Click here to switch to the map view.

The map label for this gene is rkpK [H]

Identifier: 78779695

GI number: 78779695

Start: 1221700

End: 1223124

Strand: Direct

Name: rkpK [H]

Synonym: PMT9312_1312

Alternate gene names: 78779695

Gene position: 1221700-1223124 (Clockwise)

Preceding gene: 78779694

Following gene: 78779701

Centisome position: 71.48

GC content: 33.12

Gene sequence:

>1425_bases
ATGACATTTGAAATTAAAAATATATGTTGTATTGGAGCAGGATATGTTGGTGGGCCTACAATGTCTGTTTTGGCAGATAA
ATGTCCAGAAATTCAAATTAATGTAGTGGATCTCAATGTATCGAGGATAGAGGAATGGAACTCTGATGATTTATCTAAAT
TACCAATATATGAACCTGGATTAAAAGAAATAGTTAAGAGATGTAGAGGTAAAAACTTGCATTTCACATCTGAAGTTTAT
GAAAACATCTCAATTGCAGATATGATTTTTATTTCTGTTAATACTCCTACTAAGACTAAAGGAATTGGAGCAGGACAAGC
TAGTGATACCAAATGGGTTGAAGCATGTGCCAGAGATGTTGCAAAATTTGCTAAGGGTTATACTATCGTAGTCGAAAAAA
GCACCTTACCTGTTAGAACCGCAGAAGTTATCAAGACAATTCTTGAAGCATCTGAATCATCTAAGGGCAGAAATAATTCA
GAGCCTGTAACTTTTGATGTTTTATCTAACCCAGAATTCCTTGCTGAGGGTACTGCTATCAAGGATCTAGAATTTCCTGA
TAGAGTTTTAATTGGCGGAGACAATCAAAAAGCTATTAATACTTTGAGTGCAATCTATAGAAAATGGGTCCCAAGCAAAA
AAATATTACATACCAATATATGGAGTAGTGAATTAGCTAAATTAACTGCGAACGCTTTTTTAGCTCAACGAATAAGTTCT
ATTAACTCCATAAGTGCTTTATGTGAAGCGACTGGAGCTGATATCAGAGAAGTTTCTAGAGCGATAGGATCTGATAGCAG
AATTGGATCCAAATTTCTAGAATCTGGACCAGGTTTTGGTGGAAGTTGTTTCAAAAAAGATATATTAAATCTAGTATATT
TATCGAACTACTTCGGACTACCTGAAGTTGCAAGATTTTGGGAGGAGGTTGTTAATATTAATATATGGAATCAACATAGA
ATATCACAGTTAGTTGTTAAGAAATTATTTGGAACTGTATCAGGCAAAAAAATATGTATTTTAGGTTTTGCATTTAAACC
AAATACAAACGACACAAGAGAATCATCATCTATACAAATTTGTAAAGATTTGATTGAAGAAGGCGCAGAGCTTTTTATTC
ATGACCCTAAAGTTACCCCTAAACAAATATCAAAAGATTTAGGTATGGAACAATCTAAAAAGGATAAAATTTATAATGGA
GAAGGTAGATGGTTTTTTATAGATGATATTGATTCTGAATTTGTAAATGCAGATGCTGTAGTAATCCTTACTGAATGGGA
TGATTATATGAAAATTAATTGGGCTTCCGCAGCATTTTTGATGAGAAAACCTGCCTGGATTTTTGACGTAAGATCGATAG
TGAATCCAAAAGAAATAATTAAAAATGACTTTAATTTATGGAGGATAGGGGATGGAACTCTTTAA

Upstream 100 bases:

>100_bases
AAAATTAAGAAATTCGTTTTTAAAAGTAAACCTTTTTTGAAAAAAATTATTATGAGTAATATCTTGTTGATAAGATAAGA
CAAATTTGAAATCAAATTTA

Downstream 100 bases:

>100_bases
GAATTTGATATCAAAAAATTCTTGAATAATATATTTTTAAAGTTATGCAGAAGAAAATTATATAATTTTCTAAAAGTAAA
ATTTATTTAAGTGATTAAGA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTFEIKNICCIGAGYVGGPTMSVLADKCPEIQINVVDLNVSRIEEWNSDDLSKLPIYEPGLKEIVKRCRGKNLHFTSEVY
ENISIADMIFISVNTPTKTKGIGAGQASDTKWVEACARDVAKFAKGYTIVVEKSTLPVRTAEVIKTILEASESSKGRNNS
EPVTFDVLSNPEFLAEGTAIKDLEFPDRVLIGGDNQKAINTLSAIYRKWVPSKKILHTNIWSSELAKLTANAFLAQRISS
INSISALCEATGADIREVSRAIGSDSRIGSKFLESGPGFGGSCFKKDILNLVYLSNYFGLPEVARFWEEVVNINIWNQHR
ISQLVVKKLFGTVSGKKICILGFAFKPNTNDTRESSSIQICKDLIEEGAELFIHDPKVTPKQISKDLGMEQSKKDKIYNG
EGRWFFIDDIDSEFVNADAVVILTEWDDYMKINWASAAFLMRKPAWIFDVRSIVNPKEIIKNDFNLWRIGDGTL

Sequences:

>Translated_474_residues
MTFEIKNICCIGAGYVGGPTMSVLADKCPEIQINVVDLNVSRIEEWNSDDLSKLPIYEPGLKEIVKRCRGKNLHFTSEVY
ENISIADMIFISVNTPTKTKGIGAGQASDTKWVEACARDVAKFAKGYTIVVEKSTLPVRTAEVIKTILEASESSKGRNNS
EPVTFDVLSNPEFLAEGTAIKDLEFPDRVLIGGDNQKAINTLSAIYRKWVPSKKILHTNIWSSELAKLTANAFLAQRISS
INSISALCEATGADIREVSRAIGSDSRIGSKFLESGPGFGGSCFKKDILNLVYLSNYFGLPEVARFWEEVVNINIWNQHR
ISQLVVKKLFGTVSGKKICILGFAFKPNTNDTRESSSIQICKDLIEEGAELFIHDPKVTPKQISKDLGMEQSKKDKIYNG
EGRWFFIDDIDSEFVNADAVVILTEWDDYMKINWASAAFLMRKPAWIFDVRSIVNPKEIIKNDFNLWRIGDGTL
>Mature_473_residues
TFEIKNICCIGAGYVGGPTMSVLADKCPEIQINVVDLNVSRIEEWNSDDLSKLPIYEPGLKEIVKRCRGKNLHFTSEVYE
NISIADMIFISVNTPTKTKGIGAGQASDTKWVEACARDVAKFAKGYTIVVEKSTLPVRTAEVIKTILEASESSKGRNNSE
PVTFDVLSNPEFLAEGTAIKDLEFPDRVLIGGDNQKAINTLSAIYRKWVPSKKILHTNIWSSELAKLTANAFLAQRISSI
NSISALCEATGADIREVSRAIGSDSRIGSKFLESGPGFGGSCFKKDILNLVYLSNYFGLPEVARFWEEVVNINIWNQHRI
SQLVVKKLFGTVSGKKICILGFAFKPNTNDTRESSSIQICKDLIEEGAELFIHDPKVTPKQISKDLGMEQSKKDKIYNGE
GRWFFIDDIDSEFVNADAVVILTEWDDYMKINWASAAFLMRKPAWIFDVRSIVNPKEIIKNDFNLWRIGDGTL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=459, Percent_Identity=57.0806100217865, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI296040438, Length=360, Percent_Identity=54.4444444444444, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI296040443, Length=324, Percent_Identity=53.7037037037037, Blast_Score=322, Evalue=4e-88,
Organism=Escherichia coli, GI48994968, Length=446, Percent_Identity=26.457399103139, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788340, Length=397, Percent_Identity=25.9445843828715, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560350, Length=472, Percent_Identity=52.3305084745763, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17136908, Length=467, Percent_Identity=53.5331905781585, Blast_Score=484, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 52849; Mature: 52718

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFEIKNICCIGAGYVGGPTMSVLADKCPEIQINVVDLNVSRIEEWNSDDLSKLPIYEPG
CEEEECCEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEEHHHHHCCCCCCCCCCCCCCCC
LKEIVKRCRGKNLHFTSEVYENISIADMIFISVNTPTKTKGIGAGQASDTKWVEACARDV
HHHHHHHHCCCCCEEHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
AKFAKGYTIVVEKSTLPVRTAEVIKTILEASESSKGRNNSEPVTFDVLSNPEFLAEGTAI
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHCCCCEE
KDLEFPDRVLIGGDNQKAINTLSAIYRKWVPSKKILHTNIWSSELAKLTANAFLAQRISS
ECCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
INSISALCEATGADIREVSRAIGSDSRIGSKFLESGPGFGGSCFKKDILNLVYLSNYFGL
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
PEVARFWEEVVNINIWNQHRISQLVVKKLFGTVSGKKICILGFAFKPNTNDTRESSSIQI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHH
CKDLIEEGAELFIHDPKVTPKQISKDLGMEQSKKDKIYNGEGRWFFIDDIDSEFVNADAV
HHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCCEE
VILTEWDDYMKINWASAAFLMRKPAWIFDVRSIVNPKEIIKNDFNLWRIGDGTL
EEEECCCCCEEEEHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure 
TFEIKNICCIGAGYVGGPTMSVLADKCPEIQINVVDLNVSRIEEWNSDDLSKLPIYEPG
EEEECCEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEEHHHHHCCCCCCCCCCCCCCCC
LKEIVKRCRGKNLHFTSEVYENISIADMIFISVNTPTKTKGIGAGQASDTKWVEACARDV
HHHHHHHHCCCCCEEHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
AKFAKGYTIVVEKSTLPVRTAEVIKTILEASESSKGRNNSEPVTFDVLSNPEFLAEGTAI
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHCCCCEE
KDLEFPDRVLIGGDNQKAINTLSAIYRKWVPSKKILHTNIWSSELAKLTANAFLAQRISS
ECCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
INSISALCEATGADIREVSRAIGSDSRIGSKFLESGPGFGGSCFKKDILNLVYLSNYFGL
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
PEVARFWEEVVNINIWNQHRISQLVVKKLFGTVSGKKICILGFAFKPNTNDTRESSSIQI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHH
CKDLIEEGAELFIHDPKVTPKQISKDLGMEQSKKDKIYNGEGRWFFIDDIDSEFVNADAV
HHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCCEE
VILTEWDDYMKINWASAAFLMRKPAWIFDVRSIVNPKEIIKNDFNLWRIGDGTL
EEEECCCCCEEEEHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]