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The map label for this gene is tcrA [H]

Identifier: 78779507

GI number: 78779507

Start: 1038650

End: 1039387

Strand: Direct

Name: tcrA [H]

Synonym: PMT9312_1124

Alternate gene names: 78779507

Gene position: 1038650-1039387 (Clockwise)

Preceding gene: 78779505

Following gene: 78779512

Centisome position: 60.77

GC content: 44.58

Gene sequence:

>738_bases
ATGCAATCAACTGAGCAAATCTTAGCTTCAACTCCTGGCAGTTCACAATTGCCTGCGAGCTCTCAAACCCCCTCAAGAGT
TCTTGTTGTTGAACCACACCCCACACTTAGAACGGTCCTTGTACAAAGGCTTCGTCAAGATGGCCATCTAGCTGCTGCAG
TCGGATCAGCAGCAGAAGCTGTTGACCTATGTAGAGAACAATCACCTGACCTACTAGTTAGTGCTGAAATCCTTGAGCAG
AACACTGCAATGAGACTTGCCCAACAGTTGGGTTCTTCAGTAATAGTACTAACAGCAAGATCAGGTGTTGAAGCATTAGT
TAATCTATTAGACGAAGGGGCAGATGATGTTCTTAGAAAACCGTTTGGATTAGAAGAGCTTGCAGCAAGATGTAGAACGC
TTTTAAAAAGAGGGAGAATAGGGTTACAAGAAAAAGTTGAGGTTGGGCCTCTAGAAGTTCATCTTCTTTTAAGGCAAGTA
ACTCTTAGTGAGAAGCCTGTAGAATTAAGTCCTAGGGAGTTTGCACTGCTTTGCGCTCTTCTGATGCCGCCAGGCATGGT
TAGAAGTCGTCAAGAGCTCCTAAGGATGGCATGGCCCCCTTTCAGCGGAGGGCCAAGATCTGTAGATACTCAAGTGCTAA
CATTGCGAAGAAAATTAGAGCAAGCAGGCCTGGGAGAAGGTGGTGGAATAACTACTGTTAGACAACAAGGATATCGATTT
AGTATCGACAATATTTAA

Upstream 100 bases:

>100_bases
TCAAATGATGTCATAATTCGATAAGTTCCGATTTTTATTTAGCATTTGTTATACCTTATTAAGGATGATAAAAAATTGCC
TGGTCAAACAGTAATTAAGA

Downstream 100 bases:

>100_bases
TTCAAAAAAGCAAAAAGCTCACCAATAATCATCGTAACCGAGAGTAAAGTCAATAACTTATAAGTCCAAAGAGGGGATAT
ATAAGATAATTCATTAATAG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MQSTEQILASTPGSSQLPASSQTPSRVLVVEPHPTLRTVLVQRLRQDGHLAAAVGSAAEAVDLCREQSPDLLVSAEILEQ
NTAMRLAQQLGSSVIVLTARSGVEALVNLLDEGADDVLRKPFGLEELAARCRTLLKRGRIGLQEKVEVGPLEVHLLLRQV
TLSEKPVELSPREFALLCALLMPPGMVRSRQELLRMAWPPFSGGPRSVDTQVLTLRRKLEQAGLGEGGGITTVRQQGYRF
SIDNI

Sequences:

>Translated_245_residues
MQSTEQILASTPGSSQLPASSQTPSRVLVVEPHPTLRTVLVQRLRQDGHLAAAVGSAAEAVDLCREQSPDLLVSAEILEQ
NTAMRLAQQLGSSVIVLTARSGVEALVNLLDEGADDVLRKPFGLEELAARCRTLLKRGRIGLQEKVEVGPLEVHLLLRQV
TLSEKPVELSPREFALLCALLMPPGMVRSRQELLRMAWPPFSGGPRSVDTQVLTLRRKLEQAGLGEGGGITTVRQQGYRF
SIDNI
>Mature_245_residues
MQSTEQILASTPGSSQLPASSQTPSRVLVVEPHPTLRTVLVQRLRQDGHLAAAVGSAAEAVDLCREQSPDLLVSAEILEQ
NTAMRLAQQLGSSVIVLTARSGVEALVNLLDEGADDVLRKPFGLEELAARCRTLLKRGRIGLQEKVEVGPLEVHLLLRQV
TLSEKPVELSPREFALLCALLMPPGMVRSRQELLRMAWPPFSGGPRSVDTQVLTLRRKLEQAGLGEGGGITTVRQQGYRF
SIDNI

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788394, Length=236, Percent_Identity=29.6610169491525, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.5964125560538, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=33.9366515837104, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=29.9107142857143, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.0175438596491, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790552, Length=147, Percent_Identity=36.0544217687075, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=30.2127659574468, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787229, Length=209, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367329, Length=170, Percent_Identity=34.1176470588235, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26622; Mature: 26622

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTEQILASTPGSSQLPASSQTPSRVLVVEPHPTLRTVLVQRLRQDGHLAAAVGSAAEA
CCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
VDLCREQSPDLLVSAEILEQNTAMRLAQQLGSSVIVLTARSGVEALVNLLDEGADDVLRK
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHC
PFGLEELAARCRTLLKRGRIGLQEKVEVGPLEVHLLLRQVTLSEKPVELSPREFALLCAL
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LMPPGMVRSRQELLRMAWPPFSGGPRSVDTQVLTLRRKLEQAGLGEGGGITTVRQQGYRF
HCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEE
SIDNI
ECCCC
>Mature Secondary Structure
MQSTEQILASTPGSSQLPASSQTPSRVLVVEPHPTLRTVLVQRLRQDGHLAAAVGSAAEA
CCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
VDLCREQSPDLLVSAEILEQNTAMRLAQQLGSSVIVLTARSGVEALVNLLDEGADDVLRK
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHC
PFGLEELAARCRTLLKRGRIGLQEKVEVGPLEVHLLLRQVTLSEKPVELSPREFALLCAL
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LMPPGMVRSRQELLRMAWPPFSGGPRSVDTQVLTLRRKLEQAGLGEGGGITTVRQQGYRF
HCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEE
SIDNI
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]