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The map label for this gene is ahcY [H]

Identifier: 78780103

GI number: 78780103

Start: 1605223

End: 1606641

Strand: Reverse

Name: ahcY [H]

Synonym: PMT9312_1718

Alternate gene names: 78780103

Gene position: 1606641-1605223 (Counterclockwise)

Preceding gene: 78780105

Following gene: 78780102

Centisome position: 94.0

GC content: 35.38

Gene sequence:

>1419_bases
ATGGTTATCGCAAATTCAGTTAAAAGCTCCACAACTAATTACGTAGTTGCTGATATATCTTTATCAGATTTTGGTCGTAA
AGAAATTAAAATTGCCGAAACGGAAATGCCTGGATTAATGGCACTTAGAGATAAATATCAATCTGAAAAGCCACTAAAAG
GGGCAAAAATAGCTGGAAGTCTTCATATGACTATTCAGACAGCAGTCTTAATAGAAACTCTTGTTGATCTTGGTGCAGAA
GTGAAATGGGCTTCATGCAATATTTTTTCAACTCAAGATCATGCTGCAGCAGCTATTGCAGATCAAGGAATTTCTGTGTA
TGCAAAAAAAGGTGAGACTCTTGATGAATATTGGCAATATACCCACTGTATCCTTGATTGGGGTGCAGACTCTCCAAATA
TGATTCTTGATGATGGGGGAGATGCAACTGGCTTATTGATACTTGGTAGTAAAGCAGAAAAAGATTTATCTGTTTTAGAT
AATCCCGGTAATGAAGAAGAAATTGCTTTATTCAATTCTATCAAGTATAAGTTGGAAACTGATAGTGACTTCTATTCTAG
AATTAAGAGTAATATCATTGGTGTCACTGAAGAAACTACAACGGGAGTTGCAAGACTTTATCAACTGCAAAAGCAAAATG
CTCTACCTTTCCCTGCTATCAATGTTAATGATTCAGTAACTAAGAGCAAATTTGATAATTTATATGGTTGCCGAGAATCT
CTAGTTGACAGCATAAAGCGTGCAACTGACGTGATGATTGCAGGTAAGGTCGCTTTAGTAATGGGTTTTGGAGATGTAGG
TAAAGGTTCAGCCCAGTCTCTAAGAGGACTTGGTGCAATTGTAAAAGTTGCTGAAGTTGATCCAATTTGTGCTCTTCAAG
CGGCAATGGAAGGTTTTAGCGTTGTTACATTAGACGATGTTGTGGAAGATATAGATATATTTGTTACAGCTACTGGGAAC
TATCAGGTTATAACAAACAAAAATCTTGTCAAGATGAAAGACGAGGCCATAGTCTGTAATATCGGCCATTTCGATAATGA
AATTGATGTGGCTTCATTGAAAGATTATCCATGGGAAAATATTAAGCCGCAGGTTGATCACATAACTTTACCGAGTGGTA
ATAAAATAATCCTTTTAGCTGAAGGTAGATTAGTTAATTTAGGTTGTGCCACTGGACATCCAAGCTTTGTTATGAGTAAT
TCGTTTACTAATCAAGTACTAGCTCAAATTGAACTTTTCAATAAGTCAGAAAAATATGCTAAGGAGGTTTATGTTTTACC
AAAACATTTAGATGAAATGGTAGCTAGATTACATCTTGATAAAATTGGTGCAAAATTAACAAAATTAACTGAAGAACAGG
CTGATTATATTAATGTTTCTGTTGAAGGTCCTTATAAACCAGAGCTTTATAGATACTAA

Upstream 100 bases:

>100_bases
AGAGTTTTTTTCCTAAATTTAAAGTCTCTTTTAAATTCTCAATAAACACAAAATTACACAAGAATCATTTATAGTTTAGT
AGAGAAAGTATTTACTAGAT

Downstream 100 bases:

