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The map label for this gene is bioA [H]

Identifier: 78779949

GI number: 78779949

Start: 1458657

End: 1459958

Strand: Direct

Name: bioA [H]

Synonym: PMT9312_1565

Alternate gene names: 78779949

Gene position: 1458657-1459958 (Clockwise)

Preceding gene: 78779948

Following gene: 78779952

Centisome position: 85.34

GC content: 33.79

Gene sequence:

>1302_bases
ATGAAATCTTTGGATTCAAACACTCCAAATCAAGATTGGCATCCAAATATTTGGCCTCCTTTTACTCAAATCAATACCAG
CAAACCGCAAATAGAAGTAACTCATGGTAAAGATGCCCTCCTATTTACTAAAGATCCTAAAAAAGAGCTGATAGATGCAA
TAAGTAGTTGGTGGGTAACTCTTCATGGCCATAGTAACGAATACATTGCGAATGCCATTTTCGATCAAGCAAAAAACCTT
GAGCAAGTTATCTTTGCTGATTTCTTACATCCGCAGGCAAGAAAATTGGCAGAAAGGCTTAGTAAATTAACAAAACTAGA
ACGATTATTCTTTTCTGATAACGGTTCTACTGCAGTGGAAGTAGCTTTAAAAATCGCCTTCCAATCATGGCAAAATAGAG
GAGAGACAAGATCTCAAATAGTAGCTTTTGATGGTGCATATCATGGCGATACATTTGGTGCAATGGCACTAGGTGAAAGA
AATATTTTTAATGAAAATTTCGATGATCTTATGTTCCCAGTTAGGAGAGTCCCATGGCCTTCAACTTGGATTAATGATGA
TGAAGTAGAAAACAAAGAAAATGAAGCAATCCAAAAATTAGAAACTCTTCTTAAAACTCCTACAGTAGCAGTCATCCTTG
AGCCACTTGTTCAAGGAGCAGGAGGAATGAATATGGTTAGGGCTCAGTTTATTAAAAAAGTTTCAGAAACTGTAAAAAAT
AATAATTCTTTGTTAATTGCCGATGAAGTATTAACTGGGTTTGGAAGATGTGGAAGCCTTTTCGCATTTCAAAAAGCAAA
AATCATTCCTGATTTAATAAGTATCTCAAAAGGCTTAACTGGTGGATTTTTACCAATGGGAATAACTTTATGTAAAGAAA
AAATTTTTCAATCCTTTATTGATGATTCCCCAAAAAAAACTTTTTGGCATGGACATAGTTTTACTGCTAATCCTTTAGGT
TGTGCTGCGGCAAACGCTAGCCTTGATTTATTAGAAAAAGAACCAAACAAATATCTTTCATTTGAAGAAAAACATTTATC
TCATTTAATTAAATTTAAAAAATTACCTTATATAAAAAAGATAAGAGTATCTGGAACCATTGCTGCCTTCGATTTAGAAA
TTGGGAATAAAAGAGGTTATTTTAATAATATTGGGAAAGAAATCAAGAGTCTAGCGATGGAGGAAGGTTTATTTATTAGG
CCCCTCGGGAATGTTATTTACCTCTTGCCGCCTCTTTGTATAACAGATGATCAATTAGAAAAAAGTTACTGGATAATTAG
TAAAATCTTAGACAATCTATAG

Upstream 100 bases:

>100_bases
TTACATCAAAAAAATTGATTCAAATAATTTGGATATACTATGGAAAGAACTTGACATCAAAAATAAGTTGGTCTCACTTT
TAAACTCAAAAATAAGTTAA

Downstream 100 bases:

>100_bases
ATACAAATTTAAGGTCCCTGAAGTATTGCATTTTCCACATCTTCTCTATTAATGCAATAAGAAAATAGTCTTTTAGTTTC
TTGTCCTTCACTTTCCCAGA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKSLDSNTPNQDWHPNIWPPFTQINTSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVTLHGHSNEYIANAIFDQAKNL
EQVIFADFLHPQARKLAERLSKLTKLERLFFSDNGSTAVEVALKIAFQSWQNRGETRSQIVAFDGAYHGDTFGAMALGER
NIFNENFDDLMFPVRRVPWPSTWINDDEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRAQFIKKVSETVKN
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFIDDSPKKTFWHGHSFTANPLG
CAAANASLDLLEKEPNKYLSFEEKHLSHLIKFKKLPYIKKIRVSGTIAAFDLEIGNKRGYFNNIGKEIKSLAMEEGLFIR
PLGNVIYLLPPLCITDDQLEKSYWIISKILDNL

Sequences:

>Translated_433_residues
MKSLDSNTPNQDWHPNIWPPFTQINTSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVTLHGHSNEYIANAIFDQAKNL
EQVIFADFLHPQARKLAERLSKLTKLERLFFSDNGSTAVEVALKIAFQSWQNRGETRSQIVAFDGAYHGDTFGAMALGER
NIFNENFDDLMFPVRRVPWPSTWINDDEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRAQFIKKVSETVKN
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFIDDSPKKTFWHGHSFTANPLG
CAAANASLDLLEKEPNKYLSFEEKHLSHLIKFKKLPYIKKIRVSGTIAAFDLEIGNKRGYFNNIGKEIKSLAMEEGLFIR
PLGNVIYLLPPLCITDDQLEKSYWIISKILDNL
>Mature_433_residues
MKSLDSNTPNQDWHPNIWPPFTQINTSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVTLHGHSNEYIANAIFDQAKNL
EQVIFADFLHPQARKLAERLSKLTKLERLFFSDNGSTAVEVALKIAFQSWQNRGETRSQIVAFDGAYHGDTFGAMALGER
NIFNENFDDLMFPVRRVPWPSTWINDDEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRAQFIKKVSETVKN
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFIDDSPKKTFWHGHSFTANPLG
CAAANASLDLLEKEPNKYLSFEEKHLSHLIKFKKLPYIKKIRVSGTIAAFDLEIGNKRGYFNNIGKEIKSLAMEEGLFIR
PLGNVIYLLPPLCITDDQLEKSYWIISKILDNL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=25.9615384615385, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI13994255, Length=371, Percent_Identity=26.6846361185984, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI284507298, Length=326, Percent_Identity=26.3803680981595, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI37574042, Length=444, Percent_Identity=25.6756756756757, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=26.1964735516373, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226442705, Length=372, Percent_Identity=26.6129032258064, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI24119277, Length=434, Percent_Identity=23.2718894009217, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786991, Length=415, Percent_Identity=33.4939759036145, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI145693181, Length=382, Percent_Identity=30.3664921465969, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1788044, Length=375, Percent_Identity=28.2666666666667, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789016, Length=402, Percent_Identity=28.6069651741293, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789759, Length=378, Percent_Identity=26.1904761904762, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=28.25, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=394, Percent_Identity=25.1269035532995, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=455, Percent_Identity=27.6923076923077, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=242, Percent_Identity=29.7520661157025, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=413, Percent_Identity=22.0338983050847, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=464, Percent_Identity=30.1724137931034, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323470, Length=407, Percent_Identity=27.7641277641278, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=425, Percent_Identity=27.5294117647059, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=25.4854368932039, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=24.582338902148, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI161085790, Length=402, Percent_Identity=24.8756218905473, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574759, Length=397, Percent_Identity=25.1889168765743, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48845; Mature: 48845

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLDSNTPNQDWHPNIWPPFTQINTSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCEEE
LHGHSNEYIANAIFDQAKNLEQVIFADFLHPQARKLAERLSKLTKLERLFFSDNGSTAVE
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAFQSWQNRGETRSQIVAFDGAYHGDTFGAMALGERNIFNENFDDLMFPVRRVPWP
HHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCC
STWINDDEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRAQFIKKVSETVKN
CCCCCCHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFI
CCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DDSPKKTFWHGHSFTANPLGCAAANASLDLLEKEPNKYLSFEEKHLSHLIKFKKLPYIKK
CCCCCCCEECCCCCCCCCCCHHHCCCCHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCCEE
IRVSGTIAAFDLEIGNKRGYFNNIGKEIKSLAMEEGLFIRPLGNVIYLLPPLCITDDQLE
EEECCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCHHHH
KSYWIISKILDNL
HHHHHHHHHHHCC
>Mature Secondary Structure
MKSLDSNTPNQDWHPNIWPPFTQINTSKPQIEVTHGKDALLFTKDPKKELIDAISSWWVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCEEE
LHGHSNEYIANAIFDQAKNLEQVIFADFLHPQARKLAERLSKLTKLERLFFSDNGSTAVE
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAFQSWQNRGETRSQIVAFDGAYHGDTFGAMALGERNIFNENFDDLMFPVRRVPWP
HHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCC
STWINDDEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRAQFIKKVSETVKN
CCCCCCHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFI
CCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DDSPKKTFWHGHSFTANPLGCAAANASLDLLEKEPNKYLSFEEKHLSHLIKFKKLPYIKK
CCCCCCCEECCCCCCCCCCCHHHCCCCHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCCEE
IRVSGTIAAFDLEIGNKRGYFNNIGKEIKSLAMEEGLFIRPLGNVIYLLPPLCITDDQLE
EEECCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCHHHH
KSYWIISKILDNL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]