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The map label for this gene is hisD

Identifier: 78779965

GI number: 78779965

Start: 1476862

End: 1478184

Strand: Direct

Name: hisD

Synonym: PMT9312_1581

Alternate gene names: 78779965

Gene position: 1476862-1478184 (Clockwise)

Preceding gene: 78779952

Following gene: 78779968

Centisome position: 86.41

GC content: 33.71

Gene sequence:

>1323_bases
TTGGGTCGCGAGCCTTTCAATTTGAAAAATTTAGAAATGAGGATTATAAACAATAAAAAAGACGCTATCCAAGAATTAAA
AAGGATTTCTTCTAGAACTAATTCAGAAAACAATAACAAGATAAATCTAATCGTCGAAGAAATTCTTCAAGAGGTAAAAA
CTTATGGGGATATAGCAGTTGAAAAATATACCAAAAAGTTTGATGGTTTCAACCCTGACCCTATGCAAATTAGTGAGGAT
CACTTAAAGGATGCATGGGATGAAATTGATAGCAATTTAAAGCGCTCACTTGAGGTGGCCCATAAAAGAATTAAAAAATT
CCATGAAAAGGAAATTCCACAATCTTTCACTATAAAAGGTGAACATGGTGATACAGTTCAAAGGAGATGGAGACCAGTTA
AAAATGCAGGTATTTATATTCCTGGAGGCAGAGCTGCTTATCCAAGTACTGTATTAATGAATGCAATACCTGCAAAAGTA
GCAGGAGTAGAAGAAATTATAATGGTATCTCCTGGAAATAAAGAAGGGGAAATAAACAAAACTGTTTTAGCTGCAGCTCA
CTTATCAGGGATCAAAAAAGTTTTTAGAATTGGAGGAGCTCAAGCTATTGGTGCTTTGGCATTTGGCACAAATCAAATTA
ATAAAGTTGATGTTATTACAGGTCCAGGGAATATCTATGTAACTACTGCTAAAAAACTAATTTATGGCTCTACAGGCATT
GATTCTTTAGCTGGTCCTAGTGAAATATTAGTCATTGCAGATGAAACAGCTCAAAGCACTCATATAGCTTCTGATCTCTT
AGCGCAAGCAGAACATGATCCTTTGGCTTCATCAATACTTCTAACAACATCAAAGAACCAAGCGAAAGAAGTTTTAGAGG
AACTTTATAAAAAAATAGATGATCATCCAAGAAAAGAAATTTGCATGCAATCCATAAAAAATTGGGGATTAATAGTTATT
TGCGAGAATTATGAATTATGTATCGAACTGAGCAATAACTTTGCTCCAGAACATTTAGAAATTTTAGCTTTAGATTCAAA
AAAGATTCTTGAAGGTATAGAGAATGCAGGAGCAATATTTTTAGGAAAATGGACCCCAGAAGCAGTAGGAGATTATCTGG
CTGGACCAAATCATACTTTACCTACATCAGGAAATTCTAGATTTAGCGGTTCTTTAGGAGTTGAAACTTTTATGAAAAAC
ACTTCAATAATAGAATTTAATGAAGAAAGTTTAAAAGTCAACAGTCTCGATATTATTAATCTTGCTGAGAGTGAGGGCTT
ACATAGTCATGCCAACTCAGTAAAAATAAGATTTGAAGATTAG

Upstream 100 bases:

>100_bases
GATTTGTTATTGGCCACAGAGGGTACATAAATATAAGATTTATATCATAACAAATAAATCGACTACTAATCAATCATATA
TAATTTAGAAAGGTATTAAA

Downstream 100 bases:

>100_bases
CCAACTTTTGCGGGAGAGTAAGCAACAGGAATATTGTTTTCAATTTTACCAACCAATACTTTGTCTGTAAGGTCAATGAA
TAATCCATTTTCTAATACTC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MGREPFNLKNLEMRIINNKKDAIQELKRISSRTNSENNNKINLIVEEILQEVKTYGDIAVEKYTKKFDGFNPDPMQISED
HLKDAWDEIDSNLKRSLEVAHKRIKKFHEKEIPQSFTIKGEHGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKV
AGVEEIIMVSPGNKEGEINKTVLAAAHLSGIKKVFRIGGAQAIGALAFGTNQINKVDVITGPGNIYVTTAKKLIYGSTGI
DSLAGPSEILVIADETAQSTHIASDLLAQAEHDPLASSILLTTSKNQAKEVLEELYKKIDDHPRKEICMQSIKNWGLIVI
CENYELCIELSNNFAPEHLEILALDSKKILEGIENAGAIFLGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKN
TSIIEFNEESLKVNSLDIINLAESEGLHSHANSVKIRFED

Sequences:

>Translated_440_residues
MGREPFNLKNLEMRIINNKKDAIQELKRISSRTNSENNNKINLIVEEILQEVKTYGDIAVEKYTKKFDGFNPDPMQISED
HLKDAWDEIDSNLKRSLEVAHKRIKKFHEKEIPQSFTIKGEHGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKV
AGVEEIIMVSPGNKEGEINKTVLAAAHLSGIKKVFRIGGAQAIGALAFGTNQINKVDVITGPGNIYVTTAKKLIYGSTGI
DSLAGPSEILVIADETAQSTHIASDLLAQAEHDPLASSILLTTSKNQAKEVLEELYKKIDDHPRKEICMQSIKNWGLIVI
CENYELCIELSNNFAPEHLEILALDSKKILEGIENAGAIFLGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKN
TSIIEFNEESLKVNSLDIINLAESEGLHSHANSVKIRFED
>Mature_439_residues
GREPFNLKNLEMRIINNKKDAIQELKRISSRTNSENNNKINLIVEEILQEVKTYGDIAVEKYTKKFDGFNPDPMQISEDH
LKDAWDEIDSNLKRSLEVAHKRIKKFHEKEIPQSFTIKGEHGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKVA
GVEEIIMVSPGNKEGEINKTVLAAAHLSGIKKVFRIGGAQAIGALAFGTNQINKVDVITGPGNIYVTTAKKLIYGSTGID
SLAGPSEILVIADETAQSTHIASDLLAQAEHDPLASSILLTTSKNQAKEVLEELYKKIDDHPRKEICMQSIKNWGLIVIC
ENYELCIELSNNFAPEHLEILALDSKKILEGIENAGAIFLGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKNT
SIIEFNEESLKVNSLDIINLAESEGLHSHANSVKIRFED

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=38.0281690140845, Blast_Score=304, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=36.3855421686747, Blast_Score=268, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_PROM9 (Q318Q4)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_398077.1
- ProteinModelPortal:   Q318Q4
- SMR:   Q318Q4
- STRING:   Q318Q4
- GeneID:   3766398
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1581
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   PMAR74546:PMT9312_1581-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 48593; Mature: 48462

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 337-337 ACT_SITE 338-338 BINDING 139-139 BINDING 201-201 BINDING 224-224 BINDING 247-247 BINDING 269-269 BINDING 272-272 BINDING 338-338 BINDING 371-371 BINDING 425-425 BINDING 430-430

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGREPFNLKNLEMRIINNKKDAIQELKRISSRTNSENNNKINLIVEEILQEVKTYGDIAV
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCHHH
EKYTKKFDGFNPDPMQISEDHLKDAWDEIDSNLKRSLEVAHKRIKKFHEKEIPQSFTIKG
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
EHGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVEEIIMVSPGNKEGEINK
CCCCHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHCCCEEEEEECCCCCCCCCHH
TVLAAAHLSGIKKVFRIGGAQAIGALAFGTNQINKVDVITGPGNIYVTTAKKLIYGSTGI
HHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCEEEEEECCCCEEEEEEEEEEECCCCC
DSLAGPSEILVIADETAQSTHIASDLLAQAEHDPLASSILLTTSKNQAKEVLEELYKKID
CCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHC
DHPRKEICMQSIKNWGLIVICENYELCIELSNNFAPEHLEILALDSKKILEGIENAGAIF
CCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHHCCCCEEE
LGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLKVNSLDIIN
EECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEECCEEEEE
LAESEGLHSHANSVKIRFED
ECCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
GREPFNLKNLEMRIINNKKDAIQELKRISSRTNSENNNKINLIVEEILQEVKTYGDIAV
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCHHH
EKYTKKFDGFNPDPMQISEDHLKDAWDEIDSNLKRSLEVAHKRIKKFHEKEIPQSFTIKG
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
EHGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVEEIIMVSPGNKEGEINK
CCCCHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHCCCEEEEEECCCCCCCCCHH
TVLAAAHLSGIKKVFRIGGAQAIGALAFGTNQINKVDVITGPGNIYVTTAKKLIYGSTGI
HHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCEEEEEECCCCEEEEEEEEEEECCCCC
DSLAGPSEILVIADETAQSTHIASDLLAQAEHDPLASSILLTTSKNQAKEVLEELYKKID
CCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHC
DHPRKEICMQSIKNWGLIVICENYELCIELSNNFAPEHLEILALDSKKILEGIENAGAIF
CCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHHCCCCEEE
LGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLKVNSLDIIN
EECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEECCEEEEE
LAESEGLHSHANSVKIRFED
ECCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA