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The map label for this gene is uppS [H]

Identifier: 78779486

GI number: 78779486

Start: 1016844

End: 1017647

Strand: Direct

Name: uppS [H]

Synonym: PMT9312_1103

Alternate gene names: 78779486

Gene position: 1016844-1017647 (Clockwise)

Preceding gene: 78779485

Following gene: 78779487

Centisome position: 59.49

GC content: 29.35

Gene sequence:

>804_bases
ATGAGTTTAGAGAAAATAATAGACAATAAAAATAATGACTTATCCATTAAAATAGATAAGCAAAAAGTGCCAAAACATGT
AGCAATAATTATGGACGGCAATGGGAGATGGGCGACTAGAAAAGGTTTACCCCGATCATTTGGACATAAACAGGGCGTTA
GTGTATTAAAAAAAATCCTCAAAGCTGCCAAAAATTTAGGTTGTAAGGTAATTACTGTTTATGCTTTTTCAACTGAGAAT
TGGACAAGACCAACAAAAGAAGTTAATTTTCTTATAAATCTATTTAGCGAAGTTTTAAAAAACGAAATTAAAGAGATACA
TGAAGAATCAACAAAAATAAAATTTATTGGAGATTTAACTCCTTTCCCAAAAAATTTAAAAGAAATAATCTCTAGTTCAG
AATCACTTACTAAAAACAACAATAAATTTTTATTCAATGTTTGTGTTAATTACGGCGGTAGACAAGAAATCGTAAAAGTT
GCAAAAGAACTAGCATTAAAATCTTCTTCTGGGGAAATAAAACCAAGTGAAATTAATGAAGAATTATTTAATTCAGAACT
ATTAACTGGAGGGATAAAGGATCCAGAATTACTAATAAGAACTAGTGGCGAAAAAAGGATCAGTAATTTTCTTTTATGGC
AATTAGCATATTCAGAAATTTATATATCTGACGTACTTTGGCCAGAGTTCAATGAGCATGAATTTCTTAAAGCAATAATT
GATTACCAATCAAGAAATAGACGTTTCGGCGGTATAGAATCATTACCAAATGAATCTTTTGAAGATTCTCAATATTCTAT
CTAA

Upstream 100 bases:

>100_bases
TGCTTTGTCCCAAAAGACAAATCCAAGTGATATTATTAGTGATATCAATGAAGAAGAGTCCAATAAATCAGAAATCATTA
CCGCCAAAAAGGATTAACTA

Downstream 100 bases:

>100_bases
TAAAAAATGCCTAATTCGAATAATCAGTTATTAAAAGAAATTAGGTTCGATTGGAATAAAGAGGAGATATTGGAAATACT
TGATATGCCTCTTATTGATT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSLEKIIDNKNNDLSIKIDKQKVPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKILKAAKNLGCKVITVYAFSTEN
WTRPTKEVNFLINLFSEVLKNEIKEIHEESTKIKFIGDLTPFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKV
AKELALKSSSGEIKPSEINEELFNSELLTGGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVLWPEFNEHEFLKAII
DYQSRNRRFGGIESLPNESFEDSQYSI

Sequences:

>Translated_267_residues
MSLEKIIDNKNNDLSIKIDKQKVPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKILKAAKNLGCKVITVYAFSTEN
WTRPTKEVNFLINLFSEVLKNEIKEIHEESTKIKFIGDLTPFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKV
AKELALKSSSGEIKPSEINEELFNSELLTGGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVLWPEFNEHEFLKAII
DYQSRNRRFGGIESLPNESFEDSQYSI
>Mature_266_residues
SLEKIIDNKNNDLSIKIDKQKVPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKILKAAKNLGCKVITVYAFSTENW
TRPTKEVNFLINLFSEVLKNEIKEIHEESTKIKFIGDLTPFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKVA
KELALKSSSGEIKPSEINEELFNSELLTGGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVLWPEFNEHEFLKAIID
YQSRNRRFGGIESLPNESFEDSQYSI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=40.4444444444444, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=40.4444444444444, Blast_Score=174, Evalue=7e-44,
Organism=Escherichia coli, GI1786371, Length=237, Percent_Identity=45.5696202531646, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=38.0530973451327, Blast_Score=158, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=39.0697674418605, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=34.7222222222222, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=36.2445414847162, Blast_Score=154, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30500; Mature: 30369

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEKIIDNKNNDLSIKIDKQKVPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKIL
CCCHHHHCCCCCCEEEEECHHHCCCEEEEEECCCCCEECCCCCCHHCCCHHHHHHHHHHH
KAAKNLGCKVITVYAFSTENWTRPTKEVNFLINLFSEVLKNEIKEIHEESTKIKFIGDLT
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKVAKELALKSSSGEIKPSEINE
CCCHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ELFNSELLTGGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVLWPEFNEHEFLKAII
HHHCHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DYQSRNRRFGGIESLPNESFEDSQYSI
HHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLEKIIDNKNNDLSIKIDKQKVPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKIL
CCHHHHCCCCCCEEEEECHHHCCCEEEEEECCCCCEECCCCCCHHCCCHHHHHHHHHHH
KAAKNLGCKVITVYAFSTENWTRPTKEVNFLINLFSEVLKNEIKEIHEESTKIKFIGDLT
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKVAKELALKSSSGEIKPSEINE
CCCHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ELFNSELLTGGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVLWPEFNEHEFLKAII
HHHCHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DYQSRNRRFGGIESLPNESFEDSQYSI
HHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]