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The map label for this gene is msrAB [H]

Identifier: 78779815

GI number: 78779815

Start: 1343717

End: 1344319

Strand: Reverse

Name: msrAB [H]

Synonym: PMT9312_1431

Alternate gene names: 78779815

Gene position: 1344319-1343717 (Counterclockwise)

Preceding gene: 78779816

Following gene: 78779812

Centisome position: 78.65

GC content: 34.99

Gene sequence:

>603_bases
ATGAAATATTTCTTACCTCTAATAATTGCTCTTTCAATATTTATTAATCCTGTAAACGCTTTTGCAGAGGAATTGATTCT
TGCAGGAGGTTGTTTTTGGTGTTTAGAACATGATTTAGAGTCATTAAAGGGGATAAATTTTGTACAAAGCGGCTATTCAG
GTGGAGATTTACAAAATCCTACCTACGAAAATCATGAAGGACATCAGGAAGTGGTTTTGGTTAATTATGATTCCCAATTG
GTAACTTTACCCGAGATACTTAGGCTCTATTTGAGAAATATTGATCCTCTGGACGGTAAAGGTCAATTTTGTGATCGTGG
AGATTCGTATAGGCCAGTGATATTTTTTAAAGATGCAACTGAGGAAAGTGATGCAACAAATGCAATTGTTTCGGCCTCTA
ATGAGTTGCGAGTGCCATTAGAAAAAATAGCTGTAGAACTAAAATCAAAAGGTCAATTTTGGTTGGCTGAAGAATATCAT
CAGGATTTTGCTGAGAGAAATGAATTAAAATATAAGTTCTATAGATTCTCATGTGGGAGAGATCAGAGGTTGGATAAATT
ATGGGGGAATAACGCTAGATCAACAAATCTTTGGATTGAATGA

Upstream 100 bases:

>100_bases
GGTTACACTCTTTTAAAAAAAGAATTAGGGGAAGAGGGCGTAGTCCAGCGAGCTGCTAAAGAGATTATTAATTCTATTAT
TTGAATTTTATAATAAAAAA

Downstream 100 bases:

>100_bases
TTTTAAAATAGTTATTTATTTTTAATCCATTGAACAAGAGTTTTAACTCCAAAACCGGTTGCACCTGATGGATTAATTCC
CTTATTTTTATCAGTCCAAC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MKYFLPLIIALSIFINPVNAFAEELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNPTYENHEGHQEVVLVNYDSQL
VTLPEILRLYLRNIDPLDGKGQFCDRGDSYRPVIFFKDATEESDATNAIVSASNELRVPLEKIAVELKSKGQFWLAEEYH
QDFAERNELKYKFYRFSCGRDQRLDKLWGNNARSTNLWIE

Sequences:

>Translated_200_residues
MKYFLPLIIALSIFINPVNAFAEELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNPTYENHEGHQEVVLVNYDSQL
VTLPEILRLYLRNIDPLDGKGQFCDRGDSYRPVIFFKDATEESDATNAIVSASNELRVPLEKIAVELKSKGQFWLAEEYH
QDFAERNELKYKFYRFSCGRDQRLDKLWGNNARSTNLWIE
>Mature_200_residues
MKYFLPLIIALSIFINPVNAFAEELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNPTYENHEGHQEVVLVNYDSQL
VTLPEILRLYLRNIDPLDGKGQFCDRGDSYRPVIFFKDATEESDATNAIVSASNELRVPLEKIAVELKSKGQFWLAEEYH
QDFAERNELKYKFYRFSCGRDQRLDKLWGNNARSTNLWIE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=165, Percent_Identity=30.9090909090909, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI6912516, Length=165, Percent_Identity=30.9090909090909, Blast_Score=84, Evalue=9e-17,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=31.8471337579618, Blast_Score=78, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=29.5302013422819, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45553131, Length=134, Percent_Identity=31.3432835820896, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 23037; Mature: 23037

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYFLPLIIALSIFINPVNAFAEELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNP
CCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
TYENHEGHQEVVLVNYDSQLVTLPEILRLYLRNIDPLDGKGQFCDRGDSYRPVIFFKDAT
CCCCCCCCCEEEEEECCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
EESDATNAIVSASNELRVPLEKIAVELKSKGQFWLAEEYHQDFAERNELKYKFYRFSCGR
CCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCC
DQRLDKLWGNNARSTNLWIE
CHHHHHHHCCCCCCCCCEEC
>Mature Secondary Structure
MKYFLPLIIALSIFINPVNAFAEELILAGGCFWCLEHDLESLKGINFVQSGYSGGDLQNP
CCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
TYENHEGHQEVVLVNYDSQLVTLPEILRLYLRNIDPLDGKGQFCDRGDSYRPVIFFKDAT
CCCCCCCCCEEEEEECCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
EESDATNAIVSASNELRVPLEKIAVELKSKGQFWLAEEYHQDFAERNELKYKFYRFSCGR
CCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCC
DQRLDKLWGNNARSTNLWIE
CHHHHHHHCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]