>100_bases
GTTTGAATTTAATTTTTATAAATTTTCTTACTTCAATCCCTGACTATATTAGTTTGGCTGTTGAAAAGAATTCAACAATT
GCATACCTAACAATTTGTTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MVIANSVKSSTTNYVVADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLVDLGAE
VKWASCNIFSTQDHAAAAIADQGISVYAKKGETLDEYWQYTHCILDWGADSPNMILDDGGDATGLLILGSKAEKDLSVLD
NPGNEEEIALFNSIKYKLETDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
LVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLDDVVEDIDIFVTATGN
YQVITNKNLVKMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSN
SFTNQVLAQIELFNKSEKYAKEVYVLPKHLDEMVARLHLDKIGAKLTKLTEEQADYINVSVEGPYKPELYRY

Sequences:

>Translated_472_residues
MVIANSVKSSTTNYVVADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLVDLGAE
VKWASCNIFSTQDHAAAAIADQGISVYAKKGETLDEYWQYTHCILDWGADSPNMILDDGGDATGLLILGSKAEKDLSVLD
NPGNEEEIALFNSIKYKLETDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
LVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLDDVVEDIDIFVTATGN
YQVITNKNLVKMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSN
SFTNQVLAQIELFNKSEKYAKEVYVLPKHLDEMVARLHLDKIGAKLTKLTEEQADYINVSVEGPYKPELYRY
>Mature_472_residues
MVIANSVKSSTTNYVVADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLVDLGAE
VKWASCNIFSTQDHAAAAIADQGISVYAKKGETLDEYWQYTHCILDWGADSPNMILDDGGDATGLLILGSKAEKDLSVLD
NPGNEEEIALFNSIKYKLETDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
LVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLDDVVEDIDIFVTATGN
YQVITNKNLVKMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSN
SFTNQVLAQIELFNKSEKYAKEVYVLPKHLDEMVARLHLDKIGAKLTKLTEEQADYINVSVEGPYKPELYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=463, Percent_Identity=59.1792656587473, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI239937451, Length=441, Percent_Identity=59.1836734693878, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=49.247311827957, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=49.247311827957, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=49.247311827957, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=49.247311827957, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=48.3870967741936, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17506425, Length=473, Percent_Identity=57.9281183932347, Blast_Score=507, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6320882, Length=484, Percent_Identity=55.5785123966942, Blast_Score=488, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=60.5150214592275, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=49.7854077253219, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.1079913606911, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51709; Mature: 51709

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIANSVKSSTTNYVVADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGS
CEECCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEECE
LHMTIQTAVLIETLVDLGAEVKWASCNIFSTQDHAAAAIADQGISVYAKKGETLDEYWQY
EEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCCEEEEECCCCHHHHHHH
THCILDWGADSPNMILDDGGDATGLLILGSKAEKDLSVLDNPGNEEEIALFNSIKYKLET
EEEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCCEEEEEEEEEEEEEC
DSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
CHHHHHHHHHCEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFS
HHHHHHHHHHEEEECEEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHCCCE
VVTLDDVVEDIDIFVTATGNYQVITNKNLVKMKDEAIVCNIGHFDNEIDVASLKDYPWEN
EEEHHHHHCCEEEEEEECCCEEEEECCCEEEEECCEEEEEECCCCCCCCEEECCCCCCCC
IKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFNKSEKYA
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCHHHH
KEVYVLPKHLDEMVARLHLDKIGAKLTKLTEEQADYINVSVEGPYKPELYRY
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVIANSVKSSTTNYVVADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGS
CEECCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEECE
LHMTIQTAVLIETLVDLGAEVKWASCNIFSTQDHAAAAIADQGISVYAKKGETLDEYWQY
EEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCCEEEEECCCCHHHHHHH
THCILDWGADSPNMILDDGGDATGLLILGSKAEKDLSVLDNPGNEEEIALFNSIKYKLET
EEEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCCEEEEEEEEEEEEEC
DSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
CHHHHHHHHHCEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFS
HHHHHHHHHHEEEECEEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHCCCE
VVTLDDVVEDIDIFVTATGNYQVITNKNLVKMKDEAIVCNIGHFDNEIDVASLKDYPWEN
EEEHHHHHCCEEEEEEECCCEEEEECCCEEEEECCEEEEEECCCCCCCCEEECCCCCCCC
IKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFNKSEKYA
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCHHHH
KEVYVLPKHLDEMVARLHLDKIGAKLTKLTEEQADYINVSVEGPYKPELYRY
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA