Click here to switch to the map view.

The map label for this gene is lpxC

Identifier: 78779819

GI number: 78779819

Start: 1346822

End: 1347670

Strand: Reverse

Name: lpxC

Synonym: PMT9312_1435

Alternate gene names: 78779819

Gene position: 1347670-1346822 (Counterclockwise)

Preceding gene: 78779820

Following gene: 78779818

Centisome position: 78.85

GC content: 32.98

Gene sequence:

>849_bases
GTGTTTTCTTGGCCTACTAATTATGATTCTTGCTTCACCTTGGCTGGTGTTATCTCCAGAGAAGGAATAGGCCTTCATAG
TGGAGAAAAAACAAGACTTAAAATATCTTCTTATGAAAAAGAAGGATATTATGTTTCTTTCAGAGATAAACCCAATGAGA
TTTTTAAGCTAACTCAAGATTTAATTGGAAGTTCGATGCTTTGTACGGCGGTTAAATTAGGAGGGAGGAATTTATATACT
ATTGAACATTTATTATCTTCAATGGCTGGTTGTGGGTTAAGTTATATTCATATCGAAGTTGATGGGAGAGAGATCCCGCT
TTTAGATGGATCCGCAATTCAGTGGGTTAGAGCTTTTGAAGAAGTAGGCATAAAGAAGGCACCTAAACCAGATAATTTTT
TTCGAGAAATTAATAAATCAATAATTTTAAATAAAGAAGGCTCAGTTATAGCAGCAACTCCCTCTGAAAAAACTACAATT
ATATCAACAATAAGTTTTTCTTATAAAGTAATTGGAAACCAAACTTTTGTGATTGATTTAAATCCAAAAAGTTTTGTTGA
AATGATTGCTCCAGCAAGAACATTTGGTTTTAAGGATCAATTTCAGGAGTTAAGTGAACTTGGATTAATAAAAGGAGGAA
GTTTAGAAAACGCTCTCGTTTGTGATGGTGATGCATGGGTTAATCCACCGTTAAGATTTAATAATGAACCAATAAGACAT
AAAATTTTAGACCTAATTGGGGACTTGGCTTTGGTAGGGTTACCTAAGGCACAAATTTTAGTTTATAAAGGATCACATTC
TTTAAATGCTTTATTAGCCTCATCGCTAAAAAATCAACCTTATCTTTAA

Upstream 100 bases:

>100_bases
TGGAGTGAAAACGCCTATTGGTCCATTAAGACTAGATATTGCTAGTAAGGACCTAAGTGGAGATTGGAGATATACACTTG
GAGTTGGATGGAAGTTTTAA

Downstream 100 bases:

>100_bases
TTGTTTTGGACAATAAATTATCCAGTGAAAATAATCAACTCTCCTCTGAGAAAATACTAGGTTTGTTACCTCATAGATAT
CCTTTTGCTCTTGTGGATAA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MFSWPTNYDSCFTLAGVISREGIGLHSGEKTRLKISSYEKEGYYVSFRDKPNEIFKLTQDLIGSSMLCTAVKLGGRNLYT
IEHLLSSMAGCGLSYIHIEVDGREIPLLDGSAIQWVRAFEEVGIKKAPKPDNFFREINKSIILNKEGSVIAATPSEKTTI
ISTISFSYKVIGNQTFVIDLNPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDAWVNPPLRFNNEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKNQPYL

Sequences:

>Translated_282_residues
MFSWPTNYDSCFTLAGVISREGIGLHSGEKTRLKISSYEKEGYYVSFRDKPNEIFKLTQDLIGSSMLCTAVKLGGRNLYT
IEHLLSSMAGCGLSYIHIEVDGREIPLLDGSAIQWVRAFEEVGIKKAPKPDNFFREINKSIILNKEGSVIAATPSEKTTI
ISTISFSYKVIGNQTFVIDLNPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDAWVNPPLRFNNEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKNQPYL
>Mature_282_residues
MFSWPTNYDSCFTLAGVISREGIGLHSGEKTRLKISSYEKEGYYVSFRDKPNEIFKLTQDLIGSSMLCTAVKLGGRNLYT
IEHLLSSMAGCGLSYIHIEVDGREIPLLDGSAIQWVRAFEEVGIKKAPKPDNFFREINKSIILNKEGSVIAATPSEKTTI
ISTISFSYKVIGNQTFVIDLNPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDAWVNPPLRFNNEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKNQPYL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=275, Percent_Identity=32.3636363636364, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 31194; Mature: 31194

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSWPTNYDSCFTLAGVISREGIGLHSGEKTRLKISSYEKEGYYVSFRDKPNEIFKLTQD
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHH
LIGSSMLCTAVKLGGRNLYTIEHLLSSMAGCGLSYIHIEVDGREIPLLDGSAIQWVRAFE
HHCCHHHHHHHHHCCCCEEHHHHHHHHHHCCCEEEEEEEECCCEEEEECCHHHHHHHHHH
EVGIKKAPKPDNFFREINKSIILNKEGSVIAATPSEKTTIISTISFSYKVIGNQTFVIDL
HCCCCCCCCCHHHHHHCCCEEEEECCCCEEEECCCCCEEEEEEEEEEEEEECCEEEEEEC
NPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDAWVNPPLRFNNEPIRH
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKNQPYL
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSWPTNYDSCFTLAGVISREGIGLHSGEKTRLKISSYEKEGYYVSFRDKPNEIFKLTQD
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHH
LIGSSMLCTAVKLGGRNLYTIEHLLSSMAGCGLSYIHIEVDGREIPLLDGSAIQWVRAFE
HHCCHHHHHHHHHCCCCEEHHHHHHHHHHCCCEEEEEEEECCCEEEEECCHHHHHHHHHH
EVGIKKAPKPDNFFREINKSIILNKEGSVIAATPSEKTTIISTISFSYKVIGNQTFVIDL
HCCCCCCCCCHHHHHHCCCEEEEECCCCEEEECCCCCEEEEEEEEEEEEEECCEEEEEEC
NPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDAWVNPPLRFNNEPIRH
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKNQPYL
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA