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The map label for this gene is uvrC

Identifier: 78779302

GI number: 78779302

Start: 850222

End: 852180

Strand: Direct

Name: uvrC

Synonym: PMT9312_0918

Alternate gene names: 78779302

Gene position: 850222-852180 (Clockwise)

Preceding gene: 78779301

Following gene: 78779303

Centisome position: 49.74

GC content: 27.57

Gene sequence:

>1959_bases
ATGAGTAATTCCTCTATCGAAAAAATAGATAACAAATATAATTTTAAAATTGAATATAAATTAATTAATAATAAGGAATT
ATTAAAATCAAGATTATCCGAAATTCCAAAGTCATCTGGTTGTTATCTTTTTAAAGATATTGATAATAACTTACTTTATA
TAGGTAAATCAAAAAAACTACGCAGTAGAGTAAGTAGTTATTTCAATAATTATTCAGATTTAACTCCCCGATTAAGTTTG
ATGGTTCGTCAAATAACTGAAATAGAAATAATAGTCACAGATAGCGAATATGAAGCATTAAATTTAGAGTCAAATTTAAT
TAAAACAAACAAACCATACTTTAATATTCTTTTAAAGGATGATAAGAAATATCCATATCTTTGTATAACTTGGAGTGAGA
AATATCCTCGAATATTTATTACAAGAAGAAGAAGAAATAGAAATAATTTAGATAGATATTATGGACCTTATGTTGATGTC
GGATTATTAAGGAGAACATTGTTTACGATAAAAAAGATATTTCCACTTAGACAAAGACCAAGGCCAGTCTATAAAGATAG
AACTTGTTTGAATTATTCAATAGGAAGATGTCCAGGTGTTTGCCAAGAAGTTATATCATCTGACGATTATAAAAAAATAA
TGCAACAAGTATCTATGATATTTCAGGGAAGAAATGATGACTTAGAAATATTTTTACAAAAAAAAATGCTGCAATTTTCA
AATGATTTAGATTATGAGAATGCAGCAAAAATAAGGGACCAAATTTCAGGTTTAAAATTATTAACTGAATCACAAAAAAT
ATCAATACCAGATTCTTCAATTAATAGAGATATCTTTGGAATAGTTTCAGAAAAAAATGTAGCTAGTATACAAATTTTCC
AAATGAGATCTGGTAAGCTCATTGGGAGAATTGGCTATAGTCAAAAATTAAATAATGAAGATGAAAATCATATTCTACAA
AAGATATTAGAAGAACATTATATGAATGTTGAAGCTGTAGAAATACCATCAGAAATTCTTATTCAATATAACCTTCCAAA
ACAAGCAACCATAGAGGATTGGTTAACGGAGCTAAGAAAAAAGAAAGTAAAAATATTAATCCCAAAAAGAAATAAAAAAC
ATGAAACTGTAGAAATGGTTTTAAAAAATGCGAAATTAGAATTAGATAGAATATTAAATGGGATACAAGATAATGAATCA
TCTATTGAGGATCTTGCCCAAATACTTGAATTAAGCGAACAACCTAAAAGAATTGAAGGTTATGATATAAGCCATATTCA
AGGTAGTGACCCTGTAGCATCACAAGTCGTTTTTATTGATGGGATTCCTTCTAAACAGCATTATAGGAAATATAAAATTA
AAGATCCAAACGTTTTTGTAGGACATAGTGATGATTTTGCTTCGATATATGAAGTAATACATAGAAGGTTTAAAAAATGG
TCAAGATTTAAAAAAAGCGGAGGGGATTTTTCAATATTAAATGATAAAACGAATAGTAAATTAGACAATGAACTTTTATC
AGATTGGCCTGATTTAATAATGATAGATGGAGGAAAAGGACAGTTGAATGCAGCTATTAAAGCATTAAATGAATTAAATC
TTGAGGAAGAAGTAACTATATGTTCATTAGCAAAAAAAAATGAAGAAATATTTATTCCAGGCTTTACTAAGTCTCTTGAC
ACTGATGAAAATCAGAAAGGAGTTCTTCTATTAAGAAGGGTAAGAGATGAAGCACATAGATTTGCATTATCTTTTCATAG
AGACAAAAGATCTAAGAGAATGAATAGATCTCAATTGTCCCAAATCAGTGGATTAGGACCATCAAGAATAAGAGAATTGC
TTGAGTATTTTAAATCAATAGACGCGATAAGAATAGCTAGTAAAGAGGATTTATCAAAAGTTAAAGGACTTGGAAAAAAC
TCAGTAAATGATATATATGAATATTTTAACGAGTTATAA

Upstream 100 bases:

>100_bases
CGTTTTTGTAGGAGAGGTTCAATCTGCTTATCTGAATAATGATGTTGACTCACTAAATTTATCTTCAACTGGCTGGAATT
ATGGAGGGTAATCATTATAA

Downstream 100 bases:

>100_bases
ATATTAATTAATTTTTGAAAAATAGATTTCTTGATCTTGTTAAATATAACTATATTAAAAATATATATTTTTAAATTAAT
CTATTAATTTGGCAGCTGAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSNSSIEKIDNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSL
MVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDV
GLLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMQQVSMIFQGRNDDLEIFLQKKMLQFS
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKLIGRIGYSQKLNNEDENHILQ
KILEEHYMNVEAVEIPSEILIQYNLPKQATIEDWLTELRKKKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNES
SIEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGIPSKQHYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
SRFKKSGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALNELNLEEEVTICSLAKKNEEIFIPGFTKSLD
TDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEYFKSIDAIRIASKEDLSKVKGLGKN
SVNDIYEYFNEL

Sequences:

>Translated_652_residues
MSNSSIEKIDNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSL
MVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDV
GLLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMQQVSMIFQGRNDDLEIFLQKKMLQFS
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKLIGRIGYSQKLNNEDENHILQ
KILEEHYMNVEAVEIPSEILIQYNLPKQATIEDWLTELRKKKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNES
SIEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGIPSKQHYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
SRFKKSGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALNELNLEEEVTICSLAKKNEEIFIPGFTKSLD
TDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEYFKSIDAIRIASKEDLSKVKGLGKN
SVNDIYEYFNEL
>Mature_651_residues
SNSSIEKIDNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSLM
VRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVG
LLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMQQVSMIFQGRNDDLEIFLQKKMLQFSN
DLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKLIGRIGYSQKLNNEDENHILQK
ILEEHYMNVEAVEIPSEILIQYNLPKQATIEDWLTELRKKKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESS
IEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGIPSKQHYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKWS
RFKKSGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALNELNLEEEVTICSLAKKNEEIFIPGFTKSLDT
DENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEYFKSIDAIRIASKEDLSKVKGLGKNS
VNDIYEYFNEL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=633, Percent_Identity=31.2796208530806, Blast_Score=315, Evalue=6e-87,
Organism=Escherichia coli, GI1788037, Length=208, Percent_Identity=29.8076923076923, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_PROM9 (Q31AW7)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397414.1
- ProteinModelPortal:   Q31AW7
- STRING:   Q31AW7
- GeneID:   3765720
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0918
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   PMAR74546:PMT9312_0918-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 75998; Mature: 75867

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSIEKIDNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKL
CCCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RSRVSSYFNNYSDLTPRLSLMVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHCCHHCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVGLLRRTLFTIKKIFPLRQRP
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMQQVSMIFQGRNDDLEIFLQKKMLQFS
CCCCCCCCEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKL
CCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCE
IGRIGYSQKLNNEDENHILQKILEEHYMNVEAVEIPSEILIQYNLPKQATIEDWLTELRK
EEECCCHHHCCCCCHHHHHHHHHHHHCCCCEEEECCHHHEEEECCCCCCCHHHHHHHHHH
KKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESSIEDLAQILELSEQPKRIEG
CCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YDISHIQGSDPVASQVVFIDGIPSKQHYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
CCCCCCCCCCCHHCEEEEEECCCCHHHHCEEECCCCCEEEECCCCHHHHHHHHHHHHHHH
SRFKKSGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALNELNLEEEVTI
HHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHH
CSLAKKNEEIFIPGFTKSLDTDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLS
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QISGLGPSRIRELLEYFKSIDAIRIASKEDLSKVKGLGKNSVNDIYEYFNEL
HHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNSSIEKIDNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKL
CCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RSRVSSYFNNYSDLTPRLSLMVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHCCHHCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVGLLRRTLFTIKKIFPLRQRP
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMQQVSMIFQGRNDDLEIFLQKKMLQFS
CCCCCCCCEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKL
CCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCE
IGRIGYSQKLNNEDENHILQKILEEHYMNVEAVEIPSEILIQYNLPKQATIEDWLTELRK
EEECCCHHHCCCCCHHHHHHHHHHHHCCCCEEEECCHHHEEEECCCCCCCHHHHHHHHHH
KKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESSIEDLAQILELSEQPKRIEG
CCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YDISHIQGSDPVASQVVFIDGIPSKQHYRKYKIKDPNVFVGHSDDFASIYEVIHRRFKKW
CCCCCCCCCCCHHCEEEEEECCCCHHHHCEEECCCCCEEEECCCCHHHHHHHHHHHHHHH
SRFKKSGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALNELNLEEEVTI
HHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHH
CSLAKKNEEIFIPGFTKSLDTDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLS
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QISGLGPSRIRELLEYFKSIDAIRIASKEDLSKVKGLGKNSVNDIYEYFNEL
HHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA