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The map label for this gene is purC [H]

Identifier: 78779821

GI number: 78779821

Start: 1349856

End: 1350584

Strand: Reverse

Name: purC [H]

Synonym: PMT9312_1437

Alternate gene names: 78779821

Gene position: 1350584-1349856 (Counterclockwise)

Preceding gene: 78779824

Following gene: 78779820

Centisome position: 79.02

GC content: 25.38

Gene sequence:

>729_bases
ATGAATAATAAATATGAATTAATTTATGAAGGTAAAGCAAAAAAAGTATTTTCTCATGATGATGTAGATAAAGTATTTAT
TGAATTTAAAGATGATGCAACAGCTTTTAATGCGTTGAAAAAAGCAAAATTTGAAGGGAAGGGCAAACTTAATTGTCTTA
TAAGTTCAAGAATTTTTGAACTTCTTGACAAGAGTAATATTCCAACTCATTTTCTTGAACTTAAAAATGAAAATATAATG
ATTGCACAAAAAATAAAAGTAATTCCTTTGGAAATTGTCCTTAGAAATACTGCATATGGTTCTTTATGTAAACAAACGAC
TATTAAATCAGGTACTATACTTGCAAAACCATTAATTGATATTTATCTGAAAAATGATGAACTTAATGATCCGTTAATAA
CAAAAGATAGAATTGAATTAATGAATATACTAAGCTCCAAAGATTTAGATTTAATAATAAATTTAACTTTAAAAGTTAAT
ACAATCCTGAAAAGTTTTTTTAAAAATATTCAGCTTCAACTTGTAGATTTCAAGTTGGAGTTTGGCTATAATTCTAAAAA
TAAAATACTTCTAGGGGATGAAATAAGTCCTGATAATTGTAGATTGTGGGATCTAAATCAGAAAAATGATACAATTGTAA
GCCTAGATAAAGACAGATTTAGAAATGATTTAGGTGGTCTAATTGAAGCTTATAGTGAAATAAACCGAAGAATAAACGAT
TTCATTTAA

Upstream 100 bases:

>100_bases
GAATAATCAGTTAAAATGAAATAAACTATAAAAAGTTGATCTCTACTAAATATGTTAATTACAAATCTTAATTTTAGTAA
TCAAATGAGGTCGTAAATTA

Downstream 100 bases:

>100_bases
CTCAATTCAAAAATTAATGCTTCAGATTCCATAATCAAAAAATACTATGCAAAAACATTCTTCAAAATTTAGAAAGGTTT
TCACAAATATTGCTTGTTCT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MNNKYELIYEGKAKKVFSHDDVDKVFIEFKDDATAFNALKKAKFEGKGKLNCLISSRIFELLDKSNIPTHFLELKNENIM
IAQKIKVIPLEIVLRNTAYGSLCKQTTIKSGTILAKPLIDIYLKNDELNDPLITKDRIELMNILSSKDLDLIINLTLKVN
TILKSFFKNIQLQLVDFKLEFGYNSKNKILLGDEISPDNCRLWDLNQKNDTIVSLDKDRFRNDLGGLIEAYSEINRRIND
FI

Sequences:

>Translated_242_residues
MNNKYELIYEGKAKKVFSHDDVDKVFIEFKDDATAFNALKKAKFEGKGKLNCLISSRIFELLDKSNIPTHFLELKNENIM
IAQKIKVIPLEIVLRNTAYGSLCKQTTIKSGTILAKPLIDIYLKNDELNDPLITKDRIELMNILSSKDLDLIINLTLKVN
TILKSFFKNIQLQLVDFKLEFGYNSKNKILLGDEISPDNCRLWDLNQKNDTIVSLDKDRFRNDLGGLIEAYSEINRRIND
FI
>Mature_242_residues
MNNKYELIYEGKAKKVFSHDDVDKVFIEFKDDATAFNALKKAKFEGKGKLNCLISSRIFELLDKSNIPTHFLELKNENIM
IAQKIKVIPLEIVLRNTAYGSLCKQTTIKSGTILAKPLIDIYLKNDELNDPLITKDRIELMNILSSKDLDLIINLTLKVN
TILKSFFKNIQLQLVDFKLEFGYNSKNKILLGDEISPDNCRLWDLNQKNDTIVSLDKDRFRNDLGGLIEAYSEINRRIND
FI

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=224, Percent_Identity=32.1428571428571, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI5453539, Length=224, Percent_Identity=32.1428571428571, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI119220559, Length=222, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788820, Length=239, Percent_Identity=40.5857740585774, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17531275, Length=225, Percent_Identity=32.4444444444444, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24583917, Length=248, Percent_Identity=27.8225806451613, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18860083, Length=225, Percent_Identity=28.8888888888889, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27894; Mature: 27894

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKYELIYEGKAKKVFSHDDVDKVFIEFKDDATAFNALKKAKFEGKGKLNCLISSRIFE
CCCCEEEEEECCCCEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEHHHHHHH
LLDKSNIPTHFLELKNENIMIAQKIKVIPLEIVLRNTAYGSLCKQTTIKSGTILAKPLID
HHCCCCCCHHHEEECCCCEEEEEEEEEEEEEEEEECCCCHHHHHHHHCCCCCEEECCEEE
IYLKNDELNDPLITKDRIELMNILSSKDLDLIINLTLKVNTILKSFFKNIQLQLVDFKLE
EEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHCCEEEEEEEEEE
FGYNSKNKILLGDEISPDNCRLWDLNQKNDTIVSLDKDRFRNDLGGLIEAYSEINRRIND
ECCCCCCEEEECCCCCCCCCEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FI
CC
>Mature Secondary Structure
MNNKYELIYEGKAKKVFSHDDVDKVFIEFKDDATAFNALKKAKFEGKGKLNCLISSRIFE
CCCCEEEEEECCCCEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEHHHHHHH
LLDKSNIPTHFLELKNENIMIAQKIKVIPLEIVLRNTAYGSLCKQTTIKSGTILAKPLID
HHCCCCCCHHHEEECCCCEEEEEEEEEEEEEEEEECCCCHHHHHHHHCCCCCEEECCEEE
IYLKNDELNDPLITKDRIELMNILSSKDLDLIINLTLKVNTILKSFFKNIQLQLVDFKLE
EEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHCCEEEEEEEEEE
FGYNSKNKILLGDEISPDNCRLWDLNQKNDTIVSLDKDRFRNDLGGLIEAYSEINRRIND
ECCCCCCEEEECCCCCCCCCEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]