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The map label for this gene is folP [H]

Identifier: 78779354

GI number: 78779354

Start: 904622

End: 905476

Strand: Reverse

Name: folP [H]

Synonym: PMT9312_0970

Alternate gene names: 78779354

Gene position: 905476-904622 (Counterclockwise)

Preceding gene: 78779355

Following gene: 78779352

Centisome position: 52.98

GC content: 29.12

Gene sequence:

>855_bases
TTGCCAGAATTGCAAATTATCAATAAGCAAAATCCATGGCCAAAAGGCTGGAGACAAAAAACTTCAATTATGGGAGTTAT
TAATTTAACTCCTGATTCATTTAGTGATGGTGGAGATTTAAATTCTATAAATAAAGTTTTAGATCAAGTCAATCATTTTG
TGTGTAATGGTGTGGATGTTATTGATCTTGGTGCCCAGAGTACGAGACCTGGGGCTGAAGAAGTTGGATCTAGTATAGAA
ATAAAAAGATTGATCCCATATCTTAAATTAATAAAATCTGAATATCCAGATGTTTTGATTTCTATTGATACATTTAATTC
TGAGGTAGCTTACGAAACTCTTTTAAATGGTGCTAATTGGATAAATGATGTCACTGGAGGAAGAAGAGATAGAAAAATTC
TGGATGTAGTTTCAAAATTCAAATGCCCATTTGTTATTACCCATAGTCGAGGAAATAGTCAAAATATGAATAAACTTTCC
AAATACAGTAATTTATTGAGTGAAGTTAAAACTTCTCTTGATAGTTTAATAACAATTGCTTTAGAAAGAAATATATCTAA
AAGCAATATAATTGTGGATCCCGGAATTGGTTTTTCAAAGGATATTAATCAAAATTTGAAAATTCTAAAAAACTTAGATG
TATTTAAAAACTTAAATTTACCAATATTAATTGGTGCATCAAGAAAAAGATTTTTAGGAGAAATTTTGGATGAGAAAAAT
CCCAAAGAAAGGGATATTGGAACCCTTGCAATAAGTTGTGTTTGTTCCCACTTTAATATTGATATTGTGAGAGTTCACAA
TGTAAAAATGAATTATCAAATTCTAAAAGTTGCTGATAGGATTTATAGAAAATAA

Upstream 100 bases:

>100_bases
TATGGAGGATCAGTTAAACCTAATAATATTGACGAAATAATGTCGATGAGTGATATAGATGGAGTCTTAGTTGGAGGGGC
TTCATTAGATCCAAATAGTT

Downstream 100 bases:

>100_bases
TAAGATTATTATTCTTTAACACCTTCGATTTTATCCTCTACCTCTTGATATAGTTCTTTCAACTGTTCTATATTTTCGTC
AGAAGTTTCCCAATATCCTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MPELQIINKQNPWPKGWRQKTSIMGVINLTPDSFSDGGDLNSINKVLDQVNHFVCNGVDVIDLGAQSTRPGAEEVGSSIE
IKRLIPYLKLIKSEYPDVLISIDTFNSEVAYETLLNGANWINDVTGGRRDRKILDVVSKFKCPFVITHSRGNSQNMNKLS
KYSNLLSEVKTSLDSLITIALERNISKSNIIVDPGIGFSKDINQNLKILKNLDVFKNLNLPILIGASRKRFLGEILDEKN
PKERDIGTLAISCVCSHFNIDIVRVHNVKMNYQILKVADRIYRK

Sequences:

>Translated_284_residues
MPELQIINKQNPWPKGWRQKTSIMGVINLTPDSFSDGGDLNSINKVLDQVNHFVCNGVDVIDLGAQSTRPGAEEVGSSIE
IKRLIPYLKLIKSEYPDVLISIDTFNSEVAYETLLNGANWINDVTGGRRDRKILDVVSKFKCPFVITHSRGNSQNMNKLS
KYSNLLSEVKTSLDSLITIALERNISKSNIIVDPGIGFSKDINQNLKILKNLDVFKNLNLPILIGASRKRFLGEILDEKN
PKERDIGTLAISCVCSHFNIDIVRVHNVKMNYQILKVADRIYRK
>Mature_283_residues
PELQIINKQNPWPKGWRQKTSIMGVINLTPDSFSDGGDLNSINKVLDQVNHFVCNGVDVIDLGAQSTRPGAEEVGSSIEI
KRLIPYLKLIKSEYPDVLISIDTFNSEVAYETLLNGANWINDVTGGRRDRKILDVVSKFKCPFVITHSRGNSQNMNKLSK
YSNLLSEVKTSLDSLITIALERNISKSNIIVDPGIGFSKDINQNLKILKNLDVFKNLNLPILIGASRKRFLGEILDEKNP
KERDIGTLAISCVCSHFNIDIVRVHNVKMNYQILKVADRIYRK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=257, Percent_Identity=35.408560311284, Blast_Score=176, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=32.1875, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31936; Mature: 31805

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELQIINKQNPWPKGWRQKTSIMGVINLTPDSFSDGGDLNSINKVLDQVNHFVCNGVDV
CCCCEEECCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
IDLGAQSTRPGAEEVGSSIEIKRLIPYLKLIKSEYPDVLISIDTFNSEVAYETLLNGANW
EECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCHHH
INDVTGGRRDRKILDVVSKFKCPFVITHSRGNSQNMNKLSKYSNLLSEVKTSLDSLITIA
HHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LERNISKSNIIVDPGIGFSKDINQNLKILKNLDVFKNLNLPILIGASRKRFLGEILDEKN
HHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCC
PKERDIGTLAISCVCSHFNIDIVRVHNVKMNYQILKVADRIYRK
CCHHHHHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHCC
>Mature Secondary Structure 
PELQIINKQNPWPKGWRQKTSIMGVINLTPDSFSDGGDLNSINKVLDQVNHFVCNGVDV
CCCEEECCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
IDLGAQSTRPGAEEVGSSIEIKRLIPYLKLIKSEYPDVLISIDTFNSEVAYETLLNGANW
EECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCHHH
INDVTGGRRDRKILDVVSKFKCPFVITHSRGNSQNMNKLSKYSNLLSEVKTSLDSLITIA
HHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LERNISKSNIIVDPGIGFSKDINQNLKILKNLDVFKNLNLPILIGASRKRFLGEILDEKN
HHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCC
PKERDIGTLAISCVCSHFNIDIVRVHNVKMNYQILKVADRIYRK
CCHHHHHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]