGCTCAACGTCTTGAACAACGCACAAAATATGATTTAGAAA
TGCTAAAAGAGGTTGGTTATTGTAATGGAGTTGAGAATTATGCTCGTCATTTATCAGGAAGGGAGGAAGGTTCACCGCCA
GAATGTCTAATAGATTACTTTCCTAAAGATTGGTTGTTGGTAGTCGATGAGAGTCATGTAACATGTCCTCAACTACATGC
AATGTACAATGGTGATCAATCTAGAAAAAAAGTTTTAATAGATCATGGTTTTAGATTGCCAAGTGCTGCAGATAATAGAC
CTTTAAAATGTGAGGAGTTTTGGGAAAAGTCAAAGCAGACATTATTCATAAGTGCAACTCCTGGTCAATGGGAATTAGAT
CAATGTAATGGTGAATTTGTTGAGCAAGTTATAAGACCAACTGGGGTATTAGACCCAGTAATTGATGTAAGACCTAGTGA
GGGCCAAATAGAAGATTTATTATCTGAAATAAGAATTAGAGCTGAAAAAAATCAAAGAGTGCTAGTGACTACACTTACTA
AGCGAATGGCTGAAGATCTAACTGATTTTTTATCTGAAAATAAAGTAAGAGTTAGATATTTGCATTCCGAAATCCACTCA
ATTGAAAGAATTGAAATTATTCAAGACCTCAGAATGGGCGAATATGATGTTTTGGTGGGAGTTAACTTATTAAGAGAGGG
ATTAGATCTTCCTGAGGTATCGTTAGTCGCCATTTTAGATGCTGATAAAGAAGGTTTTCTGAGAGCAGAAAGATCTTTGA
TTCAAACAATTGGAAGAGCTGCAAGACATGTTGAAGGTGTTGCCTTGCTTTATGCAGATAATTTCACAGATTCAATGAAA
CGAGCAATATCTGAAACTGAAAGAAGAAGAACTATTCAAAAAAAACATAACCAGGACAATGGCATTACTCCAAAACCTGC
AGGTAAAAAAATAGAAAATTCAATATTATCTTTTCTAGAACTTTCCAGAAAATTAGATGCTGGTGGTTTATCTAAAGATT
TAATAAATATAGTTAATAACAAAACGGATGTAATTCTCAATGCCAGCGATAATCAATGTTTGATTGAAGAATTGCCGCAC
TTGATAGATAAGTTAGAAATGAAAATGAAAGATGCTGCAAAAGAGTTAAATTTTGAAGAAGCAGCAAATTTGAGGGATAG
AATTAAAAAATTAAGACAAAAATTAGCAAGAAATAGCTAA

Upstream 100 bases:

>100_bases
CAATGATCGCGGTTGTTAGGGGTTTAAAAGAATCTTTGAAAAATTCAATAATTGGAGAAAAAATTTCTTAAAATATTAAT
ACCCTTCGGCTATTAGCTTG

Downstream 100 bases:

>100_bases
AAATAACTTATTTTTCCAATTCGAAATGATTATGAATAGCATTTACTGCTTTGTCACAATCTTTCTCTAAAACAATACAT
GAAGTTCTAATTTCACTGGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MKNYKLQAPYEPNGDQPEAIKKLVRGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSSLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQIS
VYPAKHFVTPKERLESAISAIKSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCNGEFVEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETERRRTIQKKHNQDNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDVILNASDNQCLIEELPH
LIDKLEMKMKDAAKELNFEEAANLRDRIKKLRQKLARNS

Sequences:

>Translated_679_residues
MKNYKLQAPYEPNGDQPEAIKKLVRGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSSLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQIS
VYPAKHFVTPKERLESAISAIKSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCNGEFVEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETERRRTIQKKHNQDNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDVILNASDNQCLIEELPH
LIDKLEMKMKDAAKELNFEEAANLRDRIKKLRQKLARNS
>Mature_679_residues
MKNYKLQAPYEPNGDQPEAIKKLVRGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSSLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQIS
VYPAKHFVTPKERLESAISAIKSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCNGEFVEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETERRRTIQKKHNQDNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDVILNASDNQCLIEELPH
LIDKLEMKMKDAAKELNFEEAANLRDRIKKLRQKLARNS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=674, Percent_Identity=56.5281899109792, Blast_Score=755, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77299; Mature: 77299

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYKLQAPYEPNGDQPEAIKKLVRGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFEVGKSINLRSSLRSLVENQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
TRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQIS
CCCCCEEECCEEEEECCEEECCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
VYPAKHFVTPKERLESAISAIKSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
CNGVENYARHLSGREEGSPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHEEEH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCNGEFVEQVIRPTGVLDPV
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCC
IDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTDSMKRAISETERRRTIQKKHNQDNGITPKPAGKKIENSILSFLE
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LSRKLDAGGLSKDLINIVNNKTDVILNASDNQCLIEELPHLIDKLEMKMKDAAKELNFEE
HHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLARNS
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNYKLQAPYEPNGDQPEAIKKLVRGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFEVGKSINLRSSLRSLVENQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
TRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQIS
CCCCCEEECCEEEEECCEEECCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
VYPAKHFVTPKERLESAISAIKSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
CNGVENYARHLSGREEGSPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHEEEH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCNGEFVEQVIRPTGVLDPV
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCC
IDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTDSMKRAISETERRRTIQKKHNQDNGITPKPAGKKIENSILSFLE
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LSRKLDAGGLSKDLINIVNNKTDVILNASDNQCLIEELPHLIDKLEMKMKDAAKELNFEE
HHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLARNS
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA