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The map label for this gene is prs [H]

Identifier: 78779474

GI number: 78779474

Start: 1001882

End: 1002877

Strand: Reverse

Name: prs [H]

Synonym: PMT9312_1091

Alternate gene names: 78779474

Gene position: 1002877-1001882 (Counterclockwise)

Preceding gene: 78779476

Following gene: 78779471

Centisome position: 58.68

GC content: 35.74

Gene sequence:

>996_bases
GTGACAAGTTTTATCACGGCGGTGCAGAATAAAGAATCCAATTTTAATCTAACTAATAGTAGATTAAGGTTAGTAAGTGG
AACAACAAATCCTAAATTAGCTGAAGAAATTGCATCATACTTAGGGATTGAAAATGTACCTCTGATATCAAAAAGATTTG
CTGATGGTGAACTTTATGTTCAGATTCAGCAATCTATTAGAGGTTGCGATGTATTCTTAATTCAACCTACATCTGCTCCA
GTAAACGATAGTTTAATGGAACTTATGATAATGGTTGATGCTTGCAAGAGGGCATCTGCAAGACAAATAACGGCCGTAAT
CCCTTATTTTGGATATGCAAGGGCAGATAGAAAGACTTCAGGAAGAGAATCTATAACTGCAAAACTTACTGCTAATTTAC
TAGAGAAGTCAGGAGTCGATAGAGTTCTTGCAATGGATTTGCATTCTGCTCAAATACAAGGTTATTTTGATATACCGTGC
GATCATATTTACGGATCACCTGTATTAATTGATTATTTAGAAAGTTTAAATTTAGAGGAAGTTGTGGTTGTCTCTCCCGA
TGTAGGTGGGGTATCTAGAGCAAGAGCCTTTGCAAAATTAATGAAAGATGCACCTTTGGCTATAATTGATAAAAGGAGAT
CAGCTCATAATATTGCTGAAAGTCTAACGGTTATTGGTGAAGTTAAAGGTAAAACGGCTATTCTCATAGACGATATGATA
GATACTGGAGGCACAATTTGTTCTGGAGCTCATTTATTAAAAAAAGAAGGCGCTAATAGAATATTCGCATGTGCCTCACA
TGCTGTATTTTCTCCTCCTTCTTATGAAAGATTAAGTACTAAGGATTTATTCGAACAAGTTATTGTTACCAATAGCATAC
CTGTTATTGTTAAAGATGATTTCCCGCAGTTAAAAGTCCTTTCTGTCGCAAATATGTTGGGTGAAGCCATTTGGAGAATC
CACGAAGAAAGTTCGGTTAGTTCAATGTTCAGATAA

Upstream 100 bases:

>100_bases
TTGCTTAAGAGTTGTGACTTTTGAACAGATCTAGTGATTATCTTTTGCGAAATTCACATAACCGACTACGATAAAGATAT
AGTTTTATAGTGCTAATTTC

Downstream 100 bases:

>100_bases
TTAACGAAATTATTTTTTACTTTGCTTTACAAGTTGCTTTAAACTTTTTTCATAATCTTTTTTGATATTATTTGGAATGC
TCTCAGGGCAAATTTTAAGA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTSFITAVQNKESNFNLTNSRLRLVSGTTNPKLAEEIASYLGIENVPLISKRFADGELYVQIQQSIRGCDVFLIQPTSAP
VNDSLMELMIMVDACKRASARQITAVIPYFGYARADRKTSGRESITAKLTANLLEKSGVDRVLAMDLHSAQIQGYFDIPC
DHIYGSPVLIDYLESLNLEEVVVVSPDVGGVSRARAFAKLMKDAPLAIIDKRRSAHNIAESLTVIGEVKGKTAILIDDMI
DTGGTICSGAHLLKKEGANRIFACASHAVFSPPSYERLSTKDLFEQVIVTNSIPVIVKDDFPQLKVLSVANMLGEAIWRI
HEESSVSSMFR

Sequences:

>Translated_331_residues
MTSFITAVQNKESNFNLTNSRLRLVSGTTNPKLAEEIASYLGIENVPLISKRFADGELYVQIQQSIRGCDVFLIQPTSAP
VNDSLMELMIMVDACKRASARQITAVIPYFGYARADRKTSGRESITAKLTANLLEKSGVDRVLAMDLHSAQIQGYFDIPC
DHIYGSPVLIDYLESLNLEEVVVVSPDVGGVSRARAFAKLMKDAPLAIIDKRRSAHNIAESLTVIGEVKGKTAILIDDMI
DTGGTICSGAHLLKKEGANRIFACASHAVFSPPSYERLSTKDLFEQVIVTNSIPVIVKDDFPQLKVLSVANMLGEAIWRI
HEESSVSSMFR
>Mature_330_residues
TSFITAVQNKESNFNLTNSRLRLVSGTTNPKLAEEIASYLGIENVPLISKRFADGELYVQIQQSIRGCDVFLIQPTSAPV
NDSLMELMIMVDACKRASARQITAVIPYFGYARADRKTSGRESITAKLTANLLEKSGVDRVLAMDLHSAQIQGYFDIPCD
HIYGSPVLIDYLESLNLEEVVVVSPDVGGVSRARAFAKLMKDAPLAIIDKRRSAHNIAESLTVIGEVKGKTAILIDDMID
TGGTICSGAHLLKKEGANRIFACASHAVFSPPSYERLSTKDLFEQVIVTNSIPVIVKDDFPQLKVLSVANMLGEAIWRIH
EESSVSSMFR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=41.5335463258786, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=41.5335463258786, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=41.4790996784566, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=41.4012738853503, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI4506133, Length=356, Percent_Identity=35.9550561797753, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI194018537, Length=333, Percent_Identity=33.9339339339339, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=28.4722222222222, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=28.4722222222222, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=28.4722222222222, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=28.4722222222222, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=49.8392282958199, Blast_Score=320, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI17554702, Length=331, Percent_Identity=41.0876132930514, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71989924, Length=331, Percent_Identity=41.0876132930514, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=41.9047619047619, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=42.443729903537, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17570245, Length=343, Percent_Identity=30.3206997084548, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319403, Length=328, Percent_Identity=38.4146341463415, Blast_Score=236, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6320946, Length=316, Percent_Identity=40.5063291139241, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=39.4321766561514, Blast_Score=228, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=42.1319796954315, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=117, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355239, Length=326, Percent_Identity=42.3312883435583, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI45551540, Length=349, Percent_Identity=39.541547277937, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24651458, Length=361, Percent_Identity=30.4709141274238, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651456, Length=361, Percent_Identity=30.4709141274238, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI281362873, Length=361, Percent_Identity=30.4709141274238, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651454, Length=361, Percent_Identity=30.4709141274238, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651462, Length=189, Percent_Identity=35.978835978836, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24651464, Length=189, Percent_Identity=35.978835978836, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45552010, Length=189, Percent_Identity=35.978835978836, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36282; Mature: 36151

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFITAVQNKESNFNLTNSRLRLVSGTTNPKLAEEIASYLGIENVPLISKRFADGELYV
CCCHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEEE
QIQQSIRGCDVFLIQPTSAPVNDSLMELMIMVDACKRASARQITAVIPYFGYARADRKTS
EEHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEECCCCCHHCCCCCC
GRESITAKLTANLLEKSGVDRVLAMDLHSAQIQGYFDIPCDHIYGSPVLIDYLESLNLEE
CCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCEEECCCHHHHCCCHHHHHHHHHCCCCE
VVVVSPDVGGVSRARAFAKLMKDAPLAIIDKRRSAHNIAESLTVIGEVKGKTAILIDDMI
EEEECCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHEECCCCEEEEEECHH
DTGGTICSGAHLLKKEGANRIFACASHAVFSPPSYERLSTKDLFEQVIVTNSIPVIVKDD
CCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCHHCCHHHHHHHHHHCCCCCEEECCC
FPQLKVLSVANMLGEAIWRIHEESSVSSMFR
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHCC
>Mature Secondary Structure 
TSFITAVQNKESNFNLTNSRLRLVSGTTNPKLAEEIASYLGIENVPLISKRFADGELYV
CCHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEEE
QIQQSIRGCDVFLIQPTSAPVNDSLMELMIMVDACKRASARQITAVIPYFGYARADRKTS
EEHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEECCCCCHHCCCCCC
GRESITAKLTANLLEKSGVDRVLAMDLHSAQIQGYFDIPCDHIYGSPVLIDYLESLNLEE
CCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCEEECCCHHHHCCCHHHHHHHHHCCCCE
VVVVSPDVGGVSRARAFAKLMKDAPLAIIDKRRSAHNIAESLTVIGEVKGKTAILIDDMI
EEEECCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHEECCCCEEEEEECHH
DTGGTICSGAHLLKKEGANRIFACASHAVFSPPSYERLSTKDLFEQVIVTNSIPVIVKDD
CCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCHHCCHHHHHHHHHHCCCCCEEECCC
FPQLKVLSVANMLGEAIWRIHEESSVSSMFR
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]