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The map label for this gene is yciC [H]

Identifier: 78779427

GI number: 78779427

Start: 957040

End: 958389

Strand: Direct

Name: yciC [H]

Synonym: PMT9312_1044

Alternate gene names: 78779427

Gene position: 957040-958389 (Clockwise)

Preceding gene: 78779426

Following gene: 78779428

Centisome position: 55.99

GC content: 37.33

Gene sequence:

>1350_bases
ATGAGCATCACAGATAAAATTCCCGTAACCATCCTCACTGGATTCTTAGGTTCAGGTAAGACTACTTTGCTTAATAGAAT
TTTAAGTGAAGAGCACGGAAAAAGAATAGCCGTAATTGAGAATGAATACGGTGAAGTAGGTATAGATCAAGGTCTCGTAA
TTAATGCCGATGAAGAAGTGTTTGAGATGTCAAACGGGTGCATTTGTTGTACTGTTCGCGGTGATTTAATAAGAGTCCTT
GGCAACCTTATGAAAAGAAGAGATAAGTTTGACTATGTTTTAGTAGAAACAACAGGATTAGCAGATCCAGGCCCAGTTGC
TCAGACTTTTTTCATGGATGAAGAGATTAGTTCTGAATTTACTCTTGATGGAATTGTGACTTTAGTTGATGCTGCACATA
TTGATCAACAGCTAGGCAGGAGTGACGAAAGTTCAGAACAAGTGGCATTTGCAGATGTTCTTGTCCTTAATAAAACTGAT
TTAGTCTCTGATGATGCACTAGATACTCTTGAATCGAGATTGAGAGATATGAACCGAATGACTCGAATTATTCGAGCCGA
GAATGCCAAAGTACCCATTGAAACAGTCTTAAATCTAAGTGCATTTGATCTTGATCAGATACTTAAACGCAGACCAACAT
TTCTTGAACCAGAATATCCTTTTGAATGGACAGGTGTTTACGATCTTGATGCAGGTAAATATGAATTAATGCTAGAAGAA
GGACCCGATCCAGAAATGTCCCTAGTAGCACTCGTTAACCAAGGTGAGAATGAGGAGGAACTTAAAGATGGTGCTGAATC
CTCCGTAAGACTTTATGCAGAAAAAGCTAATACTTTAGAGCCTGGAAATACTATTCCATATGGAGAACATATAAATCTCA
AATTGGAGGATAAAGGAAATAAATCCTTCATCCTGAACATAGAAAAACCAACAAAAGTTGGTTTGTTTACACAGCACACT
GCTGAAGAATTCAATATGAAAGTCATTAAAAGTGACGAAAATAAAGAGATTCCATTTAATACTGAAAGATTCTGGCAAGC
AGAGCATGAACATGATGATGAAGTTGGCTCAATTGCTATAGAGCGTTTTGGAGATGTTGACCCAGAAAAACTAAATACTT
GGATGGGAAGACTTCTCTCAGAAAAAGGGGTGGATATATTCAGAACTAAAGGGTACATAAGTTACTCAGGGAACCCAAGA
AGAATAGTTTTCCAAGGAGTACACATGTTGTTTACTGCACAACCTGATAAAGAATGGGGTAACGAACCTCGTAGAAATCA
ACTTGTTTTTATCGGTAGAAATCTAAATGAAAAAGAAATGCAAGAAGGCTTTGATAAATGCCTGATATAG

Upstream 100 bases:

>100_bases
AATGGTACAAACTTTCAGATTAAATTTTCCTAATAAAAACGGTTTTCATTTCTTATAATTACTATTATTAAAATATTGTT
TATTTAGTAAAAAGCAGTAA

Downstream 100 bases:

>100_bases
AACCATTTAGCCCAAGAGGCATGTTCCACGAGGGATGGACAGCTGAAGTTAGCGATTATGCCATAGCATGTGGCTGGGCT
CTTAAAGGGAAACAATTTAT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSITDKIPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDDALDTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
GPDPEMSLVALVNQGENEEELKDGAESSVRLYAEKANTLEPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKVGLFTQHT
AEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGYISYSGNPR
RIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI

Sequences:

>Translated_449_residues
MSITDKIPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDDALDTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
GPDPEMSLVALVNQGENEEELKDGAESSVRLYAEKANTLEPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKVGLFTQHT
AEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGYISYSGNPR
RIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI
>Mature_448_residues
SITDKIPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVLG
NLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDL
VSDDALDTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEEG
PDPEMSLVALVNQGENEEELKDGAESSVRLYAEKANTLEPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKVGLFTQHTA
EEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGYISYSGNPRR
IVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=209, Percent_Identity=45.933014354067, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI126722884, Length=209, Percent_Identity=45.933014354067, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI146231952, Length=209, Percent_Identity=45.933014354067, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI148727351, Length=209, Percent_Identity=45.4545454545455, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI223941779, Length=197, Percent_Identity=45.1776649746193, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI223941776, Length=198, Percent_Identity=43.9393939393939, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI119120938, Length=133, Percent_Identity=51.8796992481203, Blast_Score=146, Evalue=4e-35,
Organism=Escherichia coli, GI87082430, Length=215, Percent_Identity=39.5348837209302, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1788499, Length=183, Percent_Identity=30.6010928961749, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=223, Percent_Identity=33.6322869955157, Blast_Score=141, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 50826; Mature: 50695

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITDKIPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCCHHHEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHCCCE
TLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDDALDTLESRLRDMNRM
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
TRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
HHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEECEEEECCCCCEEEEEEC
GPDPEMSLVALVNQGENEEELKDGAESSVRLYAEKANTLEPGNTIPYGEHINLKLEDKGN
CCCCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
KSFILNIEKPTKVGLFTQHTAEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAI
CEEEEEECCCCEECEEECCCHHHCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
ERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGYISYSGNPRRIVFQGVHMLFTAQPDKEWG
HHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCHHHC
NEPRRNQLVFIGRNLNEKEMQEGFDKCLI
CCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SITDKIPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCHHHEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHCCCE
TLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDDALDTLESRLRDMNRM
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
TRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
HHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEECEEEECCCCCEEEEEEC
GPDPEMSLVALVNQGENEEELKDGAESSVRLYAEKANTLEPGNTIPYGEHINLKLEDKGN
CCCCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
KSFILNIEKPTKVGLFTQHTAEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAI
CEEEEEECCCCEECEEECCCHHHCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
ERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGYISYSGNPRRIVFQGVHMLFTAQPDKEWG
HHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCHHHC
NEPRRNQLVFIGRNLNEKEMQEGFDKCLI
CCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]