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The map label for this gene is ispA [C]

Identifier: 78779464

GI number: 78779464

Start: 991916

End: 992818

Strand: Direct

Name: ispA [C]

Synonym: PMT9312_1081

Alternate gene names: 78779464

Gene position: 991916-992818 (Clockwise)

Preceding gene: 78779463

Following gene: 78779465

Centisome position: 58.03

GC content: 38.21

Gene sequence:

>903_bases
ATGACTGAAGCTATAAGCAACATTTCAGATTTCGAAGAATATCTTAAAAACGCAAAAAAAGTTGTAGAAGAAGCGCTTGA
TTTCTCCCTAGGCCCTGAAAATCCTGAAATACTTAGAGAGTCAATGAGATATTCTCTTTTAGCTGGAGGGAAAAGAATAC
GTCCAATTTTATGTTTAGCCTCTTGTTCGCTGGCAGGAGGAGAACCTTCTTTAGCTGTTCCTACGGCTGTAGCTATAGAA
ATGATTCATACAATGTCTTTAATTCATGATGATTTGCCCGCTATGGACAATGATGACTTAAGAAGAGGTAGGCCAACAAA
CCATAAAGTATATGGAGATGCAATAGCTATTCTCGCAGGCGATGCTTTATTAACTAGAGCCTTTGAAATGGTCTCTTTAA
GAAGTCCAGGAGTTGATCCAACCAGATTATTAAATGTAATTGGTGAACTTTCCTTAGTAGCAGGTGCACCGGGTTTAGTT
GGAGGACAAGTTGTTGATTTAGAATGTGAAGGGAAAGAAGTTGACCTTGAAACCTTAGAGTATATTCATCTTCACAAGAC
TGGGGCTTTATTGAAAGCTTGCGTAAGAACAGGCGCGATGATCGCAGGAGCTAACGAAGAAACATTACAAGCTCTGACAA
CATATGCAGAGGGAATTGGATTAGCCTTCCAAATAATAGATGATATTCTTGATTTAACTTCAAGCAGTGAAAAGCTTGGC
AAAACTGCCGGCAAAGATCTTTTAGCTGACAAAACTACTTACCCTAAATTACTTGGAATGGAGGAGTCAAAGAAAAGAGC
ATTTGATTTAGTAGAAAACGCAAAAAAAGCAATTAAACCTTGGGGGGCAGATGCAAAGTATTTAATATCATTAGCCGACT
TTATTACAAATAGAGACAGGTAA

Upstream 100 bases:

>100_bases
ACTATTTTTAGCTGGCAAAAACAATTTGGCTTATCGTCAACCCTAAATGACCTTTTGCCATAAATCCTAAGATGAAAAAA
ATTATTTTAAAAGGTATAAA

Downstream 100 bases:

>100_bases
ATAGTTTTAATTTATGTCTGAGTTTTTTGCCTTTTTTAATAATTCAGTTCTTTTCTGGAGTTTATTATCCTGTTTACTAG
CTCAATTTTTTAAAATTGTA

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTEAISNISDFEEYLKNAKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIE
MIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPTRLLNVIGELSLVAGAPGLV
GGQVVDLECEGKEVDLETLEYIHLHKTGALLKACVRTGAMIAGANEETLQALTTYAEGIGLAFQIIDDILDLTSSSEKLG
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVENAKKAIKPWGADAKYLISLADFITNRDR

Sequences:

>Translated_300_residues
MTEAISNISDFEEYLKNAKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIE
MIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPTRLLNVIGELSLVAGAPGLV
GGQVVDLECEGKEVDLETLEYIHLHKTGALLKACVRTGAMIAGANEETLQALTTYAEGIGLAFQIIDDILDLTSSSEKLG
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVENAKKAIKPWGADAKYLISLADFITNRDR
>Mature_299_residues
TEAISNISDFEEYLKNAKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIEM
IHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPTRLLNVIGELSLVAGAPGLVG
GQVVDLECEGKEVDLETLEYIHLHKTGALLKACVRTGAMIAGANEETLQALTTYAEGIGLAFQIIDDILDLTSSSEKLGK
TAGKDLLADKTTYPKLLGMEESKKRAFDLVENAKKAIKPWGADAKYLISLADFITNRDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=235, Percent_Identity=28.936170212766, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1786623, Length=302, Percent_Identity=45.364238410596, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1789578, Length=232, Percent_Identity=32.7586206896552, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=190, Percent_Identity=30, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651612, Length=191, Percent_Identity=32.9842931937173, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32396; Mature: 32264

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAISNISDFEEYLKNAKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
SCSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHH
DALLTRAFEMVSLRSPGVDPTRLLNVIGELSLVAGAPGLVGGQVVDLECEGKEVDLETLE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHH
YIHLHKTGALLKACVRTGAMIAGANEETLQALTTYAEGIGLAFQIIDDILDLTSSSEKLG
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVENAKKAIKPWGADAKYLISLADFITNRDR
HHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEAISNISDFEEYLKNAKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLA
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
SCSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHH
DALLTRAFEMVSLRSPGVDPTRLLNVIGELSLVAGAPGLVGGQVVDLECEGKEVDLETLE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHH
YIHLHKTGALLKACVRTGAMIAGANEETLQALTTYAEGIGLAFQIIDDILDLTSSSEKLG
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVENAKKAIKPWGADAKYLISLADFITNRDR
HHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]